The Use Of Next Generation Sequencing For The Surveillance Of Drug Resistant Tuberculosis

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The Use Of Next Generation Sequencing For The Surveillance Of Drug Resistant Tuberculosis
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Author : World Health Organization
language : en
Publisher: World Health Organization
Release Date : 2023-10-17
The Use Of Next Generation Sequencing For The Surveillance Of Drug Resistant Tuberculosis written by World Health Organization and has been published by World Health Organization this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-17 with Medical categories.
This document provides practical guidance on planning and implementing next-generation sequencing (NGS) technology for the characterization of Mycobacterium tuberculosis complex (MTBC) bacteria. The aim is to detect mutations associated with drug resistance in the context of a surveillance system for tuberculosis (TB). This guide is intended to inform staff of national TB programmes and ministries of health, implementing partners, laboratory managers and technical staff, clinicians, donors, and other stakeholders engaged in the surveillance of drug-resistant TB and TB laboratory strengthening.
Who Operational Handbook On Tuberculosis Module 3
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Author : World Health Organization
language : en
Publisher: World Health Organization
Release Date : 2024-03-15
Who Operational Handbook On Tuberculosis Module 3 written by World Health Organization and has been published by World Health Organization this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-15 with Medical categories.
The “WHO operational handbook on tuberculosis. Module 3: Diagnosis - Rapid diagnostics for tuberculosis detection, third edition” is the latest edition replacing the one issued in 2021. A new class of technologies for drug susceptibility testing is endorsed by WHO and included in this edition: targeted next generation sequencing. The operational handbook aims at facilitating the implementation of the WHO recommendations by the Member States, technical partners, and others involved in managing patients with TB and DR-TB. It provides practical information on existing and new tests recommended by WHO, step-by-step advice on implementing and scale-up testing to achieve local and national impact and lastly, model diagnostic algorithms, which are updated to incorporate the latest recommendations. An overview of budgetary considerations and information sheets on each of the newly recommended tests is provided. The class of targeted next generation sequencing is recommended for the detection of resistance to a number of first- and second-line anti-TB drugs, rather than culture-based phenotypic drug susceptibility testing. The recommendations will open for faster detection of resistance to a range of anti-TB drugs directly from sputum samples.
The Use Of Next Generation Sequencing In Fighting Antimicrobial Resistant Pathogens
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Author : Ibrahim Bitar
language : en
Publisher: Frontiers Media SA
Release Date : 2023-03-07
The Use Of Next Generation Sequencing In Fighting Antimicrobial Resistant Pathogens written by Ibrahim Bitar and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-07 with Science categories.
Application Of Next Generation Sequencing Ngs In Infection Prevention
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Author : Michael Kemp
language : en
Publisher: Frontiers Media SA
Release Date : 2022-07-04
Application Of Next Generation Sequencing Ngs In Infection Prevention written by Michael Kemp and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-04 with Science categories.
Integration Of Ngs In Clinical And Public Health Microbiology Workflows Applications Compliance Quality Considerations
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Author : Varvara K. Kozyreva
language : en
Publisher: Frontiers Media SA
Release Date : 2024-02-05
Integration Of Ngs In Clinical And Public Health Microbiology Workflows Applications Compliance Quality Considerations written by Varvara K. Kozyreva and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-02-05 with Medical categories.
The expansion of NGS implementation in clinical and public health practice accelerated drastically during the SARS-CoV-2 pandemic, where NGS has been playing a vital role in tracking dangerous strains of the virus. NGS applications not only influenced public health decision-making but also have been crossing into the clinical field with individual patients’ results being potentially available to the physicians. Hence, the topic of implementation of NGS methods in clinical and public health microbiology, its challenges and special considerations, is as timely as ever. The use of Next Generation Sequencing (NGS) in clinical and public health microbiology laboratories has been steadily expanding in the past decade. However, this progress has been held back by multiple logistical challenges, like the absence of regulatory compliance framework, lack of clear quality guidelines, the need for standardization and interoperability between laboratories, as well as cost and turn-around-time limitations.
Clinical Tuberculosis
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Author : Lloyd N. Friedman
language : en
Publisher: CRC Press
Release Date : 2020-08-26
Clinical Tuberculosis written by Lloyd N. Friedman and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-26 with Medical categories.
Entirely updated and revised, the 6th edition of Clinical Tuberculosis continues to provide the TB physician with a definitive and erudite account of the latest techniques in diagnosis, treatment and control of TB, including an overview of the latest guidelines from the CDC and WHO. With an increased emphasis on the clinical aspects and treatment, this book will be an invaluable resource to the TB practitioner in public health or clinical practice and an ideal reference to laboratory staff. Key Features Completely updated and reorganized Includes brand new chapters on radiology and an overview of the latest WHO, ATS/CDC/IDSA, ERS, NICE, CTS and IUATLD guidelines Clinically focused to provide up-to-date guidance on diagnosis, treatment and control Edited by three renowned experts in the field of tuberculosis
Integrated Omics Approaches To Infectious Diseases
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Author : Saif Hameed
language : en
Publisher: Springer Nature
Release Date : 2021-07-18
Integrated Omics Approaches To Infectious Diseases written by Saif Hameed and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-18 with Medical categories.
This book examines applications of multi-omics approaches for understanding disease etiology, pathogenesis, host-pathogen interactions. It also analyzes the genetics, immunological and metabolic mechanisms underlying the infections. The book also explores genomics, transcriptomics, translational-omics, and metabolomics approaches to understand the pathogenesis and identify potential drug targets. It reviews the role of epigenetic reprogramming in shaping the host-pathogen interactions and presents bioinformatics application in the identification of drug targets. Further, it examines the potential applications of RNA sequencing and non-coding RNA profiling to identify the pathogenesis. Lastly, it offers the current challenges, technological advances, and prospects of using multi-omics technologies in infectious biology.
Optimized Broth Microdilution Plate Methodology For Drug Susceptibility Testing Of Mycobacterium Tuberculosis Complex
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Author :
language : en
Publisher: World Health Organization
Release Date : 2022-04-12
Optimized Broth Microdilution Plate Methodology For Drug Susceptibility Testing Of Mycobacterium Tuberculosis Complex written by and has been published by World Health Organization this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-12 with Medical categories.
Compendium Of Data And Evidence Related Tools For Use In Tb Planning And Programming
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Author :
language : en
Publisher: World Health Organization
Release Date : 2021-03-31
Compendium Of Data And Evidence Related Tools For Use In Tb Planning And Programming written by and has been published by World Health Organization this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-31 with Medical categories.
Over the past two decades, there has been a considerable increase in the number of tools to generate, analyse and use data and evidence, to support discussion and decision-making by national TB programmes (NTPs). Increasingly, countries are developing more robust national surveillance systems; implementing multiple health surveys; and using data analysis and visualization tools in policy, planning, programming and investment decisions. However, as more data are generated and data analysis tools evolve and increase in number, it can be challenging to understand how, why and when these tools should be implemented. The document summarizes information about the key tools related to data and evidence that are available for use in tuberculosis (TB) planning and programming, and how they can be applied. The tools that are profiled are described in terms of how they fit within the People-centred framework for TB programme planning and prioritization. It can also be used independently to inform decisions taken by NTPs about the implementation of the tools included in this document. Together with the people-centred framework, this compendium aims to enable better use of data and evidence for TB programme planning at both the national and subnational levels. It is designed to help NTPs and their national stakeholders to understand how and when different data and evidence-related tools could be used.
Tuberculous Meningitis
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Author : Jerome Chin
language : en
Publisher: Academic Press
Release Date : 2020-04-16
Tuberculous Meningitis written by Jerome Chin and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-16 with Medical categories.
Tuberculous Meningitis: Manual of Diagnosis and Therapy focuses on the most common and most lethal manifestation of tuberculosis of the central nervous system. It includes up-to-date reviews of the diagnosis, treatment, and management of tuberculous meningitis in adults and children. Extensive guidance is provided for the treatment of drug-sensitive and drug-resistant tuberculosis and tuberculous meningitis. Clinicians and researchers will find the beginning chapters on immunopathology and epidemiology of great use in their efforts to develop new strategies for the diagnosis and treatment of tuberculous meningitis.