Therapeutic Angiogenesis
DOWNLOAD
AUDIOBOOK
Download Therapeutic Angiogenesis PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Therapeutic Angiogenesis book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Therapeutic Angiogenesis
DOWNLOAD
AUDIOBOOK
Author : Yukihito Higashi
language : en
Publisher: Springer
Release Date : 2017-07-11
Therapeutic Angiogenesis written by Yukihito Higashi and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-11 with Medical categories.
The book discusses recent findings and current perspectives on therapeutic angiogenesis. Studies have shown that therapies such as cell implantation and transfer of gene encoding for angiogenic growth factors are effective in improving symptoms in patients with critical limb ischemia, who previously had no treatment option other than amputation. The book discusses these therapies and presents data collected in clinical studies over the past decade. Despite significant advances in therapeutic angiogenesis since the first clinical studies in the early 21st century, it has been largely ignored in the literature. This comprehensive book fills that gap, making it a valuable resource for both researchers and practitioners alike.
Therapeutic Angiogenesis
DOWNLOAD
AUDIOBOOK
Author : J.A. Dormandy
language : en
Publisher: Springer
Release Date : 1999-09
Therapeutic Angiogenesis written by J.A. Dormandy and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-09 with Medical categories.
Over the past decade, rapid progress had been made in elucidating the cellular and molecular mechanisms of new blood vessel formation in both health and disease. Lack of sufficient angiogenesis (new capillary development) and collateral formation (remodeling of existing blood vessels) in adult tissues (e. g. , heart, brain, skeletal muscle) during criti cal ischemia has prompted novel therapeutic strategies to stimulate/fa cilitate angiogenesis and collateral formation in ischemic conditions ("therapeutic angiogenesis"). Therapeutic angiogenesis describes a strategy of inducing new col lateral vessels that can bypass vascular obstructions caused by atherosclerotic disease and stimulating new capillaries that can en hance tissue oxygen exchange. Naturally occurring growth factors (e. g. , FGFs, VEGFs) have been identified and demonstrated to induce new blood vessel formation in the adult organism. The therapeutic ap plication of these growth factors has been demonstrated to enhance these natural processes and have been shown in a number of animal models to increase blood flow and oxygen exchange to ischemic tis sues. Therapeutic angiogenesis therefore represents a new medical principle that is anticipated to be used as an adjunct or alternative to angioplasty and/or bypass surgery. A number of strategies have been proposed and tested to deliver growth factors. One strategy is the direct administration of the growth factor protein by intramuscular, intraarte rial or intravenous delivery.
Angiogenesis And Direct Myocardial Revascularization
DOWNLOAD
AUDIOBOOK
Author : Roger J. Laham
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-11-05
Angiogenesis And Direct Myocardial Revascularization written by Roger J. Laham and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-05 with Medical categories.
An interdisciplinary panel of pioneers and opinion leaders review the basic, preclinical, clinical, and developmental pathways to new treatment strategies, such as therapeutic angiogenesis and myogenesis. The authors take advantage of new biological understanding, novel therapeutic targets, multiple available and well-studied therapeutic strategies, and the necessary imaging techniques to measure outcomes. Their in-depth discussions cover the identification of new therapeutic targets and pathways, the investigation of transcriptional factors, master switch molecules, cell-based approaches, chemokines, a better understanding of the effects of aging, endothelial dysfunction, and hypercholesterolemia in response to angiogenic stimuli. Highlights include examination of drug delivery problems, outcomes measure, stem therapy, high-risk interventions, development pathways, and future possibilities.
Therapeutic Angiogenesis For Vascular Diseases
DOWNLOAD
AUDIOBOOK
Author : Mark Slevin
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-10-11
Therapeutic Angiogenesis For Vascular Diseases written by Mark Slevin and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-11 with Medical categories.
Angiogenesis is the growth of new blood vessels and is a key process which occurs during pathological disease progression. Excessive and damaging angiogenesis occurs in diseases such as cancer, diabetic retinopathies, age-related macular degeneration and atherosclerosis. In other diseases such as stroke and myocardial infarction, insufficient or improper angiogenesis results in tissue loss and ultimately higher morbidity and mortality. In this book we will begin by providing the reader with an overview of the process of angiogenesis including normal embryological development of blood vessels. The following chapters will each focus on a key angiogenic disease incorporating current scientific knowledge concerning the causes of activation of the “angiogenic switch”, pathological consequences, current treatment options and future perspectives. Where appropriate, results from pre-clinical trials, novel imaging modalities and nanotechnological approaches will be incorporated into these sections. Finally, since it is now believed that the process of angiogenesis operated via different signalling mechanisms in different vascular beds, we will discuss our current understanding of this phenomenon. The target audience for this book would include researchers in all the basic sciences; post-graduate students at Universities and Institutes; pharmaceutical industries; clinicians working in vascular biology or tissue imaging; pathologists; neurologists; tumour biologists; ophthalmologists and cardiologists.
Biochemical Basis And Therapeutic Implications Of Angiogenesis
DOWNLOAD
AUDIOBOOK
Author : Jawahar L. Mehta
language : en
Publisher: Springer
Release Date : 2017-08-28
Biochemical Basis And Therapeutic Implications Of Angiogenesis written by Jawahar L. Mehta and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-28 with Medical categories.
This book covers the latest developments in the therapeutic implications of angiogenesis, ranging from angiogenesis in the brain, angiogenesis in cancer, angiogenesis’ role in atherosclerosis and heart disease as well as metabolic disorders and peripheral vascular disease. The book is comprehensive in its coverage of angiogenesis in a diverse set of diseases and examines the role of cellular and subcellular structures during the development of angiogenesis. Well-organized and thorough, this is an ideal book for researchers and biomedical engineers working in the field of therapeutic implications of angiogenesis. This book also: Covers the basics of the physiology of angiogenesis, including VEGF pathways in angiogenesis, integr ins in angiogenesis, angiogenesis and exercise physiology, and more Details the role of angiogenesis in atherosclerosis and heart disease, including vascular endothelial growth factor and atherosclerotic plaque progression as well as angiogenesis and heart failure Illustrates in detail brain angiogenesis after stroke and the relationship between angiogenesis and Alzheimer's disease
Arteriogenesis And Therapeutic Angiogenesis
DOWNLOAD
AUDIOBOOK
Author : Paul Quax
language : en
Publisher:
Release Date : 2022
Arteriogenesis And Therapeutic Angiogenesis written by Paul Quax and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with categories.
Although advances in therapeutic interventions improved outcomes, vascular occlusive diseases are still challenging not only afflicted but also attending physicians, requiring novel therapeutic strategies. Arteriogenesis, sometimes also called therapeutic angiogenesis, refers to the body's own capacity to create a natural bypass around a narrowing or occluded arterial vessel. This book gives an insight into current knowledge and advances in vascular sciences and future prospects of therapeutic options. The utility and relevance of circulating biomarkers together with the potential of machine learning methods are discussed as well as the challenges and prospects of novel therapies such as protein- gene-, and stem cell therapy along with multicistronic multigene vectors and the use of microRNAs, exosomes, and secretomes. Vascular smooth muscle phenotype switch as a target to promote arteriogenesis is critically addressed, highlighting the problem of promoting atherosclerosis in parallel. Two articles even deal with cold-inducible RNA-binding protein CIRP/CIRPB presenting it as promising target to promote vascularization concomitant the reduction in ischemic tissue damage. BMPR kinase inhibition is introduced to improve tissue repair in a hereditary form of vascular disorder, and the role of the AP-1 transcription factor JunB in blood vessel formation is described. Some more experimental oriented articles deal with the relevance of choosing the appropriate mouse strain for investigations as well as in vitro Matrigel plug assay as a potent method to investigate angiogenesis. Last but not least, two-photon intravital microscopy is presented as suitable tool to assess plaque angiogenesis in atherosclerotic lesions.
Arteriogenesis And Therapeutic Angiogenesis
DOWNLOAD
AUDIOBOOK
Author : Paul Quax
language : en
Publisher: Mdpi AG
Release Date : 2022-01-13
Arteriogenesis And Therapeutic Angiogenesis written by Paul Quax and has been published by Mdpi AG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-13 with Medical categories.
Although advances in therapeutic interventions improved outcomes, vascular occlusive diseases are still challenging not only afflicted but also attending physicians, requiring novel therapeutic strategies. Arteriogenesis, sometimes also called therapeutic angiogenesis, refers to the body's own capacity to create a natural bypass around a narrowing or occluded arterial vessel. This book gives an insight into current knowledge and advances in vascular sciences and future prospects of therapeutic options. The utility and relevance of circulating biomarkers together with the potential of machine learning methods are discussed as well as the challenges and prospects of novel therapies such as protein- gene-, and stem cell therapy along with multicistronic multigene vectors and the use of microRNAs, exosomes, and secretomes. Vascular smooth muscle phenotype switch as a target to promote arteriogenesis is critically addressed, highlighting the problem of promoting atherosclerosis in parallel. Two articles even deal with cold-inducible RNA-binding protein CIRP/CIRPB presenting it as promising target to promote vascularization concomitant the reduction in ischemic tissue damage. BMPR kinase inhibition is introduced to improve tissue repair in a hereditary form of vascular disorder, and the role of the AP-1 transcription factor JunB in blood vessel formation is described. Some more experimental oriented articles deal with the relevance of choosing the appropriate mouse strain for investigations as well as in vitro Matrigel plug assay as a potent method to investigate angiogenesis. Last but not least, two-photon intravital microscopy is presented as suitable tool to assess plaque angiogenesis in atherosclerotic lesions.
Arteriogenesis And Therapeutic Neovascularization
DOWNLOAD
AUDIOBOOK
Author : Elisabeth Deindl
language : en
Publisher: MDPI
Release Date : 2020-11-04
Arteriogenesis And Therapeutic Neovascularization written by Elisabeth Deindl and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-04 with Medical categories.
For many years, arteriogenesis, also called collateral formation, has been regarded as being a beneficial process to restore blood flow to distal tissues in occluded arteries. Therefore, it is frequently referred to in relation to therapeutic angiogenesis. Despite the big clinical potential and the many promising clinical trials on arteriogenesis and therapeutic angiogenesis, the exact molecular mechanisms involved in the multifactorial processes of arteriogenesis are still not completely understood. A better understanding is needed in order to define successful clinical therapies. In this Special Issue, multiple aspects of arteriogenesis and therapeutic angiogenesis will be addressed, ranging from the role of inflammatory processes and immune cells, to growth factors, microRNAs and environmental factors like hypoxia. Therapeutic angiogenesis will also be discussed in relation to the atherosclerosis and intraplaque angiogenesis in hypoxic lesions, as well as specific forms of arteriogenesis in relation to spinal cord blood supply and aorta surgery. The effects of exercise, a frequently prescribed therapy for PAD patients, on arteriogenesis are also discussed. Overall, the papers in this Special Issue on arteriogenesis and therapeutic angiogenesis provide important new insights in the underlying pathophysiological mechanism of these complex processes and may be helpful to define a successful future intervention directed at therapeutic angiogenesis.
Modern Concepts In Angiogenesis
DOWNLOAD
AUDIOBOOK
Author : Michael Simons
language : en
Publisher: World Scientific
Release Date : 2007-07-26
Modern Concepts In Angiogenesis written by Michael Simons and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-07-26 with Medical categories.
This volume addresses current emerging concepts in the field of angiogenesis, including important angiogenesis modifiers which are essential in combination with growth factors (VEGF and FGF) for the physiological process and also for therapeutic applications. It covers many of the lesser discussed areas including blood vessel growth guidance (interactions with CNS) as well as emerging practical applications of these concepts.The book comprises in-depth reviews by leading experts in several major areas: recent basic science discoveries about angiogenesis modifiers (semaphorins, ephrins and nitric oxide, for which the Nobel Prize was awarded); arterial guidance; clinical applications of new angiogenic factors (HGF, HIF and eNOS); and basic and clinical advancement of anti-angiogenic molecules for the treatment of cancer and macular degeneration (tyrosine kinase inhibitors and NO).These topics, especially their unique combination presented in this volume, are not found in any other current books on angiogenesis. This makes the book a must-read for readers both interested and actively involved in the most recent advances in basic principles and clinical applications of angiogenesis./a
Therapeutic Angiogenesis For Vascular Diseases
DOWNLOAD
AUDIOBOOK
Author :
language : en
Publisher: Springer
Release Date : 2011-07-11
Therapeutic Angiogenesis For Vascular Diseases written by and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-07-11 with categories.
