Therapeutic Potential Of Innate And Innate Like Effector Lymphocytes In Autoimmune And Inflammatory Diseases

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Therapeutic Potential Of Innate And Innate Like Effector Lymphocytes In Autoimmune And Inflammatory Diseases

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Author :
language : en
Publisher: Frontiers Media SA
Release Date : 2023-11-22

Therapeutic Potential Of Innate And Innate Like Effector Lymphocytes In Autoimmune And Inflammatory Diseases written by and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-22 with Medical categories.

Kelley S Textbook Of Rheumatology

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Author : Gary S. Firestein
language : en
Publisher: Elsevier Health Sciences
Release Date : 2013

Kelley S Textbook Of Rheumatology written by Gary S. Firestein and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Medical categories.

Helps you to better understand scientific underpinnings of rheumatic diseases, so that you can better manage your patients.

Community Series In The Role Of Cd1 And Mr1 Restricted T Cells In Immunity And Disease Volume Ii

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Author : Luc Van Kaer
language : en
Publisher: Frontiers Media SA
Release Date : 2024-09-26

Community Series In The Role Of Cd1 And Mr1 Restricted T Cells In Immunity And Disease Volume Ii written by Luc Van Kaer and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-09-26 with Medical categories.

This is the second volume in the series, the Role of CD1- and MR1-restricted T cells in Immunity and Disease. Please see volume I here. CD1 and MR1 are major histocompatibility complex (MHC) class I-related proteins that bind and present non-peptide antigens to subsets of T cells with specialized functions. CD1 proteins typically present lipid antigens to CD1-restricted T cells, whereas MR1 presents vitamin B-based ligands and a variety of drugs and drug-like molecules to MR1-restricted T cells. The CD1 family of antigen-presenting molecules has been divided into two groups: Group 1 contains CD1a, CD1b, and CD1c, and Group 2 contains CD1d. Additionally, CD1e is expressed intracellularly and is involved in the loading of lipid antigens onto Group 1 CD1 proteins. Humans express both Groups 1 and 2 CD1 proteins, whereas mice only express CD1d. Group 1 CD1 proteins present lipid antigens to T cells that generally express diverse T cell receptors (TCRs) and exhibit adaptive-like functions, whereas CD1d presents lipid antigens to subsets of T cells that express either diverse or highly restricted TCRs and exhibit innate-like functions. CD1d-restricted T cells are called natural killer T (NKT) cells, which include Type I or invariant NKT (iNKT) cells expressing semi-invariant TCRs, and Type II NKT cells expressing more diverse TCRs. CD1-restricted T cells have been implicated in a wide variety of diseases, including cancer, infections, and autoimmune, inflammatory, and metabolic diseases. Additionally, NKT cells have been targeted for immunotherapy of disease with ligands such as ‎α or α-galactosylceramide for iNKT cells, or sulfatide for Type II NKT cells.

Jak Inhibition In Autoimmune And Inflammatory Diseases

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Author : Jean-Baptiste Telliez
language : en
Publisher: Frontiers Media SA
Release Date : 2023-02-02

Jak Inhibition In Autoimmune And Inflammatory Diseases written by Jean-Baptiste Telliez and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-02-02 with Medical categories.

Role Of Inflammation In Neurodegenerative Diseases

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Author : Maya Koronyo-Hamaoui
language : en
Publisher: Frontiers Media SA
Release Date : 2022-07-13

Role Of Inflammation In Neurodegenerative Diseases written by Maya Koronyo-Hamaoui and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-13 with Medical categories.

The Role Of Inhibitory Receptors In Inflammation And Cancer

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Author : Ali A. Zarrin
language : en
Publisher: Frontiers Media SA
Release Date : 2021-02-09

The Role Of Inhibitory Receptors In Inflammation And Cancer written by Ali A. Zarrin and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-09 with Medical categories.

Topic Editor Dr. Monteiro is the co-founder of Inatherys. Topic Editor Dr. Zarrin declares no conflict of interest with regard to the Research Topic theme.

Imaging And Mechanism Of Leukocyte Recruitment And Function In Inflammation And Infections

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Author : Zhichao Fan
language : en
Publisher: Frontiers Media SA
Release Date : 2021-07-05

Imaging And Mechanism Of Leukocyte Recruitment And Function In Inflammation And Infections written by Zhichao Fan and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-05 with Science categories.

National Institute Of Allergy And Infectious Diseases Nih

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Author : Vassil St. Georgiev
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-07-29

National Institute Of Allergy And Infectious Diseases Nih written by Vassil St. Georgiev and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-07-29 with Medical categories.

National Institute of Allergy and Infectious Diseases, NIH: Volume III: Intramural Research contains a broad overview of the research activity of the NIAID intramural scientists working in the Division of Intramural Research (DIR) and the Vaccine Research Center (VRC), both in the Bethesda campus, and the Rocky Mountains Research Laboratories. Each of these laboratories employs scientists internationally recognized as leaders in their fields of biomedical research. This volume focuses on individual research contributions by internationally known scientists doing research in the NIAID laboratories.

Lymphocytes In Ms And Eae More Than Just A Cd4 World

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Author : Manu Rangachari
language : en
Publisher: Frontiers Media SA
Release Date : 2017-10-10

Lymphocytes In Ms And Eae More Than Just A Cd4 World written by Manu Rangachari and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-10 with categories.

Multiple sclerosis is degenerative disease of the central nervous system (CNS) in which myelin destruction and axon loss leads to the accumulation of physical, cognitive, and mental deficits. MS affects more than a million people worldwide and managing this chronic disease presents a significant health challenge. Multiple lines of evidence indicate that MS is an autoimmune disorder in which immune cells launch an inflammatory attack targeting myelin antigens. Indeed, myelin-reactive T cells and antibodies have been identified in MS patients and in animal models (namely experimental autoimmune encephalomyelitis, or EAE) that recapitulate many features of human disease. Animal model studies have demonstrated that T cells are both necessary and sufficient to initiate and sustain CNS autoimmunity. However, most MS animal models rely on the role played by CD4+ T cells and partially replicate the multiple aspects of MS pathogenesis. Thus, research in the past has focused heavily on the contribution of CD4+ T cells to the disease process; searching PubMed for “MS AND CD4” yields twice the results as corresponding searches for “CD8” or “B cell” and four times that for “NK cells”. While CD4+ T cells may represent the minimum requirement to mediate CNS autoimmunity, it is clear that the immune response underlying human MS is far more complex and involves numerous other immune cells and subsets. This is well illustrated by the observation that MS patients treated with an anti-CD4 depleting antibody did not gain any clinical benefits whereas removal of several lymphocyte subsets using an anti-CD52 depleting antibody has been shown to impede disease progression. In particular, the pathogenic role(s) of non-CD4+ T cell lymphocytes is relatively poorly understood and under-researched, despite evidence that these subsets contribute to disease pathology or regulation. For example, the observed oligoclonal expansion of CD8+ T cells within the CNS compartment supports a local activation. CD8+ T cells with polarized cytolytic granules are seen in close proximity to oligodendrocytes and demyelinated axons in MS tissues. The presence of B cells in inflammatory lesions and antibodies in the CSF have long been recognized as features of MS and Rituximab, a B cell depleting therapy, has been shown to be highly effective to treat MS. Intriguingly, the putative MS therapeutic reagent Daclizumab may function in part through the expansion of a subset of immunoregulatory NK cells. NKT and γδ T cells may also play a role in CNS autoimmunity, given that they respond to lipid antigens and that myelin is lipid-rich. While different animal models recapitulate some of these aspects of human disease, identifying appropriate models and measures to investigate the role of these less well-understood lymphocytes in MS remains a challenge for the field. This Frontiers research topic aims to create a platform for both animal- and human-focused researchers to share their original data, hypotheses, future perspectives and commentaries regarding the role of these less-well understood lymphocyte subsets (CD8+ T cells, B cells, NK cells, NK T cells, γδ T cells) in the pathogenesis of CNS autoimmunity.

Inflammatory Immune Disease Molecular Mechanisms Translational Approaches And Therapeutics

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Author : Tao Xu
language : en
Publisher: Frontiers Media SA
Release Date : 2022-07-05

Inflammatory Immune Disease Molecular Mechanisms Translational Approaches And Therapeutics written by Tao Xu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-05 with Science categories.