Thermodynamic Theory Of Site Specific Binding Processes In Biological Macromolecules
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Handbook Of Thermal Analysis And Calorimetry
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Author : Richard B. Kemp
language : en
Publisher: Elsevier
Release Date : 1999-12-13
Handbook Of Thermal Analysis And Calorimetry written by Richard B. Kemp and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-12-13 with Science categories.
The applications and interest in thermal analysis and calorimetry have grown enormously during the last half of the 20th century. These techniques have become indispensable in the study of processes such as catalysis, hazards evaluation etc., and in measuring important physical properties quickly, conveniently and with markedly improved accuracy. Consequently, thermal analysis and calorimetry have grown in stature and more scientists and engineers have become at least part-time, practitioners. People new to the field therefore need a source of information describing the basic principles and current state of the art. The last volume of this 4 volume handbook, devoted to many aspects of biological thermal analysis and calorimetry, completes a comprehensive review of this important area. All chapters have been prepared by recognized experts in their respective fields. The approach taken is "how and what to do and when to do it". The complete work is a valuable addition to the already existing literature.
Thermodynamic Theory Of Site Specific Binding Processes In Biological Macromolecules
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Author : Enrico Di Cera
language : en
Publisher: Cambridge University Press
Release Date : 2005-02-17
Thermodynamic Theory Of Site Specific Binding Processes In Biological Macromolecules written by Enrico Di Cera and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-02-17 with Science categories.
This book provides the first systematic treatment of the thermodynamic theory of site-specific effects in biological macromolecules. It describes the phenomenological and conceptual bases required to allow a mechanistic understanding of these effects from analysis of experimental data. The thermodynamic theory also results in novel experimental strategies that enable the derivation of information on local, site-specific properties of a macromolecular system from analysis of perturbed global properties. The treatment focuses on binding phenomena, but is amenable to extension both conceptually and formally to the analysis of other cooperative processes, such as folding and helix-coil transitions. This book will interest any scientist involved in structure-function studies of biological macromolecules, or as a text for graduate students in biochemistry and biophysics.
Energetics Of Biological Macromolecules Part D
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Author : Jo M. Holt
language : en
Publisher: Elsevier
Release Date : 2004-04-02
Energetics Of Biological Macromolecules Part D written by Jo M. Holt and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-04-02 with Science categories.
This volume focuses on the cooperative binding aspects of energetics in biological macromolecules. Methodologies such as NMR, small-angle scattering techniques for analysis, calorimetric analysis, fluorescence quenching, and time resolved FRET measurements are discussed.*Methods for Evaluating Cooperativity in a Dimeric Hemoglobin*Multiple-Binding of Ligands to a Linear Biopolymer*Fluorescence Quenching Methods to Study Protein-Nucleic Acid Interactions*Linked Equilibria in Biotin Repressor Function: Thermodynamic, Structural and Kinetic Analysis
Thermodynamic Theory Of Site Specific Binding Processes In Biological Macromolecules
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Author : Enrico Di Cera
language : en
Publisher: Cambridge University Press
Release Date : 1995-11-23
Thermodynamic Theory Of Site Specific Binding Processes In Biological Macromolecules written by Enrico Di Cera and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-11-23 with Medical categories.
Monograph on important subject in biochemistry and biophysics.
Classical And Geometrical Theory Of Chemical And Phase Thermodynamics
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Author : Frank Weinhold
language : en
Publisher: John Wiley & Sons
Release Date : 2009-02-17
Classical And Geometrical Theory Of Chemical And Phase Thermodynamics written by Frank Weinhold and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-02-17 with Science categories.
Because it is grounded in math, chemical thermodynamics is often perceived as a difficult subject and many students are never fully comfortable with it. The first authoritative textbook presentation of equilibrium chemical and phase thermodynamics in a reformulated geometrical framework, Chemical and Phase Thermodynamics shows how this famously difficult subject can be accurately expressed with only elementary high-school geometry concepts. Featuring numerous suggestions for research-level extensions, this simplified alternative to standard calculus-based thermodynamics expositions is perfect for undergraduate and beginning graduate students as well as researchers.
Biomolecular Thermodynamics
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Author : Douglas Barrick
language : en
Publisher: CRC Press
Release Date : 2017-09-11
Biomolecular Thermodynamics written by Douglas Barrick and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-11 with Medical categories.
"an impressive text that addresses a glaring gap in the teaching of physical chemistry, being specifically focused on biologically-relevant systems along with a practical focus.... the ample problems and tutorials throughout are much appreciated." –Tobin R. Sosnick, Professor and Chair of Biochemistry and Molecular Biology, University of Chicago "Presents both the concepts and equations associated with statistical thermodynamics in a unique way that is at visual, intuitive, and rigorous. This approach will greatly benefit students at all levels." –Vijay S. Pande, Henry Dreyfus Professor of Chemistry, Stanford University "a masterful tour de force.... Barrick's rigor and scholarship come through in every chapter." –Rohit V. Pappu, Edwin H. Murty Professor of Engineering, Washington University in St. Louis This book provides a comprehensive, contemporary introduction to developing a quantitative understanding of how biological macromolecules behave using classical and statistical thermodynamics. The author focuses on practical skills needed to apply the underlying equations in real life examples. The text develops mechanistic models, showing how they connect to thermodynamic observables, presenting simulations of thermodynamic behavior, and analyzing experimental data. The reader is presented with plenty of exercises and problems to facilitate hands-on learning through mathematical simulation. Douglas E. Barrick is a professor in the Department of Biophysics at Johns Hopkins University. He earned his Ph.D. in biochemistry from Stanford University, and a Ph.D. in biophysics and structural biology from the University of Oregon.
Recognition Of Carbohydrates In Biological Systems Part A General Procedures
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Author : Y. C. Lee
language : en
Publisher: Elsevier
Release Date : 2003-09-15
Recognition Of Carbohydrates In Biological Systems Part A General Procedures written by Y. C. Lee and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-09-15 with Science categories.
Recognition of carbohydrates in biological systems has been gaining more and more attention in recent years. Although methodology for studying recognition has been developing, there is no volume that covers the wide area of methodology of carbohydrate recognition. This volume, Recognition of Carbohydrates in Biological Systems, Part A: General Procedures, and its companion, Volume 363, present state-of-the-art methodologies, as well as the most recent biological observations in this area. Covers the isolation/synthesis of substances used in studying interactions involving carbohydrates Discussed the methodology for measuring such interactions Biological roles for such interactions are also covered
Biothermodynamics Part B
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Author : Michael L. Johnson
language : en
Publisher: Academic Press
Release Date : 2009-11-11
Biothermodynamics Part B written by Michael L. Johnson and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-11 with Science categories.
The use of thermodynamics in biological research can be equated to an energy book-keeping system. While the structure and function of a molecule is important, it is equally important to know what drives the energy force. These methods look to answer: What are the sources of energy that drive the function? Which of the pathways are of biological significance? As the base of macromolecular structures continues to expand through powerful techniques of molecular biology, such as X-ray crystal data and spectroscopy methods, the importance of tested and reliable methods for answering these questions will continue to expand as well. This volume presents sophisticated methods for estimating the thermodynamic parameters of specific protein-protein, protein-DNA and small molecule interactions. - Elucidates the relationships between structure and energetics and their applications to molecular design, aiding researchers in the design of medically important molecules - Provides a "must-have" methods volume that keeps MIE buyers and online subscribers up-to-date with the latest research - Offers step-by-step lab instructions, including necessary equipment, from a global research community
Advances In Dna Sequence Specific Agents
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Author : B.J. Chapman
language : en
Publisher: Elsevier
Release Date : 2002-09-17
Advances In Dna Sequence Specific Agents written by B.J. Chapman and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-09-17 with Science categories.
This series encompasses design, synthesis, application, and analytical methods (including clinical and in vitro) for the study of these critical interactions. As our understanding of the genome and proteome expands, general developments in the field of DNA sequence specific interaction are likely to play an increasingly important role. Accordingly, manuscripts have been solicited from experts covering a diverse range of fields, reflecting the cross-disciplinary and dynamic nature of the series.Volume 4 describes work on the modification of DNA by AT specific anticancer drugs, DNA alkylation events which involve metabolite generation, DNA sequence recognition by two selective binders, bulged DNA microenvironments as molecular targets, DNA sequence specific binding by short peptides and the analysis of DNA-protein interactions using DNase I footprinting methodology.Features include:• Expert contributors from the Biomedical world• Emerging areas of drug design and therapeutic applications• Nucleic acid-protein interactions• Color graphics of molecular modeling analyses• New and emerging methodologies
Thermodynamics In Biology
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Author : Enrico Di Cera
language : en
Publisher:
Release Date : 2000
Thermodynamics In Biology written by Enrico Di Cera and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Science categories.
This book describes several approaches to biological phenomena based on thermodynamics and illustrates the descriptive and predictive power of the laws that govern molecular recognition in biological systems. The current structural emphasis in the study of biological macromolecules provides the motivation for a deeper understanding of the driving forces that determine biological interactions. Because molecular explanations of biological phenomena as inferred from structural information must be informed by and consistent with the laws and principles of thermodynamics, a thorough understanding of biological function requires approaches well balanced between structure and energetics. Topics covered in this book are protein and nucleic acid folding and stability, enzyme-substrate interactions, prediction of the affinity of complexes, electrostatics, and non-equilibrium aspects of protein function. The breadth of the topics covered illustrates the growing importance of thermodynamic approaches in the study of biological phenomena. As more information continues to emerge from structural studies, and faster and more accurate computational methods are developed, we will look at biological thermodynamics with renewed interest as a fundamental tool to decipher the rules for specificity and function in proteins and nucleic acids.