Thyroid Hormone In Brain And Brain Cells
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Thyroid Hormone In Brain And Brain Cells
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Author : Frédéric Flamant
language : en
Publisher: Frontiers Media SA
Release Date : 2016-01-21
Thyroid Hormone In Brain And Brain Cells written by Frédéric Flamant and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-21 with Diseases of the endocrine glands. Clinical endocrinology categories.
Thyroid hormone signaling has been known for a long time to be required for proper neurodevelopment and the maintenance of cognitive functions in the adult brain. As thyroid hormone excess or deficiency is usually well handled by clinicians, research dedicated to the neural function of thyroid hormone, have not been a priority within the field. This is changing mainly for two reasons. First, new genetic diseases have been discovered, altering thyroid hormone signaling in brain (THRA, MCT8, SBP2), with neurodevelopmental consequences which are currently incurable. Second, there is a growing concern that exposition of the general population to environmental chemicals able to interfere with thyroid hormone signaling compromises children neurodevelopment or induces central disorders in adults. Finally thyroid hormone is acting directly on gene transcription, by binding nuclear receptors, and therefore is an interesting entry point to identify genetic programs controlling brain development and function. Reaching a broad understanding of the multiple processes involving thyroid hormone in brain is a tremendous task which will necessitate a multidisciplinary approach: animal genetics, molecular biology, brain imaging, developmental biology, genomics, etc... This topic will be the occasion to combine recent contributions in the field and to identify priorities for future investigations. Due to devastating consequences of congenital hypothyroidism, the neurodevelopmental consequences of altered thyroid hormone signaling have been extensively studied over the years. The discovery of new genetic diseases, the concern about the possible neurotoxicity of environmental thyroid hormone disruptors, recently renewed the interest for an important research field. This Ebook gathers reviews and original data from experts in various disciplines. It provides a broad view of ongoing research and outlines key issues for future investigation.
Thyroid Hormones And Brain Development
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Author : Gilman D. Grave
language : en
Publisher:
Release Date : 1977
Thyroid Hormones And Brain Development written by Gilman D. Grave and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1977 with Medical categories.
Thyroid Hormone Dependency Of Developing Brain
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Author : Ann-Charlotte Granholm
language : en
Publisher:
Release Date : 1984
Thyroid Hormone Dependency Of Developing Brain written by Ann-Charlotte Granholm and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1984 with Brain categories.
Hormones Brain Function And Behavior
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Author : Hudson Hoagland
language : en
Publisher: Elsevier
Release Date : 2012-12-02
Hormones Brain Function And Behavior written by Hudson Hoagland and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
Hormones, Brain Function, and Behavior brings together the proceedings of a conference on neuroendocrinology held in May 1956 in New York. The papers explore selected aspects of hormone actions in relation to brain function and behavior and cover topics ranging from the effects of steroid hormones on the nervous system to the behavioral consequences of sex hormones and thyroid hormones. Serotonin, epinephrine, and their metabolites are also discussed in relation to experimental psychiatry. This monograph is comprised of 12 chapters and begins with an assessment of steroid hormones in relation to neuropsychiatric disorders, as well as the influence of adrenocortical steroids on brain function and metabolism. Subsequent chapters focus on the genetic and psychological determinants of sexual behavior patterns; the role of serotonin in mental disorders; the effect of thyroid hormones on appetite for alcohol and alcoholic beverages in rats; and the link between thyroid hormones and mental health. The biochemistry of serotonin and its physiological implications are also examined. This text will appeal to biologists, neuropharmacologists, neuropsychiatrists, and psychologists.
Iodine And The Brain
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Author : G. Robert Delong
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Iodine And The Brain written by G. Robert Delong and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
This volume contains the proceedings of a conference held at the National Institutes of Health in Bethesda on March 21-23. 1988. jointly sponsored by the International Council for Control of Iodine Deficiency Disorders (ICCIDD) and the Fogarty International Center of the National Institutes of Health. Several themes converged to make this meeting timely. The first is an increasing awareness of iodine deficiency disorders as a world-wide problem of public health and a preventable cause of mental deficiency. and as a subject of scientific effort. Increased interest in these problems owes a great deal to accessibility to remote and under developed areas of the world where iodine deficiency persists. As with any subject. greater scrutiny yields unexpected complexity and interest. It is true that provision of iodine. typically as iodized salt, is the necessary and sufficient preventative for iodine deficiency disorders. without including endemic cretinism. This provision is a governmental, economic and social problem. Apart from this, however, the scientific and medical problem of iodine deficiency and its effect on brain development and function is one of great interest and importance for developmental neurology and psychology. Even though the specific preventative agent is known, we do not totally understand the neurobiological questions raised.
Hormones Regulators And Hippocampus
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Author : Gerald Litwack
language : en
Publisher: Academic Press
Release Date : 2022-02-16
Hormones Regulators And Hippocampus written by Gerald Litwack and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-16 with Science categories.
Hormones, Regulators and Hippocampus, Volume 118 in the Vitamins and Hormones serial highlights new advances in the field, with this new volume presenting interesting chapters, including Thyroid hormone regulation of adult hippocampal neurogenesis – putative molecular and cellular mechanisms, Synergistic gene regulation by thyroid hormone and glucocorticoid in the hippocampus, Oxytocin and vasopressin in the hippocampus, Steroid hormones and hippocampal neurogenesis in the adult mammalian brain, Steroidogenic enzymes in the hippocampus: transcriptional regulation aspects, Ectonucleotidases in the hippocampus: spatial distribution and expression after ovariectomy and estradiol replacement, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Vitamins and Hormones serials Updated release includes the latest information on Hormones, Regulators and Hippocampus
The Effects Of Thyroid Hormone On The Development Of Brain Cholinergic Neurons
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Author : Elizabeth Gould
language : en
Publisher:
Release Date : 1988
The Effects Of Thyroid Hormone On The Development Of Brain Cholinergic Neurons written by Elizabeth Gould and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with Cholinergic mechanisms categories.
Hormones And Brain Plasticity
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Author : Luis Miguel Garcia-Segura
language : en
Publisher: Oxford University Press
Release Date : 2009-05-05
Hormones And Brain Plasticity written by Luis Miguel Garcia-Segura and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-05-05 with Medical categories.
The nervous system has a remarkable capacity for self-reorganization, and in this first systematic analysis of the interaction between hormones and brain plasticity, Luis Miguel Garcia-Segura proposes that hormones modulate metaplasticity in the brain. He covers a wide variety of hormones, brain regions, and neuroplastic events, and also provides a new theoretical background with which to interpret the interaction of hormones and brain remodeling throughout the entire life of the organism. Garcia-Segura argues that hormones are indispensable for adequately adapting the endogenous neuroplastic activity of the brain to the incessant modifications in external and internal environments. Their regulation of neuroplastic events in a given moment predetermines new neuroplastic responses that will occur in the future, adapting brain reorganization to changing physiological and behavioral demands throughout the life of the organism. The cross-regulation of brain plasticity and hormones integrates information originated in multiple endocrine glands and body organs with information coming from the external world in conjunction with the previous history of the organism. Multiple hormonal signals act in concert to regulate the generation of morphological and functional changes in neural cells, as well as the replacement of neurons, glial, and endothelial cells in neural networks. Brain remodeling, in turn, is involved in controlling the activity of the endocrine glands and regulating hormonal secretions. This bidirectional adjustment of brain plasticity in response to hormonal inputs, and adjustment of hormonal concentrations in response to neuroplastic events are crucial for maintaining the stability of the inner milieu and for the generation of adequate behavioral responses in anticipation of--and in adaptation to--new social and environmental circumstances and life events, including pathological conditions.
Thyroid Hormones And Brain Development
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Author : Gilman D. Grave
language : en
Publisher:
Release Date :
Thyroid Hormones And Brain Development written by Gilman D. Grave and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Thyroid Hormone Disruption And Neurodevelopment
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Author : Noriyuki Koibuchi
language : en
Publisher: Springer
Release Date : 2016-11-11
Thyroid Hormone Disruption And Neurodevelopment written by Noriyuki Koibuchi and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-11 with Medical categories.
Thyroid hormone plays an important role in development and functional maintenance in the central nervous system. Deficiency of thyroid hormone during fetal and early postnatal life induces abnormal development known as cretinism in humans. However, the molecular mechanism of thyroid hormone action has not yet been fully understood. Thyroid hormone action in the brain may be disrupted under various pathological conditions. In addition, environmental factors including endocrine-disrupting chemicals and bacterial endotoxins may disrupt thyroid hormone action in brain, causing abnormal brain development and functional disruption. This is a first book to comprehensively describe the effect of thyroid hormone disruption in the central nervous system. The first section deals with the disruption of thyroid hormone action at the molecular level. First the authors provide a summary of the possible molecular mechanisms of thyroid hormone action in the brain, then they discuss several factors that may disrupt thyroid hormone action. In the second section, animal models to study thyroid hormone action will be introduced. An interesting character of thyroid hormone deficiency is that, without thyroid hormone, the thyroid hormone receptor may act as a “repressor” of gene expression, causing more severe consequence than those of thyroid hormone receptor knockout animals. Thus, several different kind of animal models may be used to clarify the role of thyroid hormone and its receptor in the brain. In the third section, human studies on thyroid disease and neurodevelopment will be introduced. Although endemic cretinism induced by iodine deficiency and sporadic cretinism by various thyroid mutation are well known, the pathophysiological mechanisms that create each abnormal phenotype are not fully understood.