Tin Based Antitumour Drugs
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Tin Based Antitumour Drugs
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Author : Marcel Gielen
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Tin Based Antitumour Drugs written by Marcel Gielen and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Medical categories.
Whereas platinum compounds are already clinically used as anticancer agents, tin compounds exhibiting high enough antitumour activity have not yet been found to enter the clinical phase. This is paradoxical with the observation that 50% of the tested compounds showed some activity, which is an abnormally high percentage. This is probably due to the fact that research of this type with tin compounds started more recently than with platinum compounds and that almost exclusively known compounds coming from laboratories working in the field of organotin compounds have been blindly tested. Some research directed towards the development of organotin compounds with some biologically favourable properties, for instance derivatives with hydrophilic or lipophilic, or with increased bio-availability characteristics, has started only recently. We thought that was now the appropriate time to bring together experts from different disciplines (biochemists, pharmacologists, organotin chemists, oncologists, etc.) working in the field of tin-based antitumour drugs, to contribute to the critical assessment of existing knowledge in this new important topic, to identify the directions for future research and to promote close working relations between the different countries and professional experiences gathered in this workshop.
Metal Based Anti Tumour Drugs
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Author : Marcel Gielen
language : en
Publisher:
Release Date : 1988
Metal Based Anti Tumour Drugs written by Marcel Gielen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with Antimitotic agents categories.
Metallotherapeutic Drugs And Metal Based Diagnostic Agents
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Author : Marcel Gielen
language : en
Publisher: John Wiley & Sons
Release Date : 2005-09-01
Metallotherapeutic Drugs And Metal Based Diagnostic Agents written by Marcel Gielen and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-09-01 with Science categories.
There are an astonishing number and variety of roles that metals play in contemporary medicine. This book contains information on the medicinal uses of inorganics, that is, of elements such as boron, lithium, selenium, to name a few, as well as metal-containing species. In keeping with the notion that healthy mammals rely on (bio-essential) metals for the normal functioning of approximately a third of their proteins and enzymes, a large number of drugs are metal-based and considerable effort is being devoted to developing both second- and third-generation drugs as well as generating novel metal-based drugs. While there is no doubt that there is an emphasis on 'Metallotherapeutics' throughout the volume, the use of metals in medicine is not restricted to metal-based drugs. The following are also covered: non-invasive radiopharmaceuticals Magnetic Resonance Imaging (MRI) mineral supplements From the foregoing and, more importantly, from the contents of the various Chapters, the reader will gain an appreciation of the very real role metal-based drugs play in modern medicine and of the considerable effort being devoted to the development of novel complexes with greater efficacy as therapeutic and diagnostic agents.
Metal Compounds In Cancer Therapy
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Author : S.P. Fricker
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Metal Compounds In Cancer Therapy written by S.P. Fricker and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The discovery of the antitumour activity of cisplatin in 1965 and its subsequent introduction into clinical trials in 1971 was the catalyst for a major international research effort investigating the potential of metal compounds in cancer therapy. Cisplatin now occupies an important place in the armamentarium of the oncologist due to its effectiveness in the treatment of testicular cancer. A second generation analogue, carbo platin, offers reduced toxicity together with therapeutic activity, which gives it a place in the front-line therapy of genitourinary cancers. These and other successes have encouraged the search for novel metal-based drugs for cancer therapy. Research has shown that metal compounds have potential for activity not only as cytotoxic antitumour agents, but also in areas such as adjuvant therapy, diagnosis and immunotherapy. The aim of this book is to review and describe the major achievements and developments arising from this international research effort. The contributing authors come from labora tories throughout Europe and America and represent the many disci plines characteristic of this research, such as clinical research, pharmacology, tumour biology and inorganic medicinal chemistry.
Cytotoxic Mutagenic And Carcinogenic Potential Of Heavy Metals Related To Human Environment
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Author : N. Hadjiliadis
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Cytotoxic Mutagenic And Carcinogenic Potential Of Heavy Metals Related To Human Environment written by N. Hadjiliadis and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Environmental pollution is one of the main problems to confront humanity, with the heavy metals occupying a leading role among the most pernicious pollutants. The metals cause cancer and other sicknesses. Their cytotoxic, mutagenic and carcinogenic potentials are not fully understood, and any thorough investigation demands the combined efforts of scientists drawn from many different disciplines. But the effects of heavy metals are not all negative: some, like cis-DDP, and some ruthenium and tin complexes, have antitumour activity. The idea underlying the present work is therefore to present a multidisciplinary perspective on heavy metals in the environment, affording a better understanding of their action on human organisms and health, aiming to make them less polluting and more environmentally friendly.
Ions Metalliques En Biologie Et En Medecine
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Author : Jane Anastassopoulou
language : en
Publisher: John Libbey Eurotext
Release Date : 1992
Ions Metalliques En Biologie Et En Medecine written by Jane Anastassopoulou and has been published by John Libbey Eurotext this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Medical categories.
Metal ions are poorly known whereas they sometimes play a role more significant than vitamins. Moreover they control many diseases, such as the zinc salts in dermatology. This book contains the proceedings of 2nd International Symposium on Metal Ions in Biology and Medicine, Athens, May 1992.
Metallo Drugs Development And Action Of Anticancer Agents
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Author : Astrid Sigel
language : en
Publisher: Walter de Gruyter GmbH & Co KG
Release Date : 2018-02-05
Metallo Drugs Development And Action Of Anticancer Agents written by Astrid Sigel and has been published by Walter de Gruyter GmbH & Co KG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-05 with Science categories.
Volume 18, entitled Metallo-Drugs: Development and Action of Anticancer Agents of the series Metal Ions in Life Sciences centers on biological, medicinal inorganic chemistry. The serendipitous discovery of the antitumor activity of cis-diamminodichloroplatinum(II) (cisplatin) by Barnett Rosenberg in the 1960s is a landmark in metallodrug-based chemotherapy. The success of cisplatin in the clinic, followed by oxaliplatin and carboplatin, along with their drawbacks relating mainly to resistance development and severe toxicity, initiated research on polynuclear platinum complexes and on Pt(IV) complexes as prodrugs. Furthermore, the indicated shortcomings led to the exploration of other transition and main group metal ions, among them Ru(II/III), Au(I/III), Ti(IV), V(IV/V), and Ga(III) including also the essential metal ions Fe(II/III), Cu(I/II), and Zn(II). Ionic as well as covalent and non-covalent interactions between structurally very different complexes and biomolecules like nucleic acids, proteins, and carbohydrates are studied and discussed with regard to their possible anticancer actions. Hence, MILS-18 summarizes the research at the forefront of medicinal inorganic chemistry, including studies on the next-generation, tailor-made anticancer drugs. All this and more is treated in an authoritative and timely manner in the 17 stimulating chapters of this book, written by 39 internationally recognized experts from 10 nations (from the US via Europe to China and Australia). The impact of this vibrant research area is manifested by more than 2700 references, nearly 150 illustrations (more than half in color) and several comprehensive tables. Metallo-Drugs: Development and Action of Anticancer Agents is an essential resource for scientists working in the wide range from enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine including the clinic ... not forgetting that it also provides excellent information for teaching.
A Commemorative Issue In Honor Of Professor Nick Hadjiliadis Metal Complex Interactions With Nucleic Acids And Or Dna
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Author : Sotiris K Hadjikakou
language : en
Publisher: MDPI
Release Date : 2019-02-05
A Commemorative Issue In Honor Of Professor Nick Hadjiliadis Metal Complex Interactions With Nucleic Acids And Or Dna written by Sotiris K Hadjikakou and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-02-05 with Biochemistry categories.
This book is a printed edition of the Special Issue "A Commemorative Issue in Honor of Professor Nick Hadjiliadis: Metal Complex Interactions with Nucleic Acids and/or DNA" that was published in IJMS
National Library Of Medicine Current Catalog
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Author : National Library of Medicine (U.S.)
language : en
Publisher:
Release Date : 1990
National Library Of Medicine Current Catalog written by National Library of Medicine (U.S.) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with Medicine categories.
Advances In Anticancer Agents In Medicinal Chemistry
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Author : Michelle Prudhomme
language : en
Publisher: Bentham Science Publishers
Release Date : 2013-06-14
Advances In Anticancer Agents In Medicinal Chemistry written by Michelle Prudhomme and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-14 with Medical categories.
Advances in Anticancer Agents in Medicinal Chemistry is an exciting eBook series comprising a selection of updated articles previously published in the peer-reviewed journal Anti-Cancer Agents in Medicinal Chemistry. The second Volume of this eBook series gathers updated reviews on several classes of molecules exhibiting anticarcinogenic potential as well as some important targets for the development of novel anticancer drugs.