Tolerogenic Antigen Presenting Cells Modulating Unwanted Immune Response At Their Core
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Tolerogenic Antigen Presenting Cells Modulating Unwanted Immune Response At Their Core
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Author : John Isaacs
language : en
Publisher: Frontiers Media SA
Release Date : 2019-12-27
Tolerogenic Antigen Presenting Cells Modulating Unwanted Immune Response At Their Core written by John Isaacs and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-27 with categories.
Tolerogenic Antigen Presenting Cells Modulating Unwanted Immune Response At Their Core
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Author : John Isaacs
language : en
Publisher:
Release Date : 2019
Tolerogenic Antigen Presenting Cells Modulating Unwanted Immune Response At Their Core written by John Isaacs and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Molecular Mechanisms Of Dendritic Cell Mediated Immune Tolerance And Autoimmunity
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Author : Fang Zhou
language : en
Publisher: Frontiers Media SA
Release Date : 2024-04-09
Molecular Mechanisms Of Dendritic Cell Mediated Immune Tolerance And Autoimmunity written by Fang Zhou and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-04-09 with Medical categories.
Dendritic cells (DCs) play a critical role in immune system, as they are necessary both for innate and adaptive immunity. According to their function, dendritic cells can be classified in immune tolerogenic or inflammatory DCs. DCs have been shown to regulate T cell-mediated immune responses and lead to immune tolerance and autoimmunity. For example, immune-tolerogenic DCs facilitate the development of regulatory T cells and inhibit T helper 17-mediated autoimmunity in mice with experimental autoimmune encephalomyelitis. Moreover, inflammatory DCs activate CD8+ and CD4+ T cells and elicit T cell-mediated inflammatory immune responses in vivo. However, the molecular and cellular mechanisms underlying DC-mediated immune tolerance and autoimmunity are still obscure.
Immune Response Activation And Immunomodulation
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Author : Rajeev Tyagi
language : en
Publisher: BoD – Books on Demand
Release Date : 2019-04-17
Immune Response Activation And Immunomodulation written by Rajeev Tyagi and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-17 with Medical categories.
Immune Response Activation and Immunomodulation has been written to address the perceived needs of both medical school and undergraduate curricula and to take advantage of new understandings in immunology. We have tried to achieve several goals and present the most important principles governing the function of the immune system. Our fundamental objective has been to synthesize the key concepts from the vast amount of experimental data that have emerged in the rapidly advancing field of immunology. The choice of what is most important is based on what is most clearly established by experimentation, what our students find puzzling, and what explains the wonderful efficiency and economy of the immune system. Inevitably, however, such a choice will have an element of bias, and our bias is toward emphasizing the cellular interactions in immune response by limiting the description of many of the underlying biochemical and molecular mechanisms to the essential facts. This book gives an insight into the role of cytokines in activating immune response during pathogenic invasion. Immunomodulation, aryl hydrocarbons, the role of the protein defensin and nucleated cells in provoking immune response, Bcl protein/gene-based apoptotic pathways, and plant-derived phytochemical-mediated immune response are all central themes of this book.
Immunopharmacology
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Author : Manzoor M. Khan
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-12-19
Immunopharmacology written by Manzoor M. Khan and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-12-19 with Medical categories.
During the past decades, with the introduction of the recombinant DNA, hybridoma and transgenic technologies there has been an exponential evolution in understanding the pathogenesis, diagnosis and treatment of a large number of human diseases. The technologies are evident with the development of cytokines and monoclonal antibodies as therapeutic agents and the techniques used in gene therapy. Immunopharmacology is that area of biomedical sciences where immunology, pharmacology and pathology overlap. It concerns the pharmacological approach to the immune response in physiological as well as pathological events. This goals and objectives of this textbook are to emphasize the developments in immunology and pharmacology as they relate to the modulation of immune response. The information includes the pharmacology of cytokines, monoclonal antibodies, mechanism of action of immune-suppressive agents and their relevance in tissue transplantation, therapeutic strategies for the treatment of AIDS and the techniques employed in gene therapy. The book is intended for health care professional students and graduate students in pharmacology and immunology.
Pharmaceutical Biotechnology
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Author : Daan J. A. Crommelin
language : en
Publisher: CRC Press
Release Date : 2002-11-14
Pharmaceutical Biotechnology written by Daan J. A. Crommelin and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-11-14 with Medical categories.
The field of pharmaceutical biotechnology is evolving rapidly. A whole new arsenal of protein pharmaceuticals is being produced by recombinant techniques for cancer, viral infections, cardiovascular and hereditary disorders, and other diseases. In addition, scientists are confronted with new technologies such as polymerase chain reactions, combinatorial chemistry and gene therapy. This introductory textbook provides extensive coverage of both the basic science and the applications of biotechnology-produced pharmaceuticals, with special emphasis on their clinical use. Pharmaceutical Biotechnology serves as a complete one-stop source for undergraduate pharmacists, and it is valuable for researchers and professionals in the pharmaceutical industry as well.
Immune Response And The Eye
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Author : J. Wayne Streilein
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 1999-01-01
Immune Response And The Eye written by J. Wayne Streilein and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-01-01 with Medical categories.
In this book, the physiologic bases of ocular immune privilege and the distinctive systemic immune responses elicited by eye derived antigens are described. Several chapters discuss the pathogeneses of these disorders which arise from infections, autoimmunity, and neoplasms. Finally, chapters devoted to corneal and retinal transplantation describe attempts to exploit ocular immune privilege to promote graft survival and thereby cure blindness. Ophthalmologists, both clinicians and physician scientists, general and tumor immunologists, transplantation biologists and anyone seeking to understand the immunopathogenic diseases that threaten vision will appreciate the information presented in this book.
Immunotherapy Of Hepatocellular Carcinoma
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Author : Tim F. Greten
language : en
Publisher: Springer
Release Date : 2017-10-04
Immunotherapy Of Hepatocellular Carcinoma written by Tim F. Greten and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-04 with Medical categories.
In this book we provide insights into liver – cancer and immunology. Experts in the field provide an overview over fundamental immunological questions in liver cancer and tumorimmunology, which form the base for immune based approaches in HCC, which gain increasing interest in the community due to first promising results obtained in early clinical trials. Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical “inflammation-induced” cancer. Immune-based treatment approaches have revolutionized oncology in recent years. Various treatment strategies have received FDA approval including dendritic cell vaccination, for prostate cancer as well as immune checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in melanoma, lung, and kidney cancer. Additionally, cell based therapies (adoptive T cell therapy, CAR T cells and TCR transduced T cells) have demonstrated significant efficacy in patients with B cell malignancies and melanoma. Immune checkpoint inhibitors in particular have generated enormous excitement across the entire field of oncology, providing a significant benefit to a minority of patients.
Gene Therapy Of Autoimmune Disease
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Author : Gerald J. Prud'homme
language : en
Publisher: Springer
Release Date : 2005-07-13
Gene Therapy Of Autoimmune Disease written by Gerald J. Prud'homme and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-07-13 with Medical categories.
Autoimmune diseases are diverse and responsible for considerable morbidity. Their etiology remains largely unknown, and current therapy with anti-inflammatory drugs is prone to adverse effects, and rarely curative. New therapies with anti-cytokine antibodies or receptors are promising, but require frequent administration of expensive protein drugs. Gene Therapy of Autoimmune Diseases comprehensively reviews research in gene therapy for autoimmune diseases with viral or non-viral vectors. Gene therapy offers the possibility of long-term, continuous delivery of a wide variety of immunosuppressive, anti-inflammatory, or tolerance-inducing agents. Moreover, highly specific genetically modified cells can be produced. This book discusses the most promising avenues in this exciting new field.
Clinical And Basic Immunodermatology
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Author : Anthony Gaspari
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-11-05
Clinical And Basic Immunodermatology written by Anthony Gaspari and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-11-05 with Medical categories.
Dermatologists are being asked to understand the pathophysiology of a number of immune-mediated skin diseases. In addition, a number of new products have appeared on the market during the past decade which requires an understanding of the mechanisms of action of these drugs. Dermatologists, however, have no easily understood book to which they can refer to regarding the disease or the drug.