Total Synthesis Of Thielocin B1 As A Protein Protein Interaction Inhibitor Of Pac3 Homodimer
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Total Synthesis Of Thielocin B1 As A Protein Protein Interaction Inhibitor Of Pac3 Homodimer
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Author : Kosuke Ohsawa
language : en
Publisher: Springer
Release Date : 2015-01-13
Total Synthesis Of Thielocin B1 As A Protein Protein Interaction Inhibitor Of Pac3 Homodimer written by Kosuke Ohsawa and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-01-13 with Science categories.
This book focuses on thielocin B1 (TB1), which was found to be an inhibitor of protein–protein interactions (PPIs) of proteasome assembling chaperone (PAC) 3 homodimer, and elucidates the mechanism by nuclear magnetic resonance (NMR) studies. Interfaces of PPIs recently have been expected to be novel therapeutic targets, while it is difficult to apply conventional methodology based on lock and key theory. The author achieved the first total synthesis of TB1 and its spin-labeled derivative to carry out NMR experiments because the supply of TB1 from natural sources was limited. Unique 2,2’,6,6’-tetrasubstituted diphenyl ether moiety of TB1 was synthesized from a depsidone skeleton by chemoselective reduction of lactone. In the process of elongating side wings, efficient formylation utilizing dichloromethyl methyl ether–silver trifluoromethanesulfonate was developed for the sterically hindered aromatic compound. NMR titration experiments and paramagnetic relaxation enhancement observation of PAC3 homodimer were performed with synthesized TB1 and its molecular probe, respectively. The results of the above NMR studies and additional in silico docking studies suggested that TB1 promotes the dissociation to monomeric PAC3 after interaction with PAC3 homodimer. The rare mechanism shown in this book indicates a potential novel drug target in the interfaces of PPIs with no cavity or groove.
Designer Biopolymers
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Author : Ayae Sugawara-Narutaki
language : en
Publisher: MDPI
Release Date : 2020-12-14
Designer Biopolymers written by Ayae Sugawara-Narutaki and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-14 with Science categories.
Nature has evolved sequence-controlled polymers, such as DNA and proteins, over its long history. The recent progress of synthetic chemistry, DNA recombinant technology, and computational science, as well as the elucidation of molecular mechanisms in biological processes, drive us to design ingenious polymers that are inspired by naturally occurring polymers, but surpass them in specialized functions. The term “designer biopolymers” refers to polymers which consist of biological building units, such as nucleotides, amino acids, and monosaccharides, in a sequence-controlled manner. This book particularly focuses on the self-assembling aspect of designer biopolymers. Self-assembly is one common feature in biopolymers that is used to realize their dynamic biological activities and is strictly controlled by the sequence of biopolymers. In a broad sense, the self-assembly of biopolymers includes a double-helix formation of DNA, protein folding, and higher-order protein assembly (e.g., viral capsids). Designer biopolymers are now going beyond what nature evolved: researchers have generated DNA origami, protein cages, peptide nanofibers, and gels. This book illustrates the latest interdisciplinary work on self-assembling designer biopolymers. As shown by this book, the self-assembly of biopolymers has a great impact on a variety of research fields, including molecular biology, neurodegenerative diseases, drug delivery, gene therapy, regenerative medicine, and biomineralization. Designer biopolymers will help researchers to better understand biological processes, as well as to create innovative molecular systems. We believe that this book will provide readers with new ideas for their molecular design strategies for frontier research.
Ionic And Organometallic Catalyzed Organosilane Reductions
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Author : Gerald L. Larson
language : en
Publisher: John Wiley & Sons
Release Date : 2009-11-19
Ionic And Organometallic Catalyzed Organosilane Reductions written by Gerald L. Larson and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-19 with Science categories.
Ionic and Organometallic-Catalyzed Organosilane Reductions provides an up-to-date, comprehensive review of reductions with organosilanes. Both ionic and catalyst-mediated reaction types are included, with appropriate reference to reaction mechanisms where they have been elucidated. The text also provides a wide variety of organic functional group reductions by organosilicon hydrides, and includes a substantial discussion of asymmetric reductions. All known examples have been compiled in thirty-four easily scanned, comprehensive tables compiled from 809 original articles. This is a must-have reference book for all synthetic organic chemists working in academic and industrial laboratories.
Silver Catalysis In Organic Synthesis
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Author : Chao-Jun Li
language : en
Publisher: John Wiley & Sons
Release Date : 2018-12-07
Silver Catalysis In Organic Synthesis written by Chao-Jun Li and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-12-07 with Science categories.
Covers all the aspects of the recent achievements in silver catalyzed reactions Silver catalysis has emerged as a powerful tool in the field of organic synthesis. This comprehensive book systematically explores the unique performance of silver catalysis, introducing all the recent progress of silver catalysis in organic synthesis. It clearly emphasizes the unique features of silver catalysis and provides the reaction mechanism involved. This two-volume book also provides vivid schematics and tables throughout to enhance the accessibility to the relevant theory and mechanisms. Silver Catalysis in Organic Synthesis begins with an introduction to Silver Chemistry before moving on to chapters covering: Silver-Catalyzed Cycloaddition Reactions; Silver-Catalyzed Cyclizations; Silver-Mediated Radical Reactions; Silver-Mediated Fluorination, Perfluoroalkylation and Trifluoromethylthiolation Reactions; Coupling Reactions and C-H Functionalization; Silver-Catalyzed CO2 Incorporation; Silver-Catalyzed Carbene, Nitrene, and Silylene Transfer Reactions; Asymmetric Silver-Catalyzed Reactions; Silver-Catalyzed Reduction and Oxidation of Aldehydes and Their Derivatives; Silver Complexes in Organic Transformations; and Silver Nanoparticles in Organic Transformations. -Covers recently developed organic reactions catalyzed by silver, along with their reaction mechanism -Introduces many new reactions and mechanisms related to silver catalysis -Offers professionals and newcomers in the related fields a survey of new advances in silver catalysis in organic synthesis Silver Catalysis in Organic Synthesis will appeal to a wide readership including chemists, biochemists, pharmaceutical scientists, biomedical researchers, agriculture scientists, and graduate students in the related fields.
Foldamers
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Author : Stefan Hecht
language : en
Publisher: John Wiley & Sons
Release Date : 2007-09-24
Foldamers written by Stefan Hecht and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-09-24 with Science categories.
This truly comprehensive treatise of foldamers, from synthesis to applications in bio-, material-, and nanoscience is at once an introduction to the topic, while providing in-depth accounts on various aspects clearly aimed at the specialist. The book is clearly structured, with the first part concentrating on structure and foldamer design concepts, while the second part covers functional aspects from properties to applications. The international team of expert authors provides overviews of synthetic approaches as well as analytical techniques.
Protective Groups In Organic Synthesis
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Author : Theodora W. Greene
language : en
Publisher:
Release Date : 1981-05-14
Protective Groups In Organic Synthesis written by Theodora W. Greene and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1981-05-14 with Science categories.
Provides comprehensive information on the most useful protective groups for the hydroxyl, amino, carboxyl, carbonyl, and sulfhydryl groups. Discusses the chemistry of the classes of protective groups, as well as that of the individual protective groups within the class using structures, equations and references. Reactivity Charts for each class of protective group serve as an aid in their appropriate choice and provide estimates of their relative reactivities toward 108 prototype reagents.
Name Reactions
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Author : Jie Jack Li
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-02-16
Name Reactions written by Jie Jack Li and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-02-16 with Science categories.
This book differs from others on name reactions in organic chemistry by focusing on their mechanisms. It covers over 300 classical as well as contemporary name reactions. Biographical sketches for the chemists who discovered or developed those name reactions have been included. Each reaction is delineated by its detailed step-by-step, electron-pushing mechanism, supplemented with the original and the latest references, especially review articles. This book contains major improvements over the previous edition and the subject index is significantly expanded.
Name Reactions
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Author : Jie Jack Li
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
Name Reactions written by Jie Jack Li and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Science categories.
This book differs from others on name reactions in organic chemistry by focusing on their mechanisms. It covers over 300 classical as well as contemporary name reactions. Biographical sketches for the chemists who discovered or developed those name reactions have been included. Each reaction is delineated by its detailed step-by-step, electron-pushing mechanism, supplemented with the original and the latest references, especially review articles. This book contains major improvements over the previous edition and the subject index is significantly expanded.
Atlas Of Soil Ascomycetes
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Author : J. Guarro
language : en
Publisher:
Release Date : 2012
Atlas Of Soil Ascomycetes written by J. Guarro and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Ascomycetes categories.
"This compendium includes almost all presently known species of ascomycetes that have been reported in soil and which sporulate in culture. They constitute a very broad spectrum of genera belonging to very diverse orders, but mainly to the Onygenales, Sordariales, Eurotiales, Thelebolales, Pezizales, Melanosporales, Pleosporales, Xylariales, Coniochaetales and Microascales. The goal of this book is to provide sufficient data for users to recognise and identify these species. It includes the description of 146 genera and 698 species. For each genus a dichotomous key to facilitate species identification is provided and for each genus and species the salient morphological features are described. These descriptions are accompanied by line drawings illustrating the most representative structures. Light micrographs, supplemented by scanning electron micrographs and Nomarski interference contrast micrographs of most of the species treated in the book are also included. In addition, numerous species not found in soil but related to those included in this book are referenced or described. This book will be of value not only to soil microbiologists and plant pathologists concerned with the soilborne fungi and diseases, but also to anyone interested in identifying fungi in general, because many of the genera included here are not confined to soil. Since most of the fungi of biotechnological or clinical interest (dermatophytes, dimorphic fungi and opportunists) are soil-borne ascomycetes, the content of this book is of interest for a wide range of scientists."--pub. desc.
Bacterial Chromatin
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Author : Remus T. Dame
language : en
Publisher: Humana
Release Date : 2024-08-23
Bacterial Chromatin written by Remus T. Dame and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-08-23 with Science categories.
This second edition brings together new and updated methods to explore the structure and function of bacterial chromatin from molecular to the cellular scale. Chapters detail experimental protocols of in vivo and in vitro approaches, approaches to genome structure modeling, and data analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Bacterial Chromatin: Methods and Protocols, Second Edition aims to be a useful up-to-date reference work for researchers currently in the field and to those entering the field.