Toxines Et Cancer
DOWNLOAD
AUDIOBOOK
Download Toxines Et Cancer PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Toxines Et Cancer book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Toxines Et Cancer
DOWNLOAD
AUDIOBOOK
Author : Françoise Goudey-Perrire
language : en
Publisher: Tec & Doc Lavoisier
Release Date : 2006
Toxines Et Cancer written by Françoise Goudey-Perrire and has been published by Tec & Doc Lavoisier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.
Toxines Et Cancer
DOWNLOAD
AUDIOBOOK
Author : GOUDEY-PERRIÈRE Françoise
language : en
Publisher: Lavoisier
Release Date : 2006-11-26
Toxines Et Cancer written by GOUDEY-PERRIÈRE Françoise and has been published by Lavoisier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-11-26 with categories.
De tout temps, l'homme a eu conscience de l'intérêt thérapeutique des toxines. Certaines toxines végétales depuis longtemps utilisées figurent encore dans la pharmacopée actuelle. Viennent s'y ajouter depuis peu des toxines microbiennes. Cependant le maniement des toxines natives ou à peine modifiées reste délicat tant est faible la marge entre les effets toxiques et l'efficacité thérapeutique. Comment, dans une perspective médicale, canaliser la puissance d'action et l'efficacité d'une toxine ? Connaître sa structure, comprendre son mécanisme d'action n'est pas suffisant : il faut aussi identifier sa cible privilégiée, autrement dit un récepteur cellulaire, faute de quoi l'entreprise apparemment chimérique d'un détournement de sa puissance et de sa spécificité reste aveugle. Ce cap est franchi, depuis un certain nombre d'années, et le développement des recherches sur les toxines axées sur la thérapeutique est devenu foisonnant. Voyez telle ou telle toxine protéique ternaire, avec ses trois domaines, de fixation sur un récepteur membranaire, de translocation qui lui permet de franchir la membrane cellulaire, et d'activité enzymatique qui va alors pouvoir s'exercer dans la cellule. Qu'on parvienne à dissocier chacun de ces trois domaines en leur conservant leurs propriétés, et des possibilités nouvelles d'utilisation thérapeutique vont s'ouvrir, presque à l'infini semble-t-il. Car chacun d'entre eux pourra être couplé à une molécule active bien ciblée, et leur efficacité sera même améliorée pour peu qu'on parvienne à conjuguer leur action. Qu'un récepteur, qu'une molécule, propres au métabolisme ou à la physiologie d'une cellule cancéreuse soient identifiés, et des toxines conjuguées à un ligand de ce récepteur, de cette molécule (ce peut être un anticorps) bloqueront les canaux ioniques ou exerceront leur effet cytolytique sur cette seule cellule, sans nuire aux cellules saines. Nous voilà dégagés de l'utopie, le contenu de cet ouvrage le prouve abondamment. Et même si la concrétisation des promesses reste délicate, le champ d'action est si vaste initialement qu'il ne saurait rester improductif : il ne l'est d'ailleurs déjà plus.
Toxins And Hemostasis
DOWNLOAD
AUDIOBOOK
Author : R. Manjunatha Kini
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-10-19
Toxins And Hemostasis written by R. Manjunatha Kini and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-19 with Medical categories.
Circulation of blood is vital for the survival of vertebrates, including man. Mainly, it plays an important role in carrying food nutrients and oxygen to every tissue and organ and in removing all waste products and carbon dioxide. Any imbalance in the hemostatic and cardiovascular systems can lead to death and severe debility. A number of animals have developed mechanisms to target these systems and exploit the vulnerability. In some species (for example, snakes), such mechanisms are used to immobilize and kill the victim/prey, whereas in others (for example, insects, such as leaches, mosquitoes and ticks), they are used to provide a continuous supply of blood. These mechanisms include, but are not limited to, procoagulant and anticoagulant actions that affect the coagulation cascade and platelet aggregation, as well as altering vasodilatory responses. In all these various animals, these mechanisms have evolved to perfection over millions of years to support their survival. In last 3-4 decades, due to the efforts of scientists from various backgrounds including biology, protein chemistry, molecular biology, pharmacology, hematology, and structural biology, significant progress in understanding the structure-function relationships, as well as the mechanism of action have been made in a number of exogenous factors that affect blood coagulation, platelet aggregation and vasodilation from various animals. These exogenous factors have contributed significantly to the development of research tools as well as providing new therapeutic agents. With the increase average age of the population coupled with changes in life style in recent years, there has been a significant increase in cardiovascular and hematological disorders. Thus scientists in both academic institutions as well as the pharmaceutical industry are developing better therapeutic agents to improve the quality of life. This impetus has lead to the search for novel agents from various sources that interfere with cardiovascular and hematalogical processes. Although at first glance exogenous factors appear to function as ‘villains’, several life-saving drugs have been developed based upon these factors. Such drugs or drug leads include those that inhibit the angiotensin converting enzymes (Captopril and Enalapril), that block platelet receptors (Eptifibatide and Tirofiban), or that digest thrombotic plugs (Alfimeprase and bat plasminogen activator) to name a few. Several new and exciting success stories are currently unfolding. In this book, recent studies on some of the exogenous factors that play crucial roles in cardiovascular and hematological disorders are reviewed in order to consolidate the efforts in this area of research and to recruit new, talented researchers. The 25-30 review chapters, each written by experts in their field, compiled herein are devoted to exogenous factors affecting platelet aggregation, anticoagulant and procoagulant proteins, fibrinolytic proteins and hypotensive agents (For details see, Contents of the Book). This book is intended to help to create elevated awareness and enthusiasm in the field of exogenous factors. I believe that this book will provide greater impetus to the search for novel proteins based on naturally occurring exogenous factors. This will be the first book dealing extensively with exogenous factors in the last 25 years. The book will provide a ready reference to the different approaches used to solve complex problems in protein chemistry and pharmacology of exogenous factors. The book will update our understanding of the structure-function relationships and mechanisms of action of exogenous factors and provide great insights into future directions for solving the remaining challenges.
Index Catalogue Of Medical And Veterinary Zoology
DOWNLOAD
AUDIOBOOK
Author :
language : en
Publisher:
Release Date : 1970
Index Catalogue Of Medical And Veterinary Zoology written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1970 with Parasites categories.
Hyperthermia In Cancer Treatment A Primer
DOWNLOAD
AUDIOBOOK
Author : Gian F. Baronzio
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-05-08
Hyperthermia In Cancer Treatment A Primer written by Gian F. Baronzio and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-05-08 with Medical categories.
Following an introductory overview, Hyperthermia In Cancer Treatment: A Primer comprehensively describes the biological reasons for associating hyperthermia with radiation and chemotherapy and the biological and clinical effects of hyperthermia on cancerous and normal tissues. The volume’s 20 chapters are arranged in three principal parts: physical and methodological studies, biologic principles, and clinical studies.
Molecular Clinical And Environmental Toxicology
DOWNLOAD
AUDIOBOOK
Author : Andreas Luch
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-03-01
Molecular Clinical And Environmental Toxicology written by Andreas Luch and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-03-01 with Medical categories.
Clinical Toxicology is the second volume of a three-volume set on molecular, clinical and environmental toxicology that offers a comprehensive and in-depth response to the increasing importance and abundance of chemicals of daily life. By providing intriguing insights far down to the molecular level, this three-volume work covers the entire range of modern toxicology with special emphasis on recent developments and achievements. It is written for students and professionals in medicine, science, public health or engineering who are demanding reliable information on toxic or potentially harmful agents and their adverse effects on the human body.
Toxins And Biologically Active Compounds From Microalgae Volume 2
DOWNLOAD
AUDIOBOOK
Author : Gian Paolo Rossini
language : en
Publisher: CRC Press
Release Date : 2014-04-24
Toxins And Biologically Active Compounds From Microalgae Volume 2 written by Gian Paolo Rossini and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-04-24 with Science categories.
Toxins and Biologically Active Compounds from Microalgae: Volume 2: Biological Effects and Risk Management is devoted to the effects toxic microalgae and their poisonous products exert on living systems and how they may affect human activities. The most advanced information regarding the molecular mechanisms of action of major groups of
Journal Of The National Cancer Institute
DOWNLOAD
AUDIOBOOK
Author :
language : en
Publisher:
Release Date : 1947
Journal Of The National Cancer Institute written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1947 with Cancer categories.
Seafood And Freshwater Toxins
DOWNLOAD
AUDIOBOOK
Author : Luis M. Botana
language : en
Publisher: CRC Press
Release Date : 2008-01-28
Seafood And Freshwater Toxins written by Luis M. Botana and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-01-28 with Technology & Engineering categories.
The occurrence of marine and freshwater toxins is a rapidly evolving problem due to ever-changing circumstances. Expanding international commerce is forcing cargo ships into virgin territory, deforestation and pollution violate the natural ecological balance, and a changing climate holds unknown potential to alter current factors and trigger toxic blooms in new forms, at new rates, and in new places. Fortunately, with notable advances in analysis technology, the body of knowledge in the field is equally dynamic. In just six years since the first edition, toxins that warranted only line listings, including pfiestra, gambierol, and polycavernoside, are now worthy of entire chapters, requiring a new edition to encompass the expanding scope of the field. Emphasizes Human Response to New Toxins Gathering contributions from international experts, Seafood and Freshwater Toxins: Pharmacology, Physiology, and Detection, Second Edition provides an overview of the current state-of-knowledge from several perspectives. Incorporating toxicology, chemistry, ecology, and economics, the book covers the biological aspects of the bloom and the effects and actions of each toxin with emphasis on human response. This edition includes more information on detection and analysis, toxicological information on previously little known toxins, and food safety issues. Incorporating Pharmacological, Legal, and Economic Aspects, this book— Begins with general information on risk assessment and analytical techniques Cover several categories of toxins by function and biomechanism Considers potential pharmacological applications and the use of toxins as precursors to therapeutic drugs Highlights the legal and economic perspectives of toxic incidence in industrial activity and international regulation and monitoring programs Describes new toxins by their individual chemical structure, ecobiology, metabolism, detection methods, determination, pharmacology, and toxicology
Advances In Molecular Toxicology
DOWNLOAD
AUDIOBOOK
Author :
language : en
Publisher: Elsevier
Release Date : 2011-07-01
Advances In Molecular Toxicology written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-07-01 with Medical categories.
Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons, and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples, the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field. Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of both progress on the molecular level and on advances in technological approaches employed. Cutting-edge reviews by leading workers in the discipline In-depth dissection of molecular aspects of interest to a broad range of scientists, physicians and any student in the allied disciplines Leading edge applications of technological innovations in chemistry, biochemistry and molecular medicine