Toxoplasma Gondii
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Toxoplasmosis Of Animals And Humans
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Author : J. P. Dubey
language : en
Publisher: CRC Press
Release Date : 2016-04-19
Toxoplasmosis Of Animals And Humans written by J. P. Dubey and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-19 with Medical categories.
Found worldwide from Alaska to Australasia, Toxoplasma gondii knows no geographic boundaries. The protozoan is the source of one of the most common parasitic infections in humans, livestock, companion animals, and wildlife, and has gained notoriety with its inclusion on the list of potential bioterrorism microbes. In the two decades since the publi
Toxoplasma Gondii
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Author : Louis M. Weiss
language : en
Publisher: Academic Press
Release Date : 2013-08-10
Toxoplasma Gondii written by Louis M. Weiss and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-08-10 with Science categories.
This 2e of Toxoplasma gondii reflects the significant advances in the field in the last 5 years, including new information on the genomics, epigenomics and proteomics of T. gondii as well as a new understanding of the population biology and genetic diversity of this organism. T. gondii remains the best model system for studying the entire Apicomplexa group of protozoans, which includes Malaria, making this new edition essential for a broad group of researchers and scientists. Toxoplasmosis is caused by a one-celled protozoan parasite known as T. gondii. The infection produces a wide range of clinical syndromes in humans, land and sea mammals, and various bird species. Most humans contract toxoplasmosis by eating contaminated, raw or undercooked meat (particularly pork), vegetables, or milk products; by coming into contact with the T. gondii eggs from cat feces; or by drinking contaminated water. The parasite damages the ocular and central nervous systems, causing behavioral and personality alterations as well as fatal necrotizing encephalitis. It is especially dangerous for the fetus of an infected pregnant woman and for individuals with compromised immune systems, such as HIV-infected patients. Completely updated, the 2e presents recent advances driven by new information on the genetics and genomics of the pathogen Provides the latest information concerning the epidemiology, diagnosis, treatment and prevention of toxoplasmosis Offers a single-source reference for a wide range of scientists and physicians working with this pathogen, including parasitologists, cell and molecular biologists, veterinarians, neuroscientists, physicians, and food scientists
Toxoplasma Gondii
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Author : Uwe Gross
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Toxoplasma Gondii written by Uwe Gross and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
For years, toxoplasmosis has been known as disease mostly affecting newborns. Since immunocompromised patients (AIDS) present a high risk of reactivation of chronic toxoplasmosis this parasitic disease has gained increasing interest. Besides presenting clinical and therapeutical concepts, this volume provides current knowledge about genetics and immunology of T. gondii and the interaction with its 'host'. Since in vivo and in vitro models of toxoplasmosis exist, and genetic manipulation has become possible, this protozoan parasite has recently been accepted as a model for understanding the pathogenesis and persistance of other intracellular parasites. The articles of the book compromise both reviewing current concepts and reporting on yet unpublished results of leading scientists in this field.
Toxoplasma Gondii Host Interactions A Story Of Immune Attack And Parasite Counterattack
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Author : Jeroen P. J. Saeij
language : en
Publisher: Frontiers Media SA
Release Date : 2020-08-10
Toxoplasma Gondii Host Interactions A Story Of Immune Attack And Parasite Counterattack written by Jeroen P. J. Saeij and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-10 with categories.
Toxoplasma gondii is an obligate intracellular parasite that can infect all warm-blooded animals, including an estimated ~30% of humans. It can cause severe disease in immune-suppressed individuals and in fetuses as well as blinding chorioretinitis in adults and children. Toxoplasma-innate immune system interactions determine early parasite control and activation of the adaptive immune system by the host and are therefore critical in determining host survival during the acute phase of infection. However, induction of an exaggerated inflammatory response can also lead to pathology. Only the chronic tissue cyst form of Toxoplasma is orally infectious. It is therefore critical for the parasite’s survival during the chronic phase to escape immune responses at this stage as well. Toxoplasma exists as genetically divergent strains mostly depending on geography, with the most strain diversity being found in South America. The key to Toxoplasma’s successful co-option of the host are proteins secreted from its rhoptry and dense granule secretory organelles. Rhoptry proteins (ROPs) are secreted into the host cell cytoplasm upon invasion while dense granule proteins (GRAs) are secreted once the parasite establishes itself in its parasitophorous vacuole (PV). GRAs can localize to the PV, the PV membrane, or are secreted beyond the PVM into the host cytoplasm. Many ROPs and GRAs are involved in modulating host cell signaling pathways and evasion of host immune responses and play important roles in Toxoplasma virulence. Polymorphisms in Toxoplasma’s ROPs and GRAs, likely determine how well these effectors bind to the divergent substrates in different host species, which can explain Toxoplasma strain differences in virulence in a particular host species. By studying Toxoplasma we have not only started to unravel how the parasite modulates immune responses to enhance its survival, replication, and transmission but we have also learned a lot about the immune system. Many unique mechanisms of immunity have indeed been defined using Toxoplasma and this parasite has aided our understanding of tissue-specific immune responses in the brain and intestine. This Research Topic will give a comprehensive overview of Toxoplasma-host immune response interactions. Most Toxoplasma virulence determinants to date have been established in murine systems and it is unclear how the parasite interacts with other intermediate hosts and humans. In addition, the interactions of Toxoplasma with some of the most relevant cell types during infection, including dendritic cells, neurons, intestinal epithelial cells or vascular endothelial cells, remain poorly understood.
Case Studies In Infectious Disease Toxoplasma Gondii
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Author : Peter Lydyard
language : en
Publisher: Garland Science
Release Date : 2009-12
Case Studies In Infectious Disease Toxoplasma Gondii written by Peter Lydyard and has been published by Garland Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-12 with Medical categories.
Case Studies in Infectious Disease: Toxoplasma gondii presents the natural history of this infection from point of entry of the pathogen through pathogenesis, clinical presentation, diagnosis, and treatment. A set of core questions explores the nature, causation, host response, manifestations, and management of this infectious process. This case also includes summary bullet points, questions and answers, and references.
Toxoplasma Gondii
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Author : Sean L. Hall
language : en
Publisher:
Release Date : 2017
Toxoplasma Gondii written by Sean L. Hall and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Medical categories.
Toxoplasma gondii is an obligate intracellular parasite that infects 10-20% of the overall population in the US with rates increasing with age. T. gondii infects most warm blooded animals where an antibody response is generated to control the infection, however, the parasite forms bradyzoite cysts in brain and muscle. It can only reproduce in felines where oocytes are excreted in the feces. Infection can occur by a variety of routes. In cats, infection occurs by eating infected prey, primarily rodents or birds. Infection in humans can occur by eating undercooked infected meat, handling infected cat feces, ingesting oocytes on unwashed fruits or vegetables, or drinking contaminated water. Another important route of infection is congenital infection. This book discusses the potential risks this parasitic infection may cause. It also reviews the parasite's life cycle.
Toxoplasma And Toxoplasmosis
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Author : Paul H. Smith
language : en
Publisher:
Release Date : 1975
Toxoplasma And Toxoplasmosis written by Paul H. Smith and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1975 with Toxoplasmosis categories.
Parasites Pussycats And Psychosis
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Author : E. Fuller Torrey
language : en
Publisher: Springer Nature
Release Date : 2021-11-29
Parasites Pussycats And Psychosis written by E. Fuller Torrey and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-29 with Medical categories.
This open access book analyzes the evidence linking Toxoplasma gondii to the increasing incidence of schizophrenia and bipolar disorder in the United States. Initially establishing that infectious agents are regularly transmitted from animals to humans, lead to human disease, and that infectious agents can cause psychosis, it then examines the protozoan parasite Toxoplasma gondii in detail. Infecting 40 million Americans, Toxoplasma gondii is known to cause congenital infections, eye disease, and encephalitis for individuals who are immunosuppressed. It has also been shown to change the behavior of nonhuman mammals, as well as to alter some personality traits in humans. After discussing the clinical evidence linking Toxoplasma gondii to human psychosis, the book elucidates the epidemiological evidence further supporting this linkage; including the proportional increase in incidence of human psychosis as cats transitioned to domestication over 800 years. Finally, the book assesses the magnitude of the problem and suggests solutions. Parasites, Pussycats and Psychosis: The Unknown Dangers of Human Toxoplasmosis provides a comprehensive review of the evidence linking human psychosis in the United States to infections of Toxoplasma gondii. It will be of interest to infectious disease specialists, general practitioners, scientists, historians, and cat-lovers.
Toxoplasma Gondii
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Author : Christopher J. Tonkin
language : en
Publisher: Humana
Release Date : 2019-11-23
Toxoplasma Gondii written by Christopher J. Tonkin and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-23 with Medical categories.
This volume covers a diverse collection of protocols currently being used by the Toxoplasma research community, and also looks at innovative methods that are pushing the boundaries of possibilities. Chapters in this book discuss topics such as isolation and genotyping of Toxoplasma gondii strains; assessing rhoptry secretion in T. gondii; plate-based quantification of stimulated Toxoplasma egress; methods to study ocular toxoplasmosis; and metabolic analysis of Toxoplasma gondii tachyzoites. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Toxoplasma gondii: Methods and Protocols is a valuable resource for students or groups starting off in the field, as well as laboratories interested in implementing the latest techniques described in the book.
Toxoplasmosis
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Author : Olgica Djurković Djaković
language : en
Publisher: BoD – Books on Demand
Release Date : 2012-09-12
Toxoplasmosis written by Olgica Djurković Djaković and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-09-12 with Medical categories.
A ubiquitous organism able to infect all mammals and birds, which has been estimated to infect one third of the global human population, Toxoplasma gondii is the most successful parasite on Earth, and toxoplasmosis a major zoonotic disease. A current approach to this zoonosis is the "one health" concept, based on the understanding that a disease occurring between animals and man in a specific environment can only be dealt with at the interface of all "players" involved. This book, composed of a series of articles which integrate human and animal data on toxoplasmosis, by authors from all over the world, offers its readers a view on the current research interests and achievements.