Transcription Factor Expression In The Central Nervous System
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Immediate Early Genes And Inducible Transcription Factors In Mapping Of The Central Nervous System Function And Dysfunction
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Author : L. Kaczmarek
language : en
Publisher: Gulf Professional Publishing
Release Date : 2002-07
Immediate Early Genes And Inducible Transcription Factors In Mapping Of The Central Nervous System Function And Dysfunction written by L. Kaczmarek and has been published by Gulf Professional Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-07 with Medical categories.
This book brings together information about the most widely studied IEG/ITF involved in a variety of neuronal activation. Written by a prominent group of authors, it attempts to unravel the complexity of the phenomena of gene expression in the central nervous system.
Transcription Factor Expression In The Central Nervous System
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Author : Joanne L. Redburn
language : en
Publisher:
Release Date : 1997
Transcription Factor Expression In The Central Nervous System written by Joanne L. Redburn and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Central nervous system categories.
Immediate Early Genes And Inducible Transcription Factors In Mapping Of The Central Nervous System Function And Dysfunction
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Author :
language : en
Publisher:
Release Date : 2002
Immediate Early Genes And Inducible Transcription Factors In Mapping Of The Central Nervous System Function And Dysfunction written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Central nervous system categories.
Immediate Early Genes In The Central Nervous System
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Author : T.R. Tölle
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Immediate Early Genes In The Central Nervous System written by T.R. Tölle and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Immediate-early genes are believed to be involved in the neuron's ability to con vert short-term synaptic stimulation into long-lasting responses and thus contribute to the adaptive alterations involved in neuronal plasticity. Cellular immediate-early genes share a close structural homology with some viral oncogenes. Recent advances in cellular biology have identified the activation and deactivation of immediate-early genes as molecular mechanisms to control regulated and deregulated growth, cellular differentiation and development. In this view immediate-early genes may function as third messengers in a stimulus transcription cascade transferring extracellular information into changes in target gene transcription, thereby changing the phenotype of neurons. Immediate-Early Genes in the Central Nervous System provides a comprehensive up-to-date overview of current methodology in the research of immediate-early genes and includes a wide range of neurobiological topics, such as regeneration, memory formation, epilepsia and nociception. The contributors to this book have been selected from among the leading experts in their field of research. T.R. TOLLE J. SCHADRACK W. ZIEGLGANSBERGER Contents Immediate-early genes -how immmediate and why early? G./. Evan .............................................. . Immediate-early gene activation as a window on mechanism in the nervous system S.P. Hunt, L.A. McNaughton, R. Jenkins, and W. Wisden. . . . . . . . . .. . . . 18 of immediate-early genes during Differential expression synaptic plasticity, seizures and brain injury suggests specific functions for these molecules in brain neurons M. Dragunow . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . 35 . . . . . . . . . .
The Transcription Factor Ap 2
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Author : Jeannette Philipp
language : en
Publisher:
Release Date : 1995
The Transcription Factor Ap 2 written by Jeannette Philipp and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with categories.
Gene Expression In The Central Nervous System
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Author : A.C.H. Yu
language : en
Publisher: Elsevier
Release Date : 1995-08-01
Gene Expression In The Central Nervous System written by A.C.H. Yu and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-08-01 with Science categories.
Gene expression is an active ongoing process that maintains a functional CNS, as proteins are being made on a continual basis. Processes such as learning and memory, nerve cell repair and regeneration and its response to stress are critically dependent on gene expression. This volume highlights the role of gene expression in normal CNS function, and presents many research methods at the cutting edge of neuroscience, which will provide insight into therapeutic approaches through which the control of gene expression may be used in the treatment of many nervous system diseases.
Transcription Factor Ap 2
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Author : Jeannette Philipp
language : de
Publisher:
Release Date : 1995
Transcription Factor Ap 2 written by Jeannette Philipp and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with categories.
Transcription Factors In The Nervous System
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Author : Gerald Thiel
language : en
Publisher: John Wiley & Sons
Release Date : 2006-05-12
Transcription Factors In The Nervous System written by Gerald Thiel and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-05-12 with Science categories.
This first book to cover neural development, neuronal survival and function on the genetic level outlines promising approaches for novel therapeutic strategies in fighting neurodegenerative disorders, such as Alzheimer's disease. Focusing on transcription factors, the text is clearly divided into three sections devoted to transcriptional control of neural development, brain function and transcriptional dysregulation induced neurological diseases. With a chapter written by Nobel laureate Eric Kandel, this is essential reading for neurobiologists, geneticists, biochemists, cell biologists, neurochemists and molecular biologists.
Transcriptional Regulation Of Neuronal Differentiation In The Drosophila Central Nervous System
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Author : Haluk Lacin
language : en
Publisher:
Release Date : 2010
Transcriptional Regulation Of Neuronal Differentiation In The Drosophila Central Nervous System written by Haluk Lacin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Electronic dissertations categories.
The central nervous system is the most complex and highly organized tissue in animals; composed of thousands of neurites connected in specific and highly reproducible ways. My thesis research has focused on the generation of neuronal diversity: specifically how neurons adopt individual, often unique, identities. Work in many labs has revealed that a large set of transcription factors act in combinatorial manner to specify the fate of individual neurons or small groups of neurons. However, in most cases, it remains unclear how individual or specific combinations of transcription factors directly control the terminal differentiation of neurons via the regulation of different genes, such as neurotransmitters. My thesis work has focused on the identification and characterization of new members of the combinatorial code of transcription factor and on initial attempts to link these transcription factors to the expression and activity of genes that contribute directly to neuronal differentiation. In chapter 2, I describe the identification and characterization of Dbx, a homedomain-containing transcription factor, expressed in a mixture of progenitor cells and a subset of GABAergic interneurons. I show that Dbx is expressed in many interneurons that are sibling to motor neurons, and that Dbx is required to promote the development of these interneurons via cross-repressive interactions with Eve and Hb9, which are expressed in the sibling motor neurons. In chapter 3, I detail the identification of FoxD, a transcription factor that is positively regulated by the homeodomain-containing transcription factor Hb9 in the Drosophila CNS. FoxD is expressed in a subset of Hb9 positive neurons and also in all octopaminergic neurons in the Drosophila embryonic CNS. I have identified the enhancers that drive expression in these neurons and have recently generated two mutant alleles of foxD. Loss of foxD appears to result in hyperactivity, which is most pronounced in males. As octopamine is the fly equivalent of norepinephrine, these results suggest that FoxD may function in specific cells to regulate the synthesis and release of octopmaine. Thus, my thesis has identified two members of the combinatorial code of transcription factors that govern neuronal identity. In addition, it has begun to place the functions of these genes within the genetic regulatory hierarchy of this code and started to link the function of individual transcription factors to the regulation of terminal differentiation genes and animal behavior.
Delivery Of Gene Therapies Into The Central Nervous System
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Author : Peter Deng
language : en
Publisher:
Release Date : 2020
Delivery Of Gene Therapies Into The Central Nervous System written by Peter Deng and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.
Therapies based on zinc finger, transcription activator-like effectors, and CRISPR/Cas9 to act as artificial transcription factors to regulate gene expression are becoming viable strategies to treat genetically linked disorders. Effective delivery methodologies for artificial transcription factors remain a major barrier in targeting the central nervous system. Chapter 1 of this dissertation broadly reviews the use of adeno-associated virus, lipid nanoparticles, and stem cell-based systems in the gene therapy field. Chapter 2 of this dissertation discusses the development of a transcription activator-like effector for the silencing of the mutant Huntingtin gene in Huntington's Disease. It further evaluates the strengths and limitations of current in-vivo artificial transcription factor delivery strategies such as adeno-associated virus and lipid nanoparticles in preclinical models of Huntington's Disease. Chapter 3 of this dissertation describes the first reported use of a mesenchymal stem/stromal cell-based delivery system for the secretion of a zinc finger protein in transgenic Angelman Syndrome mouse models and young rhesus monkeys. These secreted zinc finger proteins widely distribute in the murine brain and partially restore motor deficits in Angelman syndrome mouse models. Chapter 4 this dissertation discusses the identification and development of lead zinc finger proteins to disrupt UBE3A-ATS expression and activate paternal UBE3A expression in Angelman Syndrome patient cell models. Finally, Chapter 5 summarizes this dissertation work as a whole and speculates on future directions of the work described.