Transcriptional And Epigenetic Mechanisms Regulating Normal And Aberrant Blood Cell Development
DOWNLOAD
Download Transcriptional And Epigenetic Mechanisms Regulating Normal And Aberrant Blood Cell Development PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Transcriptional And Epigenetic Mechanisms Regulating Normal And Aberrant Blood Cell Development book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Transcriptional And Epigenetic Mechanisms Regulating Normal And Aberrant Blood Cell Development
DOWNLOAD
Author : Constanze Bonifer
language : en
Publisher: Springer Science & Business Media
Release Date : 2014-03-12
Transcriptional And Epigenetic Mechanisms Regulating Normal And Aberrant Blood Cell Development written by Constanze Bonifer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-03-12 with Medical categories.
During vertebrate hematopoiesis many specialized cell types are formed with vastly different functions such as B cells, T cells, granulocytes, macrophages, erythrocytes and megakaryocytes. To tightly control the enormous proliferative potential of developing blood cells, an intricately balanced signaling and transcription network has evolved that ensures that the different cell types are formed at the right time and in the right numbers. Intricate regulatory mechanisms ensure that blood cells function properly and have a determined life span. Moreover, in the adaptive immune system, long-lived memory cells have evolved that ensure that when pathogens have been seen once they will never cause a problem again. In this book we will therefore make a journey from asking how more primitive organisms use the epigenetic regulatory machinery to balance growth with differentiation control towards digging deep into what controls the function of specialized cells of the human immune system. We will first discover that flies make blood but exist without blood vessels, why fish make blood cells in the kidney and which precise genetic circuitries are required for these developmental pathways. We will then learn the regulatory principles that drive the differentiation of mature blood cells from stem cells and what controls their function in mammals. In the process, we will find out what unites hematopoietic stem cells and endothelial cells. Finally, we will shed light on the molecular mechanisms that either alter hematopoietic cell differentiation or lead to the development of cells with impaired function.
Transcriptional And Epigenetic Mechanisms Regulating Normal And Aberrant Blood Cell Development
DOWNLOAD
Author : Constanze Bonifer
language : en
Publisher:
Release Date : 2014-03-31
Transcriptional And Epigenetic Mechanisms Regulating Normal And Aberrant Blood Cell Development written by Constanze Bonifer and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-03-31 with categories.
Molecular Switches Of The Immune System The E Protein Id Axis In Hematopoietic Development And Function
DOWNLOAD
Author : Michele Kay Anderson
language : en
Publisher: Frontiers Media SA
Release Date : 2022-12-01
Molecular Switches Of The Immune System The E Protein Id Axis In Hematopoietic Development And Function written by Michele Kay Anderson and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-01 with Medical categories.
Transcriptional And Chromatin Regulation In Adaptive And Innate Immune Cells
DOWNLOAD
Author : Keiko Ozato
language : en
Publisher: Frontiers Media SA
Release Date : 2020-05-22
Transcriptional And Chromatin Regulation In Adaptive And Innate Immune Cells written by Keiko Ozato and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-22 with categories.
Transcription depends on an ordered sequence of events, starting with (i) setting of the enhancer and chromatin environment, (ii) assembly of DNA binding and general transcription factors, (iii) initiation, elongation, processing of mRNA and termination, followed by (iv) creation of epigenetic marks and memory formation. Highlighting the importance of these activities, more than 10% total genes are dedicated to regulating transcriptional mechanisms. This area of research is highly active and new insights are continuously being added to our knowledge. Cells of the immune system have unique features of gene regulation to support diverse tasks required for innate and adaptive immunity. Innate immunity involves the recognition of external infectious and noxious agents as well as internal cancer cell components, and the elimination of these agents by non-specific mechanisms. Adaptive immunity involves gene rearrangement to achieve highly specific T and B cell responses, imparting the capability of self and non-self discrimination. This requires transcription and epigenetic regulation. Adaptive immunity also employs epigenetic memory, enabling recapitulation of prior transcription. Recent advances in nuclear architecture, chromatin structure, and transcriptional regulation have provided new insights into immune responses. The increased understanding of these molecular mechanisms is now affording opportunities to improve therapeutic strategies for various diseases.
Transcription Factors In Blood Cell Development
DOWNLOAD
Author : Tilman Borggrefe
language : en
Publisher: Springer Nature
Release Date : 2024-07-17
Transcription Factors In Blood Cell Development written by Tilman Borggrefe and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-17 with Science categories.
This book describes transcription factors in the context of hematopoietic development and reveal mechanistic insights how they orchestrate specific gene expression patterns. Several examples from lymphoid and myeloid lineages are given as well as particular examples of leukemia fusion proteins that contain a part of a transcription factor. In the given chapters covering each one particular example, the function of transcription factors is characterized in normal as well as leukemic contexts. New technologies such as ChIP-Seq or RNA-Seq, that make use of genome-wide sequencing, have shown that such master regulators of blood cell development often work in combinatorial fashion and, when dysregulated, results in leukemogenesis. This book is not only intended for experts but it should also be a useful resource for younger scientists or scientists from other disciplines, who may use this book as a stimulating starting point for further discoveries and/ or translational endeavors.
Epigenetic Biomarker And Personalized Precision Medicine
DOWNLOAD
Author : Jiucun Wang
language : en
Publisher: Frontiers Media SA
Release Date : 2020-12-21
Epigenetic Biomarker And Personalized Precision Medicine written by Jiucun Wang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-21 with Science categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Environmental Factors Genes And The Development Of Human Cancers
DOWNLOAD
Author : Deodutta Roy
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-09-11
Environmental Factors Genes And The Development Of Human Cancers written by Deodutta Roy and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-09-11 with Medical categories.
Cancer is a complex disease. Only 5-10% of human cancers are hereditary in nature. Many of us think of environmental agents when we think of carcinogens. The environment includes all that surrounds us, and environmental influences include not only chemical, physical and biological toxicants, but also diet and lifestyle. In this broadest sense, the environment contributes substantially in the development of human cancer. This book will describe how environment contributes to malignant transformation leading to profound changes in the genetic and signaling networks that control the functioning of the cell. It will critically discuss the understanding of the effects of environment on the development, progression and metastasis of cancer with current knowledge of the signaling networks that support functioning of transformed human cells. Genes and environmental factors that influence the origins of cancer are not necessarily the same as those that contribute to its progression and metastasis. Susceptibility gene variants for each specific cancer are being identified with emerging evidence of gene–environment interaction. Gene-environment interactions will be discussed through each specific cancer-based approach to address the question of how genetic variations can influence susceptibility to the individual type of cancer. It will also highlight and summarize epigenetic changes that increase the risk for susceptibility to a particular type of cancer, particularly in the presence of specific environmental factors. Thus, this book will contain chapters from the world’s experts focused on the current evidences that support the role of environment in the cancer etiology and in the growth of malignant lesions, and discuss who may be susceptible to environmental influences.
Role Of Stem Cells In Skeletal Muscle Development Regeneration Repair Aging And Disease
DOWNLOAD
Author : Pura Muñoz-Cánoves
language : en
Publisher: Frontiers Media SA
Release Date : 2016-06-29
Role Of Stem Cells In Skeletal Muscle Development Regeneration Repair Aging And Disease written by Pura Muñoz-Cánoves and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-06-29 with Biology (General) categories.
Adult stem cells are responsible for tissue regeneration and repair throughout life. Their quiescence or activation are tightly regulated by common signalling pathways that often recapitulate those happening during embryonic development, and thus it is important to understand their regulation not only in postnatal life, but also during foetal development. In this regard, skeletal muscle is an interesting tissue since it accounts for a large percentage of body mass (about 40%), it is highly amenable to intervention through exercise and it is also key in metabolic and physiological changes underlying frailty susceptibility in the elderly. While muscle-resident satellite cells are responsible for all myogenic activity in physiological conditions and become senescent in old age, other progenitor cells such as mesoangioblasts do seem to contribute to muscle regeneration and repair after tissue damage. Similarly, fibro-adipogenic precursor cells seem to be key in the aberrant response that fills up the space left from atrophied muscle mass and which ends up with a dysfunctional muscle having vast areas of fatty infiltration and fibrosis. The complex interplay between these stem/progenitor cell types and their niches in normal and pathological conditions throughout life are the subjects of intense investigation. This eBook highlights recent developments on the role of stem cells in skeletal muscle function, both in prenatal and postnatal life, and their regulation by transcriptional, post-transcriptional and epigenetic mechanisms. Additionally, it includes articles on interventions associated with exercise, pathological changes in neuromuscular diseases, and stem cell aging.
Epigenetic Contributions In Autoimmune Disease
DOWNLOAD
Author : Esteban Ballestar
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-02-16
Epigenetic Contributions In Autoimmune Disease written by Esteban Ballestar and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-02-16 with Medical categories.
This volume focuses on the relevance of epigenetic mechanisms in autoimmune disease. It provides new directions for future research in autoimmune disease.
Psychological Support By Cognitive Behavioral Therapy For Cystic Fibrosis
DOWNLOAD
Author : Edenilson Brandl
language : en
Publisher: Edenilson Brandl
Release Date :
Psychological Support By Cognitive Behavioral Therapy For Cystic Fibrosis written by Edenilson Brandl and has been published by Edenilson Brandl this book supported file pdf, txt, epub, kindle and other format this book has been release on with Psychology categories.
Cystic fibrosis (CF) is a chronic, life-threatening genetic disorder that impacts not only the respiratory and digestive systems but also an individual's psychological well-being. The continuous battle with illness, medical treatments, and the uncertainty of the future can leave profound emotional and mental imprints on patients and their families. In recent years, the importance of psychological support for those affected by CF has come to light, and among the various therapeutic approaches, Cognitive Behavioral Therapy (CBT) stands out as an effective method for managing the psychological toll of chronic illness. This book, Psychological Support by Cognitive Behavioral Therapy for Cystic Fibrosis, is designed to serve as a comprehensive guide for understanding the psychological challenges faced by CF patients and their families. It aims to highlight how CBT can provide effective tools to help them navigate these difficulties, from managing the trauma of diagnosis to coping with the ongoing physical and emotional pain associated with the disorder. The journey of living with a genetic illness like cystic fibrosis is often filled with uncertainty, fear, and emotional strain. For patients, the impact of the disease goes beyond the physical symptoms—it affects their identity, independence, relationships, and self-worth. Families, too, must cope with the overwhelming stress of caregiving, fear of the future, and the emotional exhaustion that comes with chronic illness. In this book, I combine essential knowledge about the biology, genetics, and medical challenges of CF with an introduction to CBT techniques that can be personalized to address these psychological struggles. I delve into the science behind cystic fibrosis and the complexities of genetic mutations that drive the condition. I also explore the impact of hereditary diseases and offer insights into how behavioral genetics and epigenetics play a role in CF and similar conditions. More than just a theoretical discussion, this book offers actionable tools and strategies based on CBT principles to help CF patients and their families manage anxiety, depression, chronic pain, and the everyday emotional hurdles they encounter. From practical tips on pain management to learning how to live a fulfilling life despite the challenges, this book is meant to be a practical guide for both mental health professionals and those directly affected by CF. I hope that this book can offer not only information but also hope and empowerment for individuals and families facing cystic fibrosis. By integrating psychological support into the treatment of CF, it is possible to improve the quality of life for everyone touched by this difficult journey.