Transgenic Animal Models In Biomedical Research
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Transgenic Animal Models In Biomedical Research
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Author : Armed Forces Institute of Pathology (U.S.)
language : en
Publisher:
Release Date : 1992
Transgenic Animal Models In Biomedical Research written by Armed Forces Institute of Pathology (U.S.) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Animal models in research categories.
Transgenic Animal Models In Biomedical Research
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Author :
language : en
Publisher:
Release Date : 1992
Transgenic Animal Models In Biomedical Research written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Biomedical engineering categories.
Transgenic Animal Models In Biomedical Research
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Author : John M. Pletcher
language : en
Publisher:
Release Date : 1989
Transgenic Animal Models In Biomedical Research written by John M. Pletcher and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with categories.
Transgenic Animals As Model Systems For Human Diseases
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Author : Erwin F. Wagner
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-04-17
Transgenic Animals As Model Systems For Human Diseases written by Erwin F. Wagner and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-17 with Technology & Engineering categories.
Some of the current concepts used in transgenic research, an increasingly important tool to study the regulation and function of genes, are illustrated in this book. With these techniques, animal models can be used to study human diseases; this opens up new possibilities in both applied and basic research. Specifically, the ability to introduce genes into the germline of mice and the successful expression of the inserted gene within an organism provide new insights and opportunities for biomedical research. The discussion here shows how a detailed analysis of the underlying molecular mechanisms will provide new insights into the genetic origin of certain diseases and will lead to a better understanding of normal and abnormal physiological processes.
Animal Models For The Study Of Human Disease
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Author : Bernhard Aigner
language : en
Publisher: Elsevier Inc. Chapters
Release Date : 2013-05-29
Animal Models For The Study Of Human Disease written by Bernhard Aigner and has been published by Elsevier Inc. Chapters this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-29 with Medical categories.
Basic research of the pathobiology of diseases as well as of therapeutic strategies usually is carried out in rodents as animal models. Translational research that transfers novel results from basic research to clinical application often requires analyses in additional nonrodent models and/or large animal models that share specific pathophysiological characteristics with the human diseases in question. As prerequisites for the generation of appropriate disease models by genetic engineering, pigs exhibit suitable reproductive performance traits, pig genome analyses resulted in the availability of several resources of genomic data, and efficient and precise techniques for the genetic modification of pigs have been established. In the recent years, genetically engineered pigs were increasingly generated as biomedical research tools for specific human genetic diseases. Here, we review the current state of the techniques used for the production of genetically engineered pigs as well as the establishment of genetically engineered pigs as models for human diseases.
Transgenic And Mutant Tools To Model Brain Disorders
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Author : Allan V. Kalueff
language : en
Publisher: Humana
Release Date : 2010-01-12
Transgenic And Mutant Tools To Model Brain Disorders written by Allan V. Kalueff and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-01-12 with Medical categories.
As the presence of genetically modified animal models in research laboratories has multiplied, the role of genetic factors in the pathogenesis of brain disorders has become particularly important. The refinement of molecular genetic methods has continued to broaden our understanding of the genetic factors associated with a variety of disorders. In "Transgenic and Mutant Tools to Model Brain Disorders", leading scientists specializing in this field contribute a timely collection of recent advances featuring a vast array of topics in order to contribute to the diverse approaches taken toward the evaluation of genetically modified models in biomedical research. Opening with several chapters covering general aspects of genetically modified animal models, the book then continues with detailed chapters on models of specific human brain disorders, including OCD, Rett Syndrome, anxiety disorders, depression, and schizophrenia. As a volume in the successful NeuromethodsTM series, the chapters provide authoritative reviews covering the most commonly used approaches in the field. Cutting-edge and concise, "Transgenic and Mutant Tools to Model Brain Disorders" offers a comprehensive and descriptive overview on a variety of topics in neuroscience and biological psychiatry.
Transgenic Animal Technology
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Author : Carl A. Pinkert
language : en
Publisher: Elsevier
Release Date : 2012-12-02
Transgenic Animal Technology written by Carl A. Pinkert and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
A transgenic animal is one that is genetically modified to carry genes from another species. Transgenic species can be raised to carry potentially useful genes from a variety of species. While the topics of genetic engineering and cloning are controversial, the reality is that these technologies offer tremendous benefits to society - from offering a framework for developing and screening medical therapies, to enhancing the safety and nutrition of the food we eat. One potential application of research into transgenic animal technology is the creation of domestic animals genetically designed to express a certain human disease and therefore serve as models for the study and treatment of human illnesses. Although many mouse models of human diseases are available today, such models in large domestic animals physiologically more similar to humans are sparse and critically needed. Further research in this field will undoubtedly uncover many more direct and indirect benefits of this technology. Transgenic animal technologies and the ability to introduce functional genes into animals have revolutionized our ability to address complex biomedical and biological questions. This well-illustrated handbook covers the technical aspects of gene transfer — from molecular methods to whole animal considerations — for important laboratory and domestic animal species. It describes methodologies as employed by leading laboratories and is a key resource for researchers, as well as a tool for training technicians and students. This second edition incorporates updates on a variety of genetic engineering technologies ranging from microinjection and ES cell transfer to nuclear transfer in a broad range of animal modeling systems. Contains a comprehensive collection of transgenic animal and gene transfer methods Discusses background and introduction to techniques and animal systems Teaches practical step-by-step protocols New section on analysis
Sourcebook Of Models For Biomedical Research
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Author : P. Michael Conn
language : en
Publisher: Springer Science & Business Media
Release Date : 2008
Sourcebook Of Models For Biomedical Research written by P. Michael Conn and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Medical categories.
The collection of systems represented in Sourcebook of genomic programs, although this work is certainly well Models for Biomedical Research is an effort to re?ect the represented and indexed. diversity and utility of models that are used in biomedicine. Some models have been omitted due to page limitations That utility is based on the consideration that observations and we have encouraged the authors to use tables and made in particular organisms will provide insight into the ? gures to make comparisons of models so that observations workings of other, more complex, systems. Even the cell not available in primary publications can become useful to cycle in the simple yeast cell has similarities to that in the reader. humans and regulation with similar proteins occurs. We thank Richard Lansing and the staff at Humana for Some models have the advantage that the reproductive, guidance through the publication process. mitotic, development or aging cycles are rapid compared As this book was entering production, we learned of the with those in humans; others are utilized because individual loss of Tom Lanigan, Sr. Tom was a leader and innovator proteins may be studied in an advantageous way and that in scienti?c publishing and a good friend and colleague to have human homologs. Other organisms are facile to grow all in the exploratory enterprise. We dedicate this book to in laboratory settings or lend themselves to convenient analy- his memory. We will miss him greatly.
Welfare Aspects Of Transgenic Animals
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Author : L.F.M. van Zutphen
language : en
Publisher: Springer
Release Date : 1997-03-20
Welfare Aspects Of Transgenic Animals written by L.F.M. van Zutphen and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-03-20 with Medical categories.
The quality of animal models used in biomedical research has increased substantially since the first successful microinjections of foreign DNA fragments into a mouse zygote in the early 1980s. New well-defined animal models developed either by microinjection techniques or by homologous recombination in embryonic stem (ES) cells, have become widely available and several classical animal models have now been replaced by these transgenic models. Transgenic animals also fulfill increasingly important roles in other fields, like livestock production or in biopharming. In the framework of the European Commission's Biotechnology Programme, a workshop has been organized at Utrecht University (30 October, 1995) with leading experts in the field of animal transgenesis and animal welfare as presenting authors. This book summarizes the papers presented at the workshop.
Science Medicine And Animals
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2006-02-19
Science Medicine And Animals written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-02-19 with Science categories.
Science, Medicine, and Animals explains the role that animals play in biomedical research and the ways in which scientists, governments, and citizens have tried to balance the experimental use of animals with a concern for all living creatures. An accompanying Teacher's Guide is available to help teachers of middle and high school students use Science, Medicine, and Animals in the classroom. As students examine the issues in Science, Medicine, and Animals, they will gain a greater understanding of the goals of biomedical research and the real-world practice of the scientific method in general. Science, Medicine, and Animals and the Teacher's Guide were written by the Institute for Laboratory Animal Research and published by the National Research Council of the National Academies. The report was reviewed by a committee made up of experts and scholars with diverse perspectives, including members of the U.S. Department of Agriculture, National Institutes of Health, the Humane Society of the United States, and the American Society for the Prevention of Cruelty to Animals. The Teacher's Guide was reviewed by members of the National Academies' Teacher Associates Network. Science, Medicine, and Animals is recommended by the National Science Teacher's Association NSTA Recommends.