Translocator Protein Tspo
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Translocator Protein Tspo
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Author : Giovanni Natile
language : en
Publisher: MDPI
Release Date : 2018-03-05
Translocator Protein Tspo written by Giovanni Natile and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-05 with Electronic books categories.
This book is a printed edition of the Special Issue "Translocator Protein (TSPO)" that was published in IJMS
Translocator Protein Tspo
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Author : Giovanni Natile (Ed.)
language : en
Publisher:
Release Date : 2018
Translocator Protein Tspo written by Giovanni Natile (Ed.) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with Biology (General) categories.
The high number of papers submitted and ultimately accepted for publication in this special issue attests the great amount of research being conducted on TSPO and its role in living cells. Thus, TSPO has become an extremely attractive subcellular biomark for the early detection of disease states overexpressing this protein and for the selective delivery to mitochondria of drugs and probes. Moreover, the effort in the design and synthesis of new, more specific and effective TSPO ligands proves to be very valuable. All these topics have been addressed in the special issue.
Peripheral Benzodiazepine Receptors
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Author : Eva Giesen-Crouse
language : en
Publisher: Academic Press
Release Date : 1993-05-05
Peripheral Benzodiazepine Receptors written by Eva Giesen-Crouse and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-05-05 with Medical categories.
Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most diverse and rapidly advancing fields in the life sciences. Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop' sources of the historical, physiological, pharmacological, biochemical, molecular biological and therapeutic aspects of chosen research areas. Although peripheral type benzodiazepne recognition sites have been demonstrated in the brain and peripheral organs of various species for more than 10 years, the exact physiological function or pharmacological effects have not yet been established. Peripheral benzodiazepine literature is so overwhelming that the novice may find it virtually impossible to form a clear idea about the diverse findings. This volume, dedicated exclusively to pBR and their natural and synthetic ligands, puts the available data into perspective. A truly interdisciplinary approach has brought neuroscientists, cardiologists, endocrinologists, and immunologists together to work on the description of pBR-mediated effects. The chemistry, biochemistry, and molecular biology of the pBR receptor and its ligands are reviewed, their pharmacological usefulness is conjectured, and thus a true overview of the field is provided. * SPECIAL FEATURES * This volume follows the Neuroscience Perspectives brief of providing a historical background, pharmacological, biochemical and physiological aspects of research and therapeutic potential, of its chosen topic. * The peripheral benzodiazepine recognition site has been recognised for more than ten years, but the exact physiological and pharmacological effects have not yet been established.
Paediatric Formulation
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Author : Nunzio Denora
language : en
Publisher: MDPI
Release Date : 2021-09-02
Paediatric Formulation written by Nunzio Denora and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-02 with Science categories.
The development of paediatric medicines can be challenging since this is a different patient population with specific needs. A medicine designed for use in paediatric patients must consider the following aspects: patient population variability; the need for dose flexibility; route of administration; patient compliance; excipient tolerability. For example, the toxicity of excipients may differ in children compared to adults and children have different taste preferences. Globally, about 75% of drugs do not carry regulatory approval for use in children; worldwide, many medications prescribed for the treatment of paediatric diseases are used off-label, and less than 20% of package inserts have sufficient information for treating children. This book provides an update on both state-of-the-art methodology and operational challenges in paediatric formulation design and development. It aims at re-evaluating what is needed for more progress in the design and development of age-appropriate treatments for paediatric diseases, focusing on: formulation development; drug delivery design; efficacy, safety, and tolerability of drugs and excipients.
Molecular Basis For Mitochondrial Signaling
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Author : Tatiana K. Rostovtseva
language : en
Publisher: Springer
Release Date : 2017-05-12
Molecular Basis For Mitochondrial Signaling written by Tatiana K. Rostovtseva and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-12 with Science categories.
This book covers recent advances in the study of structure, function, and regulation of metabolite, protein and ion translocating channels, and transporters in mitochondria. A wide array of cutting-edge methods are covered, ranging from electrophysiology and cell biology to bioinformatics, as well as structural, systems, and computational biology. At last, the molecular identity of two important channels in the mitochondrial inner membrane, the mitochondrial calcium uniporter and the mitochondrial permeability transition pore have been established. After years of work on the physiology and structure of VDAC channels in the mitochondrial outer membrane, there have been multiple discoveries on VDAC permeation and regulation by cytosolic proteins. Recent breakthroughs in structural studies of the mitochondrial cholesterol translocator reveal a set of novel unexpected features and provide essential clues for defining therapeutic strategies. Molecular Basis for Mitochondrial Signaling covers these and many more recent studies of mitochondria function, their communication with other organelles, and their critical roles in development, aging, and in a plethora of stressful or degenerative events. Authored by leading researchers in the field, this volume will be an indispensable reference resource for graduate students and academics working in related areas of biophysics and cell biology as well as for professionals within industry.
The Plant Cytoskeleton
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Author : Bo Liu
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-11-23
The Plant Cytoskeleton written by Bo Liu and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-23 with Science categories.
Plant cells house highly dynamic cytoskeletal networks of microtubules and actin microfilaments. They constantly undergo remodeling to fulfill their roles in supporting cell division, enlargement, and differentiation. Following early studies on structural aspects of the networks, recent breakthroughs have connected them with more and more intracellular events essential for plant growth and development. Advanced technologies in cell biology (live-cell imaging in particular), molecular genetics, genomics, and proteomics have revolutionized this field of study. Stories summarized in this book may inspire enthusiastic scientists to pursue new directions toward understanding functions of the plant cytoskeleton. The Plant Cytoskeleton is divided into three sections: 1) Molecular Basis of the Plant Cytoskeleton; 2) Cytoskeletal Reorganization in Plant Cell Division; and 3) The Cytoskeleton in Plant Growth and Development. This book is aimed at serving as a resource for anyone who wishes to learn about the plant cytoskeleton beyond ordinary textbooks.
Asian Christian Theology
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Author : Timoteo D. Gener
language : en
Publisher: Langham Publishing
Release Date : 2019-07-31
Asian Christian Theology written by Timoteo D. Gener and has been published by Langham Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-31 with Religion categories.
Asian Christian Theology provides a survey of contextually reflective, robustly evangelical theology for students to engage with the core doctrines of Christianity and their outworking in different cultures across Asia. The contributors of the chapters come from all corners of Asia to systematically examine traditional doctrinal themes and contemporary concerns for the Asian church. Ideal for use as a companion textbook in Asian seminaries and institutions, this book will also provide excellent further reading for those outside of Asia seeking global theological perspectives, and for those in contexts of significant Asian diaspora. Many excellent books surveying theology exist, but this book is a major step forward for students and scholars seeking to understand the dynamic environment of evangelical theology in Asia.
Mitochondrial Disorders In Neurology
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Author : Anthony H.V. Schapira
language : en
Publisher: Butterworth-Heinemann
Release Date : 2013-10-22
Mitochondrial Disorders In Neurology written by Anthony H.V. Schapira and has been published by Butterworth-Heinemann this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Medical categories.
Mitochondrial Disorders in Neurology provides an overview of mitochondrial diseases. This book discusses the effects of mitochondrial dysfunction based on the relevant biochemistry and molecular genetics. The abnormal muscle and mitochondrial morphology in a variety of clinical presentations from isolated ophthalmoplegia to severe encephalopathy are also elaborated. This text likewise deliberates Leber's hereditary optic neuropathy, neurodegenerative disorders, and respiratory chain defects. Other topics covered include mitochondrial DNA and the genetics of mitochondrial disease; cytochrome oxidase deficiency; use of tissue culture in the diagnosis of mitochondrial disease; and advances in mitochondrial genetics. This publication is a good source for clinicians and students concerned with the defective mitochondrial function.
Basic Science Of Pet Imaging
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Author : Magdy M. Khalil
language : en
Publisher: Springer
Release Date : 2016-11-07
Basic Science Of Pet Imaging written by Magdy M. Khalil and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-07 with Medical categories.
This book offers a wide-ranging and up-to-date overview of the basic science underlying PET and its preclinical and clinical applications in modern medicine. In addition, it provides the reader with a sound understanding of the scientific principles and use of PET in routine practice and biomedical imaging research. The opening sections address the fundamental physics, radiation safety, CT scanning dosimetry, and dosimetry of PET radiotracers, chemistry and regulation of PET radiopharmaceuticals, with information on labeling strategies, tracer quality control, and regulation of radiopharmaceutical production in Europe and the United States. PET physics and instrumentation are then discussed, covering the basic principles of PET and PET scanning systems, hybrid PET/CT and PET/MR imaging, system calibration, acceptance testing, and quality control. Subsequent sections focus on image reconstruction, processing, and quantitation in PET and hybrid PET and on imaging artifacts and correction techniques, with particular attention to partial volume correction and motion artifacts. The book closes by examining clinical applications of PET and hybrid PET and their physiological and/or molecular basis in conjunction with technical foundations in the disciplines of oncology, cardiology and neurology, PET in pediatric malignancy and its role in radiotherapy treatment planning. Basic Science of PET Imaging will meet the needs of nuclear medicine practitioners, other radiology specialists, and trainees in these fields.
Modern Concepts Of Focal Epileptic Networks
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Author :
language : en
Publisher: Elsevier
Release Date : 2014-07-24
Modern Concepts Of Focal Epileptic Networks written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-24 with Science categories.
This volume of International Review of Neurobiology concentrates on modern concepts of focal epileptic networks. The volume addresses specific topics such as seizures (including transition and termination), limbic networks, alteration of metabolism, and neocortical focus and malformation of cortical development, among others. Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews, and thematic volumes that focus on recent progress in a specific area of neurobiology research. Our knowledge about the mechanisms involved in pathophysiology of epilepsy has rapidly expanded during last decade This special volume brings overview about modern concepts of epileptic focus organization and about the altered neural network dynamics which results in propensity of the brain tissue to generate spontaneous and repeated seizures