Transposable Elements And Evolution
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Transposable Elements And Genome Evolution
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Author : Aurélie Hua-Van
language : en
Publisher: John Wiley & Sons
Release Date : 2024-08-15
Transposable Elements And Genome Evolution written by Aurélie Hua-Van and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-08-15 with Science categories.
Since their discovery by Barbara McClintock in the mid-20th century, the importance of transposable elements in shaping the architecture, function and evolution of genomes has gradually been unveiled. These DNA sequences populate nearly all genomes and are viewed as genomic parasites. They are mobile, capable of proliferating within genomes and also commonly travel between species. These elements are mutagenic and are responsible for several human genetic disorders, but they also constitute a major source of genetic diversity. Some insertions have beneficial effects for the host and are selected for, giving rise to significant evolutionary innovations. Their dynamics within genomes are intricate, as are their interactions with other genome components. To limit their proliferation, the genome has evolved sophisticated defense mechanisms. While researchers commonly use these elements as genetic tools, their identification in newly sequenced genomes remains a challenge due not only to their extensive diversity, but also their large copy numbers.
Dynamics And Evolution Of Transposable Elements
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Author : Pierre Capy
language : en
Publisher: International Thomson Publishing Services
Release Date : 1998
Dynamics And Evolution Of Transposable Elements written by Pierre Capy and has been published by International Thomson Publishing Services this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Science categories.
This text deals with the evolution of transposable elements (TE). Two main aspects are presented. First, after a description of the main types of elements, their life and death within a species, including regulation of transposition, and their distribution in natural populations and on chromosomes are discussed. Then, the impact of TEs on the host genomes, the putative relationship between environment and transposition rates lead to a discussion of the interaction (or coevolution) between TEs and their host. Second, these results introduce the analysis of the phylogenies of TEs and their interpretations, according to different models i.e. horizontal versus vertical transmission. Finally, the questions of the origin and of the general evolution of TEs is raised from the comparison of conserved regions like reverse transcriptase or transposase-integrase domains.
Transposable Elements And Evolution
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Author : J. F. McDonald
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Transposable Elements And Evolution written by J. F. McDonald and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
In the summer of 1992 a distinguished group of molecular, population and evolutionary geneticists assembled on the campus of the University of Georgia in Athens, USA to discuss the relevance of their research to the role played by transposable elements (TEs) in evolution. The meeting consisted of a series of informal discussions of issues brought up in papers written by the participants and distributed among them prior to the meeting. These papers and the transcripts of the ensuing discussions are presented in this volume.
The Centromere
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Author : K. H. Andy Choo
language : en
Publisher: Oxford University Press, USA
Release Date : 1997
The Centromere written by K. H. Andy Choo and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Medical categories.
The centromere is an essential structure on all eukaryotic chromosomes that allows the equipartition of chromosomes during mitotic and meiotic cell divisions. Since its cytogenetic recognition as a constructed part of a chromosome many decades ago, great advances have been made in ourunderstanding of this intriguing structure, especially at the molecular level. This book brings together all available information on the centromere. It covers in details the DNA and protein components of this structure, and their individual functions, in species as diverse as budding and fissionyeasts, nematodes, Drosophila, mice, and humans; newly discovered roles of the centromere in marshalling "passenger" proteins; important emerging concepts such as latent centromeres and epigenetic factors; cytogenetic problems associated with centromere abnormalities; and practical application ofcentromere studies, such as in the construction of human artificial chromosomes for gene therapy. Supported by ample illustrations, the book is written with sufficient simplicity and detail to suit both specialist and non-specialist scholars. It is the first book on the subject
Repetitive Dna Sequences
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Author : Andrew G. Clark
language : en
Publisher: MDPI
Release Date : 2020-03-05
Repetitive Dna Sequences written by Andrew G. Clark and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-05 with Science categories.
Repetitive DNA is ubiquitous in eukaryotic genomes, and, in many species, comprises the bulk of the genome. Repeats include transposable elements that can self-mobilize and disperse around the genome, and tandemly-repeated satellite DNAs that increase in copy number due to replication slippage and unequal crossing over. Despite their abundance, repetitive DNA is often ignored in genomic studies due to technical challenges in their identification, assembly, and quantification. New technologies and methods are now providing the unprecedented power to analyze repetitive DNAs across diverse taxa. Repetitive DNA is of particular interest because it can represent distinct modes of genome evolution. Some repetitive DNA forms essential genome structures, such as telomeres and centromeres, which are required for proper chromosome maintenance and segregation, whereas others form piRNA clusters that regulate transposable elements; thus, these elements are expected to evolve under purifying selection. In contrast, other repeats evolve selfishly and produce genetic conflicts with their host species that drive adaptive evolution of host defense systems. However, the majority of repeats likely accumulate in eukaryotes in the absence of selection due to mechanisms of transposition and unequal crossing over. Even these neutral repeats may indirectly influence genome evolution as they reach high abundance. In this Special Issue, the contributing authors explore these questions from a range of perspectives.
Mobile Dna Iii
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Author : Michael Chandler
language : en
Publisher: John Wiley & Sons
Release Date : 2020-07-24
Mobile Dna Iii written by Michael Chandler and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-24 with Science categories.
An exploration of the raw power of genetic material to refashion itself to any purpose... Virtually all organisms contain multiple mobile DNAs that can move from place to place, and in some organisms, mobile DNA elements make up a significant portion of the genome. Mobile DNA III provides a comprehensive review of recent research, including findings suggesting the important role that mobile elements play in genome evolution and stability. Editor-in-Chief Nancy L. Craig assembled a team of multidisciplinary experts to develop this cutting-edge resource that covers the specific molecular mechanisms involved in recombination, including a detailed structural analysis of the enzymes responsible presents a detailed account of the many different recombination systems that can rearrange genomes examines the tremendous impact of mobile DNA in virtually all organisms Mobile DNA III is valuable as an in-depth supplemental reading for upper level life sciences students and as a reference for investigators exploring new biological systems. Biomedical researchers will find documentation of recent advances in understanding immune-antigen conflict between host and pathogen. It introduces biotechnicians to amazing tools for in vivo control of designer DNAs. It allows specialists to pick and choose advanced reviews of specific elements and to be drawn in by unexpected parallels and contrasts among the elements in diverse organisms. Mobile DNA III provides the most lucid reviews of these complex topics available anywhere.
Transposable Elements And Genome Evolution
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Author : J. F. McDonald
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Transposable Elements And Genome Evolution written by J. F. McDonald and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Once considered merely `selfish' or `parasitic' DNA, transposable elements are today recognized as being of major biological significance. Not only are these elements a major source of mutation, they have contributed both directly and indirectly to the evolution of genome structure and function. On October 8-10, 1999, 100 molecular biologists and evolutionists representing 11 countries met on the campus of The University of Georgia in Athens for the inaugural Georgia Genetics Symposium. The topics of presentations ranged from how the elements themselves have evolved to the impact transposable elements have had on the evolution of their host genomes. The papers in this volume therefore represent state-of-the-art thinking, by leading world experts in the field, on the evolutionary significance of transposable elements.
Mobile Genetic Elements
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Author : Wolfgang J. Miller
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-05
Mobile Genetic Elements written by Wolfgang J. Miller and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-05 with Medical categories.
Leading experts describe in step-by-step detail their most productive transposon-based methods and strategies for studying genome structure, function, and evolution. These readily reproducible techniques cover a wide range, including mutagenesis, transgenesis, gene silencing, and molecular systematics. Among the highlights are a series of DNA hybridization methods for analyzing the distribution and dynamics of mobile DNA at the hosts' genomic level, techniques for studying LTR retrotransposons in heterologous host systems, and mutagenesis protocols for investigating gene functions in a broad range of organisms. These cutting-edge methods offer investigators powerful genetic tools for dissecting the function of a specific gene, elaborating on the mechanisms leading to genetic change and diversity, and studying the evolutionary impact of mobile DNA on the biology and evolution of organisms.
Evolution And Impact Of Transposable Elements
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Author : Pierre Capy
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Evolution And Impact Of Transposable Elements written by Pierre Capy and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
During the last 50 years, the perception oftransposable elements (TEs) has changed considerably from selfish DNA to sequences that may contribute significantly to genome function and evolution. The recent increased interest in TEs is based on the realization that they are a major genetic component (at least 10--20%) of all organisms and a major contributor to the mutation process. It is currently estimated that 70--80% of spontaneous mutations are the result of TE-mediated insertions, deletions, or chromosomal rearrangements. Thus, it seems at least plausible that TEs may playa significant role in the adaptation and evolution of natural populations and species. The ubiquity of TEs suggests that they are an old component of genomes which have been vertically transmitted through generations over evolutionary time. However, detailed analyses carried out over the last 20 years have revealed several unusual features of TE evolution: (i) TEs can be horizontally transferred between species; (ii) TE evolutionary rates can be dramatically increased by specific inactivation processes, such as the RIP (Repeat Induced Point mutation) mechanism in fungi; (iii) TEs can influence the regulation of other TEs by insertion or deletion; (iv) different classes of TEs in even distantly related species can be remarkably similar in both structure and function.
Transposable Elements And Genome Evolution
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Author : Aurélie Hua-Van
language : en
Publisher: John Wiley & Sons
Release Date : 2024-09-24
Transposable Elements And Genome Evolution written by Aurélie Hua-Van and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-09-24 with Science categories.
Since their discovery by Barbara McClintock in the mid-20th century, the importance of transposable elements in shaping the architecture, function and evolution of genomes has gradually been unveiled. These DNA sequences populate nearly all genomes and are viewed as genomic parasites. They are mobile, capable of proliferating within genomes and also commonly travel between species. These elements are mutagenic and are responsible for several human genetic disorders, but they also constitute a major source of genetic diversity. Some insertions have beneficial effects for the host and are selected for, giving rise to significant evolutionary innovations. Their dynamics within genomes are intricate, as are their interactions with other genome components. To limit their proliferation, the genome has evolved sophisticated defense mechanisms. While researchers commonly use these elements as genetic tools, their identification in newly sequenced genomes remains a challenge due not only to their extensive diversity, but also their large copy numbers.