Ubiquitination In Immune System And Immune Response

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Ubiquitination In Immune System And Immune Response

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Author : Hongbo Hu
language : en
Publisher: Springer Nature
Release Date : 2024-11-15

Ubiquitination In Immune System And Immune Response written by Hongbo Hu and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-15 with Medical categories.

Ubiquitination is a major protein post-translational modification, which is involved in many aspects of cellular procedure. The functions of ubiquitination in immune system and immune response have been intensively studied. This book aims to introduce the latest and crucial achievements, along with the fundamental principles of ubiquitination and immune responses. It covers the proteomic aspects of ubiquitination, the function of ubiquitin in innate and adoptive immunity, the development of immune cells, and the metabolism. The active researchers in this field are invited to contribute the chapters. This book is suitable for graduate students, researchers and readers who are interested in this field. It will provide readers with comprehensive insight into how ubiquitination functions in different aspects of immune system.

How Salmonella Infection Can Inform On Mechanisms Of Immune Function And Homeostasis

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Author : Constantino López-Macías
language : en
Publisher: Frontiers Media SA
Release Date : 2016-04-12

How Salmonella Infection Can Inform On Mechanisms Of Immune Function And Homeostasis written by Constantino López-Macías and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-12 with Immunologic diseases. Allergy categories.

The use of model antigens such as haptens and ovalbumin has provided enormous insights into how immune responses develop, particularly to vaccine antigens. Furthermore, these studies are overwhelmingly performed in animals housed in clean facilities and are not known to have experienced overt clinical signs caused by infectious agents. Therefore, this is unlikely to reflect the impact more complex host-pathogen interactions can have on the host, nor the diversity in how immunity is regulated. Humans develop immune responses in the context of the periodic exposure to multiple pathogens and vaccines over a life-time. These are likely to have a long-lasting effect on who and what we are and how we respond to further antigen challenge. Therefore, studies on how infection influences immune homeostasis and how the development of responses to a pathogen reflects what is known on immune regulation will be informative on how we can translate findings from our standard models into treatments usable in humans.

One organism allows us to do just this. Bacteria of the genus Salmonella are devastating human pathogens. Nevertheless, many aspects of the diseases they cause can be successfully modelled in murine systems so that the infection is either resolving or non-resolving. This has the advantage of allowing the long-term impact of infection on immune function to be assessed. We propose to welcome key workers to write about their research that examine the consequence of Salmonella infection on the host and the elements of the bacterium that contribute to this.

Regulation Of Cancer Immune Checkpoints

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Author : Jie Xu
language : en
Publisher: Springer Nature
Release Date : 2020-03-17

Regulation Of Cancer Immune Checkpoints written by Jie Xu and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-17 with Medical categories.

This book systematically reviews the most important findings on cancer immune checkpoints, sharing essential insights into this rapidly evolving yet largely unexplored research topic. The past decade has seen major advances in cancer immune checkpoint therapy, which has demonstrated impressive clinical benefits. The family of checkpoints for mediating cancer immune evasion now includes CTLA-4, PD-1/PD-L1, CD27/CD70, FGL-1/LAG-3, Siglec-15, VISTA (PD-1L)/VSIG3, CD47/SIRPA, APOE/LILRB4, TIGIT, and many others. Despite these strides, most patients do not show lasting remission, and some cancers have been completely resistant to the therapy. The potentially lethal adverse effects of checkpoint blockade represent another major challenge, the mechanisms of which remain poorly understood. Compared to the cancer signaling pathways, such as p53 and Ras, mechanistic studies on immune checkpoint pathways are still in their infancy. To improve the responses to checkpoint blockade therapy and limit the adverse effects, it is essential to understand the molecular regulation of checkpoint molecules in both malignant and healthy cells/tissues. This book begins with an introduction to immune checkpoint therapy and its challenges, and subsequently describes the regulation of checkpoints at different levels. In closing, it discusses recent therapeutic developments based on mechanistic findings, and outlines goals for future translational studies. The book offers a valuable resource for researchers in the cancer immunotherapy field, helping to form a roadmap for checkpoint regulation and develop safer and more effective immunotherapies.

Molecular Biology Of Sars Cov 2

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Author : William A. Haseltine
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 2024-06-18

Molecular Biology Of Sars Cov 2 written by William A. Haseltine and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-18 with Medical categories.

Offering a thorough, accessible overview of the basic science and clinical data regarding the virus that causes COVID-19, Molecular Biology of SARS-CoV-2 is an excellent resource for researchers, clinical scientists, physicians, and students. This volume offers in-depth, extended content that originated with Drs. Roberto Patarca’s and William A. Haseltine’s chapter in The COVID-19 Textbook, edited by Dr. Haseltine and Dr. Patarca. The greatly expanded material in this text provides a much-needed primer in this complex area.

Host Parasite Interactions At The Cellular Tissue And Organism Level

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Author : Xuexian Yang
language : en
Publisher: Frontiers Media SA
Release Date : 2024-05-31

Host Parasite Interactions At The Cellular Tissue And Organism Level written by Xuexian Yang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-31 with Medical categories.

Protozoan and helminth parasites infect animals and humans and cause debilitating pathologies that cause a variety of morbidities and deaths worldwide. The ability of parasites to establish infection and cause disease in mammalian hosts is a result of a series of intricate mechanisms evolved by parasitic species to confront and evade the host's defensive responses, along with the ability to use the host’s metabolic and catabolic processes and host cellular organelles to their benefit. For instance, parasites may have predilection sites in the host that are not accessible to immune effector molecules and mechanisms, may acquire host-derived "masking" molecules, can vary their surface molecules, and can produce molecules that block or misguide the host immune responses. The host's interactions with the parasite, on the other hand, are critical for the initiation and induction of host signaling events that are critical in mounting formidable defensive immune responses against the invading parasite. Therefore, the ability of a parasite to successfully establish infection and cause disease largely depends on its interaction with the host and the ability of the host to mount successful and effective resistance. Thus, studying host-parasite interactions and cross-talks is critical for understanding parasite infection and adaptation mechanisms within the host, as well as for developing strategies for effective prevention and control of parasitic infections in humans and animals. The topic will cover a wide spectrum of parasitic protozoa and helminths and provide an opportunity to share new molecular and translational advances in parasitic infections and diseases.

Handbook Of Proteases In Cancer

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Author : Sajal Chakraborti
language : en
Publisher: CRC Press
Release Date : 2024-12-17

Handbook Of Proteases In Cancer written by Sajal Chakraborti and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-12-17 with Science categories.

This handbook provides comprehensive coverage of the application of proteases in cancer therapy. Proteases make up to two percent of the human genome and play a critical role in the tumor microenvironment. The book delves into the applications of natural, synthetic, and non-coding RNAs in cancer therapy. It highlights how effective targeting of relevant proteases can help in cancer diagnosis and treatment. It covers the systems biology and bioinformatics approach in cancer drug development. The book is meant for researchers and professionals in cancer research, biochemistry, and physiology.

Ubiquitin Proteasome System

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Author : Matthew Summers
language : en
Publisher: BoD – Books on Demand
Release Date : 2019-06-19

Ubiquitin Proteasome System written by Matthew Summers and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-19 with Science categories.

The human ubiquitin proteasome system (UPS) is comprised of nearly 1000 proteins. Although originally identified as a mechanism of protein destruction, the UPS has numerous additional functions and mediates central signaling events in myriad processes involved in both cellular and organismal health and homeostasis. Numerous pathways within the UPS are implicated in disease, ranging from cancer to neurodegenerative diseases such as Parkinson's. The goal of this book is to deliver a collection of synopses of current areas of UPS research that highlights the importance of understanding the biology of the UPS to identify disease-relevant pathways, and the need to elucidate the molecular machinations within the UPS to develop methods for therapeutic modulation of these pathways.

Cell And Tissue Organization In The Circulatory And Ventilatory Systems

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Author : Marc Thiriet
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-09-08

Cell And Tissue Organization In The Circulatory And Ventilatory Systems written by Marc Thiriet and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-08 with Science categories.

The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to nano- and microscopic events in a corrector scheme of regulated mechanisms. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning. The present volume is devoted to cellular events that allow adaptation to environmental conditions, particularly mechanotransduction. It begins with cell organization anda survey of cell types in the vasculature and respiratory tract. It then addresses cell structure and functions, especially in interactions with adjoining cells and matrix.

Ubiquitin And Ubiquitin Like Modifications In Viral Infection And Innate Immunity

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Author : Soham Gupta
language : en
Publisher: Frontiers Media SA
Release Date : 2023-03-13

Ubiquitin And Ubiquitin Like Modifications In Viral Infection And Innate Immunity written by Soham Gupta and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-13 with Medical categories.

The Role Of Ubiquitination In Disease Development Progression And Prognosis

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Author : Wenyi Jin
language : en
Publisher: Frontiers Media SA
Release Date : 2025-05-08

The Role Of Ubiquitination In Disease Development Progression And Prognosis written by Wenyi Jin and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-05-08 with Medical categories.

Ubiquitination, an essential post-translational modification, controls various cellular functions by attaching ubiquitin to proteins, dictating their fate from degradation to functional reorganization. This modification, catalyzed by a series of enzymes (E1, E2, E3), is crucial for maintaining cellular homeostasis and is highly involved in key processes such as signal transduction, DNA repair, and gene expression. Recent studies illustrate how ubiquitination dysfunction is linked to numerous diseases, highlighting its role in immune regulation, cancer progression, and other pathologies. However, despite significant advancements, the full mechanistic pathways and implications of ubiquitination in disease progression and immune system dysfunction remain incompletely understood. This Research Topic aims to deepen the understanding of how ubiquitination influences disease development, progression, and response to therapies. By focusing on the modulation of cell signaling and immune responses through ubiquitination, our goal is to uncover new mechanistic insights that could lead to more effective therapeutic strategies. Essential objectives include elucidating the non-degradative roles of ubiquitination in immune cell function and tumor microenvironment modulation, exploring the potential of ubiquitination as a biomarker, and advancing our understanding of its molecular mechanisms in disease contexts.