Unconventional Protein Secretion From Basic Mechanisms To Dysregulation In Disease
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Unconventional Protein Secretion From Basic Mechanisms To Dysregulation In Disease
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Author : Vivek Malhotra
language : en
Publisher: Frontiers Media SA
Release Date : 2023-01-02
Unconventional Protein Secretion From Basic Mechanisms To Dysregulation In Disease written by Vivek Malhotra and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-01-02 with Science categories.
Beta Cell Fate From Gene Circuits To Disease Mechanisms
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Author : Simona Chera
language : en
Publisher: Frontiers Media SA
Release Date : 2022-03-16
Beta Cell Fate From Gene Circuits To Disease Mechanisms written by Simona Chera and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-16 with Science categories.
Autophagy In Endocrine Metabolic Diseases Associated With Aging
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Author : Maria Ines Vaccaro
language : en
Publisher: Frontiers Media SA
Release Date : 2020-12-11
Autophagy In Endocrine Metabolic Diseases Associated With Aging written by Maria Ines Vaccaro and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-11 with Medical categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Nlrp3 Inflammasome Regulatory Mechanisms Role In Health And Disease And Therapeutic Potential
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Author : Kuo-Feng Hua
language : en
Publisher: Frontiers Media SA
Release Date : 2021-11-08
Nlrp3 Inflammasome Regulatory Mechanisms Role In Health And Disease And Therapeutic Potential written by Kuo-Feng Hua and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-08 with Medical categories.
Inflammatory Immune Disease Molecular Mechanisms Translational Approaches And Therapeutics
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Author : Tao Xu
language : en
Publisher: Frontiers Media SA
Release Date : 2022-07-05
Inflammatory Immune Disease Molecular Mechanisms Translational Approaches And Therapeutics written by Tao Xu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-05 with Science categories.
The Mononuclear Phagocyte System In Infectious Disease
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Author : Geanncarlo Lugo-Villarino
language : en
Publisher: Frontiers Media SA
Release Date : 2019-10-04
The Mononuclear Phagocyte System In Infectious Disease written by Geanncarlo Lugo-Villarino and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-04 with categories.
The Mononuclear Phagocyte System (MPS) of vertebrates is composed of monocytes, macrophages and dendritic cells. Together, they form part of the first line of immune defense against a variety of pathogens (bacteria, fungi, parasites and viruses), and thus play an important role in maintaining organism homeostasis. The mode of transmission, type of replication and mechanism of disease-causing differ significantly for each pathogen, eliciting a unique immune response in the host. Within this context, the MPS acts as both the sentinel and tailor of the immune system. As sentinels, MPS cells are found in blood and within tissues throughout the body to patrol against pathogenic insult. The strategy to detect 'microbial non-self' relies on MPS to recognize conserved microbial products known as 'pathogen-associated molecular pattern' (PAMPs). PAMPs recognition represents a checkpoint in the response to pathogens and relies on conserved 'pattern recognition receptors' (PRRs). Upon PRR engagement, MPS mount a cell-autonomous attack that includes the internalization and compartmentalization of intracellular pathogens into toxic compartments that promote destruction. In parallel, MPS cells launch an inflammatory response composed of a cellular arm and soluble factors to control extracellular pathogens. In cases when innate immunity fails to eliminate the invading microbe, MPS serves as a tailor to generate adaptive immunity for pathogen eradication and generation of "memory" cells, thus ensuring enhanced protection against re-infection. Indeed, MPS cell functions comprise the capture, process, migration and delivery of antigenic information to lymphoid organs, where type-1 immunity is tailored against intracellular microbes and type-2 immunity against extracellular pathogens. However, this potent adaptive immunity is also a double-edge sword that can cause aberrant inflammatory disorders, like autoimmunity or chronic inflammation. For this reason, MPS also tailors tolerance immunity against unwanted inflammation. Successful clearance of the microbe results in its destruction and proper collection of debris, resolution of inflammation and tissue healing for which MPS is essential. Reciprocally, as part of the evolutionary process taking place in all organisms, microbes evolved strategies to circumvent the actions bestowed by MPS cells. Multiple pathogens modulate the differentiation, maturation and activation programs of the MPS, as an efficient strategy to avoid a dedicated immune response. Among the most common evasion strategies are the subversion of phagocytosis, inhibition of PRR-mediated immunity, resistance to intracellular killing by reactive oxygen and nitrogen species, restriction of phagosome maturation, modulation of cellular metabolism and nutrient acquisition, regulation of cell death and autophagy, and modulation of pro-inflammatory responses and hijacking of tolerance mechanisms, among others. The tenet of this eBook is that a better understanding of MPS in infection will yield insights for development of therapeutics to enhance antimicrobial processes or dampen detrimental inflammation for the host's benefit. We believe that contributions to this topic will serve as a platform for discussion and debate about relevant issues and themes in this field. Our aim is to bring expert junior and senior scientists to address recent progress, highlight critical knowledge gaps, foment scientific exchange, and establish conceptual frameworks for future MPS investigation in the context of infectious disease.
Golgi Dynamics In Physiological And Pathological Conditions
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Author : Jaakko Saraste
language : en
Publisher:
Release Date : 2020
Golgi Dynamics In Physiological And Pathological Conditions written by Jaakko Saraste and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.
Articles in this collection illustrate our recent progress in understanding Golgi biology, and also outline a specific set of yet unanswered Golgi-related questions. For example, exactly how do cargo and resident proteins travel to, through and out of the Golgi? What are the exact modes, carriers and molecular machineries of bi-directional Golgi trafficking? How are Golgi structure and its various functions modified during normal (differentiation, development, etc.) and abnormal (diseases, drugs, pathogens, etc.) circumstances?
Drug Hypersensitivity From Mechanisms To Improved Diagnosis And Standards Of Care
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Author : Maria Jose Torres
language : en
Publisher: Frontiers Media SA
Release Date : 2021-08-18
Drug Hypersensitivity From Mechanisms To Improved Diagnosis And Standards Of Care written by Maria Jose Torres and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-18 with Science categories.
Textbook Of Autoinflammation
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Author : Philip J. Hashkes
language : en
Publisher: Springer
Release Date : 2019-02-13
Textbook Of Autoinflammation written by Philip J. Hashkes and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-02-13 with Medical categories.
This book, the first complete textbook on this novel field in Medicine, comprehensively covers the clinical presentation, pathogenesis, genetics, and latest management strategies for autoinflammatory disorders as well as the basic science of autoinflammation. Relevant concepts such as how translational science of genetics and immunology relates to the innate immune system and autoinflammation are covered. Descriptions of the monogenic and polygenic/complex diseases that fall under the umbrella of autoinflammatory diseases are provided. Further topics covered include the latest clinical and genetic diagnostic approaches, concepts on the relationship between autoinflammation and autoimmunity/immunodeficiency, the role of autoinflammation in cancer, treatments and management strategies for these diseases, and potential areas of future development. The Textbook of Autoinflammation systematically describes and reviews diagnostic and treatment options for autoinflammatory disorders as well as all aspects of the concept of autoinflammation, and represents a valuable resource for professionals in a variety of disciplines who encounter these patients or who study autoinflammation.
Epigenetics Of Aging
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Author : Trygve O. Tollefsbol
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-11-11
Epigenetics Of Aging written by Trygve O. Tollefsbol and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-11 with Medical categories.
Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.