Understanding Crohn S Disease Immunity Genes And Microbes
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Understanding Crohn S Disease Immunity Genes And Microbes
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Author : Amélia Sarmento
language : en
Publisher: Frontiers Media SA
Release Date : 2017-08-11
Understanding Crohn S Disease Immunity Genes And Microbes written by Amélia Sarmento and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-11 with Electronic book categories.
Crohn's disease (CD) is a chronic, relapsing, inflammatory bowel disease resulting in considerable morbidity and reduced quality of life. Although still under intense debate, CD seems to result from an enhanced and uncontrolled immune response to the gut microbiota. CD is thought to be multifactorial depending on genetic and environmental determinants. In recent years, nearly 100 single nucleotide polymorphisms (SNPs) were associated with increased risk of developing CD (some of the SNPs also associated with susceptibility to ulcerative colitis, another type of IBD). These SNPs are mostly located in genes involved in innate and adaptive immunity mechanisms, such as autophagy, expression of pattern-recognition receptors and citokine signaling. Epigenetics is also probably playing a role in CD susceptibility, as it is sensitive to environmental conditions and may mediate gene-environment interactions. Environmental factors possibly involved in CD development include diet, gut microbiota composition and infection with specific pathogens, of which the most consistently associated to CD are Mycobacterium avium subsp. paratuberculosis and adherent-invasive Escherichia coli. This Topic aimed at bringing together contributions covering different genetic, epigenetic, immunological and microbial processes involved in the development of CD, helping to drive forward the understanding of CD immunopahtology.
Inflammatory Bowel Disease
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Author : Derek J. Chadwick
language : en
Publisher: John Wiley & Sons
Release Date : 2005-06-10
Inflammatory Bowel Disease written by Derek J. Chadwick and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-06-10 with Science categories.
Inflammatory bowel disease (IBD) comprises a group of idiopathic diseases of the intestine characterized by chronic inflammation of the bowel with periods of exacerbation and remission. Although the exact cause of IBD remains undetermined, the condition appears to be related to a combination of genetic and environmental factors resulting in an aberrant activation of the mucosal immune system. This book contains a series of interdisciplinary discussions between clinical and basic scientists focusing on key issues such as: Epithelial cell and molecular biology, including apoptosis, necrosis and cell survival The role of bacterial milieu and mucosal bacteria in the IBD and of prebiotic and probiotic therapy The progress towards the identification of susceptibility genes and phenotype-determining genes The pharmacogenetics of IBD Mucosal immunology and therapeutic strategies stemming therefrom
Molecular Genetics Of Inflammatory Bowel Disease
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Author : Mauro D'Amato
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-10-05
Molecular Genetics Of Inflammatory Bowel Disease written by Mauro D'Amato and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-05 with Medical categories.
Research in Crohn’s disease (CD) and ulcerative colitis (UC), together known as the inflammatory bowel diseases (IBD), has truly seen a revolution in the last 5-10 years. This book examines how these genetic discoveries have led to the identification of biological functions not previously associated with IBD pathophysiology (e.g. autophagy), how multiple genetic risk factors for IBD converge on given biological functions and that together the identified variants in these genes have predisposing and protective roles (e.g. the multiple variants in the receptor for the IL23 cytokine and its signaling cascade), and how having such a large number of known genetic risk factors has changed our understanding not only about the genetic and molecular overlap between CD and UC, but also between these diseases and other chronic inflammatory diseases (e.g. psoriasis, multiple sclerosis, type 1 diabetes and many others).
Understanding Crohn Disease And Ulcerative Colitis
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Author : Jon Zonderman
language : en
Publisher: Univ. Press of Mississippi
Release Date : 2000
Understanding Crohn Disease And Ulcerative Colitis written by Jon Zonderman and has been published by Univ. Press of Mississippi this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Crohn's disease categories.
For patients and caregivers an overview of the nature and treatments of inflammatory bowel disease
Crohn S Disease And Ulcerative Colitis
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Author : Daniel C. Baumgart
language : en
Publisher: Springer
Release Date : 2017-03-01
Crohn S Disease And Ulcerative Colitis written by Daniel C. Baumgart and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-01 with Medical categories.
This new edition is a unique combined resource for physicians and scientists addressing the needs of both groups. In addition to stimulating exchange and collaboration and shortening the path between discovery and application of new knowledge, the book helps clinicians understand new therapeutic concepts from their origins. The volume serves as a comprehensive guide to the current diagnostic modalities, including enhanced imaging techniques such as MRI and CT enterography, virtual colonoscopy, ultrasound, and endomicroscopy, as well as conventional and complex immunomodulatory principles. The latest edition also includes revised chapters from the previous edition, as well as new chapters reflecting current developments in the field. Written by experts in their field, Crohn’s Disease and Ulcerative Colitis: From Epidemiology and Immunobiology to a Rational Diagnostic and Therapeutic Approach, Second Edition is of great value to gastroenterologists, surgeons, internists, pediatricians and gynecologists trainees, as well as all those involved in Crohn’s disease, ulcerative colitis, and related autoimmune disorders.
The Ascrs Manual Of Colon And Rectal Surgery
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Author : David E. Beck
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-06-12
The Ascrs Manual Of Colon And Rectal Surgery written by David E. Beck and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-06-12 with Medical categories.
The ASCRS Textbook of Surgery of the Colon and Rectum offers a comprehensive textbook designed to provide state of the art information to residents in training and fully trained surgeons seeking recertification. The textbook also supports the mission of the ASCRS to be the world’s authority on colon and rectal disease. The combination of junior and senior authors selected from the membership of the ASCRS for each chapter will provide a comprehensive summary of each topic and allow the touch of experience to focus and temper the material. This approach should provide the reader with a very open minded, evidence based approach to all aspects of colorectal disease. Derived from the textbook, The ASCRS Manual of Surgery of the Colon and Rectum offers a “hands on” version of the textbook, written with the same comprehensive, evidence-based approach but distilled to the clinical essentials. In a handy pocket format, readers will find the bread and butter information for the broad spectrum of practice. In a consistent style, each chapter outlines the condition or procedure being discussed in a concise outline format – easy to read, appropriately illustrated and referenced.
Microbial Ecology In States Of Health And Disease
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2014-02-18
Microbial Ecology In States Of Health And Disease written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-02-18 with Medical categories.
Individually and collectively, resident microbes play important roles in host health and survival. Shaping and shaped by their host environments, these microorganisms form intricate communities that are in a state of dynamic equilibrium. This ecologic and dynamic view of host-microbe interactions is rapidly redefining our view of health and disease. It is now accepted that the vast majority of microbes are, for the most part, not intrinsically harmful, but rather become established as persistent, co-adapted colonists in equilibrium with their environment, providing useful goods and services to their hosts while deriving benefits from these host associations. Disruption of such alliances may have consequences for host health, and investigations in a wide variety of organisms have begun to illuminate the complex and dynamic network of interaction - across the spectrum of hosts, microbes, and environmental niches - that influence the formation, function, and stability of host-associated microbial communities. Microbial Ecology in States of Health and Disease is the summary of a workshop convened by the Institute of Medicine's Forum on Microbial Threats in March 2013 to explore the scientific and therapeutic implications of microbial ecology in states of health and disease. Participants explored host-microbe interactions in humans, animals, and plants; emerging insights into how microbes may influence the development and maintenance of states of health and disease; the effects of environmental change(s) on the formation, function, and stability of microbial communities; and research challenges and opportunities for this emerging field of inquiry.
Interventional Inflammatory Bowel Disease Endoscopic Management And Treatment Of Complications
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Author : Bo Shen
language : en
Publisher: Academic Press
Release Date : 2018-01-16
Interventional Inflammatory Bowel Disease Endoscopic Management And Treatment Of Complications written by Bo Shen and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-16 with Medical categories.
Interventional Inflammatory Bowel Diseases: Endoscopic Management and Treatment of Complications covers the preparation, principle, techniques, and damage control of complications in endoscopic therapy, providing the ultimate guidance in endoscopic management of IBD. With contributions from a panel of international leading experts in the field, perspectives are included from GI pathologists, GI radiologists, gastroenterologists, advanced endoscopists, IBD specialists and colorectal surgeons. Recommendations from experts are also included within each chapter. By bridging medical and surgical treatment modalities for IBD, this is the perfect reference for GI researchers, medical students, therapeutic GI endoscopists, IBD specialists, surgeons and advanced health care providers. Incorporates state-of-the-art of research in the area of therapeutic endoscopy in Crohn’s Disease and Ulcerative Colitis Makes the connection between the understanding of the complex nature and disease course of IBD with corresponding advanced endoscopic procedures Explores endoscopic treatment as the missing link between medical and surgical treatment for complex Crohn’s Disease and Ulcerative Colitis Contains access to videos demonstrating important procedural concepts
Intestinal Immune System
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Author : Soichiro Miura
language : en
Publisher: Morgan & Claypool Publishers
Release Date : 2011
Intestinal Immune System written by Soichiro Miura and has been published by Morgan & Claypool Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Medical categories.
These negative regulatory mechanisms of the intestinal immune system are disturbed in certain disease conditions, causing the immunocompetent cells to respond to food components and commensal bacteria by becoming activated and to overproduce inflammatory cytokines and chemokines. These disease conditions include food allergies, such as celiac disease, and the inflammatory bowel diseases, such as ulcerative colitis and Crohn's disease, although their exact etiological mechanisms remain to be revealed. --Book Jacket.
Next Generation Probiotics From Commensal Bacteria To Novel Drugs And Food Supplements
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Author : Philippe Langella
language : en
Publisher: Frontiers Media SA
Release Date : 2019-11-22
Next Generation Probiotics From Commensal Bacteria To Novel Drugs And Food Supplements written by Philippe Langella and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-22 with categories.