Vaccine Delivery Technology

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Vaccine Delivery Technology

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Author : Blaine A. Pfeifer
language : en
Publisher:
Release Date : 2021

Vaccine Delivery Technology written by Blaine A. Pfeifer and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with Drug delivery systems categories.

Subunit Vaccine Delivery

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Author : Camilla Foged
language : en
Publisher: Springer
Release Date : 2014-11-22

Subunit Vaccine Delivery written by Camilla Foged and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-22 with Medical categories.

This comprehensive volume compiles the concepts essential for the understanding of the pharmaceutical science and technology associated with the delivery of subunit vaccines. Twenty-one chapters are divided into four main parts: (I) Background; (2) Delivery Systems for Subunit Vaccines; (3) Delivery Routes, Devices and Dosage Forms; and (4) Pharmaceutical Analysis and Quality Control of Vaccines. Part one provide a basic background with respect to immunology and general vaccine classification. In part two, it presents representative types of vaccine delivery systems individually with focus on the physicochemical properties of the systems and their significance for the immune response they stimulate. These delivery systems include aluminum adjuvants, emulsions, liposomes, bilosomes, cubosomes/hexosomes, ISCOMs, virus-like particles, polymeric nano- and microparticles, gels, implants and cell-based delivery systems. Following these chapters, part three addresses the challenges associated with vaccine delivery via specific routes of administration—in particular subcutaneous, intramuscular, oral, nasal, pulmonary, transdermal and vaginal administration. Furthermore, the specific administration routes are discussed in combination with device technologies relevant for the respective routes as well as dosage forms appropriate for the device technology. Finally, the fourth part concerns pharmaceutical analysis and quality control of subunit vaccines.

Novel Immune Potentiators And Delivery Technologies For Next Generation Vaccines

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Author : Manmohan Singh
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-03

Novel Immune Potentiators And Delivery Technologies For Next Generation Vaccines written by Manmohan Singh and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-03 with Medical categories.

Development of new-generation vaccines is now more challenging than ever, as identifying, purifying and evaluating vaccine antigens is a complex undertaking. Most importantly, once the relevant antigens have been identified, key focus then shifts to the development of suitable delivery systems and formulations to achieve maximum in vivo potency with minimum potential side effects. These novel formulations—many of which will be nanoparticulates—can deliver the antigens to the desired site, to the relevant antigen presenting cells, and prevent systemic exposure of the immune potentiators. The proposed book will outline all the critical steps that need to be considered for successful development of various types of nanoparticulate delivery systems for vaccine antigens. These contributions from leading experts in the area of vaccine formulation and delivery systems will tie in what is the most current status, including clinical evaluations with these novel vaccine technologies.​

Nanoparticulate Vaccine Delivery Systems

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Author : Martin J. D'Souza
language : en
Publisher: CRC Press
Release Date : 2015-06-01

Nanoparticulate Vaccine Delivery Systems written by Martin J. D'Souza and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-06-01 with Medical categories.

Recent years have seen the development of novel technologies that use nanoparticles and microparticles to deliver vaccines by the oral and microneedle-based transdermal route of administration. These new technologies enable the formulation of vaccine particles containing vaccine antigens, without loss of their biological activity during the formulation process. Also, multiple antigens, targeting ligands, and adjuvants can all be encapsulated within the same particle. When administered orally, these particles are designed to withstand the acidic environment of the stomach and are targeted to Peyer’s patches and the gut-associated mucosal immune system. Since these vaccines are particulate in nature, they are readily taken up by phagocytic antigen-presenting cells, such as M cells, dendritic cells, and macrophages in Peyer’s patches of the intestines, resulting in a strong immune response and antibody production. Since no needles are required for oral vaccines, this method of vaccine delivery is inexpensive and suitable for mass vaccination in the developing world as well as the developed world. This book discusses studies conducted on a wide array of vaccines, including vaccines for infectious diseases such as tuberculosis, typhoid, influenza, pneumonia, meningitis, human papillomavirus, and hepatitis B. It also discusses recent studies on vaccines for cancers such as melanoma and ovarian, breast, and prostate cancer.

Immunization

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Author : Ning Wang
language : en
Publisher: BoD – Books on Demand
Release Date : 2018-11-28

Immunization written by Ning Wang and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-28 with Medical categories.

Immunization plays a key role in maintaining human health and each year, saves millions of lives from lethal pathogens and other fatal diseases in the most economical way, thanks to the advanced development of model vaccines. Subunit vaccines are regarded as a safer product than the whole microbe based-conventional vaccines and can be entrapped in various nanocarriers to form a vaccine adjuvant-delivery system (VADS) able to further boost their immunostimulatory activity. In this book, six groups of authors introduce immunization advances in VADSs designed for infection prophylaxis and cancer immunotherapy, problems and their resolution in both human and poultry immunization, and also, the mathematical model for assay of the basic immunization problem (BIP) understood from a finance point of view.

Antigen Delivery Systems

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Author : Bruno Gander
language : en
Publisher: CRC Press
Release Date : 1998-01-29

Antigen Delivery Systems written by Bruno Gander and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-01-29 with Medical categories.

This text presents an up-to-date overview of recent developments in this field, reviews new trends in vaccine development programs, and emphasizes the requirements and importance of varied vaccine delivery systems.

Vaccine Adjuvants And Delivery Systems

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Author : Manmohan Singh
language : en
Publisher: John Wiley & Sons
Release Date : 2007-08-03

Vaccine Adjuvants And Delivery Systems written by Manmohan Singh and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-08-03 with Science categories.

The authoritative reference on recent developments in vaccinology New technologies, including recombinant protein and DNA, have sparked phenomenal progress in vaccine development and delivery systems. This unique resource brings scientists up to date on recent advances and provides the information they need to select candidate adjuvants. With chapters written by leading experts in their fields, Vaccine Adjuvants and Delivery Systems: * Provides a comprehensive overview of the rapidly evolving field and developing formulation methods * Covers cutting-edge technologies and gives the current status of adjuvants in clinical trials and those still in the pre-clinical stage * Includes detailed information on specific vaccine adjuvants, including MF59, TLR4 agonists, new iscoms, cytokines, polyphosphazenes, and more * Provides a historical perspective on the development of vaccine adjuvants and discusses the mechanisms of adjuvant actions * Covers some novel adjuvants and delivery systems and the safety evaluation of adjuvants A great reference for researchers, scientists, and students in vaccinology, biotechnology, immunology, and molecular biology, this resource is also valuable for researchers and scientists in veterinary medicine who work to prevent diseases in animals.

Advanced Vaccination Technologies For Infectious And Chronic Diseases

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Author : Vasso Apostolopoulos
language : en
Publisher: Elsevier
Release Date : 2024-03-25

Advanced Vaccination Technologies For Infectious And Chronic Diseases written by Vasso Apostolopoulos and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-25 with Medical categories.

The role of vaccines is emerging and even critical to ending infectious and chronic diseases and pandemics alike. The design and development of new vaccines could lead to improved health. Handbook on Advanced Vaccination Technologies for Infectious and Chronic Disease discusses these new developments and introduces the reader to the current state of the science and the outlook going forward from the discovery of vaccines to the clinical trials of personalized vaccines. Handbook on Advanced Vaccination Technologies for Infectious and Chronic Diseases is a valuable reference for occupational health professionals whose role involves supervision of immunization programs such as those working in the National Health Service, some sectors of higher education and the pharmaceutical industry. Offers comprehensive coverage of different vaccine platforms and their development Includes information on the regulatory perspective of vaccine development Describes different delivery approaches for vaccinology Explains the clinical development of vaccines along with novel platforms Covers all recent developments of vaccine production technologies, new types of vaccines, and ongoing research that could prevent future pandemics

Delivery Technologies For Biopharmaceuticals

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Author : Lene Jorgensen
language : en
Publisher: John Wiley & Sons
Release Date : 2009-10-23

Delivery Technologies For Biopharmaceuticals written by Lene Jorgensen and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-10-23 with Science categories.

Advances in biotechnology have provided scientists with an increasing number of biopharmaceuticals such as novel peptide and protein drugs as well as nucleic acid based drugs for gene therapy. However, successful delivery of these biopharmaceuticals is a major challenge because their molecular properties lead to poor physical and chemical stability in the body and limited membrane permeability. Therefore researchers are developing a range of new delivery technologies and materials to enable these new drugs to be delivered intact to their target sites. Delivery Technologies for Biopharmaceuticals describes strategies to overcome the main barriers for successful delivery of therapeutic peptides, proteins, and nucleic acid-based drugs or vaccines related to the site of administration and the target site. Many of the approaches described are reported in formulations in current clinical trials as well as in marketed products. Contents include: challenges in delivery of biopharmaceuticals novel formulation approaches for peptide and protein injectables non-viral chemical vectors and viral technology for delivery of nucleic acid based drugs immune response, adjuvants and delivery systems for vaccines several examples of delivery systems for different biopharmaceuticals a critical assessment of delivery technologies for biopharmaceuticals Delivery Technologies for Biopharmaceuticals is an essential single-volume introduction to the technologies used by researchers to ensure efficient delivery of this exciting new class of drugs. It will be of value to researchers and students working in drug delivery, formulation, biopharmaceuticals, medicinal chemistry, and new materials development.

Advances In Vaccine Technology Delivery

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Author :
language : en
Publisher:
Release Date : 2009

Advances In Vaccine Technology Delivery written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Vaccines categories.