Vaccinia Virus
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Vaccinia Virus And Poxvirology
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Author : Stuart N. Isaacs
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-03
Vaccinia Virus And Poxvirology written by Stuart N. Isaacs and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-03 with Science categories.
The Right Book at the Right Time The poxviruses comprise a family of complex DNA viruses that replicate in the cytoplasm of vertebrate or invertebrate cells. Of the eight recognized g- era of vertebrate poxviruses, those belonging to the orthopoxvirus genus have been most intensively studied. This group includes variola virus, the agent of smallpox, as well as cowpox virus and vaccinia virus. Jenner’s original sma- pox vaccine, described in 1798, consisted of live cowpox virus, but vaccinia virus later replaced it (1). There has been speculation as to the origin of v- cinia virus; the most likely idea is that it is a separate species, possibly ori- nally isolated from a horse, and is now extinct or rare in nature (2). Recent genome sequencing studies confirm the distinctness of variola virus, cowpox virus, and vaccinia virus and also their very close genetic relationship, which accounts for the cross protection of smallpox vaccines. The novelty of the smallpox vaccine can be readily appreciated by the time it took, about 80 years, before the next live vaccine against rabies was developed, and another 50 years for the yellow fever vaccine. Moreover, the eradication of smallpox in 1977 stands as a unique medical achievement. Because of its historical role, sma- pox vaccination contributed greatly to present concepts of infectious disease, immunity, and pathogenesis. Less well known, however, are the many other “firsts” for vaccinia virus.
Vaccinia Virus
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Author : Jason Mercer
language : en
Publisher:
Release Date : 2019
Vaccinia Virus written by Jason Mercer and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Medical virology categories.
This detailed book provides practical information for the laboratory that can be applied to the study of vaccinia and other poxviruses while emphasizing long-standing field standards and focusing on emerging new technologies applied in the field of poxvirology. The methods and protocols have been designed with the bench scientist in mind, being presented in a fashion that makes them useful for both starting and veteran poxvirus researchers. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Vaccinia Virus: Methods and Protocols serves as a valuable resource for scientists looking to bring new methods and procedures into their lab in order to make exciting discoveries that will continue to deepen our understanding of this fascinating virus family.
Jenner S Smallpox Vaccine
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Author : Derrick Baxby
language : en
Publisher: Heinemann Educational Publishers
Release Date : 1981
Jenner S Smallpox Vaccine written by Derrick Baxby and has been published by Heinemann Educational Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 1981 with Medical categories.
Vaccinia Viruses As Vectors For Vaccine Antigens
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Author : Gerald V. Quinnan
language : en
Publisher: Elsevier Publishing Company
Release Date : 1985
Vaccinia Viruses As Vectors For Vaccine Antigens written by Gerald V. Quinnan and has been published by Elsevier Publishing Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 1985 with Medical categories.
Poxviruses
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Author : Richard W. Moyer
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Poxviruses written by Richard W. Moyer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The purpose of this volume is to highlight some current areas of poxvirus research which are likely to be particularly fruitful in the upcoming few years. The first chapter, by Drs. Condit and Niles, discusses poxvirus genetics. Work in this area has provided mutants, produced practical procedures to simplify the manipulation of viral genes, and generated information about the molecular architecture and organization of genes characteristic of pox viruses. One of the most intensively studied regions of the viral genome is the HindIII D region of vaccinia, in which a combination of classical and molecular genetic analysis of the region has been particularly revealing. Within this region are open reading frames, some of which are expressed early and others late, organized in a fashion which is now known to be typical of these viruses. Other studies, related to temperature sensitive, drug resistant, and drug dependent mutants, are also discussed. Each of the other reviews included in this volume summarizes areas of research which have depended heavily on the genetics of the system. The intracellular site of a poxvirus infection is mostly, if not exclusively, limited to the cytoplasm which dictates several interesting biological ramifications. For example, poxvirus transcription must occur in the cytoplasm, rather than in the nucleus. The virus copes with this situation by incorporating into the virion the enzymatic machinery necessary to initiate transcription from input virus.
Studies Of The Viruses Of Vaccinia And Variola
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Author : Mervyn Henry Gordon
language : en
Publisher:
Release Date : 1925
Studies Of The Viruses Of Vaccinia And Variola written by Mervyn Henry Gordon and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1925 with Medicine categories.
Recombinant Poxviruses
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Author : Matthew M. Binns
language : en
Publisher: CRC Press
Release Date : 1992-05-27
Recombinant Poxviruses written by Matthew M. Binns and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-05-27 with Science categories.
Recombinant Poxviruses provides a comprehensive examination of poxviruses with an emphasis on the potential of these viruses as new vaccines. The book considers a wide range of issues involved in producing new genetically engineered live vaccines, such as efficacy, safety, stability, cost, host range, immune response, immunization route, use of multivalent vaccines, and need for revaccination. The opening chapter describes the origin of vaccinia virus, its use to eradicate smallpox, and the pathogenesis of poxvirus infections. Subsequent chapters examine the molecular biology of poxviruses, methods of constructing vaccinia virus recombinants, and applications; the use and immune responses induced by poxvirus recombinants as live vaccines; and the important issues of the safety and immunogenicity of vaccinia virus. The book's final two chapters report the progress that has been made developing avipoxviruses and parapoxviruses as candidate recombinant vaccines. Recombinant Poxviruses will be a welcome addition to the bookshelves of virologists, microbiologists, infectious disease specialists, and veterinarians.
Jenner S Smallpox Vaccine
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Author : Derrick Baxby
language : en
Publisher:
Release Date : 1931
Jenner S Smallpox Vaccine written by Derrick Baxby and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1931 with Smallpox categories.
The Biology Of Extracellular Enveloped Vaccinia Virus
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Author : Lendon Gervais Payne
language : en
Publisher:
Release Date : 1979
The Biology Of Extracellular Enveloped Vaccinia Virus written by Lendon Gervais Payne and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1979 with categories.
A Study Of The Growth Of Vaccinia Virus In Tissue Culture
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Author : Shirley Rae Walters
language : en
Publisher:
Release Date : 1953
A Study Of The Growth Of Vaccinia Virus In Tissue Culture written by Shirley Rae Walters and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1953 with categories.