Vascular Biochemistry
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Vascular Biochemistry
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Author : Peter Zahradka
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Vascular Biochemistry written by Peter Zahradka and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
This volume explores all aspects of vascular biochemistry and includes chapters that provide an understanding of vascular function with descriptions of tissue components present in the vascular wall as well as an exploration of the hemodynamic and metabolic activities associated with this function. In addition, some chapters explore the vasculature under conditions which mimic various disease states. The information provided in this volume will provide new insights into the mechanisms that control vascular function as well as therapies designed to treat vascular disease.
Encyclopedic Reference Of Vascular Biology Pathology
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Author : Andreas Bikfalvi
language : en
Publisher: Springer
Release Date : 2013-12-19
Encyclopedic Reference Of Vascular Biology Pathology written by Andreas Bikfalvi and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-19 with Science categories.
This reference provides a synthesis of the whole field of vascular biology, from the latest advances in the study of the structure and function of blood vessels to recent investigations of their interaction with blood cells, with non-cellular constituants of the blood, or with cells of the neighbouring tissue. The latest results from tumor angiogenesis to the latest advances in atherosclerosis research are discussed by leading experts in the field. Together with the CD-ROM this guarantees both researchers and clinicians quick and easy access to all relevant information.
Vascular Disease
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Author : Andrew H. Baker
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-01
Vascular Disease written by Andrew H. Baker and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-01 with Medical categories.
Molecular biology has revolutionized research into vascular disease. Over the past 20 years molecular techniques have enabled us to both elucidate - lecular mechanisms in vascular disease and identify appropriate therapies. The vast explosion in technical knowledge and the array of protocols that become more advanced and intricate by the day lead us into new and exciting areas of research that were previously unobtainable. Vascular Disease: Molecular Biology and Gene Transfer Protocols - scribes today’s most powerful molecular methods for the investigation of the pathogenesis of vascular disease. The protocols are highly detailed, allowing beginners who have little experience in either vascular biology or molecular biology to embark on new molecular projects. This book is also suited to more experienced molecular biologists who wish to grasp new methods for stu- ing the involvement of genes in normal vascular physiology and in diseased states. It is well established that cardiovascular disease progression has a s- stantial genetic influence. Part I describes three methods that have been used successfully to identify specific mutations in candidate genes involved in c- diovascular disorders. These mutations include both single-stranded conf- mational polymorphism analysis and heteroduplex detection methods. In addition, technology to map new genes to specific regions of chromosomes by high-resolution mapping is described.
Vascular Smooth Muscle Metabolic Ionic And Contractile Mechanisms
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Author : M.F. III Crass
language : en
Publisher: Elsevier
Release Date : 2012-12-02
Vascular Smooth Muscle Metabolic Ionic And Contractile Mechanisms written by M.F. III Crass and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Medical categories.
Vascular Smooth Muscle: Metabolic, Ionic, and Contractile Mechanisms addresses the vascular smooth muscle function by describing plasma lipoprotein structure, synthesis, and transport in relation to the concepts of altered vascular smooth muscle lipid metabolism leading to the genesis of atherosclerotic disease. This book is organized into six chapters and begins with an introduction to the complexities of energy metabolism and how metabolic events can be correlated with a simultaneous quantitative assessment of smooth muscle mechanics and the contractile machinery at the molecular level. The next two chapters offer the reader a view of smooth muscle membrane properties in terms of the distribution, transport, and metabolic control of electrolytes and specific aspects of ion conductance and electrical activity. This text also explains how smooth muscle cells regulate their contractile activity through regulation of calcium ion fluxes and the interaction, at the molecular level, of calcium ions with regulatory proteins associated with the contractile apparatus. Reference is made to the relation of possible anomalies in cellular or subcellular smooth muscle metabolic and/or ionic events to the bases of certain types of vascular disease. A chapter that examines the events leading to vascular pathology in the form of atherogenesis concludes the book. This book is intended for researchers and clinicians engaged in the study of smooth muscle and related areas.
Enzymes Of The Arterial Wall
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Author : John Esben Kirk
language : en
Publisher: Academic Press
Release Date : 2014-06-28
Enzymes Of The Arterial Wall written by John Esben Kirk and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-06-28 with Medical categories.
Enzymes of the Arterial Wall is a comprehensive up-to-date monograph, and is the first publication dealing specifically with quantitative determinations of enzyme activities in human and animal vascular tissue. All available information concerning this subject is included. This summary of all current knowledge will be very useful to scientists who lack extensive library facilities and knowledge of foreign languages necessary for a thorough and time-consuming personal search of the original literature. A systematic description is made of 98 different enzymes; nearly all enzymes in the carbohydrate metabolic pathways are included. Brevity of discussion has made it possible to incorporate all available data. The results represent 27,200 quantitative biochemical assays performed with reliable analytical techniques on both normal and arteriosclerotic tissue; 70 enzymic procedures are described. The framework for the arrangement of facts throughout the book was designed to make information easily accessible. Each enzyme is described separately, using the sequence of The Commission on Enzymes of The International Union of Biochemistry, and is followed by literature references with full titles.
Vascular Endothelium
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Author : J. Catravas
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Vascular Endothelium written by J. Catravas and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.
Beyond their obvious role of a barrier between blood and tissue, vascular endothelial cells are now firmly established as active and essential participants in a host of crucial physiological and pathophysiological functions. Probably the two most important factors responsible for promoting the current knowledge of endothelial functions are 1) observations in the late sixties-early seventies that many non-ventilatory properties of the lung could be attributed to the pulmonary endothelium and 2) the establishment, in the early and mid-seventies of procedures for routine culture of vascular endothelial cells. Many of these endothelial functions require the presence of receptors on the surface of the plasma membrane. There is now evidence for the existence among others of muscarinic, a-and /3-adrenergic, purine, insulin, histamine, bradykinin, lipoprotein, thrombin, paf, fibronectin, vitronectin, interleukin and albumin receptors. For some of these ligands, there is evidence only for the existence of endothelial binding sites. Traditionally, agonist binding must elicit a response for the binding site to be considered a receptor and, in some cases, the nature of the response resulting from the interaction of a substance with the endothelium remains unclear. It is beyond the scope of this introduction to even enumerate the various endothelial homeostatic processes. This monograph contains the proceedings of the Advanced Studies Institute on "Vascular Endothelium: Receptors and Transduction Mechanisms" held in Porto Carras, Greece from June 18-29, 1988.
Vascular Innervation And Receptor Mechanisms
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Author : Rolf Uddman
language : en
Publisher: Academic Press
Release Date : 2012-12-02
Vascular Innervation And Receptor Mechanisms written by Rolf Uddman and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Medical categories.
Vascular Innervation and Receptor Mechanisms: New Perspectives reviews the areas of structure, function, and pathophysiology of the circulatory system. The text focuses on the role of neuropeptides and structural function of endothelium. The book begins with a brief discussion on the background of autonomic and sensory nerves in the circulatory system, which is provided in Chapter 1. Having established the basic studies in the circulatory system, the book moves to the discussion on the analysis of peptidergic innervations and peptides in vascular control in various disorders. The last part of the book features the clinical applications of neuropeptides, perivascular peptides, and vasoactive peptides in different diseases and regulation, such as cardiovascular regulation, hypertension, congestive heart failure, and migraine and cluster headache. The text will be a good reference to both students and professionals in the fields of biology, chemistry, and medicine.
Biochemical Basis And Therapeutic Implications Of Angiogenesis
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Author : Jawahar L. Mehta
language : en
Publisher: Springer
Release Date : 2017-08-28
Biochemical Basis And Therapeutic Implications Of Angiogenesis written by Jawahar L. Mehta and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-28 with Medical categories.
This book covers the latest developments in the therapeutic implications of angiogenesis, ranging from angiogenesis in the brain, angiogenesis in cancer, angiogenesis’ role in atherosclerosis and heart disease as well as metabolic disorders and peripheral vascular disease. The book is comprehensive in its coverage of angiogenesis in a diverse set of diseases and examines the role of cellular and subcellular structures during the development of angiogenesis. Well-organized and thorough, this is an ideal book for researchers and biomedical engineers working in the field of therapeutic implications of angiogenesis. This book also: Covers the basics of the physiology of angiogenesis, including VEGF pathways in angiogenesis, integr ins in angiogenesis, angiogenesis and exercise physiology, and more Details the role of angiogenesis in atherosclerosis and heart disease, including vascular endothelial growth factor and atherosclerotic plaque progression as well as angiogenesis and heart failure Illustrates in detail brain angiogenesis after stroke and the relationship between angiogenesis and Alzheimer's disease
Biochemistry Of Cardiovascular Dysfunction In Obesity
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Author : Paramjit S. Tappia
language : en
Publisher: Springer Nature
Release Date : 2020-10-03
Biochemistry Of Cardiovascular Dysfunction In Obesity written by Paramjit S. Tappia and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-03 with Medical categories.
Obesity is an independent risk factor for cardiovascular disease (CVD) in adults as well as in obese children. This book will provide a description of the impact of obesity on the cardiovascular system and increased predisposition to CVD. It will identify the major biochemical mechanisms that lead to the occurrence of myocardial abnormalities and vascular alterations in obesity. We will also have some discussion on the biochemistry of the so-called obesity paradox in relation to CVD. The contributors to this book are international experts on obesity and associated cardiovascular complications. This book is also uniquely positioned as it focuses on the biochemistry of obesity-induced cardiovascular dysfunction. There are 20 chapters in 2 different parts in this book, comprising of Part A: Pathophysiology of Cardiovascular Complications in Obesity (11 chapters) and Part B: Modification of Cardiovascular Dysfunction in obesity (9 chapters). The intent of this volume is to provide current and basic understanding of the biochemical mechanisms of obesity induced cardiovascular dysfunction that will be of value not only to cardiologists and other allied health professionals, but will also stimulate and motivate biomedical researchers and scientists to find the way to prevent the epidemic of obesity associated cardiovascular abnormalities. Furthermore, this book will serve as a highly useful resource for medical students, fellows, residents and graduate students with an interest in the cardiovascular system. In summary, this book covers a broad range of biochemical mechanisms of obesity-induced cardiovascular complications. We hope that the reader will understand that obesity is linked to an increase in the risk and occurrence of fatal CVD. Furthermore, the underlying message presented in the book is that the cause of obesity related disorders is complex and that understanding the biochemistry of cardiovascular dysfunction may contribute to the development of novel interventions for the prevention and treatment of obesity associated comorbidities.
Vascular Biochemistry Of Vitmain B12
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Author : Edward Suarez Moreira
language : en
Publisher:
Release Date : 2010
Vascular Biochemistry Of Vitmain B12 written by Edward Suarez Moreira and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Cardiovascular system categories.
Cobalamins (vitamin B12 derivatives) are essential cofactors for two enzymes in mammals: cytosolic methionine synthase and mitochondrial methylmalonyl-CoA mutase. In addition to its function as cofactor, a further role as a modulator of inflammatory and immune processes has been suggested for vitamin B12. Vitamin B12 deficiency is a major health problem in the US population, especially amongst the elderly. The vascular endothelium lacks the transsulfuration pathway and hence, relies solely on the B12-dependent methionine synthase to metabolize homocysteine. Thus, vitamin B12 deficiency is the primary modifiable cause of hyperhomocysteinemia, a risk factor for cardiovascular disease, in the post folate fortification era. Although vitamin B12 has been studied for over half a century, there remains much to be discovered regarding the biochemical pathways that lead to the synthesis of the cobalamin cofactors and the potential roles of vitamin B12 beyond its function as cofactors of methionine synthase and methylmalonyl-CoA mutase. This research project has been designed to shed light on the key intermediates required for the metabolism of B12 in human cardiovascular cells and the effects of B12 status on vascular pathophysiology, independent of its actions as an enzymatic cofactor.