Vascular Complications Of Diabetes
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Vascular Complications Of Diabetes
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Author : Richard Donnelly
language : en
Publisher: John Wiley & Sons
Release Date : 2008-04-15
Vascular Complications Of Diabetes written by Richard Donnelly and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-15 with Medical categories.
Diabetes has reached epidemic proportions, and the cardiovascular complications of diabetes are life-threatening and disabling. This book is unique in providing a simple explanation of the biochemical role of PKC in diabetes complications, which allows clinicians to understand why PKC inhibitors (in development) are an exciting prospect for future treatment to slow progression of eye & foot complications. New features of this Second Edition include: Updated throughout to reflect the impact of recent major clinical trials on current clinical practice Includes a major new section on diabetic neuropathy Revised section on diabetic retinopathy Each chapter is short and succinct, focusing on ‘best practice’. There are key learning points at the end of each chapter, with numerous helpful tables, figures and clinical images.
Vascular Complications Of Diabetes
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Author : Robert Turner
language : en
Publisher:
Release Date : 1994
Vascular Complications Of Diabetes written by Robert Turner and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Diabetes categories.
Abc Of Arterial And Venous Disease
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Author : Richard Donnelly
language : en
Publisher: John Wiley & Sons
Release Date : 2009-04-08
Abc Of Arterial And Venous Disease written by Richard Donnelly and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-04-08 with Medical categories.
Structural and functional abnormalities of arteries and veinsmanifest clinically in a broad spectrum of disorders, includinganeurysmal disease, atherosclerosis, vasculitis, venousinsufficiency, microvascular complications, thrombo-embolism andlower limb ulceration. Many of these are common and/orchronic conditions which present for initial assessment by primaryhealth care workers. This new edition is a practical guide to the most commonlypresenting disorders, and provides a structured approach toclinical assessment, investigations and management. The lastfew years have seen major changes in the use of non-invasive orminimally-invasive techniques, e.g wider use of CT and MRangiography, and increasing use of percutaneous interventions forcarotid, lower limb and reno-vascular disease. The ABC of Arterial and Venous Disease (Second Edition)explains the underlying technology and the applications of newminimally-invasive methods, especially CT and MRI, and provides anup-dated, evidence-based guide to the modern day management ofpatients with common, life-threatening diseases involving differentparts of the circulation. This authoritative, full-colour, illustrated ABC is anideal reference for the primary care, non-specialist practitionerto base effective management and prevention programmes.
Vascular Complications Of Diabetes Mellitus
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Author : Samuel J. Kimura
language : en
Publisher:
Release Date : 1967
Vascular Complications Of Diabetes Mellitus written by Samuel J. Kimura and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1967 with Blood-vessels categories.
Mechanisms Of Vascular Defects In Diabetes Mellitus
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Author : C.C. Kartha
language : en
Publisher: Springer
Release Date : 2017-08-01
Mechanisms Of Vascular Defects In Diabetes Mellitus written by C.C. Kartha and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-01 with Science categories.
This book intends to bring together, a panel of renowned experts in the field of vascular biology and diabetology, to integrate the current understanding of the pathogenesis and pathophysiology of vascular diseases in diabetes mellitus. This attempt is significant given the increasing interest in this area as the prevalence of vascular diseases continues to escalate globally. Patients with diabetes are at a higher risk of structural and functional changes in all vessel walls of the human body. Vascular complications of diabetes are leading causes for both morbidity and mortality. In recent years, several articles have focused on advancing our knowledge on the profound effect of hyperglycemia and insulin resistance on building up vascular wall inflammation leading to endothelial dysfunction in patients with diabetes mellitus Other reports have elaborated on the various disorders, hyperglycemia can lead to, their therapies, adverse effects and complications. There are also studies that highlight the role of factors that induce vascular wall alterations in hyperglycemia. In this book, we attempt to discuss vascular disease progression in diabetes with a unique approach. We attempt to provide a complete perspective of the pathophysiology of vascular complications and then dissect each of the factors that play a key role in accelerating vascular wall alterations in diabetes. Each of these factors has been adversely implicated in the initiation and progression of disease to a large extent. In this collection for the first time all these factors would be described under a common canopy. Further, the text would emphasize on pathogenesis of micro vascular complications of diabetes, such as retinopathy, neuropathy and nephropathy. Pharmacological therapies for treating vascular dysfunction in diabetes mellitus would also be reviewed. This compendium hopefully would be an invaluable replacement to scores of literature on diabetic vascular disease and would be of great interest to clinicians, academicians, medical students and researchers. The book will be divided into seven sections, each emphasizing a common incentive to development of vascular disease in diabetes. Section I deals with pathophysiology of diabetic vascular disease, beginning with an update on the global burden of diabetes mellitus and its vascular complications. The pathophysiology and pathogenesis of diabetes associated macrovasculopathy, how hyperglycemia functions as an atherogenic factor, effects of hyperglycemia on smooth muscle accumulation in vascular lesions and genetic susceptibility for increased risk of vascular disease in diabetes will be discussed in the following chapters of this section. The next section (Section II) surveys the process of endothelial dysfunction under hyperglycaemia and hyperinsulinemia and their effects on angiogenesis, vascular remodeling and wound healing. A chapter is also dedicated to the endothelial progenitor cell population and its dysfunction during development of vascular complications in diabetes. Section III will highlight the molecular mechanisms underlying endothelial dysfunction, various pathways such as nitric oxide synthase pathway, oxidative stress pathway, renin – angiotensin system and increased vascular superoxide production in the initiation and progression of vascular disease in diabetes. This section also covers role of endothelin, monocyte derived cytokines, peroxynitrate and adipokines in macrovascular complications of diabetes. Metabolic factors such as advanced glycation end products, atherogenic dyslipoproteinaemia, and homocysteine will be reviewed in Section IV, whereas an overview of the hemostatic factors such as platelet dysfunction, hyperglycaemia induced thrombin formation and aberrant clot lysis will be dwelled upon in Section V.Section VI includes chapters on microvascular complications of diabetes which encompasses long term complications of diabetes affecting small blood vessels of the eye, kidneys and nervous system. The pathogenesis and mechanisms of these complications would be detailed here. The final section (Section VII) of the book will consider mechanism of action of drugs for treating endothelial dysfunction in diabetes mellitus which would elaborate on lipid regulating therapies such as statins, as well as other therapies such as ACE inhibitors, Angiotensin II receptors, insulin, metformin and their effects on enhancing vascular function in diabetes.“/div>divWe intend to invite authors who symbolize a multidisciplinary approach to this complicated disease. The proposed authors include clinicians who understand the trend of vascular complications in their long term clientele, epidemiologists with a holistic view, basic and experimental researchers with years of experience in dissecting the factors leading to endothelial dysfunction and clinical researchers with the skill of translating bench work to the bedside. We expect this book will be of significant value and interest to the same group of clinicians, researchers, post doctoral fellows and medical and non medical graduate students. The novel assimilated insights could stimulate development of mechanism based prevention and therapeutic strategies providing a promising option to limit cardiovascular complications in diabetes mellitus.
Vascular Involvement In Diabetes
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Author : Dan Cheţa
language : en
Publisher:
Release Date : 2005
Vascular Involvement In Diabetes written by Dan Cheţa and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Medical categories.
Since the 1960s we have learned that cardiovascular complications and diabetes mellitus are closely intertwined: type 2 diabetes increases the likelihood of hypertension, hyperlipidemia, and accelerated vascular disease. Thus the growing pandemic of diabetes worldwide is responsible for increasing death and disability from atherosclerotic vascular disease, the number one cause of death today. This publication spells out the enormity of the problem and the demographic forces at play. In the first part of the book the fundamental mechanisms responsible for vascular involvement in diabetes at the genetic, molecular, tissue, organ and organismal levels are described. The second part provides a detailed description of the various clinical aspects and the currently available therapeutic and preventive measures for diabetes, such as lifestyle changes, angiotensin II receptor blockers, biguanides and fibrates.
Vascular And Neurologic Complications Of Diabetes Mellitus
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Author : Francesco Belfiore
language : en
Publisher: S. Karger AG (Switzerland)
Release Date : 1987
Vascular And Neurologic Complications Of Diabetes Mellitus written by Francesco Belfiore and has been published by S. Karger AG (Switzerland) this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with Medical categories.
Microvascular Complications Of Diabetes Ecab
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Author : V Seshiah
language : en
Publisher: Elsevier Health Sciences
Release Date : 2009-09-15
Microvascular Complications Of Diabetes Ecab written by V Seshiah and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-15 with Medical categories.
The pathogenesis of microvascular complications is complex and multifactorial. Yet, hyperglycemia emerges as the most important single cause, which has been proved by the Diabetes Control and Complications Trial (DCCT). Thus, the importance of protecting the body from hyperglycemia cannot be overstated; the direct and indirect effects on the human vascular tree are the major source of morbidity and mortality in both type 1 and type 2 diabetes. Generally, the injurious effects of hyperglycemia are separated into macrovascular complications (coronary artery disease, peripheral arterial disease, and stroke) and microvascular complications (diabetic nephropathy, neuropathy, and retinopathy). It is important for physicians to understand the relationship between diabetes and vascular disease because the prevalence of diabetes continues to increase in our country, and the clinical requirements for primary and secondary prevention of these complications are also expanding.
Hyperglycemia Diabetes And Vascular Disease
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Author : Neil Ruderman
language : en
Publisher: Springer
Release Date : 2013-05-27
Hyperglycemia Diabetes And Vascular Disease written by Neil Ruderman and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-27 with Medical categories.
It is estimated that 1-5% ofthe world's population is affected by some form of diabetes. Patients with these disorders are highly likely to develop microvas cular pathology in the retina and glomerulus and they are at a 2--6-fold greater risk for atherosclerotic vascular disease than individuals without diabetes. In addition, hypertension is far more prevalent in patients with diabetes than in the general population. As a consequence of these complications, diabetes is a leading cause of blindness and renal failure in young and middle-aged adults and it is a major risk factor for coronary heart disease, stroke and peripheral vascular disease in the Western world. An understanding of the relationship of these vascular complications to diabetic hyperglycemia has become a critical issue for clinicians in recent years, since the prevalence of diabetes appears to be increasing dramatically world-wide. In addition, it is now possible to achieve improved glycemic control in many patients-although not without incurring other risks. This volume explores two principal hypotheses concerning these complications. One is that hyperglycemia underlies or at least contributes to the pathogenesis of both micro- and macrovascular disease in patients with diabetes. The other is that it does so by producing specific metabolic and biochemical alterations in the vascular wall that lead to abnormalities in its function and ultimately its structure.
Managing Cardiovascular Complications In Diabetes
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Author : D. John Betteridge
language : en
Publisher: John Wiley & Sons
Release Date : 2014-03-17
Managing Cardiovascular Complications In Diabetes written by D. John Betteridge and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-03-17 with Medical categories.
Of all the complications which arise from diabetes, cardiovascular complications are by far the most prevalent and the most deadly. Authored by some of the world's leading names in this area, this outstanding book provides all those managing diabetic patients with clinical, practical and succinct guidance to the diagnosis and management of cardiovascular complications in diabetes. With a joint endocrinology and cardiology focus, and with the very latest in clinical guidelines from the ADA, EASD, AHA, ASC and ESC, selected highlights include: The role of new biomarkers of cardiovascular disease in diabetes The latest on diagnosis of cardiovascular problems via vascular imaging Hypertension and cardiovascular disease in the diabetic patient Dyslipidaemia and its management in type 2 diabetes Management of thrombosis, acute coronary syndrome and peripheral arterial disease in diabetes Key points, case studies and self-assessment questions allow for rapid-reference, quick understanding of all topics, thus ensuring that this is perfect reading for endocrinologists, diabetes specialists and cardiologists of all levels managing patients with diabetes and associated cardiovascular problems.