Vegf Signaling
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Vegf Signaling
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Author : Lorna Fiedler
language : en
Publisher:
Release Date : 2015
Vegf Signaling written by Lorna Fiedler and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with Biochemistry categories.
Vascular Endothelial Growth Factor Vegf
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Author : Marcellus L. Parker
language : en
Publisher:
Release Date : 2013
Vascular Endothelial Growth Factor Vegf written by Marcellus L. Parker and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Medical categories.
Vascular endothelial growth factor (VEGF) is one of the most potent and specific angiogenic factors. The physiologic roles of VEGF in humans include neovascularization and endometrium implantation, and in pathological processes VEGF has been involved in the initation, growth, and metastasis of tumors. In this book, the authors discuss the biology, regulation and clinical significance of VEGF. Topics include VEGF signaling and multi-drug resistance transporter (ABCB1); clinical imaging of tumor vascularity as a biomarker during anti-VEGF therapy; VEGF and kidney cancer; the effect of VEGF on oocyte maturation and embryo development of bovine and ovine in vitro and its mechanisms; physiological functions of VEGF in the retina; VEGF in the regulation of gingival venule diameter under physiological and pathological circumstances; regulation of VEGF expression by progesterone and estradiol in normal and cancer cells; ethanol stimulated angiogenesis via VEGF and protection from ischemia and reperfusion injury; and the role of VEGF in major depression.
Vegf In Development
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Author : Christiana Ruhrberg
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-12-11
Vegf In Development written by Christiana Ruhrberg and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-12-11 with Science categories.
This book covers vascular endothelial growth factor A (VEGF or VEGFA), a secreted signaling protein. It highlights the central importance of this growth factor for vertebrate development.
Vascular Endothelial Growth Factor Vegf
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Author : Marcellus L. Parker
language : en
Publisher: Nova Science Publishers
Release Date : 2013
Vascular Endothelial Growth Factor Vegf written by Marcellus L. Parker and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Growth factors categories.
Vascular endothelial growth factor (VEGF) is one of the most potent and specific angiogenic factors. The physiologic roles of VEGF in humans include neovascularisation and endometrium implantation, and in pathological processes VEGF has been involved in the initiation, growth, and metastasis of tumors. In this book, the authors discuss the biology, regulation and clinical significance of VEGF. Topics include VEGF signalling and multi-drug resistance transporter (ABCB1); clinical imaging of tumour vascularity as a biomarker during anti-VEGF therapy; VEGF and kidney cancer; the effect of VEGF on oocyte maturation and embryo development of bovine and ovine in vitro and its mechanisms; physiological functions of VEGF in the retina; VEGF in the regulation of gingival venule diameter under physiological and pathological circumstances; regulation of VEGF expression by progesterone and estradiol in normal and cancer cells; ethanol stimulated angiogenesis via VEGF and protection from ischemia and reperfusion injury; and the role of VEGF in major depression.
Vegf Mediated Vascular Functions In Health And Disease
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Author : Ziquan Cao
language : en
Publisher: Linköping University Electronic Press
Release Date : 2015-04-24
Vegf Mediated Vascular Functions In Health And Disease written by Ziquan Cao and has been published by Linköping University Electronic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-24 with Diseases categories.
Angiogenesis is essential for physiological processes including embryonic development, tissue regeneration, and reproduction. Under various pathological conditions the same angiogenic process contribute to the onset, development, and progression of many human diseases including cancer, diabetic complications, ocular disease, chronic inflammation and cardiovascular disease. Vascular endothelial growth factor (VEGF) is a key angiogenic factor for physiological and pathological angiogenesis. In addition to its strong angiogenic activity, VEGF also potently induces vascular permeability, often causing tissue edema in various pathological tissues. VEGF transduces its vascular signal through two tyrosine kinase receptors-VEGFR1 and VEGFR2, the latter being a functional receptor that mediates both angiogenic and vascular permeability effects. To study physiological and pathological functions of VEGF, we developed novel zebrafish disease models that permit us to study hypoxia-induced retinopathy and cancer metastasis processes. We have also administered anti-VEGF and anti-VEGFR specific antibodies to healthy mice to study the homeostatic role of VEGF in the maintenance of vascular integrity and its functions in various tissues and organs. Finally, using a zebrafish model, we evaluated if VEGF expression is regulated by circadian clock genes. In paper I, we developed protocols that create hypoxia-induced retinopathy in adult zebrafish. Adult fli1:EGFP zebrafish were placed in hypoxic water for 3-10 days with retinal neovascularization being analyzed using confocal microscopy. This model provides a unique opportunity to kinetically study the development of retinopathy in adult animals using non-invasive protocols and to assess the therapeutic efficacy of orally administered anti-angiogenic drugs. In paper II, we developed a zebrafish metastasis model to dissect the complex events of hypoxia-induced tumor cell invasion and metastasis in association with angiogenesis at the single-cell level. In this model, fluorescent DiI-labeled human or mouse tumor cells were implanted into the perivitelline cavity of 48-hour-old zebrafish embryos, which were subsequently placed in hypoxic water for 3 days. Tumor cell invasion, metastasis and pathological angiogenesis were analyzed using fluorescent microscopy in the living fish. The average experimental time for this model is 7 days. Our protocol offers an opportunity to study molecular mechanisms of hypoxia-induced cancer metastasis. In paper III, we show that systemic delivery of an anti-VEGF or an anti-VEGF receptor (VEGFR)-2 neutralizing antibody cause global vascular regression in mice. Among all examined tissues, the vasculature in endocrine glands, intestinal villi, and the uterus are most affected in response to VEGF or VEGFR-2 blockades. Pro-longed anti-VEGF treatment resulted in a significant decrease in the circulating levels of the predominant thyroid hormone, free thyroxine, but not the minimal isoform of triiodothyronine, suggesting that chronic anti-VEGF treatment impairs thyroid function. These findings provide structural and functional bases of anti-VEGF-specific druginduced side effects in relation to vascular changes in healthy tissues. In paper IV, we show that disruption of the circadian clock by constant exposure to light coupled with genetic manipulation of key genes in the zebrafish led to impaired developmental angiogenesis. A bmal1-specific morpholino inhibited developmental angiogenesis in zebrafish embryos without causing obvious nonvascular phenotypes. Conversely, a period2 morpholino accelerated angiogenic vessel growth, suggesting that Bmal1 and Period2 display opposing angiogenic effects. These results offer mechanistic insights into the role of the circadian clock in regulation of developmental angiogenesis, and our findings may be reasonably extended to other types of physiological or pathological angiogenesis. Overall, the results in this thesis provide further insight to angiogenic mechanistic properties in tissues and suggest possible novel therapeutic targets for the treatment of various angiogenesis-dependent diseases.
Physiologic And Pathologic Angiogenesis
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Author : Dan Simionescu
language : en
Publisher: BoD – Books on Demand
Release Date : 2017-04-05
Physiologic And Pathologic Angiogenesis written by Dan Simionescu and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-05 with Medical categories.
The purpose of this book is to highlight novel advances in the field and to incentivize scientists from a variety of fields to pursue angiogenesis as a research avenue. Blood vessel formation and maturation to capillaries, arteries, or veins is a fascinating area which can appeal to multiple scientists, students, and professors alike. Angiogenesis is relevant to medicine, engineering, pharmacology, and pathology and to the many patients suffering from blood vessel diseases and cancer, among others. We are hoping that this book will become a source of inspiration and novel ideas for all.
Vegf And Cancer
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Author : Judith H. Harmey
language : en
Publisher: Springer Science & Business Media
Release Date : 2004
Vegf And Cancer written by Judith H. Harmey and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Medical categories.
VEGF and Canceris a comprehensive and up to date review of current knowledge on the role of vascular endothelial growth factor (VEGF) in cancer. Key Features: -Discussion of VEGF as potent angiogenic factor and its role in tumor angiogenesis, -Review of the biology, molecular properties and regulation of VEGF, -Discussion of the role of VEGF in a range of different tumor types, both solid tumors and haematological cancers, -Review of the therapeutic potential of different approaches to block VEGF, -Review of recent evidence that in addition to its role as an endothelial cell mitogen, VEGF may also be an autocrine growth factor for tumor cells, regulating survival and invasion. This book is aimed at scientists new to angiogenesis and VEGF biology and provides new information for established researchers and scientists. It will also be a useful text for clinicians interested in anti-angiogenic therapy for treatment of human cancers.
Molecular Mechanisms And Signaling In Endothelial Cell Biology And Vascular Heterogeneity
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Author : Bin Ren
language : en
Publisher: Frontiers Media SA
Release Date : 2022-02-02
Molecular Mechanisms And Signaling In Endothelial Cell Biology And Vascular Heterogeneity written by Bin Ren and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-02 with Science categories.
Vegf In Development
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Author : Christiana Ruhrberg
language : en
Publisher: Springer
Release Date : 2008-04-21
Vegf In Development written by Christiana Ruhrberg and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-21 with Science categories.
This book covers vascular endothelial growth factor A (VEGF or VEGFA), a secreted signaling protein. It highlights the central importance of this growth factor for vertebrate development.
Tumor Angiogenesis
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Author : Dieter Marmé
language : en
Publisher: Springer
Release Date : 2019-10-18
Tumor Angiogenesis written by Dieter Marmé and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-18 with Medical categories.
This exhaustive work shows that new therapies using anti-angiogenic drugs are of particular importance because they can be used against many different types of cancer, as tumor angiogenesis seems to be involved in most if not all solid metastasizing malignancies. The first part of this book summarizes the knowledge acquired on the molecular entities that play a role in tumor angiogenesis and their mechanisms of action. Furthermore, the identification of molecular markers and their validation as predictive and/or prognostic tools is reviewed. In the second and most important part, the clinical applications of anti-angiogenic treatments are documented for a wide variety of tumors. In particular, the modes of combination with other targeted and/or cytotoxic cancer therapies are presented.