Viral Proteases And Antiviral Protease Inhibitor Therapy
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Viral Proteases And Antiviral Protease Inhibitor Therapy
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Author : Uwe Lendeckel
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-06-19
Viral Proteases And Antiviral Protease Inhibitor Therapy written by Uwe Lendeckel and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-06-19 with Medical categories.
The 8th volume in the Proteases in Biology and Disease series focuses on the role of proteases in virus function and their potential as anti-viral targets. Viral infections are still difficult to threat and some remained life-threatening diseases in spite of antiviral drug research over decades. Proteases are still regarded as an Achilles’ heel of the pathogens and, thus, protease inhibitors may help to handle the known and the emerging viral threads. The book discusses viral proteases of the most important pathogenic viruses, responsible for severe diseases: AIDS, SARS, Hepatitis, Cytomegalovirus, T-cell lymphotropic virus, Picornavirus. This book focuses specifically on the viral proteases, crucial prerequisites for viral entry into cells and viral replication. Viral proteases represent an important pharmaceutical target. The current stage of protease inhibitor development and therapy are summarised and discussed by experts in the field. This volume represents a timely and valuable continuation of the Proteases in Biology and Disease series. The reader will learn the potential for proteases as targets for effective anti-virals. This book will be a valuable source of information on viral proteases and provoke further research in this important field.
Viral Proteases And Antiviral Protease Inhibitor Therapy
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Author : Uwe Lendeckel
language : en
Publisher: Springer
Release Date : 2009-08-29
Viral Proteases And Antiviral Protease Inhibitor Therapy written by Uwe Lendeckel and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-08-29 with Medical categories.
The 8th volume in the Proteases in Biology and Disease series focuses on the role of proteases in virus function and their potential as anti-viral targets. Viral infections are still difficult to threat and some remained life-threatening diseases in spite of antiviral drug research over decades. Proteases are still regarded as an Achilles’ heel of the pathogens and, thus, protease inhibitors may help to handle the known and the emerging viral threads. The book discusses viral proteases of the most important pathogenic viruses, responsible for severe diseases: AIDS, SARS, Hepatitis, Cytomegalovirus, T-cell lymphotropic virus, Picornavirus. This book focuses specifically on the viral proteases, crucial prerequisites for viral entry into cells and viral replication. Viral proteases represent an important pharmaceutical target. The current stage of protease inhibitor development and therapy are summarised and discussed by experts in the field. This volume represents a timely and valuable continuation of the Proteases in Biology and Disease series. The reader will learn the potential for proteases as targets for effective anti-virals. This book will be a valuable source of information on viral proteases and provoke further research in this important field.
Viral Proteases And Their Inhibitors
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Author : Satya Prakash Gupta
language : en
Publisher: Academic Press
Release Date : 2017-07-03
Viral Proteases And Their Inhibitors written by Satya Prakash Gupta and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-03 with Science categories.
Viral Proteases and Their Inhibitors provides a thorough examination of viral proteases from their molecular components, to therapeutic applications. As information on three dimensional structures and biological functions of these viral proteases become known, unexpected protein folds and unique mechanisms of proteolysis are realized. This book investigates how this facilitates the design and development of potent antiviral agents used against life-threatening viruses. Users will find descriptions of each virus that detail the structure and function of viral proteases, discuss the design and development of inhibitors, and analyze the structure-activity relationships of inhibitors. This book is ideal biochemists, virologists and those working on antiviral agents. Provides comprehensive, state-of-the-art coverage of virus infections, the virus lifecycle, and mechanisms of protease inhibition Analyzes structure-activity relationships of inhibitors of each viral protease Presents an in-depth view of the structure and function of viral proteases
Proteases As Targets For Therapy
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Author : Klaus, von der Helm
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Proteases As Targets For Therapy written by Klaus, von der Helm and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
With contributions by numerous experts
Activation Of Viruses By Host Proteases
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Author : Eva Böttcher-Friebertshäuser
language : en
Publisher: Springer
Release Date : 2018-05-22
Activation Of Viruses By Host Proteases written by Eva Böttcher-Friebertshäuser and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-22 with Medical categories.
This book will give an overview on viruses undergoing proteolytic activation through host proteases. The chapters will be organized in three themed parts, the first part describing respective viruses and their characteristics in detail. In the second part the molecular and cellular biology of the proteases involved as well as their physiological functions will be further explored. The third part will contain a chapter on protease inhibitors that are promising tools for antiviral therapy. This book will engage scholars in virology and medical microbiology as well as researchers with an interest in enzymology and protein structure and function relationship.
Protease Inhibitors In Aids Therapy
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Author : Richard C. Ogden
language : en
Publisher: CRC Press
Release Date : 2001-01-24
Protease Inhibitors In Aids Therapy written by Richard C. Ogden and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-01-24 with Medical categories.
Details the evolution of HIV protease inhibitors from molecular development through medical applications! Considering the latest class of revolutionary drugs fighting against HIV infection and AIDS, this comprehensive reference thoroughly examines the development and properties of HIV protease inhibitors from clinical and scientific perspectives, discussing how protease inhibitors changed the FDA approval process-enhancing the collaboration between regulatory authorities and drug developers. Spotlights protease inhibitors as the cornerstone drugs of the first HAART regimens-key components of long-term viral suppression and immune restoration, and in secondary and tertiary regimens! Evaluating protease inhibitors as therapeutic options and research tools, Protease Inhibitors in AIDS Therapy reviews the impact of advances in recombinant DNA technology for understanding and treating HIV and AIDS highlights a variety of strategies and techniques for drug discovery and development illustrated by success stories of pharmaceutical companies and biotechnology start-up firms summarizes the pharmacokinetics, metabolism, and drug interactions of protease inhibitors details preliminary clinical studies on oral bioavailability, pharmacokinetic profiling, efficacy, resistance, and tolerability describes available efficacy data for marketed inhibitors and those in clinical development reports on efforts to manage antiviral resistance in the clinic and improve patient adherence to complex drug therapy and more! Containing more than 600 helpful literature references, drawings, photographs, and tables, Protease Inhibitors in AIDS Therapy serves for an essential reference for infectious disease specialists, epidemiologists, virologists, immunologists, pharmacologists, medicinal chemists and biochemists, microbiologists, hematologists, hepatologists, and medical students in these disciplines.
Retroviral Proteases
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Author : Lawrence C. Kuo
language : en
Publisher: Gulf Professional Publishing
Release Date : 1994-09-22
Retroviral Proteases written by Lawrence C. Kuo and has been published by Gulf Professional Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-09-22 with Medical categories.
Methods included in this volume apply to the expression and characterization of retroviral proteases and their inhibitor/substrate design.
Targeting Viral Protease Enzymes As A Treatment For Hiv Aids And Covid 19
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Author : Shefali Srivastava
language : en
Publisher:
Release Date : 2020
Targeting Viral Protease Enzymes As A Treatment For Hiv Aids And Covid 19 written by Shefali Srivastava and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with Antiviral agents categories.
Encyclopedia Of Molecular Pharmacology
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Author : Stefan Offermanns
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-08-14
Encyclopedia Of Molecular Pharmacology written by Stefan Offermanns and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-08-14 with Medical categories.
An essential text, this is a fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short keyword entries define common acronyms, terms and phrases. In addition, detailed essays provide in-depth information on drugs, cellular processes, molecular targets, techniques, molecular mechanisms, and general principles.
Antiviral Drug Strategies
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Author : Erik De Clercq
language : en
Publisher: John Wiley & Sons
Release Date : 2011-04-08
Antiviral Drug Strategies written by Erik De Clercq and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-08 with Medical categories.
By focusing on general molecular mechanisms of antiviral drugs rather than therapies for individual viruses, this ready reference provides the critical knowledge needed to develop entirely novel therapeutics and to target new viruses. It begins with a general discussion of antiviral strategies, followed by a broad survey of known viral targets, such as reverse transcriptases, proteases, neuraminidases, RNA polymerases, helicases and primases, as well as their known inhibitors. The final section contains several cases studies of recent successful antiviral drug development. Edited by Erik de Clercq, the world authority on small molecule antiviral drugs, who has developed more new antivirals than anyone else.