Virus Bioinformatics
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Virus Bioinformatics
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Author : Dmitrij Frishman
language : en
Publisher: CRC Press
Release Date : 2021-08-18
Virus Bioinformatics written by Dmitrij Frishman and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-18 with Computers categories.
Viruses are the most numerous and deadliest biological entities on the planet, infecting all types of living organisms—from bacteria to human beings. The constantly expanding repertoire of experimental approaches available to study viruses includes both low-throughput techniques, such as imaging and 3D structure determination, and modern OMICS technologies, such as genome sequencing, ribosomal profiling, and RNA structure probing. Bioinformatics of viruses faces significant challenges due to their seemingly unlimited diversity, unusual lifestyle, great variety of replication strategies, compact genome organization, and rapid rate of evolution. At the same time, it also has the potential to deliver decisive clues for developing vaccines and medications against dangerous viral outbreaks, such as the recent coronavirus pandemics. Virus Bioinformatics reviews state-of-the-art bioinformatics algorithms and recent advances in data analysis in virology. FEATURES Contributions from leading international experts in the field Discusses open questions and urgent needs Covers a broad spectrum of topics, including evolution, structure, and function of viruses, including coronaviruses The book will be of great interest to computational biologists wishing to venture into the rapidly advancing field of virus bioinformatics as well as to virologists interested in acquiring basic bioinformatics skills to support their wet lab work.
Virus Bioinformatics
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Author : Manja Marz
language : en
Publisher:
Release Date : 2020
Virus Bioinformatics written by Manja Marz and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with Biology (General) categories.
Virus bioinformatics is evolving and succeeding as an area of research in its own right, representing the interface of virology and computer science. Bioinformatic approaches to investigate viral infections and outbreaks have become central to virology research, and have been successfully used to detect, control, and treat infections of humans and animals. As part of the Third Annual Meeting of the European Virus Bioinformatics Center (EVBC), we have published this Special Issue on Virus Bioinformatics.
New Insights Into Virus Bioinformatics
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Author : Jake Mason
language : en
Publisher: Callisto Reference
Release Date : 2023-09-19
New Insights Into Virus Bioinformatics written by Jake Mason and has been published by Callisto Reference this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-19 with Science categories.
Viruses are microscopic and infectious microorganisms that are made up of genetic material enclosed in a protein coating. They cause a variety of serious infectious diseases including influenza, hepatitis, common cold, rabies, AIDS, smallpox, dengue fever and measles. Viruses are classified into four types based on the host cell that they infect, and these include plant viruses, bacteriophages, animal viruses and fungal viruses. Virology is the scientific study of viruses and virus-like agents. The study of viral infections and outbreaks using methods of bioinformatics has become essential to virology research. These methods have been used effectively to diagnose, treat and prevent infections in both animals and humans. Bioinformatics investigations that can be performed on viruses include motif and epitope recognition, homology searching, identification of open reading frames, sequence alignment, and gene prediction. This book provides new insights into virus bioinformatics. It presents researches and studies performed by experts across the globe. The extensive content of this book provides the readers with a thorough understanding of the subject.
Virus Discovery By Metagenomics The Im Possibilities
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Author : Bas E. Dutilh
language : en
Publisher: Frontiers Media SA
Release Date : 2017-10-25
Virus Discovery By Metagenomics The Im Possibilities written by Bas E. Dutilh and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-25 with Electronic book categories.
Since the late 1800s, the discovery of new viruses was a gradual process. Viruses were described one by one using a suite of techniques such as (electron) microscopy and viral culture. Investigators were usually interested in a disease state within an organism, and expeditions in viral ecology were rare. The advent of metagenomics using high-throughput sequencing has revolutionized not only the rate of virus discovery, but also the nature of the discoveries. For example, the viral ecology and etiology of many human diseases are being characterized, non-pathogenic viral commensals are ubiquitous, and the description of environmental viromes is making progress. This Frontiers in Virology Research Topic showcases how metagenomic and bioinformatic approaches have been combined to discover, classify and characterize novel viruses.
Viral Molecular Machines
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Author : Michael G. Rossmann
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-02-02
Viral Molecular Machines written by Michael G. Rossmann and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-02-02 with Medical categories.
This book will contain a series of solicited chapters that concern with the molecular machines required by viruses to perform various essential functions of virus life cycle. The first three chapters (Introduction, Molecular Machines and Virus Architecture) introduce the reader to the best known molecular machines and to the structure of viruses. The remainder of the book will examine in detail various stages of the viral life cycle. Beginning with the viral entry into a host cell, the book takes the reader through replication of the genome, synthesis and assembly of viral structural components, genome packaging and maturation into an infectious virion. Each chapter will describe the components of the respective machine in molecular or atomic detail, genetic and biochemical analyses, and mechanism. Topics are carefully selected so that the reader is exposed to systems where there is a substantial infusion of new knowledge in recent years, which greatly elevated the fundamental mechanistic understanding of the respective molecular machine. The authors will be encouraged to simplify the detailed knowledge to basic concepts, include provocative new ideas, as well as design colorful graphics, thus making the cutting-edge information accessible to broad audience.
The International Virus Bioinformatics Meeting 2022
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Author : Franziska Hufsky
language : en
Publisher:
Release Date : 2022
The International Virus Bioinformatics Meeting 2022 written by Franziska Hufsky and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with categories.
Translational Informatics
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Author : Bairong Shen
language : en
Publisher: Springer Nature
Release Date : 2022-05-20
Translational Informatics written by Bairong Shen and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-20 with Medical categories.
This book introduces the translational informatics applied to most aspects of virus infection, including tracking of virus origin, detection and prevention of infection, drug discovery, and vaccine design as well as smart city-level monitoring and controlling of the virus epidemic by government. It covers the informatics for data mining and modelling at molecular, tissue/organ, individual, and population levels. The informatics for immunological mechanisms and the personalized prediction and treatment of infected patients are also summarized. The perspectives on the application of artificial intelligence to the prevention of virus outbreaks are also given. This book will be helpful to readers who are interested in prevention of virus infection, biomedical informatics, and artificial intelligence in medicine and healthcare.
The Evolution And Emergence Of Rna Viruses
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Author : Edward C. Holmes
language : en
Publisher: Oxford University Press
Release Date : 2009-06-25
The Evolution And Emergence Of Rna Viruses written by Edward C. Holmes and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-06-25 with Language Arts & Disciplines categories.
While the study of viral evolution has developed rapidly in the last 30 years, little attention has been directed toward linking the mechanisms of viral evolution to the epidemiological outcomes of these processes. This book intends to fill this gap by considering the patterns and processes of viral evolution at all its spatial and temporal scales.
Translational Bioinformatics In Healthcare And Medicine
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Author :
language : en
Publisher: Academic Press
Release Date : 2021-05-13
Translational Bioinformatics In Healthcare And Medicine written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-13 with Business & Economics categories.
Translational Bioinformatics in Healthcare and Medicine offers an overview of main principles of bioinformatics, biological databases, clinical informatics, health informatics, viroinformatics and real-case applications of translational bioinformatics in healthcare. Written by experts from both technology and clinical sides, the content brings together essential knowledge to make the best of recent advancements of the field. The book discusses topics such as next generation sequence analysis, genomics in clinical care, IoT applications, blockchain technology, patient centered interoperability of EHR, health data mining, and translational bioinformatics methods for drug discovery and drug repurposing. In addition, it discusses the role of bioinformatics in cancer research and viroinformatics approaches to counter viral diseases through informatics. This is a valuable resource for bioinformaticians, clinicians, healthcare professionals, graduate students and several members of biomedical field who are interested in learning more about how bioinformatics can impact in their research and practice. Covers recent advancements in translational bioinformatics and its healthcare applications Discusses integrative and multidisciplinary approaches to U-healthcare systems development and management Bridges the gap among various knowledge domains in the field, integrating both technological and clinical knowledge into practical content
Sequence Based Bioinformatics Approaches To Predict Virus Host Relationships In Archaea And Eukaryotes
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Author : Yingshan Li
language : en
Publisher:
Release Date : 2022
Sequence Based Bioinformatics Approaches To Predict Virus Host Relationships In Archaea And Eukaryotes written by Yingshan Li and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with categories.
Viral metagenomics is independent of lab culturing and capable of investigating viromes of virtually any given environmental niches. While numerous sequences of viral genomes have been assembled from metagenomic studies over the past years, the natural hosts for the majority of these viral contigs have not been determined. Different computational approaches have been developed to predict hosts of bacteria phages. Nevertheless, little progress has been made in the virus-host prediction, especially for viruses that infect eukaryotes and archaea. In this study, by analyzing all documented viruses with known eukaryotic and archaeal hosts, we assessed the predictive power of four computational approaches in viral host prediction. The use of the following biological relationships among viruses and hosts were explored: 1. Sequence similarity between virus and host genome, where direct genetic interactions between viruses and hosts are assumed to leave traces of historical infections. 2. Co-evolution between viruses and hosts, where the viral dependency on their hosts for replication is assumed to result in similar genomic features including nucleotide composition and codon usage. 3. Sequence similarity between viruses, where closely related viruses are assumed to infect the same hosts. And 4. genomic feature similarities between viruses based on nucleotide compositions and dinucleotide/codon/bicodon usage biases. We assume that viruses with similar genomic features tend to share the same hosts. We showed that using any of the four approaches produced better predictions than uninformed guesses, indicating that our current knowledge of virus-host interaction and co-evolution can be exploited to help predict natural hosts among eukaryotes and archaea for viral contigs. Overall, the third and fourth approaches (prediction based on virus-virus genomic sequence similarity and genomic feature similarity) had the highest prediction accuracy. The second approach (prediction based on virus-host co-evolution) has the least predictive power. We also discuss the biological underpinnings of different predictive power shown in each of these approaches. We anticipate a significant increase in predictive capacity as more training data and knowledge of virus-host relationships are accumulated in the future.