Virus Like Particles
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Virus Like Particles
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Author : Paul Pumpens
language : en
Publisher: CRC Press
Release Date : 2022-05-22
Virus Like Particles written by Paul Pumpens and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-22 with Medical categories.
This book represents the first complete and systematic guide to the virus-like particles (VLPs) and their applications as vaccines, therapeutic tools, nanomaterials, and nanodevices. The grouping of the VLPs follows the most recent virus taxonomy and the traditional Baltimore classification of viruses, which are based on the genome structure and mechanism of mRNA synthesis. Within each of the seven Baltimore classes, the order taxon serves as a framework of the chapter’s arrangement. The term "VLP" is used as a universal designation for the virus-, core-, or capsid-like structures, which became an important part of the modern molecular virology. The 3D structures, expression systems, and nanotechnological applications are described for VLPs in the context of the original viruses and uncover their evolving potential as novel vaccines and medical interventions. Key Features Presents the first full guide to the VLP nanotechnology, classified by current viral taxonomy Outlines specific structural properties and interconnection of the virions and VLPs Explains generation and characteristics of VLPs produced by various expression systems Offers up-to-date summary of VLPs designed as vaccines and delivery tools Unveils interconnection of VLPs with novel organic and inorganic nanomaterials
Virus Like Particle Vaccines
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Author : Martin F Bachmann
language : en
Publisher: Mdpi AG
Release Date : 2020-09-16
Virus Like Particle Vaccines written by Martin F Bachmann and has been published by Mdpi AG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-16 with Science categories.
The structure, uniformity, stability, and functions of virus-like particles (VLPs) have encouraged scientists to utilize them as a unique tool in various applications in biomedical fields. Their interaction with the innate immune system is of major importance for the adaptive immune response they induce. The innate immune cells and molecules recognize and interact with VLPs on the basis of two major characteristics: size and surface geometry. VLP-based vaccines against hepatitis B, human papilloma, malaria, and hepatitis E have been developed and are available in many countries around the world. Given the inherent immunogenicity of VLPs, they render themselves ideal for the development of new vaccines against infectious diseases as well as noncommunicable diseases, such as chronic inflammation or cancer. This Special Issue is designed to provide an up-to-date view of the latest progress in the development of VLP-based prophylactic and therapeutic vaccines and technologies for their generation.
Chimeric Virus Like Particles As Vaccines
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Author : Wolfram H. Gerlich
language : en
Publisher: S Karger Ag
Release Date : 1996-01-01
Chimeric Virus Like Particles As Vaccines written by Wolfram H. Gerlich and has been published by S Karger Ag this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-01-01 with Medical categories.
In recent years the use of chimeric virus-like particles (VLPs) as vaccines and gene vectors has gained increasing importance in both basic and applied research. In this publication 16 groups present their views and experimental data on the expression, morphogenesis, structure and immunogenicity of VLPs derived from hepatitis B virus core or surface protein, HIV gag protein, papillomaviruses, rhinoviruses, and various plant viruses. Classical expression systems of such particles in animal cell cultures are complemented by expression in yeast and transgenic plants. The advantages offered by certain chimeric particles, such as the induction of a cytolytic T lymphocyte immune response following administration of recombinant HBsAg, make VLPs promising candidates for new vaccines. DNA vaccination, a further novel mode of inducing protection against infectious agents, is also considered. Researchers and teachers in virology, immunology, molecular biology and infectious diseases will greatly appreciate this comprehensive survey of an important field of modern vaccine development.
Virus Protein And Nucleoprotein Complexes
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Author : J. Robin Harris
language : en
Publisher: Springer
Release Date : 2018-06-13
Virus Protein And Nucleoprotein Complexes written by J. Robin Harris and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-13 with Science categories.
The Subcellular Biochemistry series has recently embarked upon an almost encyclopaedic coverage of topics relating to the structure and function of macromolecular complexes (Volumes 82, 83 and 87). The present multi-author text covers numerous aspects of current research into molecular virology, with emphasis upon viral protein and nucleoprotein structure and function. Structural data from cryo-electron microscopy and X-ray crystallography is displayed throughout the book. The 17 chapters in the book cover diverse interesting topics, all currently under investigation, contributed by authors who are active actively involved in present-day research. Whilst structural aspects predominate, there is much consideration of the structure-function relationship. In addition, the book correlates with and extends from Volume 68 of the series “Structure and Physics of Viruses: An Integrated Textbook”. This book is directed primarily at professionals that work in the broad field of Structural Biology and will be of particular interest to Structural Virologists. The editors, David Bhella and Robin Harris, have much experience in virology and protein structure, respectively. Dr Bhella is Director of the Scottish Macromolecular Imaging Centre. Professor Robin Harris is the long-standing Series Editor of the Subcellular Biochemistry series. He has edited and contributed to several books in the series.
Virus Like Particles In Vaccine Development
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Author : Future Medicine Ltd
language : en
Publisher:
Release Date : 2014
Virus Like Particles In Vaccine Development written by Future Medicine Ltd and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Drug development categories.
The Bunyaviridae
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Author : Richard M. Elliott
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
The Bunyaviridae written by Richard M. Elliott and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Medical categories.
In this comprehensive reference, leading researchers examine the biology, molecular biology, and diseases of the Bunyaviridae, and provide up-to-date information on the genetic characterization and variations of this virus group. Chapters deal with the molecular biology of five genera: Bunyavirus, Hantavirus, Nairovirus, Phlebovirus, and Tospovirus. Chapters examine Bunyaviridae assembly and intracelluar protein transport as well as Bunyaviridae genetics. Contributors discuss the Bunyaviridae diseases, including the hantavirus pulmonary syndrome.
Biomedical Innovations To Combat Covid 19
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Author : Sergio Rosales-Mendoza
language : en
Publisher: Academic Press
Release Date : 2021-10-15
Biomedical Innovations To Combat Covid 19 written by Sergio Rosales-Mendoza and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-15 with Medical categories.
Biomedical Innovations to Combat COVID-19 provides an updated overview on the development of vaccines, antiviral drugs and nanomaterials, and diagnostic methods for the fight against COVID-19. Perspectives on such technologies are identified, discussed, and enriched with figures for easy understanding and applicability. Furthermore, it contains basic aspects of virology, immunology, and antiviral drugs that are needed to fully appreciate these innovations. This book is split into four sections: introduction, presenting basic virologic and epidemiological aspects of COVID-19; vaccines against COVID-19, discussing their different types and applications used to develop them; diagnostic approaches for SARS-CoV-2, encompassing advanced sensing and microfluidic-based biosensors; and drug development and delivery, where antivirals based on nanomaterials or drugs are presented. It is a valuable source for virologists, biotechnologists, and members of biomedical field interested in learning more about how novel technologies can be applied to fasten the eradication of the COVID-19 and similar pandemics. Presents updated literature coverage summarizing the most relevant information on COVID-19 Written by experts from diverse scientific domains in order to provide readers with a thorough view on the subject Encompasses tables, figures and information trees especially developed for the book in order to condense and highlight key points for quick reference
Micro And Nanotechnology In Vaccine Development
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Author : Mariusz Skwarczynski
language : en
Publisher: William Andrew
Release Date : 2016-09-20
Micro And Nanotechnology In Vaccine Development written by Mariusz Skwarczynski and has been published by William Andrew this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-20 with Medical categories.
This book provides a comprehensive overview of how use of micro- and nanotechnology (MNT) has allowed major new advance in vaccine development research, and the challenges that immunologists face in making further progress. MNT allows the creation of particles that exploit the inherent ability of the human immune system to recognize small particles such as viruses and toxins. In combination with minimal protective epitope design, this permits the creation of immunogenic particles that stimulate a response against the targeted pathogen. The finely tuned response of the human immune system to small particles makes it unsurprising that many of the lead adjuvants and vaccine delivery systems currently under investigation are based on nanoparticles. Provides a comprehensive and unparalleled overview of the role of micro- and nanotechnology in vaccine development Allows researchers to quickly familiarize themselves with the broad spectrum of vaccines and how micro- and nanotechnologies are applied to their development Includes a combination of overview chapters setting out general principles, and focused content dealing with specific vaccines, making it useful to readers from a variety of disciplines
Viruses And Nanotechnology
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Author : Marianne Manchester
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-10-02
Viruses And Nanotechnology written by Marianne Manchester and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-10-02 with Medical categories.
Nanotechnology is a collective term describing a broad range of relatively novel topics. Scale is the main unifying theme, with nanotechnology being concerned with matter on the nanometer scale. A quintessential tenet of nanotechnology is the precise self-assembly of nanometer-sized components into ordered devices. Nanotechnology seeks to mimic what nature has achieved, with precision at the nanometer level down to the atomic level. Nanobiotechnology, a division of nanotechnology, involves the exploitation of biomaterials, devices or methodologies in the nanoscale. In recent years a set of b- molecules has been studied and utilized. Virus particles are natural nanomaterials and have recently received attention for their tremendous potential in this field. The extensive study of viruses as pathogens has yielded detailed knowledge about their biological, genetic, and physical properties. Bacterial viruses (bacte- ophages), plant and animal eukaryotic viruses, and viruses of archaea have all been characterized in this manner. The knowledge of their replicative cycles allows manipulation and tailoring of particles, relying on the principles of self-assembly in infected hosts to build the base materials. The atomic resolution of the virion structure reveals ways in which to tailor particles for higher-order functions and assemblies.
Nanovaccines
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Author : Sergio Rosales-Mendoza
language : en
Publisher: Springer Nature
Release Date : 2019-11-07
Nanovaccines written by Sergio Rosales-Mendoza and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-07 with Technology & Engineering categories.
This book provides a compilation of the current developments in mucosal nanovaccines, which are an attractive approach to fight against infectious and non-communicable diseases. Since nanomaterials possess unique properties; many of them have a positive effect on vaccine efficacy when used as antigen carriers and have been applied in vaccinology with significant advances over the past years. This book addresses the methodologies for mucosal nanovaccines synthesis; based on the following nanomaterials: gold, PLGA, silica, and chitosan nanoparticles; as well as nanogels, carbon nanotubes, liposomes, and Virus-like particles. A description of the immunogenic properties of the mucosal nanovaccines is presented, highlighting the improvements achieved with this approach when compared to conventional formulations. Mucosal vaccines constitute the most practical immunization approach since they are easy to administer (promoting patient ́s comfort and increasing compliance), allow triggering relevant immune responses at both the site of administration and distant compartments, and thus may protect the main entry portal for pathogens (oral, nasal, and genital mucosae). In this context, the potential of nanovaccines to result in new mucosal formulations in the benefit of global health is analyzed. Covers the synthesis and functionalization of nanomaterials for the development of nanovaccines; Discusses the underlying mechanisms involved in the induction of immune responses through mucosal compartments and the advantages of nanomaterials in the formulation of nanovaccines; Transmits the state of the art for the development of mucosal nanovaccines; Provides routes for the design and evaluation of mucosal nanovaccines; Presents key perspectives for the field of mucosal vaccine development.