Voltage And Calcium Activated Potassium Channel Voltage Sensor Remodeling By Modulatory Beta Subunits And Heme
DOWNLOAD
Download Voltage And Calcium Activated Potassium Channel Voltage Sensor Remodeling By Modulatory Beta Subunits And Heme PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Voltage And Calcium Activated Potassium Channel Voltage Sensor Remodeling By Modulatory Beta Subunits And Heme book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Voltage And Calcium Activated Potassium Channel Voltage Sensor Remodeling By Modulatory Beta Subunits And Heme
DOWNLOAD
Author : Saemi Park
language : en
Publisher:
Release Date : 2014
Voltage And Calcium Activated Potassium Channel Voltage Sensor Remodeling By Modulatory Beta Subunits And Heme written by Saemi Park and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.
Large-conductance voltage- and Ca2+-activated K+ channels (BK) have a broad distribution of expression in mammalian cells. BK channels are activated by the membrane depolarization and elevation of intracellular free calcium. When the channel is activated, it allows an increase in potassium permeability, which hyperpolarizes the membrane electrical potential, suppressing cellular excitability. This membrane hyperpolarization decreases the activity of voltage-gated channels, including Ca2+ channels: the latter confers a significant role of BK channels in the internal calcium homeostasis. BK channels are involved in various fundamental physiological processes including the control of blood pressure and neuronal excitability. The BK channel is a homotetramer consisting of four pore-forming alpha subunits, which encode for seven membrane-spanning domains (S0-S6) and two large intracellular domains, RCK1 and RCK2. S0-S4 segments are known as the voltage sensing domain (VSD); S5 and S6 form the pore region and are involved in ion selectivity, while the RCK domains assemble into the ligand-sensing Gating Ring superstructure. In different tissues, the activity of BK alpha subunits is tuned by their association with modulatory beta subunits, beta1-4. The first project investigated the voltage-dependent structural rearrangements of the human BK channel in the presence of beta1 subunit. The data showed that the association of beta 1 remodeled the VSD movements. It is postulated that the association with beta1 destabilizes the active conformation of the voltage sensor in the absence of Ca2+, thus producing an overall right shift in its voltage dependence. BK channels are also modulated by small cytosolic ligands such as heme. The RCK1-RCK2 linker possesses a conserved heme regulation motif (HRM) and exhibited structural homology to cytochrome C (CytC), a hemoprotein. In particular, BK Methionine-691 aligned with M80 of the CytC, the second axial ligand (outside the HRM) to the heme iron. The goal of the second project aimed to understand the role of M691 in the BK regulation by heme. The mutation M691A dramatically diminished the inhibition of BK channel opening by heme (100 nM) compared with the wild-type BK, suggesting that M691 is critical for heme binding.
Regulatory Mechanisms Of Ca2 Activated Ion Channels And Their Impacts On Physiological Pathophysiological Functions
DOWNLOAD
Author : Yoshiaki Suzuki
language : en
Publisher: Frontiers Media SA
Release Date : 2022-04-27
Regulatory Mechanisms Of Ca2 Activated Ion Channels And Their Impacts On Physiological Pathophysiological Functions written by Yoshiaki Suzuki and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-27 with Science categories.
Low Voltage Activated T Type Calcium Channels
DOWNLOAD
Author : Richard W. Tsien
language : en
Publisher:
Release Date : 1998
Low Voltage Activated T Type Calcium Channels written by Richard W. Tsien and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Calcium categories.
Ion Channels And Disease
DOWNLOAD
Author : Frances M. Ashcroft
language : en
Publisher: Academic Press
Release Date : 1999-10-20
Ion Channels And Disease written by Frances M. Ashcroft and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-10-20 with Science categories.
Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies. Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered. This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology. Introduces the relevant aspects of molecular biology and biophysics Describes the principal methods used to study channelopathies Considers single classes of ion channels with summaries of the physiological role, subunit composition, molecular structure and chromosomal location, plus the relationship between channel structure and function Looks at those diseases associated with defective channel structures and regulation, including mutations affecting channel function and to what extent this change in channel function can account for the clinical phenotype
Mitochondrial Oxidative Phosphorylation
DOWNLOAD
Author : Bernhard Kadenbach
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-06-23
Mitochondrial Oxidative Phosphorylation written by Bernhard Kadenbach and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-06-23 with Medical categories.
This book will describe the nuclear encoded genes and their expressed proteins of mitochondrial oxidative phosphorylation. Most of these genes occur in eukaryotic cells, but not in bacteria or archaea. The main function of mitochondria, the synthesis of ATP, is performed at subunits of proton pumps (complexes I, III, IV and V), which are encoded on mitochondrial DNA. The nuclear encoded subunits have mostly a regulatory function. However, the specific physiological functions of the nuclear encoded subunits of complexes I, III, IV, and V are mostly unknown. New data indicates that they are essential for life of higher organisms, which is characterized by an adult life without cell division (postmeiotic stage) in most tissues, after the juvenile growth. For complex IV (cytochrome c oxidase) some of these subunits occur in tissue-specific (subunits IV, VIa, VIb, VIIa, VIII), developmental-specific (subunits IV, VIa, and VIIa) as well as species-specific isoforms. Defective genes of some subunits were shown to induce mitochondrial diseases. Mitochondrial genes and human diseases will also be covered.
The Endothelium
DOWNLOAD
Author : Michel Félétou
language : en
Publisher: Morgan & Claypool Publishers
Release Date : 2011
The Endothelium written by Michel Félétou and has been published by Morgan & Claypool Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Science categories.
The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References
Handbook Of Ion Channels
DOWNLOAD
Author : Jie Zheng
language : en
Publisher: CRC Press
Release Date : 2015-02-25
Handbook Of Ion Channels written by Jie Zheng and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-02-25 with Medical categories.
The New Benchmark for Understanding the Latest Developments of Ion ChannelsIon channels control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli, and regulate the response to physical stimuli. They can often interact with the cellular environment due to their location at the surface of ce
Regulation Of Coronary Blood Flow
DOWNLOAD
Author : Michitoshi Inoue
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-09
Regulation Of Coronary Blood Flow written by Michitoshi Inoue and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-09 with Medical categories.
Research centering on blood flow in the heart continues to hold an important position, especially since a better understanding of the subject may help reduce the incidence of coronary arterial disease and heart attacks. This book summarizes recent advances in the field; it is the product of fruitful cooperation among international scientists who met in Japan in May, 1990 to discuss the regulation of coronary blood flow.
Classical And Quantum Dynamics In Condensed Phase Simulations Proceedings Of The International School Of Physics
DOWNLOAD
Author : Bruce J Berne
language : en
Publisher: World Scientific
Release Date : 1998-06-17
Classical And Quantum Dynamics In Condensed Phase Simulations Proceedings Of The International School Of Physics written by Bruce J Berne and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-06-17 with Science categories.
The school held at Villa Marigola, Lerici, Italy, in July 1997 was very much an educational experiment aimed not just at teaching a new generation of students the latest developments in computer simulation methods and theory, but also at bringing together researchers from the condensed matter computer simulation community, the biophysical chemistry community and the quantum dynamics community to confront the shared problem: the development of methods to treat the dynamics of quantum condensed phase systems.This volume collects the lectures delivered there. Due to the focus of the school, the contributions divide along natural lines into two broad groups: (1) the most sophisticated forms of the art of computer simulation, including biased phase space sampling schemes, methods which address the multiplicity of time scales in condensed phase problems, and static equilibrium methods for treating quantum systems; (2) the contributions on quantum dynamics, including methods for mixing quantum and classical dynamics in condensed phase simulations and methods capable of treating all degrees of freedom quantum-mechanically.
Disorders Of Voluntary Muscle
DOWNLOAD
Author : George Karpati
language : en
Publisher: Cambridge University Press
Release Date : 2001-07-12
Disorders Of Voluntary Muscle written by George Karpati and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-07-12 with Medical categories.
Rewritten and redesigned, this remains the one essential text on the diseases of skeletal muscle.