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Voltage Gated Sodium Channels Structure Function And Channelopathies

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Voltage Gated Sodium Channels Structure Function And Channelopathies

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Author : Mohamed Chahine
language : en
Publisher: Springer
Release Date : 2018-06-04

Voltage Gated Sodium Channels Structure Function And Channelopathies written by Mohamed Chahine and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-04 with Medical categories.

This book provides a timely state-of-the-art overview of voltage-gated sodium channels, their structure-function, their pharmacology and related diseases. Among the topics discussed are the structural basis of Na+ channel function, methodological advances in the study of Na+ channels, their pathophysiology and drugs and toxins interactions with these channels and their associated channelopathies.

Marine Bioactive Peptides Structure Function And Therapeutic Potential

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Author : Tatiana V. Ovchinnikova
language : en
Publisher: MDPI
Release Date : 2019-10-25

Marine Bioactive Peptides Structure Function And Therapeutic Potential written by Tatiana V. Ovchinnikova and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-25 with Medical categories.

This Special Issue Book, “Marine Bioactive Peptides: Structure, Function, and Therapeutic Potential" includes up-to-date information regarding bioactive peptides isolated from marine organisms. Marine peptides have been found in various phyla, and their numbers have grown in recent years. These peptides are diverse in structure and possess broad-spectrum activities that have great potential for medical applications. Various marine peptides are evolutionary ancient molecular factors of innate immunity that play a key role in host defense. A plethora of biological activities, including antibacterial, antifungal, antiviral, anticancer, anticoagulant, endotoxin-binding, immune-modulating, etc., make marine peptides an attractive molecular basis for drug design. This Special Issue Book presents new results in the isolation, structural elucidation, functional characterization, and therapeutic potential evaluation of peptides found in marine organisms. Chemical synthesis and biotechnological production of marine peptides and their mimetics is also a focus of this Special Issue Book.

Molecular Mechanisms Of Voltage Gating In Ion Channels

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Author : Gildas Loussouarn
language : en
Publisher: Frontiers Media SA
Release Date : 2021-11-03

Molecular Mechanisms Of Voltage Gating In Ion Channels written by Gildas Loussouarn and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-03 with Science categories.

Ion Channels And Disease

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Author : Frances M. Ashcroft
language : en
Publisher: Academic Press
Release Date : 2000

Ion Channels And Disease written by Frances M. Ashcroft and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Medical categories.

Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies. Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered. This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology. Introduces the relevant aspects of molecular biology and biophysics Describes the principal methods used to study channelopathies Considers single classes of ion channels with summaries of the physiological role, subunit composition, molecular structure and chromosomal location, plus the relationship between channel structure and function Looks at those diseases associated with defective channel structures and regulation, including mutations affecting channel function and to what extent this change in channel function can account for the clinical phenotype

From Peptide And Protein Toxins To Ion Channel Structure Function And Drug Design

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Author : Victor I. Tsetlin
language : en
Publisher: Frontiers Media SA
Release Date : 2020-12-09

From Peptide And Protein Toxins To Ion Channel Structure Function And Drug Design written by Victor I. Tsetlin and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-09 with Science categories.

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Neuroscience In The 21st Century

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Author : Donald W. Pfaff
language : en
Publisher: Springer Nature
Release Date : 2022-10-17

Neuroscience In The 21st Century written by Donald W. Pfaff and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-17 with Medical categories.

Edited and authored by a wealth of international experts in neuroscience and related disciplines, this key new resource aims to offer medical students and graduate researchers around the world a comprehensive introduction and overview of modern neuroscience. Neuroscience research is certain to prove a vital element in combating mental illness in its various incarnations, a strategic battleground in the future of medicine, as the prevalence of mental disorders is becoming better understood each year. Hundreds of millions of people worldwide are affected by mental, behavioral, neurological and substance use disorders. The World Health Organization estimated in 2002 that 154 million people globally suffer from depression and 25 million people from schizophrenia; 91 million people are affected by alcohol use disorders and 15 million by drug use disorders. A more recent WHO report shows that 50 million people suffer from epilepsy and 24 million from Alzheimer’s and other dementias. Because neuroscience takes the etiology of disease—the complex interplay between biological, psychological, and sociocultural factors—as its object of inquiry, it is increasingly valuable in understanding an array of medical conditions. A recent report by the United States’ Surgeon General cites several such diseases: schizophrenia, bipolar disorder, early-onset depression, autism, attention deficit/ hyperactivity disorder, anorexia nervosa, and panic disorder, among many others. Not only is this volume a boon to those wishing to understand the future of neuroscience, it also aims to encourage the initiation of neuroscience programs in developing countries, featuring as it does an appendix full of advice on how to develop such programs. With broad coverage of both basic science and clinical issues, comprising around 150 chapters from a diversity of international authors and including complementary video components, Neuroscience in the 21st Century in its third edition serves as a comprehensive resource to students and researchers alike.

Cell Signaling And Neural Circuits In Chronic Diseases Of The Central Nervous System

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Author : Francesco Ferraguti
language : en
Publisher: Frontiers Media SA
Release Date : 2021-12-30

Cell Signaling And Neural Circuits In Chronic Diseases Of The Central Nervous System written by Francesco Ferraguti and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-30 with Science categories.

Multiscale Modeling From Macromolecules To Cell Opportunities And Challenges Of Biomolecular Simulations

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Author : Valentina Tozzini
language : en
Publisher: Frontiers Media SA
Release Date : 2020-10-27

Multiscale Modeling From Macromolecules To Cell Opportunities And Challenges Of Biomolecular Simulations written by Valentina Tozzini and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-27 with Science categories.

Neurologic Channelopathies

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Author :
language : en
Publisher: Elsevier
Release Date : 2024-08-20

Neurologic Channelopathies written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-08-20 with Medical categories.

In the last 15 years, a combination of detailed clinical, genetic, molecular electrophysiological and immunological research has combined to result in a deep understanding of a subgroup of neurological diseases spanning the central and peripheral nervous system and which have become known collectively as the Neurological Channelopathies.Ion channels are critical membrane bound proteins that underpin many fundamental processes in the central and peripheral nervous system including action potential generation and propagation and the control of neurotransmitter release at all CNS synapses as well as at the neuromuscular junction. Ion channels are consequently essential for all motor actions, cognitive functions and sensory perceptions. Although it was originally considered that significant ion channel dysfunction would not be compatible with life, we now know this is often not the case, although severe disease can often be the result. Given the fundamental processes that are dependent on ion channel function, it is perhaps unsurprising that genetic or immunologically mediated ion channel dysfunction can result in almost any neurological symptom; patients may present to virtually any subspecialty within both adult and child neurology. The advances that have been made here have not only increased knowledge about the fundamental molecular mechanisms at play, but have also improved our ability to both diagnose and treat many of these disorders in clinical practice. Given these major advances, it is now the right time to combine this knowledge into a single HCN volume dedicated to the Neurological Channelopathies.The book will begin with an introductory overview highlighting common mechanistic themes that cut across different CNS and PNS presentations but with potential for common treatment approaches. This initial chapter considers the classification, genetics, and fundamental physiology of ion channels. Subsequent chapters present a detailed consideration of all genetic and immunological channelopathies. Each chapter will consider•Pathophysiological underpinnings - genetic or immunological•Clinical presentations•Diagnostic approach•Treatment and management - Identifies importance of ion channels to CNS & PNS function - Considers the classification, genetics, and physiology of ion channels - Presents all major immunological and genetic channelopathies - Provides clinical presentation, diagnosis, and treatment of channelopathies

Lifestyle In Heart Health And Disease

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Author : Ronald Ross Watson
language : en
Publisher: Academic Press
Release Date : 2018-01-18

Lifestyle In Heart Health And Disease written by Ronald Ross Watson and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-18 with Health & Fitness categories.

Lifestyle and Heart Health and Disease provides a comprehensive evaluation of lifestyle factors that modify heart function and structure. It includes coverage of a wide range of lifestyle factors, including physical activity, alcohol, tobacco, drugs of abuse, nutrition and psychosocial factors. The book clearly presents the scientific evaluation of published research relating to general responses by scientists, physicians and patients, along with new research on the role of lifestyle in the prevention, amelioration and causation of cardiac remodeling and disease. - Explains the pathogenic mechanisms of cardiovascular diseases and the targets of therapy - Presents methods contained within the book that can be applied to the diagnosis of heart disease - Contains a concise summary with recommendations for actions and conclusions - Provides a one-stop-shopping synopsis of key ideas associated with many aspects of lifestyle

Voltage Gated Sodium Channels Structure Function And Channelopathies

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