Actin Binding Proteins And Disease
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Actin Binding Proteins And Disease
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Author : Cris dos Remedios
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-01-08
Actin Binding Proteins And Disease written by Cris dos Remedios and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-01-08 with Science categories.
There are scattered reports in the published literature citing relationships between actin, actin-binding proteins and disease. This volume brings this information together for the first time, with a focus on human disorders. The volume is relevant to a wide readership including cell biologists interested in understanding how structural and functional changes in proteins impact on the organism as a whole.
Evolution Emerging Functions And Structure Of Actin Binding Proteins
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Author : Lei-Miao Yin
language : en
Publisher: Frontiers Media SA
Release Date : 2022-02-02
Evolution Emerging Functions And Structure Of Actin Binding Proteins written by Lei-Miao Yin and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-02 with Science categories.
Molecular Interactions Of Actin
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Author : C.G. dos Remedios
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Molecular Interactions Of Actin written by C.G. dos Remedios and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Actin is one of the most widespread proteins in eukaryotic cells. This book and its companion (Molecular Interactions of Actin. Actin-Myosin Interaction, Actin-Based Regulation) provide an authoritative and opinionated view of the structure and function of this essential protein. Each section includes an historical perspective and a detailed commentary on actin protein chemistry, molecular and cell biology of actin. While some chapters review the body of knowledge of the subject, others contain new experimental data. This book will appeal to research scientists seeking contemporary overviews of actin and its binding proteins. Contributors include senior scientists as well as the new breed of younger scientists.
Actin A Dynamic Framework For Multiple Plant Cell Functions
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Author : Christopher J. Staiger
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-04-17
Actin A Dynamic Framework For Multiple Plant Cell Functions written by Christopher J. Staiger and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-17 with Science categories.
Actin is an extremely abundant protein that comprises a dynamic polymeric network present in all eukaryotic cells, known as the actin cytoskeleton. The structure and function of the actin cytoskeleton, which is modulated by a plethora of actin-binding proteins, performs a diverse range of cellular roles. Well-documented functions for actin include: providing the molecular tracks for cytoplasmic streaming and organelle movements; formation of tethers that guide the cell plate to the division site during cytokinesis; creation of honeycomb-like arrays that enmesh and immobilize plastids in unique subcellular patterns; supporting the vesicle traffic and cytoplasmic organization essential for the directional secretory mechanism that underpins tip growth of certain cells; and coordinating the elaborate cytoplasmic responses to extra- and intracellular signals. The previous two decades have witnessed an immense accumulation of data relating to the cellular, biochemical, and molecular aspects of all these fundamental cellular processes. This prompted the editors to put together a diverse collection of topics, contributed by established international experts, related to the plant actin cytoskeleton. Because the actin cytoskeleton impinges on a multitude of processes critical for plant growth and development, as well as for responses to the environment, the book will be invaluable to any researcher, from the advanced undergraduate to the senior investigator, who is interested in these areas of plant cell biology.
Frontiers In The Actin Cytoskeleton
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Author : Francisco Rivero
language : en
Publisher: MDPI
Release Date : 2020-12-02
Frontiers In The Actin Cytoskeleton written by Francisco Rivero and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-02 with Science categories.
This Special Issue of IJMS covers a broad range of cutting-edge aspects related to the organization, function, and role in disease of the actin cytoskeleton. This cellular structure is of fundamental importance for the homeostasis of every eukaryotic cell, from the simplest unicellular organism to the most complex animal cell. The actin cytoskeleton contributes to developing and maintaining cell shape and tissue integrity and is crucial for cell migration, movement of organelles, vesicle trafficking, and the completion of cell division. Elaborate structures like the sarcomere, the inner ear cell stereocilia, and the brush border microvilli are built on actin filament scaffolds. Dozens of actin-binding proteins orchestrate the dynamic remodeling of the actin cytoskeleton and integrate it with microtubules and intermediate filaments and with the cell signaling machinery. Playing such fundamental roles in a plethora of cellular processes, it comes as no surprise that defects in actin and associated proteins have been found to be implicated in pathological conditions as diverse as myopathies and neurodegenerative diseases. This Special Issue gathers 15 contributions highlighting the impressive advances made in recent years in this exciting field.
Actin
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Author : James E. Estes
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Actin written by James E. Estes and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
During the period August 5-9, 1992, and immediately preceding the 1992 Gordon Research Conference on Motile and Contractile Systems, the "Third International Conference on the Structure and Function of Ubiquitous Cellular Protein Actin" was held at the Emma Willard School in Troy, New York, under the title "ACTIN '92". This conference focused on the fundamental properties and cellular functions of actin and actin based microfilament systems. The first conference in this series was held in 1982, in Sydney, Australia, and hosted by Dr. Cristobal G. dos Remedios and Dr. Julian A. Barden, both from the University of Sydney (New South Wales, Austrailia). The second conference convened in Monza, Italy in June 1987, and was organized by Dr. Roberto Colombo, University of Milan (Italy). This third gathering of researchers devoted to the study of actin and actin-associated proteins was organized by Dr. James E. Estes, Albany Stratton V A Medical Center and Dr. Paul 1. Higgins, Albany Medical College, who were assisted by an Organizing Committee consisting of Dr. Edward D. Korn (National Heart, Lung and Blood Institute, NIH), Dr. Thomas P. Stossel (Massachusetts General Hospital), Dr. Fumio Matsumura (Rutgers University), and Dr. Stephen Farmer (Boston University). This meeting was dedicated to the many pioneering contributions of Professor Fumio Oosawa to the field of actin research.
Actin Monomer Binding Proteins
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Author : Pekka Lappalainen
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-05-14
Actin Monomer Binding Proteins written by Pekka Lappalainen and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-05-14 with Science categories.
This book provides a comprehensive view on actin monomer-binding proteins and the mechanisms by which they contribute to actin dynamics and various actin-dependent cellular processes. This new title contains chapters that describe the basic mechanisms of actin dynamics as well as the structural principles by which various actin-binding proteins interact with actin. The book is suitable further reading for students in advanced cell biology classes.
The Actin Cytoskeleton And Bacterial Infection
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Author : Hans Georg Mannherz
language : en
Publisher: Springer
Release Date : 2017-02-07
The Actin Cytoskeleton And Bacterial Infection written by Hans Georg Mannherz and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-02-07 with Medical categories.
This volume describes the mechanisms which bacteria have created to secure their survival, proliferation and dissemination by subverting the actin cytoskeleton of host cells. Bacteria have developed a veritable arsenal of toxins, effector proteins and virulence factors that allow them to modify the properties of the intracellular actin cytoskeleton for their own purposes. Bacterial factors either modify actin directly as the main component of this part of the cytoskeleton or functionally subvert regulatory or signalling proteins terminating at the actin cytoskeleton. In short, this volume provides an overview of the various tricks bacteria have evolved to “act on actin” in order to hijack this essential host cell component for their own needs. As such, it will be of interest to scientists from many fields, as well as clinicians whose work involves infectious diseases.
The Motile Actin System In Health And Disease
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Author : Anja Lambrechts
language : en
Publisher:
Release Date : 2008-01-01
The Motile Actin System In Health And Disease written by Anja Lambrechts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-01-01 with Actin categories.
The actin cytoskeleton has been studied for more than fifty years now. Ample studies have documented its fundamental role in cell motility and migration and, especially in the last two decades, tremendous progress has been made to understand the biochemistry of this complex system in relation to its cellular function. The actin system is a multipurpose machine for the cell and is essential for virtually all cellular processes. The actin cytoskeleton is an architectural element, it generates the force for cell migration and for muscle contraction, it is involved in endocytosis, and filaments serve as tracks for sorting cellular components. In the various chapters of this book the role of the actin cytoskeleton in these very different cellular processes is described. As a consequence of its multitasking function, abnormalities in this essential structural component frequently result in disease. Mutations and deregulation of cytoskeletal proteins cause a wide variety of disorders, including muscle and cardiac myopathies, neuronadegenerative diseases and cancer. The first three chapters deal with various molecular properties of components of the actin cytoskeleton in relation to cellular function (and dysfunction). In Chapter 1 Vandamme and coworkers discuss the major building block of the actin cytoskeleton, the actin molecule itself. The paper focuses on gene structures and the tissue and developmental regulation of the six mammalian actin isoforms. Mutations in the actin molecule leading to diseases are discussed as are pathophysiological situations connected to particular actin isoforms. In Chapter 2 the group of Prof. Hüttelmaier gives an overview of an emerging field in actin cytoskeleton research; that of subcellular sorting of the cytoplasmic actin isoforms and its role in establishing polarity via posttranscriptional control of gene expression. Intriguing is the dual property of actin in this, it functions as a track and anchoring scaffold for its own synthesis. In a next chapter by Veniere et al. the biochemistry of actin and actin binding proteins is summarized and put into a context of the formation of subcellular structures, lamellipodia, filopodia and stress fibers, typically associated with cell migration. In the last decade, the actin cytoskeleton also gained clinical importance with the growing awareness of its crucial role during deregulated tumor cell invasion. Therefore two chapters are entirely devoted to the actin cytoskeleton in cancer cell migration. In Chapter 4 Prof. Roy and his team describe the deregulations in the actin system leading to tumor cell migration, expanding on the regulation by Rho-GTPases and polyphosphoinositides. In Chapter 5, Debeir and colleagues outline the rationales for using particular tools to study cell migration assays and discusses, in-depth, global and single cell assays, microscopy and image acquisition technologies, and software tools to study the migratory behavior of cancer cells in in vitro and in vivo model systems. The next four chapters focus on specialized systems. In Chapter 6 Prof. Dent updates on progress made on the role of the actin cytoskeleton in the differentiation of neurons including neuronal migration through axon outgrowth and guidance to synaptogenesis. In Chapter 7, Dr. Sonnemann and Prof. Ervasti, revisit some actin isoforms for their role in muscle development and formation of substructures that are typical for muscle cells and also describe actin diseases in skeletal and cardiac muscle. Dr. Hinz describes, in Chapter 8, the intricate relation between the (maturing) adhesion machinery and the actin cytoskeleton, its role in mechanosensing and in transmitting mechanical stress signals. An equally complex interplay exists between the actin cytoskeleton and the plasma membrane. Prof. Qualmann and coworkers discuss this in the final chapter giving an extensive overview of multidisciplinary research that has advanced our understanding on the cellular pathways and coordinated events leading to formation of vesicles, in which the actin cytoskeleton is instrumental. We acknowledge all authors for their expert contributions. No book of this size on the actin cytoskeleton can be complete, but with this book we have covered a large part of the current research directions in this field. As is evident from the concluding remarks in each of the chapters our work for understanding the role of the actin cytoskeleton is far from complete. Despite many years of intensive and elegant research, many intriguing questions remain but we hope by publishing this book we incite (young) scientists to take up research in the wonderful world of the actin cytoskeleton.
Cytoskeleton
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Author : Jose C. Jimenez-Lopez
language : en
Publisher: BoD – Books on Demand
Release Date : 2017-05-17
Cytoskeleton written by Jose C. Jimenez-Lopez and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-17 with Science categories.
The cytoskeleton is a highly dynamic intracellular platform constituted by a three-dimensional network of proteins responsible for key cellular roles as structure and shape, cell growth and development, and offering to the cell with "motility" that being the ability of the entire cell to move and for material to be moved within the cell in a regulated fashion (vesicle trafficking). The present edition of Cytoskeleton provides new insights into the structure-functional features, dynamics, and cytoskeleton's relationship to diseases. The authors' contribution in this book will be of substantial importance to a wide audience such as clinicians, researches, educators, and students interested in getting updated knowledge about molecular basis of cytoskeleton, such as regulation of cell vital processes by actin-binding proteins as cell morphogenesis, motility, their implications in cell signaling, as well as strategies for clinical trial and alternative therapies based in multitargeting molecules to tackle diseases, that is, cancer.