Activity Dependent Plasticity Of Neuronal Excitability
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Activity Dependent Plasticity Of Neuronal Excitability
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Author : Ingrid van Welie
language : en
Publisher:
Release Date : 2004
Activity Dependent Plasticity Of Neuronal Excitability written by Ingrid van Welie and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.
Activity Dependent Regulation Of Neuronal Excitability In Hippocampal Neurons
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Author : Karunesh Ganguly
language : en
Publisher:
Release Date : 2002
Activity Dependent Regulation Of Neuronal Excitability In Hippocampal Neurons written by Karunesh Ganguly and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with categories.
Activity Dependent Plasticity Of The Intrinsic Membrane Excitability In Hippocampal Ca1 Pyramidal Neurons
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Author : Yuan Fan
language : en
Publisher:
Release Date : 2005
Activity Dependent Plasticity Of The Intrinsic Membrane Excitability In Hippocampal Ca1 Pyramidal Neurons written by Yuan Fan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with categories.
Neuromodulation
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Author : Leonard K. Kaczmarek
language : en
Publisher: Oxford University Press, USA
Release Date : 1987
Neuromodulation written by Leonard K. Kaczmarek and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with Medical categories.
This volume provides an introduction to the general principles of neuromodulation--the key neurobiological process for understanding how the brain works. Emphasizing ion channels and biochemical mechanisms of protein phosphorylation, the book shows how neurons regulate their intracellular calcium concentration by modulating the activity of certain ion channels. It goes on to explain the function of intracellular calcium and describes some fascinating neuromodulatory phenomena in the mammalian brain that have long awaited the kind of mechanistic investigations possible in simpler systems. Bridging the gap between neurochemistry and neurophysiology, the authors make complex concepts and research approaches comprehensible to scientists in either field.
Inhibitory Synaptic Plasticity
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Author : Melanie A. Woodin
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-11-02
Inhibitory Synaptic Plasticity written by Melanie A. Woodin and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-02 with Medical categories.
This volume will explore the most recent findings on cellular mechanisms of inhibitory plasticity and its functional role in shaping neuronal circuits, their rewiring in response to experience, drug addiction and in neuropathology. Inhibitory Synaptic Plasticity will be of particular interest to neuroscientists and neurophysiologists.
Spike Timing Dependent Plasticity
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Author : Henry Markram
language : en
Publisher: Frontiers E-books
Release Date :
Spike Timing Dependent Plasticity written by Henry Markram and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Hebb's postulate provided a crucial framework to understand synaptic alterations underlying learning and memory. Hebb's theory proposed that neurons that fire together, also wire together, which provided the logical framework for the strengthening of synapses. Weakening of synapses was however addressed by "not being strengthened", and it was only later that the active decrease of synaptic strength was introduced through the discovery of long-term depression caused by low frequency stimulation of the presynaptic neuron. In 1994, it was found that the precise relative timing of pre and postynaptic spikes determined not only the magnitude, but also the direction of synaptic alterations when two neurons are active together. Neurons that fire together may therefore not necessarily wire together if the precise timing of the spikes involved are not tighly correlated. In the subsequent 15 years, Spike Timing Dependent Plasticity (STDP) has been found in multiple brain brain regions and in many different species. The size and shape of the time windows in which positive and negative changes can be made vary for different brain regions, but the core principle of spike timing dependent changes remain. A large number of theoretical studies have also been conducted during this period that explore the computational function of this driving principle and STDP algorithms have become the main learning algorithm when modeling neural networks. This Research Topic will bring together all the key experimental and theoretical research on STDP.
Activity Dependent Integration And Plasticity Of New Neurons During Postnatal Neurogenesis
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Author : Chia-Wei Lin
language : en
Publisher:
Release Date : 2010
Activity Dependent Integration And Plasticity Of New Neurons During Postnatal Neurogenesis written by Chia-Wei Lin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.
Most neurons are born during the embryonic period to become the building blocks for a variety of brain circuits. However, two brain regions only start to assemble during the postnatal period. Both brain areas, olfactory bulb and dentate gyrus, mainly accommodate the integration of new neurons during the postnatal period, and continuously receive new neurons throughout animals' life. In this thesis, I used the rat olfactory bulb (OB) as a model system to address two important issues regarding the integration and plasticity of new neurons generated during the postnatal period. The first feature of postnatal neurogenesis is that when new neurons arrive and integrate into an adult OB, only half of neurons can ultimately survive. However, what form of activity pattern determines the survival of new neurons remains unclear. Using NaChBac sodium channels to selectively alter the intrinsic excitability of new neurons in vivo, this manipulation reveals that neuronal survival critically depends on the level of membrane depolarization. Once neurons integrate and survive in the brain circuits, neurons have the capability of monitoring their activity level and adaptively maintain their membrane excitability within the operational range. How they achieve the long-term stability of membrane excitability remains unclear. By altering the resting membrane potential of individual neurons in vivo, OB granule neurons are found to use a subthreshold parameter, resting membrane potential, to guide the compensatory changes of intrinsic ion channels and synaptic receptors. In summary, studies from this thesis have revealed the cellular mechanisms underlying neuronal survival in an in vivo brain circuit. I also uncover a novel form of homeostatic computation by which granule neurons preferentially use the subthreshold membrane potential response rather than spiking rates as a set point.
Activity Dependent Long Term Potentiation Of Intrinsic Excitability In Hippocampal Ca1 Pyramidal Neurons
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Author : Jun Xu
language : en
Publisher:
Release Date : 2005
Activity Dependent Long Term Potentiation Of Intrinsic Excitability In Hippocampal Ca1 Pyramidal Neurons written by Jun Xu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with categories.
Cortical Plasticity
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Author : Sam Fazeli
language : en
Publisher: Garland Science
Release Date : 2020-08-18
Cortical Plasticity written by Sam Fazeli and has been published by Garland Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-18 with Science categories.
This book provides an insight into the rapidly growing field of cortical plasticity. It brings together diverse experimental approaches to the study of activity-dependent changes in neuronal connections, as exemplified by long-term potentiation (LTP) and long-term depression (LTD).
Regulation Of Voltage Gated K Currents In Motor Neurons
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Author : Dalia Salloum
language : en
Publisher:
Release Date : 2017
Regulation Of Voltage Gated K Currents In Motor Neurons written by Dalia Salloum and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
Neuronal output is shaped by extrinsic modulation as well as modulation of intrinsic properties of individual neurons, mediated by activity-dependent changes in the expression levels of voltage-gated ionic currents. Activity-dependent regulation of ionic currents is a mechanism by which electrical output of a neuron feeds back onto the expression of its own ion channels to alter cellular excitability in response to stimuli. Neurons alter their intrinsic properties to achieve long lasting changes involved in development, learning and memory formation and vital functions of organ systems such as locomotion and digestion. At the same time, plasticity of neuronal excitability driven by previous experience requires mechanisms to promote stability to maintain physiological function, and many examples of this type of homeostatic plasticity changes have been reported. At the same time, neuromodulation can alter electrical output indirectly via ligand-gated receptors and second messenger pathways and potentially affect activity-dependent effects. Activity-dependent regulation of ionic currents functions to allow neurons to track their own electrical activity and adjust their intrinsic properties in response to changing synaptic drive or other inputs to maintain their functional output. This phenomenon has been demonstrated to occur over the course of minutes and is a relatively fast process. Neuromodulators exert long-term effects on ionic currents via activation of cellular signaling pathways that do not directly affect ionic current levels. Neuromodulation and activity-dependent effects can alter neuronal networks on different time scales, e.g. over several hours to days to accommodate the needs of the behaving organism such as in transitions between sleep and waking states. However, this is not necessarily so, and the possibility of real-time interactions exist and needs to be examined.