Adenovirus Dna
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Adenovirus Dna
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Author : Walter Doerfler
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Adenovirus Dna written by Walter Doerfler and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Molecular Biology Of Adenoviruses
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Author : L. Philipson
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Molecular Biology Of Adenoviruses written by L. Philipson and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
I. Introduction In his biography "Arrow in the Blue" the author Arthur Koestler suggests ironically that the fate of an individual may be predicted by examining the content of the newspapers at birth. Adenoviruses were discovered in 1953 (ROWE et al. , 1953; HILLEMAN and WERNER, 1954). At this time the Salk poliomyelitis vaccine was developed (SALK et al. , 1954) and in the same year the discovery of the double helical structure of DNA (WATSON and CRICK, 1953) and the plaque assay for one animal virus (DULBECCO and VOGT, 1953) was announced. Thus, this new group of viruses was born with great hopes for progress in molecular biology and for the control of animal virus infections. In the short interval be tween 1953 and 1956 the adenoviruses were discovered, methods for laboratory diagnosis and serotyping were established, the epidemiology was clarified and a highly effective vaccine was developed and approved (for a review see HILLE MAN, 1966). Succeeding years showed, however, that the vaccines were contami nated with the oncogenic SV 40 virus and that the adenoviruses themselves were tumorigenic. Since the discovery of adenoviruses animal virology was developed into a quantitative science offering explanation for viral functions at the molecular level. Precise biochemical tools to characterize the genome and its transcription products as well as the structural proteins of these viruses are now available.
Adenoviruses Model And Vectors In Virus Host Interactions
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Author : Walter Doerfler
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09
Adenoviruses Model And Vectors In Virus Host Interactions written by Walter Doerfler and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Medical categories.
After three volumes on adenoviruses in 1995 the past years have seen rapid progress in the field of adenovirus research. Moreover, adenoviruses have attracted considerable interest as vectors in gene transfer regimens.
The Adenoviruses
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Author : Harold S. Ginsberg
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-08
The Adenoviruses written by Harold S. Ginsberg and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-08 with Medical categories.
The discovery of adenoviruses naturally induced a new interest in viruses of the human upper respiratory tract since previously unknown viruses infecting this portion of the human body had not been identified in 20 years, and their unique characteristics stimulated investigations into the biochemical events essential for replication of animal viruses. Indeed, the field of molecular virology has evolved during the period since their dis covery, and adenoviruses have played a major role in this development. The exciting discoveries made with adenoviruses have had such a pro found effect on knowledge in basic virology, molecular biology, viral ge netics, human and animal infections, and cell transformation that this seemed a propitious time to have some of the major contributors review this field. This volume pays tribute to the late Wallace Rowe, Robert Huebner, and Maurice Hilleman whose initial discoveries of adenoviruses have tremendously enriched virology. Harold S. Ginsberg vii Contents Chapter 1 An Overview 1 Harold S. Ginsberg Chapter 2 The Architecture of Adenoviruses M. V. Nermut I. Introduction ................................... . 5 II. Chemical and Physical Properties ................... . 6 III. Virus Capsid: Composition and Organization .......... . 7 A. Hexon ..................................... . 10 B. Penton .................................... . 12 C. Other Virus Polypeptides Associated with the Capsid 13 D. Organization of the Capsid ..................... . 14 IV. Virus Core .................................... . 15 A. Evidence for the Core Shell ..................... . 17 B. Organization of the DNA-Protein Complex (Nucleoc- sid) ....................................... . 18 C. Tentative Model of the Adenovirus Nucleocapsid ... . 22 V. Model of the Adenovirion ......................... . 29 32 References .......................................... .
The Molecular Biology Of Adenoviruses 2
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Author : W. Doerfler
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Molecular Biology Of Adenoviruses 2 written by W. Doerfler and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The Molecular Biology Of Adenoviruses I
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Author : W. Doerfler
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Molecular Biology Of Adenoviruses I written by W. Doerfler and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
A puzzling epidemiological problem was the driving force behind the discovery of human adenoviruses by Wallace Rowe and his colleagues 30 years ago. The de velopment of a plaque assay for poliomyelitis virus in 1953 led us to the threshold of quantitative virology, and in the same year the double-helical structure of DNA was discovered and became a cornerstone of mo lecular biology. The potential of adenoviruses as research tools in the molecular and cellular biology of eukaryotic cells was recognized as early as the late 1950s and early 1960s by several investigators. Structural and biochemical stu dies dominated the early years. In 1962, some of the adenoviruses were the first human viruses shown to be oncogenic in experimental animals. Thus adenovirology offered the investigator the entire gamut of host cell interactions, productive and abortive, as well as trans formed and tumor cell systems. The possibilities that adenoviruses afforded for the study of the molecular biology and genetics of eukaryotic cells were fully rea lized in the late 1960s and the 1970s.
The Molecular Biology Of Adenoviruses 3
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Author : W. Doerfler
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Molecular Biology Of Adenoviruses 3 written by W. Doerfler and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The Molecular Repertoire Of Adenoviruses I
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Author : Walter Doerfler
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Molecular Repertoire Of Adenoviruses I written by Walter Doerfler and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
For decades this virus system has served - and continues to do so - to pioneer investigations on the molecular biology, biochemistry and genetics of mammalian cell systems. This three volume work presents an up-to-date account of recent basic research in one of the most important experimental systems for biochemical, cell biological, genetic, virological, and epidemiological investigations in mammalian molecular biology. In this, the first of the three volumes, an overview of adenovirus research is presented with emphasis on the structure and assembly of adenoviruses, viral infections, and viral gene products. The chapters have been written by an international group of leading experts in their respective fields of interest.
Human Adenoviruses From Villains To Vectors
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Author : Flint S Jane
language : en
Publisher: World Scientific
Release Date : 2016-12-21
Human Adenoviruses From Villains To Vectors written by Flint S Jane and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-21 with Medical categories.
Human adenoviruses play a central role in human diseases and as vectors for vaccines and gene delivery. This monograph describes the underlying principles of adenovirus molecular and structural biology, pathogenesis, antiviral measures and vector development. Much of the history of this virus and the many contributions made by its study are embedded in these discussions. Topics and questions that require further investigation are also considered. Although current virology textbooks cover topics related to adenoviruses, this book provides a comprehensive description of the virus and its interactions with the host. Students and researchers with a particular interest in adenoviruses, gene therapists, and virologists interested in viral pathogenesis will benefit from this book, which presents a unique integration of the basics with applied research in the field.
Adenoviruses Model And Vectors In Virus Host Interactions
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Author : Walter Doerfler
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09
Adenoviruses Model And Vectors In Virus Host Interactions written by Walter Doerfler and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Medical categories.
After three volumes on adenoviruses in 1995 the past years have seen rapid progress in the field of adenovirus research. Moreover, adenoviruses have attracted considerable interest as vectors in gene transfer regimens. After the first volume on virion and structure, viral replication and host-cell interaction this second volume deals with the immune system, oncogenesis and gene therapy.