Alzheimer S Disease Biology Biophysics And Computational Models
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Alzheimer S Disease Biology Biophysics And Computational Models
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Author : Don Kulasiri
language : en
Publisher: World Scientific
Release Date : 2022-01-06
Alzheimer S Disease Biology Biophysics And Computational Models written by Don Kulasiri and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-06 with Medical categories.
Alzheimer's disease (AD) is the leading cause of dementia and, unfortunately, remains incurable. The social, emotional and financial implications of AD are immeasurable, and about 47 million people worldwide are affected by AD or other forms of dementia. As lifespans are improved by healthcare systems worldwide, age-associated neurodegenerative diseases are imposing an increasing challenge to science. It is becoming imperative for us to understand the causes of these diseases, AD in particular, at molecular and cellular levels. Starting with the broader picture from a biological perspective, this book takes the reader through fascinating dynamics within and outside of neurons in the brain.Alzheimer's Disease: Biology, Biophysics and Computational Models helps the reader to understand AD from mechanistic and biochemical perspectives at intra- and inter-cellular levels. It focuses on biochemical pathways and modeling associated with AD. Some of the recent research on biophysics and computational models related to AD are explained using context-driven computational and mathematical modeling and essential biology is discussed to understand the modeling research.
Computational Systems Biology Of Synaptic Plasticity Modelling Of Biochemical Pathways Related To Memory Formation And Impairement
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Author : Kulasiri Don
language : en
Publisher: #N/A
Release Date : 2017-06-09
Computational Systems Biology Of Synaptic Plasticity Modelling Of Biochemical Pathways Related To Memory Formation And Impairement written by Kulasiri Don and has been published by #N/A this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-09 with Computers categories.
This book demonstrates the power of mathematical thinking in understanding the biological complexity that exists within the brain. It looks at the latest research on modelling of biochemical pathways within synapses, and provides a clear background for the study of mathematical models related to systems biology. Discussion then focusses on developments in computational models based on networks linked to synaptic plasticity. The models are used to understand memory formation and impairment and they provide a mathematical basis for memory research. Computational Systems Biology of Synaptic Plasticity is a valuable source of knowledge to postgraduate students and researchers in computational systems biology, and as a reference book for various techniques that are needed in modelling biological processes.
Computational Neurogenetic Modeling
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Author : Lubica Benuskova
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-05-05
Computational Neurogenetic Modeling written by Lubica Benuskova and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-05-05 with Technology & Engineering categories.
This is a student text, introducing the scope and problems of a new scientific discipline - Computational Neurogenetic Modeling (CNGM). CNGM is concerned with the study and development of dynamic neuronal models for modeling brain functions with respect to genes and dynamic interactions between genes. These include neural network models and their integration with gene network models. This new area brings together knowledge from various scientific disciplines.
Computational And Experimental Studies In Alzheimer S Disease
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Author : Kunal Bhattacharya
language : en
Publisher: CRC Press
Release Date : 2024-03-29
Computational And Experimental Studies In Alzheimer S Disease written by Kunal Bhattacharya and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-29 with Science categories.
This reference book compiles the recent advances in computational and experimental modelling to screen and manage Alzheimer’s disease. It covers basic etiopathology and various in vitro and in vivo strategies of disease intervention. The book discusses how computer-aided drug design approaches reduce costs and increase biological test efficiency. It reviews the screening for anti-Alzheimer drugs and biomarker analysis of disease inhibitors. The book also explores mechanistic aspects of neurodegeneration and the use of natural products as therapeutics for Alzheimer’s disease. Key features: Elaborates on the computational modelling of protein target inhibitors as anti-Alzheimer’s agents Explains the role of phytomolecules and natural products in Alzheimer’s therapy Reviews preclinical ways to assess drugs focusing on Alzheimer’s disease Covers biomarker analysis for Alzheimer’s disease Discusses the onset and progression of Alzheimer’s disease The book is meant for professionals, researchers, and students of neuroscience, psychology, and computational neurosciences.
Biophysics And Biochemistry Of Protein Aggregation Experimental And Theoretical Studies On Folding Misfolding And Self Assembly Of Amyloidogenic Peptides
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Author : Yuan Jian-min
language : en
Publisher: World Scientific
Release Date : 2017-06-02
Biophysics And Biochemistry Of Protein Aggregation Experimental And Theoretical Studies On Folding Misfolding And Self Assembly Of Amyloidogenic Peptides written by Yuan Jian-min and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-02 with Science categories.
This book reviews current research on the important processes involved in neurodegenerative diseases (e.g. Alzheimer's disease) and the peptides and proteins involved in the amyloidogenic processes. It covers the design and developments of anti-amyloid inhibitors, and gives readers a fundamental understanding of the underlying oligomerization and aggregation processes of these diseases from both computational and experimental points of view.
Current Trends In Computational Modeling For Drug Discovery
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Author : Supratik Kar
language : en
Publisher: Springer Nature
Release Date : 2023-06-30
Current Trends In Computational Modeling For Drug Discovery written by Supratik Kar and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-30 with Science categories.
This contributed volume offers a comprehensive discussion on how to design and discover pharmaceuticals using computational modeling techniques. The different chapters deal with the classical and most advanced techniques, theories, protocols, databases, and tools employed in computer-aided drug design (CADD) covering diverse therapeutic classes. Multiple components of Structure-Based Drug Discovery (SBDD) along with its workflow and associated challenges are presented while potential leads for Alzheimer’s disease (AD), antiviral agents, anti-human immunodeficiency virus (HIV) drugs, and leads for Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) disease are discussed in detail. Computational toxicological aspects in drug design and discovery, screening adverse effects, and existing or future in silico tools are highlighted, while a novel in silico tool, RASAR, which can be a major technique for small to big datasets when not much experimental data are present, is presented. The book also introduces the reader to the major drug databases covering drug molecules, chemicals, therapeutic targets, metabolomics, and peptides, which are great resources for drug discovery employing drug repurposing, high throughput, and virtual screening. This volume is a great tool for graduates, researchers, academics, and industrial scientists working in the fields of cheminformatics, bioinformatics, computational biology, and chemistry.
Genedis 2020
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Author : Panayiotis Vlamos
language : en
Publisher: Springer Nature
Release Date : 2022-01-01
Genedis 2020 written by Panayiotis Vlamos and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-01 with Science categories.
The 4th World Congress on Genetics, Geriatrics and Neurodegenerative Diseases Research (GeNeDis 2020) focuses on the latest major challenges in scientific research, new drug targets, the development of novel biomarkers, new imaging techniques, novel protocols for early diagnosis of neurodegenerative diseases, and several other scientific advances, with the aim of better, safer, and healthier aging. Computational methodologies for implementation on the discovery of biomarkers for neurodegenerative diseases are extensively discussed. This volume focuses on the sessions from the conference regarding computational biology and bioinformatics.
Systems Biology Of Alzheimer S Disease
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Author : Juan I. Castrillo
language : en
Publisher: Humana
Release Date : 2016-10-15
Systems Biology Of Alzheimer S Disease written by Juan I. Castrillo and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-15 with Medical categories.
Alzheimer’s disease (AD) and many other neurodegenerative disorders are multifactorial in nature, involving a combination of genomic, epigenomic, network dynamic and environmental factors. A proper investigation requires new integrative Systems Biology approaches, at both the experimental and computational level. The interplay of disease mechanisms and homeostatic networks will underlie the time of onset and rate of progression of the disease. This book addresses such an integrated approach to AD. It aims to present Systems Biology, including both experimental and computational approaches, as a new strategy for the study of AD and other multifactorial diseases, with the hope that the results will translate into more effective diagnosis and treatment, as well as improved public health policies. Written for the highly successful Methods in Molecular Biology series, practical and cutting-edge, Systems Biology of Alzheimer’s Disease is intended for post-graduate students, post-doctoral researchers and experts in different fields with an interest in comprehensive Systems Biology strategies applicable to AD and other complex multifactorial diseases (including other neurodegenerative diseases and cancers). This book aims to complement other excellent volumes and monographs on AD that cover fundamental, physiological or medical aspects of the disease.
Computational Neurogenetic Modeling
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Author : Lubica Benuskova
language : en
Publisher: Springer
Release Date : 2008-10-17
Computational Neurogenetic Modeling written by Lubica Benuskova and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-10-17 with Technology & Engineering categories.
This is a student text, introducing the scope and problems of a new scientific discipline - Computational Neurogenetic Modeling (CNGM). CNGM is concerned with the study and development of dynamic neuronal models for modeling brain functions with respect to genes and dynamic interactions between genes. These include neural network models and their integration with gene network models. This new area brings together knowledge from various scientific disciplines.
Biomat 2005
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Author : Rubem P. Mondaini
language : en
Publisher: World Scientific
Release Date : 2006
Biomat 2005 written by Rubem P. Mondaini and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Mathematics categories.
This volume contains the contributions of the keynote speakers to the BIOMAT 2005 symposium, as well as a collection of selected papers by pioneering researchers. It provides a comprehensive review of the mathematical modeling of cancer development, Alzheimer''s disease, malaria, and aneurysm development. Various models for the immune system and epidemiological issues are analyzed and reviewed. The book also explores protein structure prediction by optimization and combinatorial techniques (Steiner trees). The coverage includes bioinformatics issues, regulation of gene expression, evolution, development, DNA and array modeling, and small world networks. Sample Chapter(s). Chapter 1: Modelling Aspects of Vascular Cancer Development (581 KB). Contents: Biological Modeling: A Mathematical Analysis of Cylindrical Shaped Aneurysms (T A Kwembe & S N Jones); On the Origin of Metazoans (F W Cummings); Optimal Control of Distributed Systems Applied to the Problems of Ambient Pollution (S F Arantes & J E M Rivera); Epidemiology and Immunology: Modeling the in Vivo Dynamics of Viral Infections (R M Ribeiro); The Basic Reproductive Rate in the Malaria Model (A P Wyse et al.); Epidemiological Model with Fast Dispersion (M R Ricard et al.); Protein Structure: Structure Prediction of Alpha-Helical Proteins (S R McAllister & C A Floudas); Steiner Minimal Trees, Twist Angles, and the Protein Folding Problem (J M Smith); Steiner Trees as Intramolecular Networks of the Biomacromolecular Structures (R P Mondaini); Bioinformatics: Optimization of Between Group Analysis of Gene Expression Disease Class Prediction (F Baty et al.); On Biclustering with Features Selection for Microarray Data Sets (P M Pardalos et al.); Simple and Effective Classifiers to Model Biological Data (R L Salvini et al.); and other papers. Readership: Graduate students and researchers in biology, mathematics and physics."