Amyloid Fibrils And Prefibrillar Aggregates

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Amyloid Fibrils And Prefibrillar Aggregates

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Author : Daniel Erik Otzen
language : en
Publisher: John Wiley & Sons
Release Date : 2013-06-04

Amyloid Fibrils And Prefibrillar Aggregates written by Daniel Erik Otzen and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-04 with Science categories.

Summing up almost a decade of biomedical research, this topical and eagerly awaited handbook is the first reference on the topic to incorporate recent breakthroughs in amyloid research. The first part covers the structural biology of amyloid fibrils and pre-fibrillar assemblies, including a description of current models for amyloid formation. The second part looks at the diagnosis and biomedical study of amyloid in humans and in animal models, while the final section discusses pharmacological approaches to manipulating amyloid and also looks at its physiological roles in lower and higher organisms. For Biochemists, Molecular Biologists, Neurobiologists, Neurophysiologists and those working in the Pharmaceutical Industry.

Protein Folding Misfolding And Aggregation

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Author : Victor Muñoz
language : en
Publisher: Royal Society of Chemistry
Release Date : 2008

Protein Folding Misfolding And Aggregation written by Victor Muñoz and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Science categories.

Protein folding and aggregation is the process by which newly synthesized proteins fold into the specific three-dimensional structures defining their biologically active states. It has always been a major focus of research in biochemistry and has often been seen as the unsolved second part of the genetic code. In the last 10 years we have witnessed a quantum leap in the research in this exciting area. Computational methods have improved to the extent of making possible to simulate the complete folding process of small proteins and the early stages of protein aggregation. Experimental methods h.

Amyloidosis New Insights For The Healthcare Professional 2012 Edition

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Author :
language : en
Publisher: ScholarlyEditions
Release Date : 2012-12-10

Amyloidosis New Insights For The Healthcare Professional 2012 Edition written by and has been published by ScholarlyEditions this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-10 with Medical categories.

Amyloidosis: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Amyloidosis in a concise format. The editors have built Amyloidosis: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Amyloidosis in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Amyloidosis: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Non Fibrillar Amyloidogenic Protein Assemblies Common Cytotoxins Underlying Degenerative Diseases

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Author : Farid Rahimi
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-01-13

Non Fibrillar Amyloidogenic Protein Assemblies Common Cytotoxins Underlying Degenerative Diseases written by Farid Rahimi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-13 with Medical categories.

Amyloid-forming proteins are implicated in over 30 human diseases. The proteins involved in each disease have unrelated sequences and dissimilar native structures, but they all undergo conformational alterations to form fibrillar polymers. The fibrillar assemblies accumulate progressively into disease-specific lesions in vivo. Substantial evidence suggests these lesions are the end state of aberrant protein folding whereas the actual disease-causing culprits likely are soluble, non-fibrillar assemblies preceding the aggregates. The non-fibrillar protein assemblies range from small, low-order oligomers to spherical, annular, and protofibrillar species. Oligomeric species are believed to mediate various pathogenic mechanisms that lead to cellular dysfunction, cytotoxicity, and cell loss, eventuating in disease-specific degeneration and systemic morbidity. The particular pathologies thus are determined by the afflicted cell types, organs, systems, and the proteins involved. Evidence suggests that the oligomeric species may share structural features and possibly common mechanisms of action. In many cases, the structure–function interrelationships amongst the various protein assemblies described in vitro are still elusive. Deciphering these intricate structure–function correlations will help understanding a complex array of pathogenic mechanisms, some of which may be common across different diseases albeit affecting different cell types and systems.

Alzheimer S Disease Pathogenesis

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Author : Suzanne De La Monte
language : en
Publisher: BoD – Books on Demand
Release Date : 2011-09-12

Alzheimer S Disease Pathogenesis written by Suzanne De La Monte and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-12 with Medical categories.

Alzheimer's Disease Pathogenesis: Core Concepts, Shifting Paradigms, and Therapeutic Targets, delivers the concepts embodied within its title. This exciting book presents the full array of theories about the causes of Alzheimer's, including fresh concepts that have gained ground among both professionals and the lay public. Acknowledged experts provide highly informative yet critical reviews of the factors that most likely contribute to Alzheimer's, including genetics, metabolic deficiencies, oxidative stress, and possibly environmental exposures. Evidence that Alzheimer's resembles a brain form of diabetes is discussed from different perspectives, ranging from disease mechanisms to therapeutics. This book is further energized by discussions of how neurotransmitter deficits, neuro-inflammation, and oxidative stress impair neuronal plasticity and contribute to Alzheimer's neurodegeneration. The diversity of topics presented in just the right depth will interest clinicians and researchers alike. This book inspires confidence that effective treatments could be developed based upon the expanding list of potential therapeutic targets.

Conjugated Polyelectrolytes

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Author : Bin Liu
language : en
Publisher: John Wiley & Sons
Release Date : 2013-08-07

Conjugated Polyelectrolytes written by Bin Liu and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-08-07 with Technology & Engineering categories.

This is the first monograph to specifically focus on fundamentals and applications of polyelectrolytes, a class of molecules that gained substantial interest due to their unique combination of properties. Combining both features of organic semiconductors and polyelectrolytes, they offer a broad field for fundamental research as well as applications to analytical chemistry, optical imaging, and opto-electronic devices. The initial chapters introduce readers to the synthesis, optical and electrical properties of various conjugated polyelectrolytes. This is followed by chapters on the applications of these materials in optical sensing and imaging with emphasis on biological systems, while the final section addresses the emerging applications of conjugated polyelectrolytes in optoelectronic devices, concluding with an in-depth discussion of structure-property relationship. The editors and contributors are all pioneers and experts in this expanding field. This monograph is not only for chemists, materials scientists, and physicists, but also a unique source of knowledge for readers with scientific background interested in polyelectrolytes.

Protein Misfolding In Neurodegenerative Diseases

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Author : Neha Gogia
language : en
Publisher: Elsevier
Release Date : 2025-03-17

Protein Misfolding In Neurodegenerative Diseases written by Neha Gogia and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-03-17 with Science categories.

Approx.280 pages - Discusses underlying cellular and molecular mechanisms altered in protein-associated neurodegenerative disorders - Describes methods for detection and analysis of protein aggregates - Features advancements in therapeutics and emerging techniques to treat these disorders - Covers implications in a variety of neurodegenerative diseases, including Alzheimer's, Parkinson's, ALS, Creutzfeldt-Jakob disease, Cystic fibrosis, Gaucher's disease, and Polyglutamine diseases, including Huntington's and other related proteinopathies

Peptide Based Biomaterials

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Author : Mustafa O. Guler
language : en
Publisher: Royal Society of Chemistry
Release Date : 2020-11-18

Peptide Based Biomaterials written by Mustafa O. Guler and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-18 with Science categories.

Research and new tools in biomaterials development by using peptides are currently growing, as more functional and versatile building blocks are used to design a host of functional biomaterials via chemical modifications for health care applications. It is a field that is attracting researchers from across soft matter science, molecular engineering and biomaterials science. Covering the fundamental concepts of self-assembly, design and synthesis of peptides, this book will provide a solid introduction to the field for those interested in developing functional biomaterials by using peptide derivatives. The bioactive nature of the peptides and their physical properties are discussed in various applications in biomedicine. This book will help researchers and students working in biomaterials and biomedicine fields and help their understanding of modulating biological processes for disease diagnosis and treatments.

Biopolymer Based Formulations

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Author : Kunal Pal
language : en
Publisher: Elsevier
Release Date : 2020-01-18

Biopolymer Based Formulations written by Kunal Pal and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-18 with Technology & Engineering categories.

Biopolymer-Based Formulations: Biomedical and Food Applications presents the latest advances in the synthesis and characterization of advanced biopolymeric formulations and their state-of-the-art applications across biomedicine and food science. Sections cover the fundamentals, applications, future trends, environmental, ethical and medical considerations, and biopolymeric architectures that are organized in nano, micro and macro scales. The final section of the book focuses on novel applications and recent developments. This book is an essential resource for researchers, scientists and advanced students in biopolymer science, polymer science, polymer chemistry, polymer composites, plastics engineering, biomaterials, materials science, biomedical engineering, and more. It will also be of interest to R&D professionals, scientists and engineers across the plastics, food, biomedical and pharmaceutical industries. - Provides in-depth coverage of methods for the characterization of the physical properties of biopolymeric architectures - Supports a range of novel applications, including scaffolds, implant coatings, drug delivery, and nutraceutical encapsulation systems - Includes the use of experimental data and mathematical modeling, thus enabling the reader to analyze and compare the properties of different polymeric gels

Amyloidosis

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Author : Morie A. Gertz
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-06-14

Amyloidosis written by Morie A. Gertz and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-06-14 with Medical categories.

An up-to-date reference on this fascinating set of complex disorders, this book features the most comprehensive strategies for diagnosing, classifying, imaging, treating, and managing amyloidosis in multiple organ systems. Beneficial to the spectrum of practitioners from residents to sub-specialists, this book is a succinct authoritative text written by leaders in the field. The authors provide instruction on all forms of amyloidosis - including primary amyloidosis (AL), secondary amyloidosis (AA), and familial amyloidosis. With essential treatment algorithms, Amyloidosis: Diagnosis and Treatment is the gold-standard for all hematologists, oncologists, and internists caring for patients with this complex disease.