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Peptide Based Biomaterials

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Peptide Based Biomaterials

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Author : Mustafa O. Guler
language : en
Publisher: Royal Society of Chemistry
Release Date : 2020-11-18

Peptide Based Biomaterials written by Mustafa O. Guler and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-18 with Science categories.

Research and new tools in biomaterials development by using peptides are currently growing, as more functional and versatile building blocks are used to design a host of functional biomaterials via chemical modifications for health care applications. It is a field that is attracting researchers from across soft matter science, molecular engineering and biomaterials science. Covering the fundamental concepts of self-assembly, design and synthesis of peptides, this book will provide a solid introduction to the field for those interested in developing functional biomaterials by using peptide derivatives. The bioactive nature of the peptides and their physical properties are discussed in various applications in biomedicine. This book will help researchers and students working in biomaterials and biomedicine fields and help their understanding of modulating biological processes for disease diagnosis and treatments.

Peptides And Peptide Based Biomaterials And Their Biomedical Applications

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Author : Anwar Sunna
language : en
Publisher: Springer
Release Date : 2017-10-26

Peptides And Peptide Based Biomaterials And Their Biomedical Applications written by Anwar Sunna and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-26 with Science categories.

Solid-binding peptides have been used increasingly as molecular building blocks in nanobiotechnology as they can direct the assembly and functionalisation of a diverse range of materials and have the ability to regulate the synthesis of nanoparticles and complex nanostructures. Nanostructured materials such as β-sheet fibril-forming peptides and α-helical coiled coil systems have displayed many useful properties including stimulus-responsiveness, modularity and multi-functionality, providing potential technological applications in tissue engineering, antimicrobials, drug delivery and nanoscale electronics. The current situation with respect to self-assembling peptides and bioactive matrices for regenerative medicine are reviewed, as well as peptide-target modeling and an examination of future prospects for peptides in these areas.

Peptide Based Biomaterials

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Author : Mustafa O. Guler
language : en
Publisher: Royal Society of Chemistry
Release Date : 2020-11-18

Design And Characterization Of Peptide Based Biomaterials

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Author : Sivakumar Ramachandran
language : en
Publisher:
Release Date : 2007

Design And Characterization Of Peptide Based Biomaterials written by Sivakumar Ramachandran and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Biomedical materials categories.

The main objective of this dissertation is to lay out the design principles involved in assembling stimuli-sensitive, peptide-based biomaterials that has potential for various biomedical applications like tissue engineering and drug delivery. Supramolecular systems, which enable one to assemble novel materials from molecular level, have fascinated researchers in many disciplines. Inspired by such systems, a set of mutually complementary, self-repulsive oligopeptide modules (with alternating polar-apolar amino acid sequence) were designed to gain better control and wide range of tunability over the assembling process. These peptide modules (at 0.25 wt% in aqueous buffer) assembled into a hydrogel network with change in pH/ionic strength (self-assembly) and upon mixing the two mutually-complementary peptide modules (co-assembly). Mixing induced hydrogels are particularly attractive as they can be easily assembled by simple mixing of peptide solutions prior to application. Another advantage of mixing-induced gelation is that it preserves the pH and ionic strength of the original peptide solutions. Circular dichroism spectroscopy of individual decapeptide solutions revealed their random coil conformation. Transmission electron microscopy images showed the nanofibrillar network structure of the hydrogel. Dynamic rheological characterization revealed its high elasticity and shear-thinning nature. Furthermore, the co-assembled hydrogel was capable of rapid recoveries from repeated shear-induced breakdowns, a property desirable for designing injectable biomaterials. A systematic variation of the neutral amino acids in the sequence revealed some of the design principles for this class of biomaterials. First, viscoelastic properties of the hydrogels can be tuned through adjusting the hydrophobicity of the neutral amino acids. Second, the beta-sheet propensity of the neutral amino acid residue in the peptides is critical for hydrogelation. The compatibility of these hydrogels with entrapped biomolecules (molecular biocompatibility) was confirmed using high-resolution, 1H-15N heteronuclear NMR spectroscopy. Sticky-ends in the peptide fibers did not provide any advantages over blunt-ends in terms of biomaterial property, suggesting that peptides might be aligned perpendicular to the fiber axis. Once the design principles of these peptide-based biomaterials are laid out, the next step would be to incorporate biological functionalities like cell-adhesive motifs and enzyme recognition sequences at strategic positions of these biomaterials for specific tissue engineering or drug delivery applications.

Self Assembling Biomaterials

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Author : Helena S. Azevedo
language : en
Publisher: Woodhead Publishing
Release Date : 2018-04-17

Self Assembling Biomaterials written by Helena S. Azevedo and has been published by Woodhead Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-04-17 with Technology & Engineering categories.

Self-assembling biomaterials: molecular design, characterization and application in biology and medicine provides a comprehensive coverage on an emerging area of biomaterials science, spanning from conceptual designs to advanced characterization tools and applications of self-assembling biomaterials, and compiling the recent developments in the field. Molecular self-assembly, the autonomous organization of molecules, is ubiquitous in living organisms and intrinsic to biological structures and function. Not surprisingly, the exciting field of engineering artificial self-assembling biomaterials often finds inspiration in Biology. More important, materials that self-assemble speak the language of life and can be designed to seamlessly integrate with the biological environment, offering unique engineering opportunities in bionanotechnology. The book is divided in five parts, comprising design of molecular building blocks for self-assembly; exclusive features of self-assembling biomaterials; specific methods and techniques to predict, investigate and characterize self-assembly and formed assemblies; different approaches for controlling self-assembly across multiple length scales and the nano/micro/macroscopic properties of biomaterials; diverse range of applications in biomedicine, including drug delivery, theranostics, cell culture and tissue regeneration. Written by researchers working in self-assembling biomaterials, it addresses a specific need within the Biomaterials scientific community. - Explores both theoretical and practical aspects of self-assembly in biomaterials - Includes a dedicated section on characterization techniques, specific for self-assembling biomaterials - Examines the use of dynamic self-assembling biomaterials

Mimicking The Extracellular Matrix

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Author : Gregory H. Hudalla
language : en
Publisher: Royal Society of Chemistry
Release Date : 2015-11-18

Mimicking The Extracellular Matrix written by Gregory H. Hudalla and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-18 with Medical categories.

Mimicking the Extracellular Matrix approaches this topic from both basic science and practical engineering perspectives. Suitable for undergraduates, postgraduates, and academics, this text aims to unify the current knowledge of ECM biology and matrix-mimicking biomaterials.

Peptide Based Materials

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Author : Timothy Deming
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-01-13

Peptide Based Materials written by Timothy Deming and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-13 with Technology & Engineering categories.

Synthesis of Polypeptides by Ring-Opening Polymerization of α-Amino Acid N-Carboxyanhydrides, by Jianjun Cheng and Timothy J. Deming.- Peptide Synthesis and Self-Assembly, by S. Maude, L. R. Tai, R. P. W. Davies, B. Liu, S. A. Harris, P. J. Kocienski and A. Aggeli.- Elastomeric Polypeptides, by Mark B. van Eldijk, Christopher L. McGann, Kristi L. Kiick andJan C. M. van Hest.- Self-Assembled Polypeptide and Polypeptide Hybrid Vesicles: From Synthesis to Application, by Uh-Joo Choe, Victor Z. Sun, James-Kevin Y. Tan and Daniel T. Kamei.- Peptide-Based and Polypeptide-Based Hydrogels for Drug Delivery and Tissue Engineering, by Aysegul Altunbas and Darrin J. Pochan.-

Marine Biomaterials

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Author : Se-Kwon Kim
language : en
Publisher: CRC Press
Release Date : 2013-04-11

Marine Biomaterials written by Se-Kwon Kim and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-11 with Medical categories.

Oceans are an abundant source of diverse biomaterials with potential for an array of uses. Marine Biomaterials: Characterization, Isolation and Applications brings together the wide range of research in this important area, including the latest developments and applications, from preliminary research to clinical trials. The book is divided into four parts, with chapters written by experts from around the world. Biomaterials described come from a variety of marine sources, such as fish, algae, microorganisms, crustaceans, and mollusks. Part I covers the isolation and characterization of marine biomaterials—bioceramics, biopolymers, fatty acids, toxins and pigments, nanoparticles, and adhesive materials. It also describes problems that may be encountered in the process as well as possible solutions. Part II looks at biological activities of marine biomaterials, including polysaccharides, biotoxins, and peptides. Chapters examine health benefits of the biomaterials, such as antiviral activity, antidiabetic properties, anticoagulant and anti-allergic effects, and more. Part III discusses biomedical applications of marine biomaterials, including nanocomposites, and describes applications of various materials in tissue engineering and drug delivery. Part IV explores commercialization of marine-derived biomaterials—marine polysaccharides and marine enzymes—and examines industry perspectives and applications. This book covers the key aspects of available marine biomaterials for biological and biomedical applications, and presents techniques that can be used for future isolation of novel materials from marine sources.

Advanced Biomaterials In Biomedical Engineering And Drug Delivery Systems

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Author : Naoya Ogata
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Advanced Biomaterials In Biomedical Engineering And Drug Delivery Systems written by Naoya Ogata and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Technology & Engineering categories.

First of all, I would like to share the great pleasure of the successful five-day symposium with every participant in the 5th Iketani Conference which was held in Kagoshima from April1S (Tuesday) to 22 (Saturday), 1995. Outstanding speakers enthusiastically presented their up-to-the-minute results. Relatively little time was allotted for each presentation to ensure asdnuch time· as possible for intensive discussions on the particular topics that had just been p~esented: I was delighted to see that the lectures were of high quality, and the discu,ssionswere lively, exciting, and productive in a congenial atmosphere. We also had 92 papers in the poster ·session, in which young (and relatively young) scientists made every effort to present the novel results of their research in advanced biomaterials and drug delivery systems (DDS). I believe some of the research is most promising and will become noteworthy in the twenty-first century. It was a privilege for me to deliver a lecture at the special session of the symposium. In my introductory remarks, I pointed out five key terms in multifaceted biomaterials research: materials design, concept or methodology, devices, properties demanded, and fundamentals. I am confident that innovative progress in device manufacturing for end-use, e.g., artificial organs, vascular grafts, and DDS, can be brought about only through properly designed advanced materials that exhibit the desired functionality at the interface with any living body.

Amino Acids And Peptides

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Author : G. C. Barrett
language : en
Publisher: Cambridge University Press
Release Date : 1998-10-29

Amino Acids And Peptides written by G. C. Barrett and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-10-29 with Science categories.

This text is suitable for advanced undergraduate and beginning graduate students in chemistry and biochemistry studying amino acids and peptides. The authors concentrate on amino acids and peptides without detailed discussions of proteins, although the book gives all the essential background chemistry, including sequence determination, synthesis and spectroscopic methods, to enable the reader to appreciate protein behaviour at the molecular level. The approach is intended to encourage the reader to cross classical boundaries, as in the later chapters on the biological roles of amino acids and the design of peptide-based drugs. For example, there is a section on the enzyme-catalysed synthesis of peptides, with suitable examples, an area often neglected in texts describing peptide synthesis. This modern text will be of value in the amino acid, peptide and protein field, to advanced undergraduates, graduate students and research workers.

Peptide Based Biomaterials

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