Amyloid Protein Precursor In Development Aging And Alzheimer S Disease
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Amyloid Protein Precursor In Development Aging And Alzheimer S Disease
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Author : C.L. Masters
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-04-17
Amyloid Protein Precursor In Development Aging And Alzheimer S Disease written by C.L. Masters and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-17 with Science categories.
This book summarizes the last ten years' research on Alzheimer's disease. Genetic mutations in the gene which codes for amyloid precursor protein (APP) have now been shown to cause Alzheimer's disease in some families. Other genetic loci are now being discovered which relate to Alzheimer's disease in some families. Understanding the normal structure and function of the APP gene product will eventually provide avenues for developing specific therapeutic strategies targeted at the amyloid deposition in the Alzheimer's disease brain. Drugs which can inhibit or dissolve the amyloid, affect the synthesis and proteolysis of APP, or which regulate the activity of the APP gene all hold the promise of eventually yielding an effective treatment for Alzheimer's disease.
Amyloid Protein Precursor In Development Aging And Alzheimer S Disease
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Author : Colin L. Masters
language : en
Publisher: Springer Verlag
Release Date : 1994-01-01
Amyloid Protein Precursor In Development Aging And Alzheimer S Disease written by Colin L. Masters and has been published by Springer Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-01-01 with Medical categories.
Amyloid Beta Clearance In Alzheimer S Disease
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Author : Robert Marr
language : en
Publisher: Frontiers Media SA
Release Date : 2015-03-24
Amyloid Beta Clearance In Alzheimer S Disease written by Robert Marr and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-24 with Neurosciences. Biological psychiatry. Neuropsychiatry categories.
Strong evidence continues to accumulate indicating that amyloid-beta (Aß) is a central part of Alzheimer’s disease (AD) pathogenesis in spite of the negative evidence coming from failed clinical trials. Therefore, mechanisms of clearance of Aß are of great interest in understanding AD pathogenesis and the development of effective treatments. This topic focuses on the issues related to Aß clearance in AD. The topics covered include proteases that degrade Aß and their localization, regulation, and functions. This topic also covers issues related to clearance through uptake by glia and through low-density lipoprotein (LDL) receptor mediated mechanisms. Signal transduction related to AD pathology and clearance is also addressed. Finally, immunotherapy and other novel therapeutic approaches are discussed.
Molecular Mechanisms Of Aging
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Author : Konrad Beyreuther
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Molecular Mechanisms Of Aging written by Konrad Beyreuther and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Progress Report On Alzheimer S Disease
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Author :
language : en
Publisher:
Release Date : 1995
Progress Report On Alzheimer S Disease written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with Alzheimer's disease categories.
Presenilins And Alzheimer S Disease
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Author : Steven G. Younkin
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Presenilins And Alzheimer S Disease written by Steven G. Younkin and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The role of the familial Alzheimer's Disease genes called "presenilins" in causing neuronal cell death and Alzheimer-related pathology.
Molecular Aspects Of Development And Aging Of The Nervous System
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Author : Jean Lauder
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-21
Molecular Aspects Of Development And Aging Of The Nervous System written by Jean Lauder and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-21 with Science categories.
The rapidly expanding fields of molecular and cellular neurobiology are the newest frontiers of neuroscience. This book represents the continuing efforts of the Institute of Developmental Neuroscience and Aging (IDNA) to disseminate the most recent advances on the developing and aging nervous system at the molecular and cellular levels. A group of neuroscientists presented and discussed their findings at a recent IDNA conference held in Athens, Greece, June 15-18, 1988. This meeting was sponsored by the National Hellenic Research Foundation, FIDIA, the Ministry of Research and Technology, the Tourism Organization of Greece, and the National Institute of Child Health and Human Development, NIH. The Directors of the IDNA are grateful to the local committee, Drs. Eleni Fleischer, Costas Sekeris, Michael Alexis, Theony Valcana, and Elias Kouvelas, for their efforts in organizing this meeting and for their successful integration of science and culture for the participants. This volume provides a comprehensive overview of the information presented at this conference, including in-depth discussions of each topic by the participants. The chapters are grouped into five general categories which correspond to the subject areas covered during the meeting. These include: Gene and Phenotypic Expression, Growth Factors and Oncogenes, Cytoskeletal and Extracellular Molecules, Neurotransmitters and Hormones, and Molecular Aspects of Aging and Alzheimer's Disease. The section on Gene and Phenotypic Expression includes discussions of transient gene expression in the nervous system (Herschman), developmental regulation of myelin-associated genes (Gordon et al.
Alzheimer S Disease
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Author : Sangram S. Sisodia
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-02-16
Alzheimer S Disease written by Sangram S. Sisodia and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-02-16 with Medical categories.
This book examines every major aspect of Alzheimer disease at a time when there has been no scholarly research volume on the subject published in the last 3-5 years. This edition includes expanded coverage of the cellular-level exploration of related dementing disorders, with in-depth presentation of prion diseases, Pick's disease, fronto-temporal disorders, transgenic models, and biochemistry of presenilins.
Molecular Mechanisms Of Dementia
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Author : Wilma Wasco
language : en
Publisher: Springer Science & Business Media
Release Date : 1996-11-01
Molecular Mechanisms Of Dementia written by Wilma Wasco and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-11-01 with Medical categories.
The past decade has witnessed a revolution in the attempts of scientists to under stand the molecular basis of dementia. Although dementia, as defined by global cogni tive decline involving gradual loss of memory, reasoning, judgment, and orientation, presents most commonly in the form of Alzheimer's disease (AD), an assortment of other less common disorders, such as prion and Pick's disease, can also lead to symp toms that are similar to those observed in patients with AD. The primary goal of Molecular Mechanisms of Dementia is to address the various mechanisms and multi faceted approaches currently being employed to more clearly delineate the etiological and pathogenic events responsible for the onset of dementia. Perhaps the greatest boon to obtaining a clearer understanding of the causes of AD has come from genetic and molecular biological studies carried out over the past decade. At the genetic level, it has become increasingly clear that AD is a heteroge neous disorder that can be broadly classified into two categories. "Late onset" (>60 yr) cases, which account for the vast majority of AD, genetically involve "susceptibility" genes representing risk factors for the disease (e. g. , inheritance of the 84 allele of the Apolipoprotein E gene). In many cases, the susceptibility gene can act as a "modifier" that modulates the pathogenic cascade occurring subsequent to a separate etiological event "initiating" or "causing" the disorder.
The Physiological Functions Of The Amyloid Precursor Protein Gene Family
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Author : Ulrike C. Müller
language : en
Publisher: Frontiers Media SA
Release Date : 2017-12-28
The Physiological Functions Of The Amyloid Precursor Protein Gene Family written by Ulrike C. Müller and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-12-28 with Electronic book categories.
The amyloid precursor protein APP plays a key role in the pathogenesis of Alzheimer’s disease (AD), as proteolytical cleavage of APP gives rise to the Aβ peptide which is deposited in the brains of Alzheimer patients. Despite this, our knowledge of the normal cell biological and physiological functions of APP and the closely related APLPs is limited. This may have hampered our understanding of AD, since evidence has accumulated that not only the production of the Aβ peptide but also the loss of APP-mediated functions may contribute to AD pathogenesis. Thus, it appears timely and highly relevant to elucidate the functions of the APP gene family from the molecular level to their role in the intact organism, i.e. in the context of nervous system development, synapse formation and adult synapse function, as well as neural homeostasis and aging. Why is our understanding of the APP functions so limited? APP and the APLPs are multifunctional proteins that undergo complex proteolytical processing. They give rise to an almost bewildering array of different fragments that may each subserve specific functions. While Aβ is aggregation prone and neurotoxic, the large secreted ectodomain APPsα - produced in the non-amyloidogenic α-secretase pathway - has been shown to be neurotrophic, neuroprotective and relevant for synaptic plasticity, learning and memory. Recently, novel APP cleavage pathways and enzymes have been discovered that have gained much attention not only with respect to AD but also regarding their role in normal brain physiology. In addition to the various cleavage products, there is also solid evidence that APP family proteins mediate important functions as transmembrane cell surface molecules, most notably in synaptic adhesion and cell surface signaling. Elucidating in more detail the molecular mechanisms underlying these divers functions thus calls for an interdisciplinary approach ranging from the structural level to the analysis in model organisms. Thus, in this research topic of Frontiers we compile reviews and original studies, covering our current knowledge of the physiological functions of this intriguing and medically important protein family.