An Introduction To High Content Screening
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An Introduction To High Content Screening
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Author : Steven A. Haney
language : en
Publisher: John Wiley & Sons
Release Date : 2014-12-22
An Introduction To High Content Screening written by Steven A. Haney and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-22 with Science categories.
Using a collaborative and interdisciplinary author base with experience in the pharmaceutical industry and academia, this book is a practical resource for high content (HC) techniques. • Instructs readers on the fundamentals of high content screening (HCS) techniques • Focuses on practical and widely-used techniques like image processing and multiparametric assays • Breaks down HCS into individual modules for training and connects them at the end • Includes a tutorial chapter that works through sample HCS assays, glossary, and detailed appendices
Neurobiology Of Huntington S Disease
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Author : Donald C. Lo
language : en
Publisher: CRC Press
Release Date : 2010-07-02
Neurobiology Of Huntington S Disease written by Donald C. Lo and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-07-02 with Medical categories.
In 1993, the genetic mutation responsible for Huntington's disease (HD) was identified. Considered a milestone in human genomics, this discovery has led to nearly two decades of remarkable progress that has greatly increased our knowledge of HD, and documented an unexpectedly large and diverse range of biochemical and genetic perturbations that see
An Introduction To High Content Screening
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Author : Steven A. Haney
language : en
Publisher: John Wiley & Sons
Release Date : 2015-01-07
An Introduction To High Content Screening written by Steven A. Haney and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-01-07 with Science categories.
Using a collaborative and interdisciplinary author base with experience in the pharmaceutical industry and academia, this book is a practical resource for high content (HC) techniques. • Instructs readers on the fundamentals of high content screening (HCS) techniques • Focuses on practical and widely-used techniques like image processing and multiparametric assays • Breaks down HCS into individual modules for training and connects them at the end • Includes a tutorial chapter that works through sample HCS assays, glossary, and detailed appendices
Optimal High Throughput Screening
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Author : Xiaohua Douglas Zhang
language : en
Publisher: Cambridge University Press
Release Date : 2011-02-21
Optimal High Throughput Screening written by Xiaohua Douglas Zhang and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-02-21 with Medical categories.
This concise, self-contained and cohesive book focuses on commonly used and recently developed methods for designing and analyzing high-throughput screening (HTS) experiments from a statistically sound basis. Combining ideas from biology, computing and statistics, the author explains experimental designs and analytic methods that are amenable to rigorous analysis and interpretation of RNAi HTS experiments. The opening chapters are carefully presented to be accessible both to biologists with training only in basic statistics and to computational scientists and statisticians with basic biological knowledge. Biologists will see how new experiment designs and rudimentary data-handling strategies for RNAi HTS experiments can improve their results, whereas analysts will learn how to apply recently developed statistical methods to interpret HTS experiments.
High Content Screening
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Author : D. Lansing Taylor
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-04
High Content Screening written by D. Lansing Taylor and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-04 with Science categories.
There has always been some tension between proponents of hypothesis-driven and discovery-driven research in the broad field of life sciences. Academic research has been primarily focused on hypothesis-driven research. However, the success of the human genome project, a discovery-driven research approach, has opened the door to adding other types of discovery-driven research to a continuum of research approaches. In contrast, drug discovery research in the pharmaceutical industry has embraced discovery-driven research for many years. A good example has been the discovery of active compounds from large chemical libraries, through screening campaigns. The success of the human genome project has also demonstrated the need for both academic researchers and industrial researchers to now understand the functions of genes and gene products. The cell is the basic unit of life and it has been at the cellular level where function can be demonstrated most cost-effectively and rapidly. High content screening (HCS) was developed by Cellomics Inc. in the mid-1990s to address the need for a platform that could be used in the discovery-driven research and development required to understand the functions of genes and gene products at the level of the cell.
Cell Based Assays For High Throughput Screening
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Author : Paul A. Clemons
language : en
Publisher: Humana Press
Release Date : 2009-04-28
Cell Based Assays For High Throughput Screening written by Paul A. Clemons and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-04-28 with Science categories.
As the use of high-throughput screening expands and creates more interest in the academic community, the need for detailed reference materials becomes ever more pressing. Cell-Based Assays for High-Throughput Screening: Methods and Protocols aims to fill an important part of this need by providing an easily accessible reference volume for cell-based phenotypic screening. Leading researchers in the field contribute state-of-the-art methods with actionable protocols covering four major areas of study: model biological systems, screening modalities and assay systems, detection technologies, and approaches to data analysis. Written in the highly successful Methods in Molecular BiologyTM series format, each chapter includes a brief introduction to the subject, lists of necessary materials and reagents, step-by-step laboratory protocols, and a Notes section detailing tips on troubleshooting and avoiding known pitfalls. Cutting-edge and easy-to-use, Cell-Based Assays for High-Throughput Screening: Methods and Protocols presents an overview of relevant approaches, enabling the direct application of existing methods to new discoveries while also inspiring researchers to approach their screening projects in a conceptually modular fashion, enhancing the power to discover through new combinations of existing approaches.
Special Topics In Drug Discovery
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Author : Taosheng Chen
language : en
Publisher: BoD – Books on Demand
Release Date : 2016-11-30
Special Topics In Drug Discovery written by Taosheng Chen and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-30 with Medical categories.
Drug discovery involves multiple disciplines, technologies, and approaches. This book selects important topics related to drug discovery, including emerging tool (Chapter 1), cutting-edge approaches (Chapters 2, 3, and 4), examples of specific therapeutic area (Chapter 5), quality control in drug development (Chapter 6), and job and career opportunities in the pharmaceutical sector, a topic rarely covered by other books (Chapter 7). This book draws knowledge from experts actively involved in different areas of drug discovery from both industrial and academic settings. We hope that this book will facilitate your efforts in drug discovery.
High Content Screening
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Author : Steven A. Haney
language : en
Publisher: John Wiley & Sons
Release Date : 2008-01-18
High Content Screening written by Steven A. Haney and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-01-18 with Medical categories.
The authoritative reference on High Content Screening (HCS) in biological and pharmaceutical research, this guide covers: the basics of HCS: examples of HCS used in biological applications and early drug discovery, emphasizing oncology and neuroscience; the use of HCS across the drug development pipeline; and data management, data analysis, and systems biology, with guidelines for using large datasets. With an accompanying CD-ROM, this is the premier reference on HCS for researchers, lab managers, and graduate students.
High Throughput Screening In Drug Discovery
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Author : Jörg Hüser
language : en
Publisher: John Wiley & Sons
Release Date : 2006-12-13
High Throughput Screening In Drug Discovery written by Jörg Hüser and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-12-13 with Science categories.
Backed by leading authorities, this is a professional guide to successful compound screening in pharmaceutical research and chemical biology, including the chemoinformatic tools needed for correct data evaluation. Chapter authors from leading pharmaceutical companies as well as from Harvard University discuss such factors as chemical genetics, binding, cell-based and biochemical assays, the efficient use of compound libraries and data mining using cell-based assay results. For both academics and professionals in the pharma and biotech industries working on small molecule screening.
High Throughput Image Reconstruction And Analysis
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Author : A. Ravishankar Rao
language : en
Publisher: Artech House
Release Date : 2009
High Throughput Image Reconstruction And Analysis written by A. Ravishankar Rao and has been published by Artech House this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Medical categories.
This innovative volume surveys the latest image acquisition advances in serial block face techniques in scanning electron microscopy, knife-edge scanning microscopy, and 4D imaging of multi-component biological systems. The book introduces parallel processing for biological applications. You learn advanced parallelization techniques for decomposing a problem domain and mapping it onto a parallel processing architecture using the message-passing interface (MPI) and OpenMP. Case studies show how these techniques have been successfully used in simulation tasks, data mining, and graphical visualization of biological datasets. You also find coverage of methods for developing scalable biological image databases and for facilitating greater interactive visualization of large image sets.