Applications Of Lc Ms In Toxicology
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Applications Of Lc Ms In Toxicology
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Author : Aldo Polettini
language : en
Publisher: Pharmaceutical Press
Release Date : 2006
Applications Of Lc Ms In Toxicology written by Aldo Polettini and has been published by Pharmaceutical Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Analytical toxicology categories.
Analytical toxicologists are involved in the analysis of drugs and poisons in biological samples in different environments. Many scientists in the field of analytical toxicology have adopted LC-MS in their daily work, and this is illustrated by the increasing numbers of research papers published and presented at relevant conferences.
Lc Ms In Drug Bioanalysis
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Author : Q. Alan Xu
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-07-15
Lc Ms In Drug Bioanalysis written by Q. Alan Xu and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-07-15 with Science categories.
Clinical pharmacology plays an important role in today’s medicine. Due to the high sensitivity, selectivity, and affordability of a mass spectrometer (MS), the high performance liquid chromatography – mass spectrometry (LC-MS) analytical technique is widely used in the determination of drugs in human biological matrixes for clinical pharmacology. Specifically, LC-MS is used to analyze: anticancer drugs antidementia drugs antidepressant drugs antiepileptic drugs antifundal drug antimicrobial drugs antipsychotic drugs antiretroviral drugs anxiolytic/hypnotic drugs cardiac drugs drugs for addiction immunosuppressant drugs mood stabilizer drugs This book will primarily cover the various methods of validation for LC-MS techniques and applications used in modern clinical pharmacology.
Lc Ms In Drug Analysis
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Author : Loralie J. Langman
language : en
Publisher: Humana Press
Release Date : 2012-07-06
Lc Ms In Drug Analysis written by Loralie J. Langman and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-07-06 with Medical categories.
Liquid-Chromatography-Mass-Spectrometry procedures have been shown to be successful when applied to drug development and analysis. LC-MS in Drug Analysis: Methods and Protocols provides detailed LC-MS/MS procedures for the analysis of several compounds of clinical significance. The first chapters provide the reader with an overview of mass spectroscopy, its place in clinical practice, its application of MS to TDM and toxicology, and the merits of LC-MS(/MS) and new sample preparation techniques. The following chapters discuss different approaches to screening for drugs of abuse and for general unknowns, as well as targeted measurement of specific analytes or classes of analytes including abused drugs, toxic compounds, and therapeutic agents. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, LC-MS in Drug Analysis: Methods and Protocols seeks to serve both professionals and novices with its well-honed methodologies.
Clinical Applications Of Mass Spectrometry In Drug Analysis
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Author : Uttam Garg
language : en
Publisher: Springer Nature
Release Date : 2023-11-30
Clinical Applications Of Mass Spectrometry In Drug Analysis written by Uttam Garg and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-30 with Science categories.
This fully updated volume describes methods and protocols for a number of drugs and toxins in a stepwise manner. Exploring the versatility and flexibility of mass spectrometry, the book covers the advantages of this technology, which typically include elimination of the need for special reagents such as antibodies, increased sensitivity and specificity, and multi-component analysis enabling the screening of tens to hundreds of compounds in a single assay run. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Clinical Applications of Mass Spectrometry in Drug Analysis: Methods and Protocols, Second Edition serves as a valuable resource for laboratory professionals who are already utilizing mass spectrometry or considering bringing this technology to their labs.
Chromatographic Methods In Clinical Chemistry And Toxicology
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Author : Roger Bertholf
language : en
Publisher: John Wiley & Sons
Release Date : 2007-01-30
Chromatographic Methods In Clinical Chemistry And Toxicology written by Roger Bertholf and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-01-30 with Science categories.
This book aims to fill the gap that exists between theoretical treatments of chromatography, and clinical chemistry and toxicology texts, which focus almost exclusively on clinical relevance and applications. Chromatography has a vast array of clinical applications, and though the chromatographic methods were first introduced decades ago, new applications of this technology are being used to explore previously inaccessible frontiers in clinical diagnostics and toxicological testing. An up-to-date book devoted to clinical and toxicological applications of chromatographic methods will serve as an instructional and reference text, useful to students, laboratory technicians, and researchers.
Mass Spectrometry For The Clinical Laboratory
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Author : Hari Nair
language : en
Publisher: Academic Press
Release Date : 2016-11-02
Mass Spectrometry For The Clinical Laboratory written by Hari Nair and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-02 with Medical categories.
Mass Spectrometry for the Clinical Laboratory is an accessible guide to mass spectrometry and the development, validation, and implementation of the most common assays seen in clinical labs. It provides readers with practical examples for assay development, and experimental design for validation to meet CLIA requirements, appropriate interference testing, measuring, validation of ion suppression/matrix effects, and quality control. These tools offer guidance on what type of instrumentation is optimal for each assay, what options are available, and the pros and cons of each. Readers will find a full set of tools that are either directly related to the assay they want to adopt or for an analogous assay they could use as an example. Written by expert users of the most common assays found in a clinical laboratory (clinical chemists, toxicologists, and clinical pathologists practicing mass spectrometry), the book lays out how experts in the field have chosen their mass spectrometers, purchased, installed, validated, and brought them on line for routine testing. The early chapters of the book covers what the practitioners have learned from years of experience, the challenges they have faced, and their recommendations on how to build and validate assays to avoid problems. These chapters also include recommendations for maintaining continuity of quality in testing. The later parts of the book focuses on specific types of assays (therapeutic drugs, Vitamin D, hormones, etc.). Each chapter in this section has been written by an expert practitioner of an assay that is currently running in his or her clinical lab. Provides readers with the keys to choosing, installing, and validating a mass spectrometry platform Offers tools to evaluate, validate, and troubleshoot the most common assays seen in clinical pathology labs Explains validation, ion suppression, interference testing, and quality control design to the detail that is required for implementation in the lab
Therapeutic Drug Monitoring And Toxicology By Liquid Chromatography
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Author : Steven H.Y. Wong
language : en
Publisher: Routledge
Release Date : 2017-09-19
Therapeutic Drug Monitoring And Toxicology By Liquid Chromatography written by Steven H.Y. Wong and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-19 with Medical categories.
First Published in 2017. Routledge is an imprint of Taylor & Francis, an Informa company.
Principles Of Forensic Toxicology
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Author : Barry Levine
language : en
Publisher: Amer. Assoc. for Clinical Chemistry
Release Date : 2003
Principles Of Forensic Toxicology written by Barry Levine and has been published by Amer. Assoc. for Clinical Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Law categories.
Sensitive Selective And Rapid Lc Ms Ms Methods For The Determination Of Selected Drugs In Human Plasma And Its Applications To Pharmacokinetic Studies
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Author : Kakarla Sreekanth
language : en
Publisher: Independent Author
Release Date : 2023-03-22
Sensitive Selective And Rapid Lc Ms Ms Methods For The Determination Of Selected Drugs In Human Plasma And Its Applications To Pharmacokinetic Studies written by Kakarla Sreekanth and has been published by Independent Author this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-22 with Medical categories.
In the bioanalytical arena, gas-chromatography (GC) has long been established as the "gold standard" for the separation of small molecules. However, with the recent developments in LC-MS, this approach has become increasingly important for robust and reliable assays in the fields of clinical and forensic toxicology and doping control. LC has become an attractive alternative to GC, with the ability to analyse hydrophilic, thermolabile and non-volatile analytes, which were not sufficiently covered by GC. Additionally, LC-MS offers a fast, sensitive and selective approach where the simple sample preparation is amenable to fast, high-throughput assays and limits potential sources of error. Apart from that, small, polar molecules present formidable challenges during LC-MS/MS analysis, such as (a) separation of metabolites from intended analyte, (b) analysis of thermally degradable drugs during ionisation, (c) separation of interfering/co-eluting peaks from the analyte and (d) elimination of the matrix effect. The above goals were resolved in order to avoid biased results for pharmacokinetics analysis. The use of highly specific and sensitive analytical procedures is therefore required to achieve low limits of detection. The aim of this study was the development of sensitive and new analytical procedures for the accurate and specific determination of the selected drugs in human plasma, based on liquid chromatography-tandem mass spectrometry by overcoming above challenges. The following drugs; Prasugrel active metabolite R-138727 (PAM), Triamcinolone acetonide (TRI), Ropinirole (ROP), Levodopa (LEV), Carbidopa (CAR) were selected to develop sensitive and reproducible LC-MS/MS bioanalytical methods for their estimation as individual or in combination in human plasma. The above selected drugs have unique challenges as mentioned above to develop highly sensitive and rugged methods. It would be useful for worldwide generic industry to expedite their regulatory filings.
Sample Preparation In Lc Ms Bioanalysis
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Author : Wenkui Li
language : en
Publisher: John Wiley & Sons
Release Date : 2019-03-12
Sample Preparation In Lc Ms Bioanalysis written by Wenkui Li and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-12 with Science categories.
Revised and Expanded Handbook Provides Comprehensive Introduction and Complete Instruction for Sample Preparation in Vital Category of Bioanalysis Following in the footsteps of the previously published Handbook of LC-MS Bioanalysis, this book is a thorough and timely guide to all important sample preparation techniques used for quantitative Liquid Chromatography–Mass Spectrometry (LC-MS) bioanalysis of small and large molecules. LC-MS bioanalysis is a key element of pharmaceutical research and development, post-approval therapeutic drug monitoring, and many other studies used in human healthcare. While advances are continually being made in key aspects of LC-MS bioanalysis such as sensitivity and throughput, the value of research/study mentioned above is still heavily dependent on the availability of high-quality data, for which sample preparation plays the critical role. Thus, this text provides researchers in industry, academia, and regulatory agencies with detailed sample preparation techniques and step-by-step protocols on proper extraction of various analyte(s) of interest from biological samples for LC-MS quantification, in accordance with current health authority regulations and industry best practices. The three sections of the book with a total of 26 chapters cover topics that include: Current basic sample preparation techniques (e.g., protein precipitation, liquid-liquid extraction, solid-phase extraction, salting-out assisted liquid-liquid extraction, ultracentrifugation and ultrafiltration, microsampling, sample extraction via electromembranes) Sample preparation techniques for uncommon biological matrices (e.g., tissues, hair, skin, nails, bones, mononuclear cells, cerebrospinal fluid, aqueous humor) Crucial aspects of LC-MS bioanalytical method development (e.g., pre-analytical considerations, derivation strategies, stability, non-specific binding) in addition to sample preparation techniques for challenging molecules (e.g., lipids, peptides, proteins, oligonucleotides, antibody-drug conjugates) Sample Preparation in LC-MS Bioanalysis will prove a practical and highly valuable addition to the reference shelves of scientists and related professionals in a variety of fields, including pharmaceutical and biomedical research, mass spectrometry, and analytical chemistry, as well as practitioners in clinical pharmacology, toxicology, and therapeutic drug monitoring.