Assessing Bioavailablility Of Drug Delivery Systems
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Assessing Bioavailablility Of Drug Delivery Systems
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Author : Jean-Maurice Vergnaud
language : en
Publisher: CRC Press
Release Date : 2005-05-26
Assessing Bioavailablility Of Drug Delivery Systems written by Jean-Maurice Vergnaud and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-05-26 with Medical categories.
Exploring how to apply in vitro/in vivo correlations for controlled release dosage forms, Bioavailability of Drug Delivery Systems: Mathematical Modeling clearly elucidates this complex phenomena and provides a guide for the respective mathematical modeling. The book introduces mathematical modeling methods for calculating the profiles of plasma levels obtained with controlled release dosage forms and provides examples and case studies to illustrate the techniques employed. The author has considerable experience in investigating mathematical fundamentals that are related to pharmaco- and toxicokinetics, modified-release drug products, physiologic pharmacokinetics and statistical treatment in clinical situations. The mathematical models he has developed are particularly powerful because they account for such major parameters as the kinetics of drug release controlled by diffusion or by erosion, and the kinetics of absorption into and elimination out of the plasma. They are also able to solve the problem of determining the drug level in plasma as a result of patient non-compliance, incorrect dosage, and incorrect frequency and to determine the best dosage forms necessary for therapy. Using master curves, the book highlights the inter-variability of the patients often expressed by different responses towards a drug. Thus, after evaluating a patient's pharmacokinetic parameters, the dose can be adapted to the patient, with the expectation of decreasing the side effects for each patient. Using dimensionless numbers in repeated doses, either for the time or for the plasma drug concentration, makes the master curves useful for every drug, providing that its pharmacokinetics was linear. These master curves address clear information either to the patients or to the therapists in a didactic and easy way. The patients can see from first look the effects of non-compliance and therapists can see the dramatic effects of inter-variability of patients towards a drug. Drug discovery and dosage forms have become an increasingly time-consuming and expensive process. The development of a single drug can leave behind more than 10 to 15 years of work. Discussing time and cost-effective methods as alternatives to conventional in vivo methods, the book helps you analyze and integrate in vitro/in vivo correlations and apply them to patient care and drug consultation situations.
Topical Drug Bioavailability Bioequivalence And Penetration
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Author : Vinod P. Shah
language : en
Publisher: Springer
Release Date : 2015-01-30
Topical Drug Bioavailability Bioequivalence And Penetration written by Vinod P. Shah and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-01-30 with Medical categories.
This authoritative volume explores advances in the techniques used to measure percutaneous penetration of drugs and chemicals to assess bioavailability and bioequivalence and discusses how they have been used in clinical and scientific investigations. Seven comprehensive sections examine topics including in vitro drug release, topical drugs products, clinical studies, and guidelines and workshop reports, among others. The book also describes how targeted transdermal drug delivery and more sophisticated mathematical modelling can aid in understanding the bioavailability of transdermal drugs. The first edition of this book was an important reference guide for researchers working to define the effectiveness and safety of drugs and chemicals that penetrated the skin. This second edition contains cutting-edge advances in the field and is a key resource to those seeking to define the bioavailability and bioequivalence of percutaneously active compounds to improve scientific and clinical investigation and regulation.
Drug Delivery Trends
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Author : Ranjita Shegokar
language : en
Publisher: Elsevier
Release Date : 2020-03-01
Drug Delivery Trends written by Ranjita Shegokar and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-01 with Medical categories.
Drug Delivery Trends examines a drift in the pharmaceutical field across the wide range of dosage forms, drug delivery systems (micro and nanoparticulate), at the regulatory front and on new types of therapies in the market. This volume additionally covers the challenges on drug delivery systems in terms of preclinical and current ways of determining quality and the options to solve the challenges associated with this. Most small-medium scale industries and academics struggle with initial regulatory challenges so a detailed discussion on regulatory trend covers the necessary basic understanding of regulatory procedures and provides the required guidance. The series Expectations and Realities of Multifunctional Drug Delivery Systems examines the fabrication, optimization, biological aspects, regulatory and clinical success of wide range of drug delivery carriers. This series reviews multifunctionality and applications of drug delivery systems, industrial trends, regulatory challenges and in vivo success stories. Throughout the volumes discussions on diverse aspects of drug delivery carriers, such as clinical, engineering, and regulatory, facilitate insight sharing across expertise area and form a link for collaborations between industry-academic scientists and clinical researchers. Expectations and Realities of Multifunctional Drug Delivery Systems connects formulation scientists, regulatory experts, engineers, clinical experts and regulatory stake holders. The wide scope of the book ensures it as a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about drug delivery systems. Encompasses trends in drug delivery systems and selected dosage forms Illustrates regulatory, preclinical and quality principles Contains in-depth investigation of upcoming types of drug delivery systems
Oral Drug Delivery For Modified Release Formulations
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Author : Edmund S. Kostewicz
language : en
Publisher: John Wiley & Sons
Release Date : 2022-04-26
Oral Drug Delivery For Modified Release Formulations written by Edmund S. Kostewicz and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-26 with Medical categories.
ORAL DRUG DELIVERY FOR MODIFIED RELEASE FORMULATIONS Provides pharmaceutical development scientists with a detailed reference guide for the development of MR formulations Oral Drug Delivery for Modified Release Formulations is an up-to-date review of the key aspects of oral absorption from modified-release (MR) dosage forms. This edited volume provides in-depth coverage of the physiological factors that influence drug release and of the design and evaluation of MR formulations. Divided into three sections, the book begins by describing the gastrointestinal tract (GIT) and detailing the conditions and absorption processes occurring in the GIT that determine a formulation’s oral bioavailability. The second section explores the design of modified release formulations, covering early drug substance testing, the biopharmaceutics classification system, an array of formulation technologies that can be used for MR dosage forms, and more. The final section focuses on in vitro, in silico, and in vivo evaluation and regulatory considerations for MR formulations. Topics include biorelevant dissolution testing, preclinical evaluation, and physiologically-based pharmacokinetic modelling (PBPK) of in vivo behaviour. Featuring contributions from leading researchers with expertise in the different aspects of MR formulations, this volume: Provides authoritative coverage of physiology, physicochemical determinants, and in-vitro in-vivo correlation (IVIVC) Explains the different types of MR formulations and defines the key terms used in the field Discusses the present status of MR technologies and identifies current gaps in research Includes a summary of regulatory guidelines from both the US and the EU Shares industrial experiences and perspectives on the evaluation of MR dosage formulations Oral Drug Delivery for Modified Release Formulations is an invaluable reference and guide for researchers, industrial scientists, and graduate students in general areas of drug delivery including pharmaceutics, pharmaceutical sciences, biomedical engineering, polymer and materials science, and chemical and biochemical engineering.
Drug Product Design And Performance
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Author : Victor F. Smolen
language : en
Publisher: Wiley-Interscience
Release Date : 1984
Drug Product Design And Performance written by Victor F. Smolen and has been published by Wiley-Interscience this book supported file pdf, txt, epub, kindle and other format this book has been release on 1984 with Bioavailability categories.
Oral Mucosal Drug Delivery And Therapy
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Author : Michael J. Rathbone
language : en
Publisher: Springer
Release Date : 2015-03-13
Oral Mucosal Drug Delivery And Therapy written by Michael J. Rathbone and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-13 with Medical categories.
This volume provides a comprehensive overview of the current issues facing scientists working on delivering drugs locally and systemically via the membranes that line the mouth. The book describes the anatomical and physiological challenges of this route for drug delivery and how they impact the design of oral mucosal drug delivery systems. It also provides a detailed description of current oral mucosal drug delivery technologies that overcome these challenges alongside research, development and assessment methods. In 11 authoritative chapters, the book affords an in-depth evaluation of the major issues associated with this route of administration, namely the retention of the drug/product at the site of administration and increasing drug permeability through the oral mucosa. The book provides insights into the in vitro and in vivo methods available to assess drug permeability and retention, offers solutions on how to improve the permeation of the drugs through the oral mucosa, and explores approaches to prolong drug/product retention at the site of administration. It also indicates future directions in research and product development. Oral Mucosal Drug Delivery and Therapy is a key resource for those wishing to extend their knowledge of this field.
Drug Delivery Approaches
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Author : Bret Berner
language : en
Publisher: John Wiley & Sons
Release Date : 2021-08-31
Drug Delivery Approaches written by Bret Berner and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-31 with Medical categories.
Explore this comprehensive discussion of the application of physiologically- and physicochemical-based models to guide drug delivery edited by leading experts in the field Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics delivers a thorough discussion of drug delivery options to achieve target profiles and approaches as defined by physical and pharmacokinetic models. The book offers an overview of drug absorption and physiological models, chapters on oral delivery routes with a focus on both PBPK and multiple dosage form options. It also provides an explanation of the pharmacokinetics of the formulation of drugs delivered by systemic transdermal routes. The distinguished editors have included practical and accessible resources that address the biological and delivery approaches to pulmonary and mucosal delivery of drugs. Emergency care settings are also described, with explorations of the relationship between parenteral infusion profiles and PK/PD. The future of drug delivery is addressed via discussions of virtual experiments to elucidate mechanisms and approaches to drug delivery and personalized medicine. Readers will also benefit from the inclusion of: A thorough introduction to the utility of mathematical models in drug development and delivery An exploration of the techniques and applications of physiologically based models to drug delivery Discussions of oral delivery and pharmacokinetic models and oral site-directed delivery A review of integrated transdermal delivery and pharmacokinetics in development An examination of virtual experiment methods for integrating pharmacokinetic, pharmacodynamic, and drug delivery mechanisms Alternative endpoints to pharmacokinetics for topical delivery Perfect for researchers, industrial scientists, graduate students, and postdoctoral students in the area of pharmaceutical science and engineering, Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics will also earn a place in the libraries of formulators, pharmacokineticists, and clinical pharmacologists.
Controlled Release In Oral Drug Delivery
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Author : Clive G. Wilson
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-09-22
Controlled Release In Oral Drug Delivery written by Clive G. Wilson and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-22 with Medical categories.
Controlled Release in Oral Drug Delivery provides focus on specific topics, complementing other books in the initial CRS series. Each chapter sets the context for the inventions described and describe the latitude that the inventions allow. In order to provide some similar look to each chapter, the coverage includes the historical overview, candidate drugs, factors influencing design and development, formulation and manufacturing and delivery system design. This volume was written along three main sections: the relevant anatomy and physiology, a discussion on candidates for oral drug delivery and the major three groups of controlled release systems: diffusion control (swelling and inert matrices); environmental control (pH sensitive coatings, time control, enzymatic control, pressure control) and finally lipidic systems.
Oral Bioavailability
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Author : Xiaoling Li
language : en
Publisher: John Wiley & Sons
Release Date : 2011-08-09
Oral Bioavailability written by Xiaoling Li and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-08-09 with Medical categories.
Understand and assess the design, delivery, and efficacy of orally administered drugs A practical guide to understanding oral bioavailability, one of the major hurdles in drug development and delivery, Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications is designed to help chemists, biologists, life science researchers, pharmaceutical scientists, pharmacologists, clinicians, and graduate and students become familiar with the fundamentals and practices of the science of oral bioavailability. The difference in rate and extent between a drug taken orally and the actual amount of a drug reaching the circulatory system, oral bioavailability is an essential parameter for determining the efficacy and adverse effects of new and developing medications, as well as finding an optimal dosing regimen. This book provides a much-needed one-stop resource to help readers better understand and appreciate the many facets and complex problems of oral bioavailability, including the basic barriers to oral bioavailability, the methods used to determine relevant parameters, and the challenges of drug delivery. In addition, this comprehensive book discusses biological and physicochemical methods for improving bioavailability, integrates physicochemistry with physiology and molecular biology, and includes several state-of-the-art technologies and approaches—Caco-2 cell culture model, MDCK, and other related cell culture models—which are used to study the science of oral bioavailability.
Design And Evaluation Of Gastric Floating Drug Delivery Systems
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Author : Venkata Srikanth Meka
language : en
Publisher: LAP Lambert Academic Publishing
Release Date : 2012
Design And Evaluation Of Gastric Floating Drug Delivery Systems written by Venkata Srikanth Meka and has been published by LAP Lambert Academic Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.
The tasks of achieving efficient delivery of drugs that have poor bioavailability or narrow absorption window have plagued the pharmaceutical research scientists for decades. Thus, much research has been dedicated to the development of novel polymeric based gastroretentive drug delivery systems that may optimize the bioavailability and subsequent therapeutic efficacy of such drugs. An effective approach of achieving this is through the prolongation of the gastric residence time employing several gastroretentive drug delivery mechanisms. Of these various approaches tried, gastric floating drug delivery systems have lower bulk density than gastric fluids and therefore remain buoyant on the stomach contents. These systems are generally not affected by the gastric emptying rate. They are gaining importance due to improvement in the bioavailability and their convenience of large scale manufacture because many of these dosage forms are tablets.