Asymmetric Synthesis Of Non Proteinogenic Amino Acids
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Asymmetric Synthesis Of Non Proteinogenic Amino Acids
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Author : Ashot S. Saghyan
language : en
Publisher: John Wiley & Sons
Release Date : 2016-11-14
Asymmetric Synthesis Of Non Proteinogenic Amino Acids written by Ashot S. Saghyan and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-14 with Science categories.
Authored by two internationally recognized experts with an excellent track record, this much-needed reference summarizes latest research in the rapidly developing field of stereoselective synthesis of enantiomerically enriched amino acids, particularly of non-proteinogenic origin. It highlights several different catalytic and stoichiometric asymmetric methods for their synthesis and also provides information on origin, biological properties, different synthetic strategies and important applications in medicine and pharmacology. Essential reading for synthetic chemists working in the field of asymmetric synthesis, natural products and peptide synthesis, stereochemistry, medicinal chemistry, biochemistry, pharmacology, and biotechnology.
Catalytic And Biocatalytic Methods For The Efficient Synthesis Of Biologically Relevant Non Proteinogenic Amino Acids
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Author : Anke Lemke
language : en
Publisher: Cuvillier Verlag
Release Date : 2014-04-29
Catalytic And Biocatalytic Methods For The Efficient Synthesis Of Biologically Relevant Non Proteinogenic Amino Acids written by Anke Lemke and has been published by Cuvillier Verlag this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-04-29 with Science categories.
Non-proteinogenic amino acids are often important constituents of biologically potent natural products. The synthesis of these amino acids is often time-consuming, non-trivial and not sustainable. Thus, the central topic of this work was the formation of unusual amino acid structures by biocatalytic and catalytic methods. For the elucidation of the biosynthetic pathway of Streptomyces-produced muraymycins and related natural products, a ‘biosynthetic tool kit’ was compiled and prepared. This does not only comprehend the completed synthesis of deuterium-labeled compounds, such as (3R)- and (3S)-3-hydroxy-[5-2H]-l-arginine and other potential intermediates with a nucleosidic structure, but it also includes the development of fermentation methodology including the possibility to detect the muraymycin derivatives by LC MS. Furthermore, different synthetic routes with catalytic key steps for the preparation of the non-proteinogenic amino acid enduracididine were investigated.
Asymmetric Synthesis Of Non Proteinogenic Amino Acids
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Author : Ashot S. Saghyan
language : en
Publisher: John Wiley & Sons
Release Date : 2016-08-08
Asymmetric Synthesis Of Non Proteinogenic Amino Acids written by Ashot S. Saghyan and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-08 with Science categories.
Authored by two internationally recognized experts with an excellent track record, this much-needed reference summarizes latest research in the rapidly developing field of stereoselective synthesis of enantiomerically enriched amino acids, particularly of non-proteinogenic origin. It highlights several different catalytic and stoichiometric asymmetric methods for their synthesis and also provides information on origin, biological properties, different synthetic strategies and important applications in medicine and pharmacology. Essential reading for synthetic chemists working in the field of asymmetric synthesis, natural products and peptide synthesis, stereochemistry, medicinal chemistry, biochemistry, pharmacology, and biotechnology.
Asymmetric Synthesis Of Natural Products
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Author : Ari M. P. Koskinen
language : en
Publisher: John Wiley & Sons
Release Date : 2022-11-30
Asymmetric Synthesis Of Natural Products written by Ari M. P. Koskinen and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-30 with Science categories.
Asymmetric Synthesis of Natural Products Fully updated learning resource covering the concept of using natural product chemistry for strategies in asymmetric synthesis The third edition of Asymmetric Synthesis of Natural Products introduces students to the rapidly growing field of natural products in organic chemistry, discussing the practical, mainly pharmacological, importance of selected compounds and emphasizing the target-oriented approach of organic synthesis which is key in industrial strategies. To aid in reader comprehension, the text includes key references and an Index of Compounds. The textbook is based on two lecture courses (Asymmetric Synthesis & Asymmetric Synthesis of Natural Products), which the author has delivered more than 50 times over the past 20 years in Finland, the UK, Italy, and Greece. This third edition is fully updated from the earlier versions (published by Wiley in 1993 and 2012). The importance of natural products as truly renewable raw materials in sustainable chemistry and circular economy is illustrated through applications of e.g. organocatalysis, organometallic catalysis, and biocatalysis. The contents consist of traditional text supplemented with illustrations (such as chemical drawings and structural formulae). Three dimensional aspects are also discussed with the use of 3D renderings of structures for both reaction mechanisms (molecular modeling) and crystallographic data. Sample topics covered in the textbook include: The foundations of asymmetric synthesis, including the theory and applications of individual asymmetric reactions Sustainable development, the circular economy, and use of renewable raw materials that have become prominent in many fields of science and technology Various natural product classes, including carbohydrates, amino acids, peptides, proteins, nucleosides, nucleotides, nucleic acids, and polyketides The properties of these natural product classes, including their structures, biosynthesis, and interrelationships, as well as examples of asymmetric syntheses and the practical value of these compounds Asymmetric Synthesis of Natural Products is a comprehensive, authoritative, and up-to-date learning resource on the subject for advanced level undergraduate or early-stage graduate students. It is also useful for specialists already working in synthesis who wish to learn about asymmetric synthesis.
Asymmetric Synthesis And Application Of Alpha Amino Acids
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Author : Vadim A Soloshonok
language : en
Publisher: American Chemical Society
Release Date : 2009-07-09
Asymmetric Synthesis And Application Of Alpha Amino Acids written by Vadim A Soloshonok and has been published by American Chemical Society this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-07-09 with Language Arts & Disciplines categories.
This volume presents the most recent and comprehensive collection of reviews on methodological developments in the field of alpha-amino acids.
Organo Catalytic Strategies Towards Alpha Alpha Disubstituted Amino Acid Derivatives
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Author : Henning Vogt
language : en
Publisher:
Release Date : 2006
Organo Catalytic Strategies Towards Alpha Alpha Disubstituted Amino Acid Derivatives written by Henning Vogt and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.
The class of non-proteinogenic a,a u2011disubstituted amino acids and their derivatives is of high interest to biochemical and pharmacological research. This predicates on their ability to alter certain chemical and physicochemical properties of peptides and related structures. Moreover, the close structural relatedness to biologically relevant endogenous amino acid derivatives qualifies them in many cases to act as enzyme inhibitors or receptor antagonists.In the present study, the development of new strategies towards the synthesis of N u2011protected a,a u2011disubstituted amino aldehydes and their derivatives is demonstrated. Starting from ketones, a,a u2011disubstituted aldehydes were prepared in two or three steps. These aldehydes were subjected to stereoselective organo-catalysed a u2011amination reactions. The transfer of a procedure known for the a u2011amination of a u2011unbranched aldehydes with azodicarboxylates to racemic a u2011branched aldehydes delivered N u2011protected aminoaldehydes in up to 87 % yield and 86 % ee. The conversion of the amination products to the corresponding N u2011protected 4,4 u2011disubstituted oxazolidinones was accomplished, after in situ-reduction, in two additional steps.In addition to this method, a new strategy was devised using sulfonyl azides as aminating agent to deliver a u2011sulfamidated a,a u2011disubstituted aldehydes in up to 55 % yield and 86 % ee. A mechanism was proposed, which differs fundamentally from the mechanistic model usually ascribed to enamine catalysis. The transformation of the sulfamidation product into the free amino acid was accomplished in two steps.Since the two concepts follow different mechanistic routes, different enantiomers of N u2011protected, a,a u2011disubstituted aminoaldehydes are accessible by one catalyst. All reactions involved in the latter approach are free of transition metals. Therefore, the presented strategy could prove to be especially useful for medicinal chemistry.
Non Proteinogenic Amino Acids
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Author : Nina Filip
language : en
Publisher: BoD – Books on Demand
Release Date : 2018-12-05
Non Proteinogenic Amino Acids written by Nina Filip and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-12-05 with Science categories.
The first description of homocysteine (Hcy), a non-proteinogenic amino acid, was introduced in a case study more than 70 years ago. In recent years, numerous studies have shown a positive correlation between serum levels and various diseases, especially vascular pathology. Vitamins B6, B12, and folic acid play a major role in controlling homocysteine levels. In this book are presented both methods for the determination of homocysteine and its involvement in human pathology. Homocysteine levels can be taken as an early indicator for the detection of cardiovascular diseases because Hcy levels increase after a myocardial infarction or stroke.
Asymmetric Phase Transfer Catalysis
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Author : Keiji Maruoka
language : en
Publisher: John Wiley & Sons
Release Date : 2008-03-31
Asymmetric Phase Transfer Catalysis written by Keiji Maruoka and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-03-31 with Science categories.
Edited by the leading expert on the topic, this is the first book to present the latest developments in this exciting field. Alongside the theoretical aspects, the top contributors provide practical protocols to give readers additional important information otherwise unavailable. A must for every synthetic chemist in academia and industry.
Advances In Asymmetric Synthesis
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Author :
language : en
Publisher: Elsevier
Release Date : 1995-03-01
Advances In Asymmetric Synthesis written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-03-01 with Science categories.
Advances in Asymmetric Synthesis
Fluorine Containing Amino Acids
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Author : Valery P. Kukhar
language : en
Publisher: John Wiley & Sons
Release Date : 1995-04-06
Fluorine Containing Amino Acids written by Valery P. Kukhar and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-04-06 with Science categories.
In recent years, organo-fluorine chemistry has made a marked impact on the design and synthesis of a large variety of biologically active molecules, such as steroids, carbohydrates, amines, amino acids, peptides and other natural products. Naturally occurring amino acids play a pivotal role in living systems, and therefore synthetic fluorine-containing amino acids have been of significant interest to researchers working towards the understanding and modification of physiological processes. Fluorine-containing Amino Acids: is the first volume devoted to the synthesis and properties of fluorine-containing amino acids pays special attention to the preparation of enantiomerically pure acids (which are essential to the modern pharmaceutical industry) deals with a rapidly expanding field of research has been written by experienced researchers who are responsible for many developments in the field highlights the interdisciplinary nature of this topic Fluorine-containing Amino Acids is the only dedicated reference in this subject and will be essential for researchers in synthetic organic, peptide, natural product, and medicinal chemistry and biochemistry.