Automation In Proteomics And Genomics

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Automation In Proteomics And Genomics
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Author : Gil Alterovitz
language : en
Publisher: John Wiley & Sons
Release Date : 2009-03-16
Automation In Proteomics And Genomics written by Gil Alterovitz and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-03-16 with Science categories.
In the last decade DNA sequencing costs have decreased over a magnitude, largely because of increasing throughput by incremental advances in tools, technologies and process improvements. Further cost reductions in this and in related proteomics technologies are expected as a result of the development of new high-throughput techniques and the computational machinery needed to analyze data generated. Automation in Proteomics & Genomics: An Engineering Case-Based Approach describes the automation technology currently in the areas of analysis, design, and integration, as well as providing basic biology concepts behind proteomics and genomics. The book also discusses the current technological limitations that can be viewed as an emerging market rather than a research bottleneck. Topics covered include: molecular biology fundamentals: from ‘blueprint’ (DNA) to ‘task list’ (RNA) to ‘molecular machine’ (protein); proteomics methods and technologies; modelling protein networks and interactions analysis via automation: DNA sequencing; microarrays and other parallelization technologies; protein characterization and identification; protein interaction and gene regulatory networks design via automation: DNA synthesis; RNA by design; building protein libraries; synthetic networks integration: multiple modalities; computational and experimental methods; trends in automation for genomics and proteomics new enabling technologies and future applications Automation in Proteomics & Genomics: An Engineering Case-Based Approach is an essential guide to the current capabilities and challenges of high-throughput analysis of genes and proteins for bioinformaticians, engineers, chemists, and biologists interested in developing a cross-discipline problem-solving based approach to systems biology.
Automation Genomic And Functional Analyses
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Author :
language : en
Publisher: Academic Press
Release Date : 1999-04-13
Automation Genomic And Functional Analyses written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-04-13 with Science categories.
Automation is the major future trend for many areas in microbiology, molecular biology, and biochemistry, among other disciplines. It is an enormously exciting area, where techniques and assays that were once repetitive, tedious, and time consuming can be performed robotically, liberating the time of researchers and hospital laboratory workers for more interesting work. Many techniques have now been automated and often miniaturized, including PCR analysis, DNA/RNA preparation, diagnostic test (e.g., Pap tests), compound screening, and of course, sequencing. Some major advances, notably in Professor Leroy Hood's group, have resulted in the ability to perform thousands of assays simultaneously on a normal microscope slide. Automation, edited by two of the leading experts in the field, presents the very latest experimental techniques explained in detail. This book has succeeded in bringing together researchers at the forefront of clone library construction, genome analysis, sequencing, computational data evaluation and functional analysis, to provide insight into this "new age" of research based on genomic and chemical screening. - Describes automated procedures used in microbiology and molecular biology - Includes developments in robotics and vision systems - Features automation in library picking, presentation and analysis - Discusses paralogous duplications in microbial genomes - Covers deciphering genomes through automated large-scale sequencing - Describes and stresses the need for functional analyses - Internationally acclaimed contributors, including Professor Leroy Hood
The Dictionary Of Genomics Transcriptomics And Proteomics
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Author : Guenter Kahl
language : en
Publisher: John Wiley & Sons
Release Date : 2015-05-21
The Dictionary Of Genomics Transcriptomics And Proteomics written by Guenter Kahl and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-05-21 with Science categories.
Now in its fifth edition and for the first time available as an electronic product with all entries cross-linked. This very successful long-seller has once again been thoroughly updated and greatly expanded. It now contains over 13,000 entries, and comprehensively covering genomics, transcriptomics, and proteomics. Each entry contains an extensive explanation, including a comprehensive listing of synonyms and acronyms, and all formulas have been redrawn to create a uniform style, while most of the figures are custom designed for this dictionary. The ultimate reference for all terms in the -omics fields.
Structural Genomics And High Throughput Structural Biology
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Author : Michael Sundstrom
language : en
Publisher: CRC Press
Release Date : 2005-08-23
Structural Genomics And High Throughput Structural Biology written by Michael Sundstrom and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-08-23 with Medical categories.
Researchers in structural genomics continue to search for biochemical and cellular functions of proteins as well as the ways in which proteins assemble into functional pathways and networks using either experimental or computational approaches. Based on the experience of leading international experts, Structural Genomics and High Throughput Stru
Devices And Systems For Laboratory Automation
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Author : Kerstin Thurow
language : en
Publisher: John Wiley & Sons
Release Date : 2022-08-08
Devices And Systems For Laboratory Automation written by Kerstin Thurow and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-08 with Science categories.
Devices and Systems for Laboratory Automation Structured Overview on the Available Systems and Devices for Laboratory Automation Choosing the right systems and devices for the automation in any given laboratory is an essential part for the process to succeed. As relevant information to make an informed choice is not always readily available, a structured overview is essential for modern scientists. This book provides an introduction into laboratory automation and an overview of the necessary devices and systems. Sample topics discussed by the two well-qualified authors include: Specific requirements the automation needs to fulfill such as liquid delivery, low volume delivery, solid delivery, and sample preparation An overview on robots and mobile robots Common interfaces in laboratory automation For scientists and all individuals working in laboratories, the work serves as an indispensable resource in helping to make laboratory processes more streamlined, effective, and efficient.
Structural Proteomics
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Author : Bostjan Kobe
language : en
Publisher: Humana Press
Release Date : 2008-03-03
Structural Proteomics written by Bostjan Kobe and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-03-03 with Science categories.
The objective of this volume is to provide readers with a current view of all aspects of the 'pipeline' that takes protein targets to structures and how these have been optimised. This volume includes chapters describing, in-depth, the individual steps in the Structural Genomics pipeline, as well as less detailed overviews of individual Structural Genomics initiatives. It is the first book of protocols to cover techniques in a new and emerging field.
Evolution Of Translational Omics
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2012-09-13
Evolution Of Translational Omics written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-09-13 with Science categories.
Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.
Proteomics
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Author : Stephen R. Pennington
language : en
Publisher: Garland Science
Release Date : 2001
Proteomics written by Stephen R. Pennington and has been published by Garland Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Mathematics categories.
Proteomics is an emerging research area, and the book reviews genome projects in relation to the need for complementary proteomics programmes.
Proteogenomics
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Author : Ákos Végvári
language : en
Publisher: Springer
Release Date : 2016-09-29
Proteogenomics written by Ákos Végvári and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-29 with Science categories.
This book highlights key technologies and identifies areas for further development in proteogenomics. The utility and usefulness of very large Omics data sets (Next Gen Sequencing of DNA, RNA-seq, ribosome profiling, mass spectrometry- and antibody-based proteomics) is discussed and opportunities and challenges of related bioinformatics applications are outlined. The reader will be able to appreciate the interdisciplinary nature of the continuously evolving area of proteogenomics, which has already grown beyond its original concept of verifying gene annotations by proteomics. The chapters presented in this book are arranged to offer a general overview, rather than to provide detailed descriptions of technologies. The selected applications will provide useful insight into the level of detail that can be obtained in relation to certain diseases areas, including cancer biology and personalized medicine. The readers will find that each chapter delivers a comprehensive approach to proteogenomics, each from the point of view of a specific application. Research scientists interested in innovative processes that can offer a unique and at the same time a more complete access to technological developments and concepts that in turn can contribute to a better understand biological functions should read this book.
Proteomic And Genomic Analysis Of Cardiovascular Disease
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Author : Jennifer E. Van Eyk
language : en
Publisher: John Wiley & Sons
Release Date : 2006-03-06
Proteomic And Genomic Analysis Of Cardiovascular Disease written by Jennifer E. Van Eyk and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-03-06 with Science categories.
This is the very first book to focus on this new approach that will eventually aid in developing new diagnostic markers and therapies for controlling and treating heart disease - the number-one killer in the industrialized world. Divided into two parts, the book describes not only the potentials, but also the limitations of these technologies. The editors, both well known within the scientific community, provide new insights into the biochemical and cellular mechanisms of cardiovascular disease, as well as covering the transition into clinical applications. In so doing, they highlight the various strategies and technical aspects so as to assist the growing number of researchers intending to utilize these approaches. The result is an excellent way of educating and informing graduate students, post-doctoral fellows as well as researchers in academia and industry about the latest developments in this area.