Autophagosome And Phagosome
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Autophagosome And Phagosome
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Author : Vojo Deretic
language : en
Publisher: Humana Press
Release Date : 2010-12-09
Autophagosome And Phagosome written by Vojo Deretic and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-09 with Science categories.
Autophagy and phagocytosis are distinct yet partially morphologically similar processes. Understanding them is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. This book presents autophagosome and phagosome methods for novices and advanced researchers alike. Comprehensive and forward-thinking, the book offers a valuable guide to both cellular processes while inciting researchers to explore their potentially important connections.
Autophagy
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Author : Shintaro Seto
language : en
Publisher: Elsevier Inc. Chapters
Release Date : 2013-09-03
Autophagy written by Shintaro Seto and has been published by Elsevier Inc. Chapters this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-09-03 with Medical categories.
Alveolar macrophages are the lung’s first line of defense against infection by pathogenic microbes. Despite this, Mycobacterium tuberculosis can proliferate in alveolar macrophages by inhibiting phagolysosome biogenesis. Differential recruitment of Rab GTPases, which regulate phagosome maturation, to mycobacterial phagosomes contributes to the inhibition of phagolysosome biogenesis. Recruitment of Coronin-1a, an actin binding protein, to mycobacterial phagosomes is also thought to inhibit their fusion with lysosomes. Host defense mechanisms exploit autophagy to control the proliferation of intracellular pathogens, including M. tuberculosis. On the other hand, several intracellular bacteria can evade the elimination induced by the autophagic process. M. tuberculosis also escapes being targeted for autophagosomal uptake. We have demonstrated that the depletion of Coronin-1a inhibits mycobacterial survival in macrophages, since Coronin-1a depletion facilitates the formation of autophagosomes around mycobacterial phagosomes. These results suggest that Coronin-1a inhibits autophagosome formation in regard to M. tuberculosis, thereby allowing mycobacterial survival in alveolar macrophages.
Handbook Of Tuberculosis
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Author : Stefan H. E. Kaufmann
language : en
Publisher: Wiley-Blackwell
Release Date : 2008-03-17
Handbook Of Tuberculosis written by Stefan H. E. Kaufmann and has been published by Wiley-Blackwell this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-03-17 with Science categories.
Coinciding with the first TB therapies to enter clinical trials in 60 years, this is the most comprehensive account of the latest developments in clinical, therapeutic and basic research into the disease, presented by the most prolific of all researchers in the field. Divided into three clearly structured volumes, the first deals with molecular biology and biochemistry of the pathogen, including genetics and genomics, as well as drug design. The second volume covers cell biology, immunology and vaccine development, while the third is devoted to epidemiology and clinical approaches, including drug resistance, veterinary aspects and clinical field trials. With one new infection worldwide every second, this is an essential reference for bacteriologists, immunologists, pathologists and pathophysiologists, molecular and cell biologists, as well as those working in the pharmaceutical industry.
Non Canonical Autophagy
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Author : Giulia Petroni
language : en
Publisher: Academic Press
Release Date : 2021-04-21
Non Canonical Autophagy written by Giulia Petroni and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-21 with Science categories.
Non-canonical Autophagy: Mechanisms and Pathophysiological Implications outlines the differences between ‘canonical’ and ‘non-canonical’ forms of autophagy, highlighting the discoveries concerning the molecular mechanisms underlying these unconventional forms of autophagy and the advancements in pathophysiological features of ‘non-canonical’ autophagy. The book discusses all forms of ‘non-canonical’ autophagy and the complexity of autophagy-dependent cell death. Readers will gain a better understanding of mechanisms underlying ‘non-canonical’ autophagy so that they can interpret the biological effects of autophagy correctly and identify reliable, novel and effective treatment strategies. Presents the most advanced information surrounding the molecular mechanisms underlying non-canonical autophagy Outlines the increasing evidence regarding the involvement of non-canonical autophagy in multiple physiological and pathological processes Discusses the therapeutic potential of autophagy modulators and the obstacles that have limited their development
Autophagy Cancer Other Pathologies Inflammation Immunity Infection And Aging
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Author : M. A. Hayat
language : en
Publisher: Academic Press
Release Date : 2016-12-28
Autophagy Cancer Other Pathologies Inflammation Immunity Infection And Aging written by M. A. Hayat and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-28 with Medical categories.
Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is an eleven volume series that discusses in detail all aspects of autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. This series discusses the characterization of autophagosome-enriched vaccines and its efficacy in cancer immunotherapy. Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis. Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward-thinking, these books offer a valuable guide to cellular processes while also inciting researchers to explore their potentially important connections. Presents the most advanced information regarding the role of the autophagic system in life and death Examines whether autophagy acts fundamentally as a cell survivor or cell death pathway or both Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation Features recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, including atherosclerosis and CNS tumors, and their development and treatment Includes chapters authored by leaders in the field around the globe—the broadest, most expert coverage available
Autophagy Biology And Diseases
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Author : Zheng-Hong Qin
language : en
Publisher: Springer Nature
Release Date : 2019-11-27
Autophagy Biology And Diseases written by Zheng-Hong Qin and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-27 with Science categories.
This book series consists of 3 volumes covering the basic science (Volume 1), clinical science (Volume 2) and the technology and methodology (Volume 3) of autophagy. Volume 1 focuses on the biology of autophagy, including the signaling pathways, regulating processes and biological functions. Autophagy is a fundamental physiological process in eukaryotic cells. It not only regulates normal cellular homeostasis, and organ development and function, but also plays an important role in the pathogenesis of a wide range of human diseases. Thanks to the rapid development of molecular biology and omic technologies, research on autophagy has boomed in recent decades, and more and more cellular and animal models and state-of the-art technologies are being used to shed light on the complexity of signaling networks involved in the autophagic process. Further, its involvement in biological functions and the pathogenesis of various diseases has attracted increased attention around the globe. Presenting cutting-edge knowledge, this book series is a useful reference resource for researchers and clinicians who are working on or interested in autophagy.
Autophagy And Cancer
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Author : Hong-Gang Wang
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-30
Autophagy And Cancer written by Hong-Gang Wang and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-30 with Medical categories.
With the explosion of information on autophagy in cancer, this is an opportune time to speed the efforts to translate our current knowledge about autophagy regulation into better understanding of its role in cancer. This book will cover the latest advances in this area from the basics, such as the molecular machinery for autophagy induction and regulation, up to the current areas of interest such as modulation of autophagy and drug discovery for cancer prevention and treatment. The text will include an explanation on how autophagy can function in both oncogenesis and tumor suppression and a description of its function in tumor development and tumor suppression through its roles in cell survival, cell death, cell growth as well as its influences on inflammation, immunity, DNA damage, oxidative stress, tumor microenvironment, etc. The remaining chapters will cover topics on autophagy and cancer therapy. These pages will serve as a description on how the pro-survival function of autophagy may help cancer cells resist chemotherapy and radiation treatment as well as how the pro-death functions of autophagy may enhance cell death in response to cancer therapy, and how to target autophagy for cancer prevention and therapy − what to target and how to target it.
Autophagy Networks In Inflammation
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Author : Maria Chiara Maiuri
language : en
Publisher: Springer
Release Date : 2016-08-17
Autophagy Networks In Inflammation written by Maria Chiara Maiuri and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-17 with Medical categories.
Autophagy principally serves an adaptive function to protect organisms against diverse human pathologies, including cancer and neurodegeneration. Recent developments using in vitro, ex vivo and in vivo models show the involvement of the autophagy pathway in immunity and inflammation. Moreover, direct interactions between autophagy proteins and immune signalling molecules have also been demonstrated. Defects in autophagy - similar to cancer, neurodegenerative diseases and aging - through autophagy gene mutation and/or microbial antagonism, may underlie the pathogenesis of many infectious diseases and inflammatory syndromes. In spite of the increasing awareness of the importance of autophagy in these pathophysiological conditions, this process remains underestimated and is often overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these diseases are still poorly understood. This book reviews the recent advances regarding the functions of the autophagy pathway and autophagy proteins in immunity and inflammation, focusing on their role in self-nonself distinction, their implications in innate and adaptive immune responses and their dysregulation in the pathology of certain inflammatory and autoimmune diseases.
Autophagy Biology And Diseases
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Author : Zhiping Xie
language : en
Publisher: Springer Nature
Release Date : 2021-07-14
Autophagy Biology And Diseases written by Zhiping Xie and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-14 with Medical categories.
This book series consists of 3 volumes covering the basic science (Volume 1), clinical science (Volume 2) and the technology and methodology (Volume 3) of autophagy. Volume 3 focuses on the technical aspects of autophagy research. It is comprised of two parts. The first part discusses the basic process of autophagy, including its overall classification and individual stages in the life cycle of autophagosomes. The second part discusses the tools, strategies, and model systems in current autophagy research, including cell and animal models, detection and manipulation methods, as well as screening, genomic, proteomic and bioinformatic approaches. The book is written and edited by a team of active scientists. It is intended as a practical reference resource for interested researchers to get started on autophagy studies.
Macrophage Activation
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Author : Khalid Hussain Bhat
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-03-25
Macrophage Activation written by Khalid Hussain Bhat and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-25 with Medical categories.
Macrophages are the sentinels of the immune system whose role has evolved beyond providing aseptic conditions to homeostasis, immune regulation, development, and behaviour. These cells have varied ontogenetic origins which reflects in their phenotypic and functional heterogeneity. Macrophage functions are fine-tuned by exogenous and endogenous signals and once tweaked, the information is included in their genetic makeup, albeit not indefinitely. Subversion of the macrophage functions is the hallmark of many pathogenic organisms and modulation of macrophage activity is pivotal to many therapeutic strategies. Fascinating and rapid developments in this field have necessitated the maintenance of currency of knowledge. This book provides a current account of information on varied topics in macrophage biology. Literature surveys have been presented in a captivating and lucid language. The contributing authors have also provided brief accounts of their own research. Every chapter provides a future perspective of what more could be achieved in the context of the current knowledge. The book will be of interest to students and researchers in microbiology, immunobiology, translational research, pathology, and related fields.