Macrophage Activation
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Macrophage Activation
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Author : Khalid Hussain Bhat
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-03-25
Macrophage Activation written by Khalid Hussain Bhat and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-25 with Medical categories.
Macrophages are the sentinels of the immune system whose role has evolved beyond providing aseptic conditions to homeostasis, immune regulation, development, and behaviour. These cells have varied ontogenetic origins which reflects in their phenotypic and functional heterogeneity. Macrophage functions are fine-tuned by exogenous and endogenous signals and once tweaked, the information is included in their genetic makeup, albeit not indefinitely. Subversion of the macrophage functions is the hallmark of many pathogenic organisms and modulation of macrophage activity is pivotal to many therapeutic strategies. Fascinating and rapid developments in this field have necessitated the maintenance of currency of knowledge. This book provides a current account of information on varied topics in macrophage biology. Literature surveys have been presented in a captivating and lucid language. The contributing authors have also provided brief accounts of their own research. Every chapter provides a future perspective of what more could be achieved in the context of the current knowledge. The book will be of interest to students and researchers in microbiology, immunobiology, translational research, pathology, and related fields.
Macrophage Activation
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Author : Dolph O. Adams
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
Macrophage Activation written by Dolph O. Adams and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Medical categories.
Macrophage Biology And Activation
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Author : Stephen W. Russell
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Macrophage Biology And Activation written by Stephen W. Russell and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The amazing world of the mononuclear phagocytes keeps expanding at a truly awesome pace. As a result, maintaining currency with the latest developments and controversies that pertain to this cell type is increasingly difficult. The aspects covered in this volume have been selected to provide an overview of subject areas that either have recently become much better understood or hold the promise of new levels of understanding as they are developed in the future. The scope of topics ranges from how these cells develop, through the means that are used to regulate them, to the roles that they have in different tissues and in a variety of infectious diseases.
Immunobiology Of The Macrophage
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Author : David S. Nelson
language : en
Publisher: Academic Press
Release Date : 2014-06-28
Immunobiology Of The Macrophage written by David S. Nelson and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-06-28 with Nature categories.
Immunobiology of the Macrophage presents an account of the state of knowledge of the immunobiology of the macrophage. The book’s contributors—immunologists of diverse scientific and geographic backgrounds—have been encouraged to give personal accounts of developments in their special fields of interest as well as critical surveys of the backgrounds leading to these developments. The book begins with a study on the functions of macrophages in the initiation and regulation of antibody responses in vitro. This is followed by separate chapters on topics such as the role of macrophages in making antigen more immunogenic and less tolerogenic; functional distinctions between macrophages at different sites; and the role of the macrophage in antigen recognition by T lymphocytes. Subsequent chapters examine interactions between macrophages and lymphocytes in the production of interferon and other mediators of cellular immunity; macrophage cell lines and their uses in immunobiology; and cytotoxic macrophages in allograft rejection.
Transcriptional Control Points During Macrophage Development That Influence The Macrophage Activation Response
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Author : Mary Ann McDowell
language : en
Publisher:
Release Date : 1995
Transcriptional Control Points During Macrophage Development That Influence The Macrophage Activation Response written by Mary Ann McDowell and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with categories.
The Macrophage
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Author : Claire E. Lewis
language : en
Publisher: Oxford University Press, USA
Release Date : 1992
The Macrophage written by Claire E. Lewis and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Macrophages categories.
Historically, the study of immunology has focused to a large extent on the central role of antigen recognition and antibody structure and function in the response of the host to infection. In the last two decades, however, scientists have been turning their attention to the involvement of various cell types in host defense. This volume provides a collection of absorbing reviews written by expert scientists on this developing topic. A broad range of material is included relating to the molecular and cell biology of the macrophage and its host defence activity in human disease. The important role that these cells play in hemopoiesis and the functioning of the nervous system is also discussed. Advanced students and researchers in immunology, cell biology, and medicine will find The Macrophage a valuable source of current research into this emerging field.
T Cell Signaling Of Macrophage Activation
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Author : Robert D. Stout
language : en
Publisher:
Release Date : 1995-01-01
T Cell Signaling Of Macrophage Activation written by Robert D. Stout and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-01-01 with Cell interaction categories.
Describes the progress that has been made in the understanding of how macrophages are activated to display inflammatory and effector function, beginning with a definition of what is meant by macrophage activation, and progressing through the LPS plus IFN(gamma) model for macrophage activation to the unraveling of how T cells may interact with, and activate effector function in, antigen presenting macrophages. Annotation copyright by Book News, Inc., Portland, OR
The M2 Macrophage
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Author : Tamás Röszer
language : en
Publisher: Springer Nature
Release Date : 2020-08-03
The M2 Macrophage written by Tamás Röszer and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-03 with Medical categories.
Macrophages are core components of the innate immune system. Once activated, they may have either pro- or anti-inflammatory effects that include pathogen killing, safe disposal of apoptotic cells or tissue renewal. The activation state of macrophages is conceptualized by the so-called M1/M2 model of polarization. M2 macrophages are not simply antagonists of M1 macrophages; rather, they represent a network of tissue resident macrophages with roles in tissue development and organ homeostasis. M2 macrophages govern functions at the interfaces of immunity, tissue development and turnover, metabolism, and endocrine signaling. Dysfunction in M2 macrophages can ruin the healthy interplay between the immune system and metabolic processes, and lead to diseases such as insulin resistance, metabolic syndrome, and type 1 and 2 diabetes mellitus. Furthermore, M2 macrophages are essential for healthy tissue development and immunological self-tolerance. Worryingly, these functions of M2 macrophages can also be disrupted, resulting in tumor growth and autoimmunity. This book comprehensively discusses the biology of M2 macrophages, summarizes the current state of knowledge, and highlights key questions that remain unanswered.
Macrophages And Dendritic Cells
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Author : Neil E. Reiner
language : en
Publisher: Humana Press
Release Date : 2014-11-26
Macrophages And Dendritic Cells written by Neil E. Reiner and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-26 with Medical categories.
In light of the critical contributions of macrophages and dendritic cells to diverse inflammatory diseases and to immunity and host defense, state-of-the-art approaches to the investigation of their behavior are essential. In Macrophages and Dendritic Cells: Methods and Protocols, expert researchers contribute laboratory protocols involving these two vital cell types functioning at the junction of the innate and acquired immune systems. The volume delves first into isolation and cell culturing then continues with topics such as phagocytosis, genetic manipulation, macrophage activation, and lipid signaling. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include brief introductions to their respective subjects, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Macrophages and Dendritic Cells: Methods and Protocols provides a timely and useful guide for both seasoned investigators and neophytes pursuing this imperative field of study.
Macrophages Biology And Role In The Pathology Of Diseases
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Author : Subhra K. Biswas
language : en
Publisher: Springer
Release Date : 2014-11-12
Macrophages Biology And Role In The Pathology Of Diseases written by Subhra K. Biswas and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-12 with Medical categories.
Macrophages are a key component of the innate immune system and play an integral role in host defense and homeostasis. On one hand, these cells contribute to host defence by triggering inflammation, displaying microbicidal/tumoricidal properties, regulating the activation of adaptive immunity and promoting resolution of inflammation. On the other hand, they contribute to essential trophic functions such as neural patterning, bone morphogenesis and ductal branching in mammary glands. Thus, macrophages are extremely versatile cells that can respond efficiently to tissue micro environmental cues by polarizing to distinct phenotypes, depending on the functions they need to perform. Indeed, functional diversity and plasticity are hallmarks of these cells. Macrophages may also play a detrimental role. An overwhelming body of literature has indicated their crucial role in pathogenesis. The list includes sepsis, cancer, metabolic syndrome, immunodeficiency, auto-immune disease-virtually impacting every major pathology that we know. These observations have suggested macrophages and their related molecules as potential targets in therapeutic applications. Available evidence proclaims macrophages as a key player in homeostasis, host defense and disease. Crucial developments in the past few years call for a re-evaluation and update of our understanding of macrophages. The present book is an endeavour that attempts provide state-of-the art knowledge of these cells in health and disease.