Macrophages Biology And Role In The Pathology Of Diseases
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Macrophages Biology And Role In The Pathology Of Diseases
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Author : Subhra K. Biswas
language : en
Publisher: Springer
Release Date : 2014-11-12
Macrophages Biology And Role In The Pathology Of Diseases written by Subhra K. Biswas and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-12 with Medical categories.
Macrophages are a key component of the innate immune system and play an integral role in host defense and homeostasis. On one hand, these cells contribute to host defence by triggering inflammation, displaying microbicidal/tumoricidal properties, regulating the activation of adaptive immunity and promoting resolution of inflammation. On the other hand, they contribute to essential trophic functions such as neural patterning, bone morphogenesis and ductal branching in mammary glands. Thus, macrophages are extremely versatile cells that can respond efficiently to tissue micro environmental cues by polarizing to distinct phenotypes, depending on the functions they need to perform. Indeed, functional diversity and plasticity are hallmarks of these cells. Macrophages may also play a detrimental role. An overwhelming body of literature has indicated their crucial role in pathogenesis. The list includes sepsis, cancer, metabolic syndrome, immunodeficiency, auto-immune disease-virtually impacting every major pathology that we know. These observations have suggested macrophages and their related molecules as potential targets in therapeutic applications. Available evidence proclaims macrophages as a key player in homeostasis, host defense and disease. Crucial developments in the past few years call for a re-evaluation and update of our understanding of macrophages. The present book is an endeavour that attempts provide state-of-the art knowledge of these cells in health and disease.
The Macrophage
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Author : Bernard Burke
language : en
Publisher: Oxford University Press, USA
Release Date : 2002
The Macrophage written by Bernard Burke and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Medical categories.
The Macrophage, second edition provides a unique, comprehensive review of the current scientific knowledge of the multifaceted role of this important and intriguing cell in health and disease. In 16 chapters, written by experts in the field, it covers the basic biology and diverse functions of macrophages in specific diseases and the complex interactions between macrophages and other cells. Ranging from their role in the defence against pathogens, their role as hosts for pathogens (including HIV), their complex roles in diseases such as arthritis and cancer, and their potential for use in novel gene therapy approaches to disease treatment, the book gives an up to the minute account of active macrophage research.
Macrophage Activation
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Author : Khalid Hussain Bhat
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-03-25
Macrophage Activation written by Khalid Hussain Bhat and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-25 with Medical categories.
Macrophages are the sentinels of the immune system whose role has evolved beyond providing aseptic conditions to homeostasis, immune regulation, development, and behaviour. These cells have varied ontogenetic origins which reflects in their phenotypic and functional heterogeneity. Macrophage functions are fine-tuned by exogenous and endogenous signals and once tweaked, the information is included in their genetic makeup, albeit not indefinitely. Subversion of the macrophage functions is the hallmark of many pathogenic organisms and modulation of macrophage activity is pivotal to many therapeutic strategies. Fascinating and rapid developments in this field have necessitated the maintenance of currency of knowledge. This book provides a current account of information on varied topics in macrophage biology. Literature surveys have been presented in a captivating and lucid language. The contributing authors have also provided brief accounts of their own research. Every chapter provides a future perspective of what more could be achieved in the context of the current knowledge. The book will be of interest to students and researchers in microbiology, immunobiology, translational research, pathology, and related fields.
The Biology And Pathology Of Innate Immunity Mechanisms
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Author : Yona Keisari
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-07-06
The Biology And Pathology Of Innate Immunity Mechanisms written by Yona Keisari and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-07-06 with Medical categories.
In recent years increased scientific attention has been given to immediate defense mechanisms based on non-clonal recognition of microbial components. These mechanisms constitute the innate immunity arm of the body s defense. Identification of pathogens by these mechanisms involves primarily receptors recognizing sugar moieties of various microorganisms. Innate immunity based mechanisms are essential for the existence of multicellular organisms. They are evolutionarily conserved and designed to provide immediate protection against microbial pathogens to eradicate infection. Activation of innate immunity is crucial for transition to specific immunity and for its orientation, and to assist the specific immune response in the recognition of pathogens and their destruction. Innate immunity is regularly involved in the arrest of bacterial, mycotic, viral and parasitic infections, giving the specific immune response time to become effective. It becomes critically essential in immunocompromised patients who fail to mount specific immune responses due to congenital or acquired immunodeficiencies as a result of chemotherapy, dialysis, immunosuppressive drugs, or HIV infection. The Innate Immunity arsenal constitutes polymorphonuclear and mononuclear phagocytes, mast cells, the complement system, Natural Killer cells, antimicrobial peptides, and presumably a subset of T lymphocytes with TCRl receptors.
Macrophages Biology And Tissue Inflammation In Health And Disease
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Author : Stuart Goodman
language : en
Publisher: Academic Press
Release Date : 2024-07-10
Macrophages Biology And Tissue Inflammation In Health And Disease written by Stuart Goodman and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-10 with Medical categories.
Macrophages Biology and Tissue Inflammation in Health and Disease outlines the important role of macrophages—keys cells in the innate immune system—as regulators and orchestrators of inflammation and repair in health and disease. It contains chapters by leading authors on the basic and translational aspects of macrophage biology, covering how to maintained tissue homeostatis and how to deal with internal and external biological threats. Outlines the important role of macrophages as regulators and orchestrators of inflammation and repair in health and disease Contains chapters by leading authors on the basic and translational aspects of macrophage biology in maintaining tissue homeostasis Deals with internal and external treats
Handbook Of Macrophages
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Author : Hibiki Kai
language : en
Publisher: Nova Science Publishers
Release Date : 2012
Handbook Of Macrophages written by Hibiki Kai and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Immunity categories.
Macrophages are widely distributed innate immune cells, which play a pivotal role not only in the primary response to pathogens but also in adaptive immune response, in tissue repair and in the maintenance of local tissue homoeostasis. This book includes current research in the life cycle, functions and diseases associated with macrophages. Topics discussed include macrophages as regulatory and effector cells in the immune system; macrophages from human pluripotent stem cells; mucosal macrophage phenotype and functionality in homoeostasis and pathology; macrophage plasticity and polarization; defective macrophage function in Crohn's disease; macrophages in viral infection and atherosclerosis; and macrophage polarization in the course and treatment of autoimmune diseases.
Mononuclear Phagocytes
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Author : R. van Furth
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-04-17
Mononuclear Phagocytes written by R. van Furth and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-17 with Medical categories.
Mononuclear phagocytes, which include macrophages, monocytes and their precursor cells, are the most important cells in the host defence against micro-organisms and tumor cells. During the last twenty-five years research on the biology of mononuclear phagocytes has increased tremendously. This motivated Professor R. van Furth to organize five international conferences on this subject in Leiden, the Netherlands. The edited proceedings of these meethings were published: in 1970 Mononuclear Phagocytes; in 1975 Mononuclear Phagocytes in Immunity, Infections and Pathology; in 1980 Mononuclear Phagocytes -- Functional Aspects; and in 1985 Mononuclear Phagocytes -- Characteristics, Physiology and Function. Reviews of these volumes, published in international journals, praised them as the most up-to-date state of the art publications. The publication of 1991 includes 88 chapters written by more than 200 authors.
Disorders Of The Monocyte Macrophage System
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Author : F. Schmalzl
language : en
Publisher: Springer
Release Date : 1981-12-01
Disorders Of The Monocyte Macrophage System written by F. Schmalzl and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1981-12-01 with Science categories.
The origin and function of normal monocytes and macrophages have been clearly defined by extensive investigations in human and in animal models. The central importance ofthis cell system for the biological defense mecha nisms is well established: phagocytosis, inactivation and destruction of organic and inorganic materials, an important role in the initiation ofhumo ral and cell mediated immunological responses, and the secretion of a varie ty of chemical mediator and effector substances are the most important fea tures of this ontogenetically ancient cell system. However, the data on this cellular system are rather recent, and this may explain why relatively little attention has been payed to the pathology of the monocyte-macrophage system (MMS) until now. In addition, this monograph should focus attention on the secondarypa thophysiological implications of the MMS in disorders not primarily origi nating from this system. Several techniques are available to identify even abnormal individuals of this cell system and, therefore, can be employed for the study of severely altered or neoplastic monocytic cells.
Cells Tissues And Disease
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Author : Guido Majno
language : en
Publisher: Oxford University Press
Release Date : 2004-08-26
Cells Tissues And Disease written by Guido Majno and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-08-26 with Medical categories.
This book lays out the principles of general pathology for biomedical researchers, grad students, medical students, and physicians, with elegance and deep insight. Disease processes are explained in the light of malfunctions at the cellular level, offering a rich understanding of the clinical correlates of all aspects of fundamental cellular physiology and basic biomedicine. The book has been fully revised and updated to present a current but deep understanding of disease states at the cell and tissue levels - cellular pathology, inflammation, immunopathology vascular disturbance, and tumor biology.
One No One One Hundred Thousand The Multifaceted Role Of Macrophages In Health And Disease Part A
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Author :
language : en
Publisher: Academic Press
Release Date : 2022-04-20
One No One One Hundred Thousand The Multifaceted Role Of Macrophages In Health And Disease Part A written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-20 with Science categories.
One, No one, One Hundred Thousand - The Multifaceted Role of Macrophages in Health and Disease - Part A, provides in-depth reviews on the last progresses on the role of macrophages in health and diseases with a special focus on the role of macrophages in SARS-COV2, breast cancer, liver and salivary glands. Provides accurate reviews from selected experts on the topic of macrophages in different tissues such as lung, uterus, breast and liver Each chapter of the volume provides useful graphic material for ease of reading of the audience Provides the latest insights and future perspectives on macrophage heterogeneity in different diseases