Bacteriocins Microcins And Lantibiotics
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Bacteriocins Microcins And Lantibiotics
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Author : Richard James
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Bacteriocins Microcins And Lantibiotics written by Richard James and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.
Presented here are recent findings on bacteriocins: plasmid-encoded toxins produced by bacteria, which differ from traditional antibiotics in killing only bacteria that are closely related to the producing strain. Included are introductory chapters on bacteriocins, microcins (low molecular weight bacteriocins), and lantibiotics (peptide antibiotics containing lanthionine), further, contributions on pore forming bacteriocins, the mechanisms of immunity to bacteriocins, uptake and secretion, as well as evolution of bacteriocins. It is of particular interest that the lantibiotic nisin is approved for use as food preservative and another lantibiotic, epidermin, has potential as a therapeutic drug against acne.
Bacteriocins Of Lactic Acid Bacteria
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Author : Luc De Vuyst
language : en
Publisher: Springer
Release Date : 2012-12-06
Bacteriocins Of Lactic Acid Bacteria written by Luc De Vuyst and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
As antibacterial compounds, bacteriocins have always lived in the shadow of those medically important, efficient and often broad-spectrum low-molecular mass antimicrobials, well known even to laypeople as antibiotics. This is despite the fact that bacteriocins were discovered as early as 1928, a year before the penicillin saga started. Bacteriocins are antimicrobial proteins or oligopeptides, displaying a much narrower activity spectrum than antibiotics; they are mainly active against bacterial strains taxonomically closely related to the producer strain, which is usually immune to its own bacteriocin. They form a heterogenous group with regard to the taxonomy of the producing bacterial strains, mode of action, inhibitory spectrum and protein structure and composition. Best known are the colicins and microcins produced by Enterobacteriaceae. Many other Gram-negative as well as Gram-positive bacteria have now been found to produce bacteriocins. In the last decade renewed interest has focused on the bacteriocins from lactic acid bacteria, which are industrially and agriculturally very important. Some of these compounds are even active against food spoilage bacteria and endospore formers and also against certain clinically important (food-borne) pathogens. Recently, bacteriocins from lactic acid bacteria have been studied intensively from every possible scientific angle: microbiology, biochemistry, molecular biology and food technology. Intelligent screening is going on to find novel compounds with unexpected properties, just as has happened (and is still happening) with the antibiotics. Knowledge, especially about bacteriocins from lactic acid bacteria, is accumulating very rapidly.
Bacteriocins And Other Ribosomally Synthesised And Post Translationally Modified Peptides Ripps As Alternatives To Antibiotics
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Author : Harsh Mathur
language : en
Publisher: Frontiers Media SA
Release Date : 2021-08-17
Bacteriocins And Other Ribosomally Synthesised And Post Translationally Modified Peptides Ripps As Alternatives To Antibiotics written by Harsh Mathur and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-17 with Science categories.
Prof Upton is the director of Amprologix, a company developing new bacteriocins; the other editors declare no competing interest in regard to editing this Research Topic.
The Bacteriocins
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Author : Robert L. Dorit
language : en
Publisher: Caister Academic Press Limited
Release Date : 2016
The Bacteriocins written by Robert L. Dorit and has been published by Caister Academic Press Limited this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with Medical categories.
Bacteriocins are potent protein toxins produced by virtually every bacterial and archeal species examined to date. These bactericidal peptides play an important role in regulating competitive interactions in natural microbial systems. From the perspective of human health, the bacteriocins represent a library of potential lead compounds honed over three billion years of evolution. Their narrow target range, high activity, surprising stability and low toxicity position them as viable alternatives or complements to existing small molecule antibiotics. The rise of antibiotic resistant pathogens and the growing awareness of the importance of the microbiome to human health underscore the need for this new class of antimicrobials, emblematic of a new approach to the treatment of infectious disease.In this volume, a range of experts explore our current understanding of the biology of these important compounds, and identify the prospects for their use in medical and veterinary applications. In so doing, this volume introduces the vast diversity of bacteriocin molecules and mechanisms and brings readers to the cutting edge of a new XXIst century approach to antibiotic discovery and design. Topics covered include: the natural history of bacteriocins; killing strategies and applications of microcins; the mode of action of nuclease colicins; the role of the van der Waals zone in the design of a new family of bacteriocins; the use of pyocins in the treatment of infections; the role of streptococccal bacteriocins as oral probiotics; veterinary applications of bacteriocins (nisin) in treating mastitis, and an exploration of the genetics of bacteriocin resistance.This volume is essential reading for everyone involved in antimicrobial research in academia, biotechnology companies, and the pharmaceutical industry and a recommended volume for all microbiology libraries
Bacteriocins Of Lactic Acid Bacteria
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Author : Luc De Vuyst
language : en
Publisher: Springer
Release Date : 1994-01-15
Bacteriocins Of Lactic Acid Bacteria written by Luc De Vuyst and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-01-15 with Juvenile Nonfiction categories.
As antibacterial compounds, bacteriocins have always lived in the shadow of those medically important, efficient and often broad-spectrum low-molecular mass antimicrobials, well known even to laypeople as antibiotics. This is despite the fact that bacteriocins were discovered as early as 1928, a year before the penicillin saga started. Bacteriocins are antimicrobial proteins or oligopeptides, displaying a much narrower activity spectrum than antibiotics; they are mainly active against bacterial strains taxonomically closely related to the producer strain, which is usually immune to its own bacteriocin. They form a heterogenous group with regard to the taxonomy of the producing bacterial strains, mode of action, inhibitory spectrum and protein structure and composition. Best known are the colicins and microcins produced by Enterobacteriaceae. Many other Gram-negative as well as Gram-positive bacteria have now been found to produce bacteriocins. In the last decade renewed interest has focused on the bacteriocins from lactic acid bacteria, which are industrially and agriculturally very important. Some of these compounds are even active against food spoilage bacteria and endospore formers and also against certain clinically important (food-borne) pathogens. Recently, bacteriocins from lactic acid bacteria have been studied intensively from every possible scientific angle: microbiology, biochemistry, molecular biology and food technology. Intelligent screening is going on to find novel compounds with unexpected properties, just as has happened (and is still happening) with the antibiotics. Knowledge, especially about bacteriocins from lactic acid bacteria, is accumulating very rapidly.
Lantibiotics And Related Peptides
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Author : Ralph W. Jack
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-09
Lantibiotics And Related Peptides written by Ralph W. Jack and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-09 with Science categories.
In the last 10 years a proliferation of information concerning the lantibiotics and related peptide antibiotics has come to the fore. This is the first book to summarize this information comprehensively and concisely. Unlike other reviews, which consider the lantibiotics in isolation, this book brings together for the first time the concepts and interrelationships between lantibiotics and other antibiotics, bacteriocins and antimicrobial peptides. This conceptualization should stimulate new ideas, discussion and research in many areas of antibiotic research.
Prokaryotic Antimicrobial Peptides
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Author : Djamel Drider
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-03-08
Prokaryotic Antimicrobial Peptides written by Djamel Drider and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-03-08 with Science categories.
The book will provide an overview of the advancement of fundamental knowledge and applications of antimicrobial peptides in biomedical, agricultural, veterinary, food, and cosmetic products. Antimicrobial peptides stand as potentially great alternatives to current antibiotics, and most research in this newly-created area has been published in journals and other periodicals. It is the editors’ opinion that it is timely to sum up the most important achievements in the field and provide the scientific community in a reference book. The goals of this project include illustrating the achievements made so far, debating the state of the art, and drawing new perspectives.
Lasso Peptides
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Author : Yanyan Li
language : en
Publisher: Springer
Release Date : 2014-10-21
Lasso Peptides written by Yanyan Li and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-21 with Medical categories.
Lasso peptides form a growing family of fascinating ribosomally-synthesized and post-translationally modified peptides produced by bacteria. They contain 15 to 24 residues and share a unique interlocked topology that involves an N-terminal 7 to 9-residue macrolactam ring where the C-terminal tail is threaded and irreversibly trapped. The ring results from the condensation of the N-terminal amino group with a side-chain carboxylate of a glutamate at position 8 or 9, or an aspartate at position 7, 8 or 9. The trapping of the tail involves bulky amino acids located in the tail below and above the ring and/or disulfide bridges connecting the ring and the tail. Lasso peptides are subdivided into three subtypes depending on the absence (class II) or presence of one (class III) or two (class I) disulfide bridges. The lasso topology results in highly compact structures that give to lasso peptides an extraordinary stability towards both protease degradation and denaturing conditions. Lasso peptides are generally receptor antagonists, enzyme inhibitors and/or antibacterial or antiviral (anti-HIV) agents. The lasso scaffold and the associated biological activities shown by lasso peptides on different key targets make them promising molecules with high therapeutic potential. Their application in drug design has been exemplified by the development of an integrin antagonist based on a lasso peptide scaffold. The biosynthesis machinery of lasso peptides is therefore of high biotechnological interest, especially since such highly compact and stable structures have to date revealed inaccessible by peptide synthesis. Lasso peptides are produced from a linear precursor LasA, which undergoes a maturation process involving several steps, in particular cleavage of the leader peptide and cyclization. The post-translational modifications are ensured by a dedicated enzymatic machinery, which is composed of an ATP-dependent cysteine protease (LasB) and a lactam synthetase (LasC) that form an enzymatic complex called lasso synthetase. Microcin J25, produced by Escherichia coli AY25, is the archetype of lasso peptides and the most extensively studied. To date only around forty lasso peptides have been isolated, but genome mining approaches have revealed that they are widely distributed among Proteobacteria and Actinobacteria, particularly in Streptomyces, making available a rich resource of novel lasso peptides and enzyme machineries towards lasso topologies.
Bacteriocins
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Author : Margaret A. Riley
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-11-10
Bacteriocins written by Margaret A. Riley and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-11-10 with Science categories.
Microbes produce an extraordinary array of defense systems. This book tells the fascinating story about the evolutionary histories of bacteriocins and the ecological roles of these biological weapons in microbial communities. The book makes compelling reading for a multi-faceted scientific audience, including those working in the fields of biodiversity and biotechnology, notably in the human and animal health domain.
Peptide Applications In Biomedicine Biotechnology And Bioengineering
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Author : Sotirios Koutsopoulos
language : en
Publisher: Woodhead Publishing
Release Date : 2017-11-16
Peptide Applications In Biomedicine Biotechnology And Bioengineering written by Sotirios Koutsopoulos and has been published by Woodhead Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-16 with Technology & Engineering categories.
Peptide Applications in Biomedicine, Biotechnology and Bioengineering summarizes the current knowledge on peptide applications in biomedicine, biotechnology and bioengineering. After a general introduction to peptides, the book addresses the many applications of peptides in biomedicine and medical technology. Next, the text focuses on peptide applications in biotechnology and bioengineering and reviews of peptide applications in nanotechnology. This book is a valuable resource for biomaterial scientists, polymer scientists, bioengineers, mechanical engineers, synthetic chemists, medical doctors and biologists. Presents a self-contained work for the field of biomedical peptides Summarizes the current knowledge on peptides in biomedicine, biotechnology and bioengineering Covers current and potential applications of biomedical peptides