Bifunctional Guidance Cues In Axon Pathfinding
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Bifunctional Guidance Cues In Axon Pathfinding
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Author : Anna Malgorzata Ustaszewska
language : en
Publisher:
Release Date : 2007
Bifunctional Guidance Cues In Axon Pathfinding written by Anna Malgorzata Ustaszewska and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with categories.
Role Of Dscam In Netrin 1 Mediated Axon Repulsion And Neuronal Migration
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Author : Anish A. Purohit
language : en
Publisher:
Release Date : 2011
Role Of Dscam In Netrin 1 Mediated Axon Repulsion And Neuronal Migration written by Anish A. Purohit and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Axons categories.
Axon pathfinding and neuronal migration are key events for proper nervous system development and function. Neuronal growth cones explore the environment for extracellular cues, which guide the axons along specific paths towards their targets. Netrin-1, a bifunctional guidance cue, binds to receptors deleted in colorectal cancer (DCC) and Down syndrome cell adhesion molecule (DSCAM) mediating axon attraction, and uncoordinated-5 (UNC5) mediating axon repulsion. The DCC/UNC5 heterodimer also modulates netrin-1 repulsion in the developing nervous system. We found that DSCAM interacts with UNC5C and netrin-1 stimulation increases this interaction in postnatal cerebellar cells. Therefore, we hypothesize that DSCAM may play a role in netrin-1 repulsion. Here we show that in an in vitro growth cone collapse assay, netrin-1 induces mouse cerebellum external granule layer (EGL) cell growth cone collapse. The DSCAM intracellular domain modulates netrin-1 induced axon repulsion. Inhibiting DSCAM intracellular signaling causes aberrant neuronal migration in the postnatal cerebellar EGL cells ex vivo. Thus, DSCAM plays a critical role in netrin-1 repulsion.
Cellular Migration And Formation Of Neuronal Connections
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Author :
language : en
Publisher: Academic Press
Release Date : 2013-05-06
Cellular Migration And Formation Of Neuronal Connections written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-06 with Science categories.
The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. Each volume in the series consists of review style articles that average 15-20pp and feature numerous illustrations and full references. Volume 2 offers 56 high level articles devoted mainly to Formation of Axons and Dendrites, Migration, Synaptogenesis, Developmental Sequences in the Maturation of Intrinsic and Synapse Driven Patterns. Series offers 144 articles for 2904 full color pages addressing ways in which the nervous system and its components develop Features leading experts in various subfields as Section Editors and article Authors All articles peer reviewed by Section Editors to ensure accuracy, thoroughness, and scholarship Volume 2 sections include coverage of mechanisms which regulate: the formation of axons and dendrites, cell migration, synapse formation and maintenance during development, and neural activity, from cell-intrinsic maturation to early correlated patterns of activity
Receptor Tyrosine Kinases Family And Subfamilies
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Author : Deric L. Wheeler
language : en
Publisher: Springer
Release Date : 2015-07-31
Receptor Tyrosine Kinases Family And Subfamilies written by Deric L. Wheeler and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-31 with Science categories.
This book devotes a chapter to each RTK family and the multiple receptors within each family, thoroughly covering all of the RTKs. The chapters all follow the same structure, presenting this essential information in an accessible and user-friendly format. Each chapter covers one specific family of receptors and begins with a general introduction to that family and a comprehensive discussion of that receptor’s family in development and human disease. Following are in-depth analyses of each family’s receptors with discussions on the gene, protein, ligands, activation, and signaling pathways along with discussion of receptor processing and signal attenuation. Further, cross talk with other receptors systems, post-translational modification and specific unique characteristics to each RTK are discussed. Because it isolates and explains each family, this book is an essential companion volume to Receptor Tyrosine Kinases: Structure, Functions and Role in Human Disease, by the same authors, which talks about RTKs more generally and without the family-by-family detail.
Neuronal Guidance
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Author : Marc Tessier-Lavigne
language : en
Publisher:
Release Date : 2011
Neuronal Guidance written by Marc Tessier-Lavigne and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Medical categories.
During the development of the brain growing nerves send out neuronal processes (axons and dendrites) that connect them to other nerve cells, sensory organs, and muscle tissue. Correct targeting of these is the basis for wiring of the entire nervous system and depends on attractive and repulsive molecular cues that guide the developing neurons to the appropriate destination. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines the mechanisms underlying neuronal guidance and branching and their roles in the development and function of the nervous system. The contributors examine the major guidance cues and their receptors, the intracellular signaling pathways they activate, and their function in the context of important phenomena such as laminar organization and dendrite spacing. Other chapters consider the roles of guidance cues in development of neuronal circuits dedicated to the processing of particular sensory stimuli, such as the visual and olfactory systems. In addition, they cover the roles played by guidance cues and their receptors in neuronal regeneration and human genetic disorders, revealing important clinical implications of work in this field. The book also contains chapters discussing the function of guidance molecules in other processes, such as neuronal cell body migration, axon pruning, and regulation of neuronal cell death. In addition, it explores their roles outside the nervous system for example, in development of the vasculature. This volume is thus of general interest to cell and developmental biologists, as well as all neurobiologists interested in how the nervous system develops and functions.
Patterning And Cell Type Specification In The Developing Cns And Pns
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Author : Bin Chen
language : en
Publisher: Academic Press
Release Date : 2020-06-02
Patterning And Cell Type Specification In The Developing Cns And Pns written by Bin Chen and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-02 with Medical categories.
Patterning and Cell Type Specification in the Developing CNS and PNS, Second Edition, the latest release in the Comprehensive Developmental Neuroscience series, presents recent advances in genetic, molecular and cellular methods that have generated a massive increase in new information. The book provides a much-needed update to underscore the latest research in this rapidly evolving field, with new section editors discussing the technological advances that are enabling the pursuit of new research on brain development. This volume focuses on neural patterning and cell type specification in the developing central and peripheral nervous systems. Features leading experts in various subfields as section editors and article authors Contains articles that are peer reviewed to ensure accuracy, thoroughness and scholarship Covers mechanisms which control regional specification, regulate proliferation of neuronal progenitors, control differentiation and survival of specific neuronal subtypes, and control the development of non-neural cells
Kaufman S Atlas Of Mouse Development Supplement
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Author : Richard Baldock
language : en
Publisher: Academic Press
Release Date : 2015-09-23
Kaufman S Atlas Of Mouse Development Supplement written by Richard Baldock and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-23 with Science categories.
Kaufman's Atlas of Mouse Development: With Coronal Sections continues the stellar reputation of the original Atlas by providing updated, in-depth anatomical content and morphological views of organ systems.The publication offers written descriptions of the developmental origins of the organ systems alongside high-resolution images for needed visualization of developmental processes. Matt Kaufman himself has annotated the coronal images in the same clear, meticulous style of the original Atlas. Kaufman's Atlas of Mouse Development: With Coronal Sections follows the original Atlas as a continuation of the standard in the field for developmental biologists and researchers across biological and biomedical sciences studying mouse development. Provides high-resolution images for best visualization of key developmental processes and structures Offers in-depth anatomy and morphological views of organ systems Written descriptions convey developmental origins of the organ systems
Rna Metabolism In Neurodegenerative Diseases
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Author : Rita Sattler
language : en
Publisher: Springer
Release Date : 2018-06-18
Rna Metabolism In Neurodegenerative Diseases written by Rita Sattler and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-18 with Medical categories.
It has become evident over the last years that abnormalities in RNA processing play a fundamental part in the pathogenesis of neurodegenerative diseases. Cellular viability depends on proper regulation of RNA metabolism and subsequent protein synthesis, which requires the interplay of many processes including transcription, pre--‐mRNA splicing, mRNA editing as well as mRNA stability, transport and translation. Dysfunction in any of these processes, often caused by mutations in the coding and non--‐ coding RNAs, can be very destructive to the cellular environment and consequently impair neural viability. The result of this RNA toxicity can lead to a toxic gain of function or a loss of function, depending on the nature of the mutation. For example, in repeat expansion disorders, such as the newly discovered hexanucleotide repeat expansion in theC9orf72 gene found in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), a toxic gain of function leads to the formation of RNA foci and the sequestration of RNA binding proteins (RBPs). This in return leads to a loss of function of those RBPs, which is hypothesized to play a significant part in the disease progression of ALS and FTD. Other toxicities arising from repeat expansions are the formation of RNA foci, bi--‐directional transcription and production of repeat associated non--‐ATG (RAN) translation products. This book will touch upon most of these disease mechanisms triggered by aberrant RNA metabolism and will therefore provide a broad perspective of the role of RNA processing and its dysfunction in a variety of neurodegenerative disorders, including ALS, FTD, Alzheimer’s disease, Huntington’s disease, spinal muscular atrophy, myotonic dystrophy and ataxias. The proposed authors are leading scientists in the field and are expected to not only discuss their own work, but to be inclusive of historic as well as late breaking discoveries. The compiled chapters will therefore provide a unique collection of novel studies and hypotheses aimed to describe the consequences of altered RNA processing events and its newest molecular players and pathways.
Glycobiology Of The Nervous System
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Author : Robert K. Yu
language : en
Publisher: Springer
Release Date : 2014-08-23
Glycobiology Of The Nervous System written by Robert K. Yu and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-08-23 with Medical categories.
A thorough introduction is provided to the variety and complexity of the roles that glycoconjugates play in the cells of the nervous system. Basic information as well as the latest developments in neural glycobiology are discussed. Topics covered range from the structure and metabolism of the saccharide chains and current approaches used in their study, to changes glycoconjugates undergo during development and aging of the nervous system and the roles they have in neurological disease. The breadth and depth of topics covered make it an essential reference for those new to the field as well more seasoned investigators.
International Review Of Cell And Molecular Biology
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Author : Kwang W. Jeon
language : en
Publisher: Academic Press
Release Date : 2008-06-02
International Review Of Cell And Molecular Biology written by Kwang W. Jeon and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-06-02 with Science categories.
International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology—both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research. Authored by some of the foremost scientists in the field Provides up-to-date information and directions for future research Valuable reference material for advanced undergraduates, graduate students and professional scientists