Bioinformatics Analysis Of Omics Data For Biomarker Identification In Clinical Research
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Bioinformatics Analysis Of Omics Data For Biomarker Identification In Clinical Research
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Author : Lixin Cheng
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-10
Bioinformatics Analysis Of Omics Data For Biomarker Identification In Clinical Research written by Lixin Cheng and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-10 with Science categories.
Bioinformatics Analysis Of Omics Data For Biomarker Identification In Clinical Research Volume Ii
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Author : Lixin Cheng
language : en
Publisher: Frontiers Media SA
Release Date : 2023-09-05
Bioinformatics Analysis Of Omics Data For Biomarker Identification In Clinical Research Volume Ii written by Lixin Cheng and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-05 with Science categories.
This Research Topic is part of a series with, "Bioinformatics Analysis of Omics Data for Biomarker Identification in Clinical Research - Volume I" (https://www.frontiersin.org/research-topics/13816/bioinformatics-analysis-of-omics-data-for-biomarker-identification-in-clinical-research) The advances and the decreasing cost of omics data enable profiling of disease molecular features at different levels, including bulk tissues, animal models, and single cells. Large volumes of omics data enhance the ability to search for information for preclinical study and provide the opportunity to leverage them to understand disease mechanisms, identify molecular targets for therapy, and detect biomarkers of treatment response. Identification of stable, predictive, and interpretable biomarkers is a significant step towards personalized medicine and therapy. Omics data from genomics, transcriptomics, proteomics, epigenomics, metagenomics, and metabolomics help to determine biomarkers for prognostic and diagnostic applications. Preprocessing of omics data is of vital importance as it aims to eliminate systematic experimental bias and technical variation while preserving biological variation. Dozens of normalization methods for correcting experimental variation and bias in omics data have been developed during the last two decades, while only a few consider the skewness between different sample states, such as the extensive over-repression of genes in cancers. The choice of normalization methods determines the fate of identified biomarkers or molecular signatures. From these considerations, the development of appropriate normalization methods or preprocessing strategies may promote biomarker identification and facilitate clinical decision-making.
Evolution Of Translational Omics
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2012-09-13
Evolution Of Translational Omics written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-09-13 with Science categories.
Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.
The Hidden World Of Protein Aggregation
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Author :
language : en
Publisher: Elsevier
Release Date : 2024-05-30
The Hidden World Of Protein Aggregation written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-30 with Science categories.
The Hidden World of Protein Aggregation, Volume 206 provides a comprehensive exploration of protein aggregation, uncovering the factors behind the formation of amorphous aggregates and ordered structures called amyloid fibrils. It delves into the advantages and disadvantages of protein aggregates, addressing topics such as cytotoxicity and disorders linked to misfolding. Specific chapters in this release include Protein Aggregation: An Overview, Pathways of Amyloid Fibril Formation and Aggregation, Factors Influencing Amyloid Fibril Formation, Morphological Features and Types of Aggregated Structures, Each big journey starts with a first step: Importance of Oligomerization, Liquid-Liquid Phase Separation as Triggering Factor of Fibril Formation, and more.Additional sections cover Experimental Techniques for Detecting and Evaluating the Amyloid Fibrils, Prediction of Protein Aggregation, Amyloid Fibril Cytotoxicity and Associated Disorders, Inhibitors of Amyloid Fibril Formation, Therapeutic Approaches in Proteinopathies, Functional Amyloids, Biotechnological Applications of Amyloid Fibrils, and The Hidden World of Protein Aggregation. - Provides an introduction to the folding of protein and associated conditions leading to aggregation and linked pathology - Discusses structural biology and computational methodologies for analysis of protein (mis)folding and aggregation - Describes functional amyloids and their biotechnological applications
Exploring Noninvasive Disease Biomarkers With Urinary Omics Analysis
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Author : Arup Giri
language : en
Publisher: Academic Press
Release Date : 2025-05-30
Exploring Noninvasive Disease Biomarkers With Urinary Omics Analysis written by Arup Giri and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-05-30 with Science categories.
Exploring Noninvasive Disease Biomarkers with Urinary Omics Analysis offers a transformative journey into the world of non-invasive diagnostics. This comprehensive volume delves into the molecular foundations of urinary biomarkers, illuminating the intricate signatures that indicate various pathological conditions and elucidating the mechanisms behind their release into urine. Readers will gain invaluable insights into cutting-edge analytical technologies, methodologies, and data integration techniques essential for biomarker discovery. From genomic approaches to transcriptomics, proteomics, and metabolomics, each chapter provides a thorough examination of the latest advancements, accompanied by practical guidance and case studies showcasing their clinical applications across diverse health conditions.In addition to the foundational knowledge, the book highlights the clinical applications of urinary omics in diagnosing renal disorders, metabolic syndromes, and infectious diseases. It equips professionals and students with the tools needed to navigate the complexities of urinary omics, revolutionize personalized medicine, and advance transformative healthcare solutions. The practical guidance and case studies included in the book make it an invaluable resource for those looking to implement these advanced diagnostic techniques in clinical settings. - Provides a comprehensive exploration of urinary omics, including an in-depth analysis of genomics, proteomics, and metabolomics - Highlights advances in analytical technologies for analyzing urinary biomarkers, offering a comprehensive overview - Elucidates clinical application across health conditions, highlighting a holistic examination of urine's potential as a diagnostic reservoir
Cancer Biomarkers In Diagnosis And Therapeutics
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Author : Adeeb Shehzad
language : en
Publisher: Springer Nature
Release Date : 2022-05-27
Cancer Biomarkers In Diagnosis And Therapeutics written by Adeeb Shehzad and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-27 with Medical categories.
This book illustrates the basics and underlying molecular machinery of cancer cells and biochemical assays that detect the type and stage of cancer through cell signaling biomarkers. It starts with a brief introduction to cancer biomarkers and addresses technologies for identifying and validating cancer biomarkers, biomarkers for cancer drug development, prognostic and diagnostic biomarkers, and microbiome as cancer biomarkers. It reviews predictive biomarkers for anticancer drugs, biomarkers in cancer survival and drug resistance, biomarkers in tumor recurrence and metastasis, the role of the biomarker in immunotherapy and personalized medicine, and the development of a novel cancer biomarker. Finally, this book also underpins the role of nanotechnology in the use and detection of cancer biomarkers for enhanced sensitivity and specificity. Lastly, it discusses the challenges with biomarkers in cancer drug discovery and development. This volume is an indispensable tool for researchers working in the field of cancer and also for clinical oncologists.
Bioinformatics For Diagnosis Prognosis And Treatment Of Complex Diseases
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Author : Bairong Shen
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-25
Bioinformatics For Diagnosis Prognosis And Treatment Of Complex Diseases written by Bairong Shen and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-25 with Science categories.
The book introduces the bioinformatics tools, databases and strategies for the translational research, focuses on the biomarker discovery based on integrative data analysis and systems biological network reconstruction. With the coming of personal genomics era, the biomedical data will be accumulated fast and then it will become reality for the personalized and accurate diagnosis, prognosis and treatment of complex diseases. The book covers both state of the art of bioinformatics methodologies and the examples for the identification of simple or network biomarkers. In addition, bioinformatics software tools and scripts are provided to the practical application in the study of complex diseases. The present state, the future challenges and perspectives were discussed. The book is written for biologists, biomedical informatics scientists and clinicians, etc. Dr. Bairong Shen is Professor and Director of Center for Systems Biology, Soochow University; he is also Director of Taicang Center for Translational Bioinformatics.
Biomarker Detection Algorithms And Tools For Medical Imaging Or Omic Data
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Author : Fengfeng Zhou
language : en
Publisher: Frontiers Media SA
Release Date : 2022-07-13
Biomarker Detection Algorithms And Tools For Medical Imaging Or Omic Data written by Fengfeng Zhou and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-13 with Science categories.
Biomarkers In Drug Development
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Author : Michael R. Bleavins
language : en
Publisher: John Wiley & Sons
Release Date : 2011-09-20
Biomarkers In Drug Development written by Michael R. Bleavins and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-20 with Medical categories.
Discover how biomarkers can boost the success rate of drug development efforts As pharmaceutical companies struggle to improve the success rate and cost-effectiveness of the drug development process, biomarkers have emerged as a valuable tool. This book synthesizes and reviews the latest efforts to identify, develop, and integrate biomarkers as a key strategy in translational medicine and the drug development process. Filled with case studies, the book demonstrates how biomarkers can improve drug development timelines, lower costs, facilitate better compound selection, reduce late-stage attrition, and open the door to personalized medicine. Biomarkers in Drug Development is divided into eight parts: Part One offers an overview of biomarkers and their role in drug development. Part Two highlights important technologies to help researchers identify new biomarkers. Part Three examines the characterization and validation process for both drugs and diagnostics, and provides practical advice on appropriate statistical methods to ensure that biomarkers fulfill their intended purpose. Parts Four through Six examine the application of biomarkers in discovery, preclinical safety assessment, clinical trials, and translational medicine. Part Seven focuses on lessons learned and the practical aspects of implementing biomarkers in drug development programs. Part Eight explores future trends and issues, including data integration, personalized medicine, and ethical concerns. Each of the thirty-eight chapters was contributed by one or more leading experts, including scientists from biotechnology and pharmaceutical firms, academia, and the U.S. Food and Drug Administration. Their contributions offer pharmaceutical and clinical researchers the most up-to-date understanding of the strategies used for and applications of biomarkers in drug development.
Artificial Intelligence Bioinformatics Development And Application Of Tools For Omics And Inter Omics Studies
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Author : Angelo Facchiano
language : en
Publisher: Frontiers Media SA
Release Date : 2020-06-18
Artificial Intelligence Bioinformatics Development And Application Of Tools For Omics And Inter Omics Studies written by Angelo Facchiano and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-18 with categories.