Bioinformatics Analysis Of Omics Data For Biomarker Identification In Clinical Research
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Bioinformatics Analysis Of Omics Data For Biomarker Identification In Clinical Research
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Author : Lixin Cheng
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-10
Bioinformatics Analysis Of Omics Data For Biomarker Identification In Clinical Research written by Lixin Cheng and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-10 with Science categories.
Bioinformatics Analysis Of Omics Data For Biomarker Identification In Clinical Research Volume Ii
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Author : Lixin Cheng
language : en
Publisher: Frontiers Media SA
Release Date : 2023-09-05
Bioinformatics Analysis Of Omics Data For Biomarker Identification In Clinical Research Volume Ii written by Lixin Cheng and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-05 with Science categories.
This Research Topic is part of a series with, "Bioinformatics Analysis of Omics Data for Biomarker Identification in Clinical Research - Volume I" (https://www.frontiersin.org/research-topics/13816/bioinformatics-analysis-of-omics-data-for-biomarker-identification-in-clinical-research) The advances and the decreasing cost of omics data enable profiling of disease molecular features at different levels, including bulk tissues, animal models, and single cells. Large volumes of omics data enhance the ability to search for information for preclinical study and provide the opportunity to leverage them to understand disease mechanisms, identify molecular targets for therapy, and detect biomarkers of treatment response. Identification of stable, predictive, and interpretable biomarkers is a significant step towards personalized medicine and therapy. Omics data from genomics, transcriptomics, proteomics, epigenomics, metagenomics, and metabolomics help to determine biomarkers for prognostic and diagnostic applications. Preprocessing of omics data is of vital importance as it aims to eliminate systematic experimental bias and technical variation while preserving biological variation. Dozens of normalization methods for correcting experimental variation and bias in omics data have been developed during the last two decades, while only a few consider the skewness between different sample states, such as the extensive over-repression of genes in cancers. The choice of normalization methods determines the fate of identified biomarkers or molecular signatures. From these considerations, the development of appropriate normalization methods or preprocessing strategies may promote biomarker identification and facilitate clinical decision-making.
The Hidden World Of Protein Aggregation
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Author :
language : en
Publisher: Elsevier
Release Date : 2024-05-30
The Hidden World Of Protein Aggregation written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-30 with Science categories.
The Hidden World of Protein Aggregation, Volume 206 provides a comprehensive exploration of protein aggregation, uncovering the factors behind the formation of amorphous aggregates and ordered structures called amyloid fibrils. It delves into the advantages and disadvantages of protein aggregates, addressing topics such as cytotoxicity and disorders linked to misfolding. Specific chapters in this release include Protein Aggregation: An Overview, Pathways of Amyloid Fibril Formation and Aggregation, Factors Influencing Amyloid Fibril Formation, Morphological Features and Types of Aggregated Structures, Each big journey starts with a first step: Importance of Oligomerization, Liquid-Liquid Phase Separation as Triggering Factor of Fibril Formation, and more.Additional sections cover Experimental Techniques for Detecting and Evaluating the Amyloid Fibrils, Prediction of Protein Aggregation, Amyloid Fibril Cytotoxicity and Associated Disorders, Inhibitors of Amyloid Fibril Formation, Therapeutic Approaches in Proteinopathies, Functional Amyloids, Biotechnological Applications of Amyloid Fibrils, and The Hidden World of Protein Aggregation. - Provides an introduction to the folding of protein and associated conditions leading to aggregation and linked pathology - Discusses structural biology and computational methodologies for analysis of protein (mis)folding and aggregation - Describes functional amyloids and their biotechnological applications
Exploring Noninvasive Disease Biomarkers With Urinary Omics Analysis
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Author : Arup Giri
language : en
Publisher: Academic Press
Release Date : 2025-05-30
Exploring Noninvasive Disease Biomarkers With Urinary Omics Analysis written by Arup Giri and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-05-30 with Science categories.
Exploring Noninvasive Disease Biomarkers with Urinary Omics Analysis offers a transformative journey into the world of non-invasive diagnostics. This comprehensive volume delves into the molecular foundations of urinary biomarkers, illuminating the intricate signatures that indicate various pathological conditions and elucidating the mechanisms behind their release into urine. Readers will gain invaluable insights into cutting-edge analytical technologies, methodologies, and data integration techniques essential for biomarker discovery. From genomic approaches to transcriptomics, proteomics, and metabolomics, each chapter provides a thorough examination of the latest advancements, accompanied by practical guidance and case studies showcasing their clinical applications across diverse health conditions.In addition to the foundational knowledge, the book highlights the clinical applications of urinary omics in diagnosing renal disorders, metabolic syndromes, and infectious diseases. It equips professionals and students with the tools needed to navigate the complexities of urinary omics, revolutionize personalized medicine, and advance transformative healthcare solutions. The practical guidance and case studies included in the book make it an invaluable resource for those looking to implement these advanced diagnostic techniques in clinical settings. - Provides a comprehensive exploration of urinary omics, including an in-depth analysis of genomics, proteomics, and metabolomics - Highlights advances in analytical technologies for analyzing urinary biomarkers, offering a comprehensive overview - Elucidates clinical application across health conditions, highlighting a holistic examination of urine's potential as a diagnostic reservoir
Cancer Biomarkers In Diagnosis And Therapeutics
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Author : Adeeb Shehzad
language : en
Publisher: Springer Nature
Release Date : 2022-05-27
Cancer Biomarkers In Diagnosis And Therapeutics written by Adeeb Shehzad and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-27 with Medical categories.
This book illustrates the basics and underlying molecular machinery of cancer cells and biochemical assays that detect the type and stage of cancer through cell signaling biomarkers. It starts with a brief introduction to cancer biomarkers and addresses technologies for identifying and validating cancer biomarkers, biomarkers for cancer drug development, prognostic and diagnostic biomarkers, and microbiome as cancer biomarkers. It reviews predictive biomarkers for anticancer drugs, biomarkers in cancer survival and drug resistance, biomarkers in tumor recurrence and metastasis, the role of the biomarker in immunotherapy and personalized medicine, and the development of a novel cancer biomarker. Finally, this book also underpins the role of nanotechnology in the use and detection of cancer biomarkers for enhanced sensitivity and specificity. Lastly, it discusses the challenges with biomarkers in cancer drug discovery and development. This volume is an indispensable tool for researchers working in the field of cancer and also for clinical oncologists.
Biomarker Detection Algorithms And Tools For Medical Imaging Or Omic Data
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Author : Fengfeng Zhou
language : en
Publisher: Frontiers Media SA
Release Date : 2022-07-13
Biomarker Detection Algorithms And Tools For Medical Imaging Or Omic Data written by Fengfeng Zhou and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-13 with Science categories.
Multimodal And Integrative Analysis Of Single Cell Or Bulk Sequencing Data
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Author : Geng Chen
language : en
Publisher: Frontiers Media SA
Release Date : 2021-04-07
Multimodal And Integrative Analysis Of Single Cell Or Bulk Sequencing Data written by Geng Chen and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-07 with Science categories.
Noninvasive Molecular Markers In Gynecologic Cancers
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Author : Debmalya Barh
language : en
Publisher: CRC Press
Release Date : 2015-01-22
Noninvasive Molecular Markers In Gynecologic Cancers written by Debmalya Barh and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-01-22 with Medical categories.
Early detection is critical for any given cancer. With the advent of the latest omics technologies, molecular markers in combination with conventional diagnostic and screening methods are emerging as next-generation early diagnostic and prognostic strategies that can allow early-stage diagnosis, resulting in more effective treatment and patient car
Identification Of Multi Biomarker For Cancer Diagnosis And Prognosis Based On Network Model And Multi Omics Data
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Author : Chunquan Li
language : en
Publisher: Frontiers Media SA
Release Date : 2023-03-02
Identification Of Multi Biomarker For Cancer Diagnosis And Prognosis Based On Network Model And Multi Omics Data written by Chunquan Li and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-02 with Science categories.
Biochemical Aspects Of Metabolic Disorders
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Author : Muhammad Sajid Hamid Akash
language : en
Publisher: Academic Press
Release Date : 2025-05-17
Biochemical Aspects Of Metabolic Disorders written by Muhammad Sajid Hamid Akash and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-05-17 with Medical categories.
Biochemical Aspects of Metabolic Disorders offers a comprehensive exploration of the intricate biochemical mechanisms and/or pathways underlying a wide array of metabolic disorders. From the genetic basis of inherited metabolic conditions to the environmental factors impacting metabolic dysregulation, each chapter investigates the molecular insights essential for understanding and managing these complex diseases. Covering topics such as carbohydrate and lipid metabolism disorders, amino acid catabolism, hepatic and renal metabolism, mitochondrial dysfunction, pediatric obesity, and diagnostic approaches, this book will serve as a requisite resource for researchers, clinicians, and students alike looking for unravel the biochemical intricacies of metabolic disorders. - Provides comprehensive coverage of various aspects of metabolic disorders, including carbohydrate and lipid metabolism disorders and amino acid metabolism disorders - Offers detailed molecular insight into the biochemical mechanisms and/or pathways involved in metabolic disorders, helping readers understand the underlying mechanisms driving disease pathogenesis - Includes diagnostic algorithms and therapeutic approaches, enabling readers to apply biochemical knowledge to real-world clinical scenarios