Bioinformatics Analysis Of Omics Data For Biomarker Identification In Clinical Research Volume Ii
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Bioinformatics Analysis Of Omics Data For Biomarker Identification In Clinical Research Volume Ii
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Author : Lixin Cheng
language : en
Publisher: Frontiers Media SA
Release Date : 2023-09-05
Bioinformatics Analysis Of Omics Data For Biomarker Identification In Clinical Research Volume Ii written by Lixin Cheng and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-05 with Science categories.
This Research Topic is part of a series with, "Bioinformatics Analysis of Omics Data for Biomarker Identification in Clinical Research - Volume I" (https://www.frontiersin.org/research-topics/13816/bioinformatics-analysis-of-omics-data-for-biomarker-identification-in-clinical-research) The advances and the decreasing cost of omics data enable profiling of disease molecular features at different levels, including bulk tissues, animal models, and single cells. Large volumes of omics data enhance the ability to search for information for preclinical study and provide the opportunity to leverage them to understand disease mechanisms, identify molecular targets for therapy, and detect biomarkers of treatment response. Identification of stable, predictive, and interpretable biomarkers is a significant step towards personalized medicine and therapy. Omics data from genomics, transcriptomics, proteomics, epigenomics, metagenomics, and metabolomics help to determine biomarkers for prognostic and diagnostic applications. Preprocessing of omics data is of vital importance as it aims to eliminate systematic experimental bias and technical variation while preserving biological variation. Dozens of normalization methods for correcting experimental variation and bias in omics data have been developed during the last two decades, while only a few consider the skewness between different sample states, such as the extensive over-repression of genes in cancers. The choice of normalization methods determines the fate of identified biomarkers or molecular signatures. From these considerations, the development of appropriate normalization methods or preprocessing strategies may promote biomarker identification and facilitate clinical decision-making.
Bioinformatics Analysis Of Omics Data For Biomarker Identification In Clinical Research
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Author : Lixin Cheng
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-10
Bioinformatics Analysis Of Omics Data For Biomarker Identification In Clinical Research written by Lixin Cheng and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-10 with Science categories.
The Hidden World Of Protein Aggregation
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Author :
language : en
Publisher: Elsevier
Release Date : 2024-05-30
The Hidden World Of Protein Aggregation written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-30 with Science categories.
The Hidden World of Protein Aggregation, Volume 206 provides a comprehensive exploration of protein aggregation, uncovering the factors behind the formation of amorphous aggregates and ordered structures called amyloid fibrils. It delves into the advantages and disadvantages of protein aggregates, addressing topics such as cytotoxicity and disorders linked to misfolding. Specific chapters in this release include Protein Aggregation: An Overview, Pathways of Amyloid Fibril Formation and Aggregation, Factors Influencing Amyloid Fibril Formation, Morphological Features and Types of Aggregated Structures, Each big journey starts with a first step: Importance of Oligomerization, Liquid-Liquid Phase Separation as Triggering Factor of Fibril Formation, and more.Additional sections cover Experimental Techniques for Detecting and Evaluating the Amyloid Fibrils, Prediction of Protein Aggregation, Amyloid Fibril Cytotoxicity and Associated Disorders, Inhibitors of Amyloid Fibril Formation, Therapeutic Approaches in Proteinopathies, Functional Amyloids, Biotechnological Applications of Amyloid Fibrils, and The Hidden World of Protein Aggregation. - Provides an introduction to the folding of protein and associated conditions leading to aggregation and linked pathology - Discusses structural biology and computational methodologies for analysis of protein (mis)folding and aggregation - Describes functional amyloids and their biotechnological applications
Bioinformatics Tools And Web Server For Cancer Biomarker Development Volume Ii
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Author : Xiangqian Guo
language : en
Publisher: Frontiers Media SA
Release Date : 2022-06-16
Bioinformatics Tools And Web Server For Cancer Biomarker Development Volume Ii written by Xiangqian Guo and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-16 with Science categories.
Omics Data Integration Towards Mining Of Phenotype Specific Biomarkers In Cancer Volume Ii
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Author : Liang Cheng
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-29
Omics Data Integration Towards Mining Of Phenotype Specific Biomarkers In Cancer Volume Ii written by Liang Cheng and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-29 with Science categories.
Exploring Noninvasive Disease Biomarkers With Urinary Omics Analysis
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Author : Arup Giri
language : en
Publisher: Academic Press
Release Date : 2025-05-30
Exploring Noninvasive Disease Biomarkers With Urinary Omics Analysis written by Arup Giri and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-05-30 with Science categories.
Exploring Noninvasive Disease Biomarkers with Urinary Omics Analysis offers a transformative journey into the world of non-invasive diagnostics. This comprehensive volume delves into the molecular foundations of urinary biomarkers, illuminating the intricate signatures that indicate various pathological conditions and elucidating the mechanisms behind their release into urine. Readers will gain invaluable insights into cutting-edge analytical technologies, methodologies, and data integration techniques essential for biomarker discovery. From genomic approaches to transcriptomics, proteomics, and metabolomics, each chapter provides a thorough examination of the latest advancements, accompanied by practical guidance and case studies showcasing their clinical applications across diverse health conditions.In addition to the foundational knowledge, the book highlights the clinical applications of urinary omics in diagnosing renal disorders, metabolic syndromes, and infectious diseases. It equips professionals and students with the tools needed to navigate the complexities of urinary omics, revolutionize personalized medicine, and advance transformative healthcare solutions. The practical guidance and case studies included in the book make it an invaluable resource for those looking to implement these advanced diagnostic techniques in clinical settings. - Provides a comprehensive exploration of urinary omics, including an in-depth analysis of genomics, proteomics, and metabolomics - Highlights advances in analytical technologies for analyzing urinary biomarkers, offering a comprehensive overview - Elucidates clinical application across health conditions, highlighting a holistic examination of urine's potential as a diagnostic reservoir
Cancer Biomarkers In Diagnosis And Therapeutics
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Author : Adeeb Shehzad
language : en
Publisher: Springer Nature
Release Date : 2022-05-27
Cancer Biomarkers In Diagnosis And Therapeutics written by Adeeb Shehzad and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-27 with Medical categories.
This book illustrates the basics and underlying molecular machinery of cancer cells and biochemical assays that detect the type and stage of cancer through cell signaling biomarkers. It starts with a brief introduction to cancer biomarkers and addresses technologies for identifying and validating cancer biomarkers, biomarkers for cancer drug development, prognostic and diagnostic biomarkers, and microbiome as cancer biomarkers. It reviews predictive biomarkers for anticancer drugs, biomarkers in cancer survival and drug resistance, biomarkers in tumor recurrence and metastasis, the role of the biomarker in immunotherapy and personalized medicine, and the development of a novel cancer biomarker. Finally, this book also underpins the role of nanotechnology in the use and detection of cancer biomarkers for enhanced sensitivity and specificity. Lastly, it discusses the challenges with biomarkers in cancer drug discovery and development. This volume is an indispensable tool for researchers working in the field of cancer and also for clinical oncologists.
Rna Modifications And Epitranscriptomics Volume Ii
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Author : Giovanni Nigita
language : en
Publisher: Frontiers Media SA
Release Date : 2023-06-30
Rna Modifications And Epitranscriptomics Volume Ii written by Giovanni Nigita and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-30 with Science categories.
Computational Genomics And Structural Bioinformatics In Personalized Medicines Volume Ii
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Author : George Priya Doss C
language : en
Publisher: Frontiers Media SA
Release Date : 2023-11-06
Computational Genomics And Structural Bioinformatics In Personalized Medicines Volume Ii written by George Priya Doss C and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-06 with Medical categories.
Medical Biochemistry E Book
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Author : John W Baynes
language : en
Publisher: Elsevier Health Sciences
Release Date : 2018-01-03
Medical Biochemistry E Book written by John W Baynes and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-03 with Medical categories.
Now fully revised, this acclaimed textbook efficiently links basic biochemistry with the day-to-day practice of medicine. You will learn basic science concepts and see them illustrated by clinical cases that describe patients you will likely encounter in your clinical training. You will also learn about the use of laboratory tests to diagnose and monitor the most important conditions. Brought to you in a thorough yet accessible manner, this new edition of Medical Biochemistry highlights the latest developments in regulatory and molecular biology, signal transduction, biochemistry and biomarkers of chronic disease, and bioinformatics and the '–omics'. It highlights the most important global medical issues: diabetes mellitus, obesity and malnutrition, cancer and atherosclerotic cardiovascular disease, and addresses the role of nutrition and exercise in medicine. Featuring a team of expert contributors that includes investigators involved in cutting-edge research as well as experienced clinicians, this book offers a unique combination of research and clinical practice tailored to today's integrated courses. - Read organ-focused chapters addressing the biochemistry of the bone, kidney, liver, lungs and muscle; and system-focused ones addressing the biochemistry of the immune and endocrine systems, neurochemistry and neurotransmission, and cancer - Featuring a team of expert contributors that includes investigators involved in cutting-edge research as well as experienced clinicians, this book offers a unique combination of research and clinical practice tailored to today's integrated courses. - Read organ-focused chapters addressing the biochemistry of the bone, kidney, liver, lungs and muscle; and system-focused ones addressing the biochemistry of the immune and endocrine systems, neurochemistry and neurotransmission, and cancer