Bioinformatics Analysis Of Omics Data For Biomarker Identification In Clinical Research Volume Ii
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Bioinformatics Analysis Of Omics Data For Biomarker Identification In Clinical Research Volume Ii
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Author : Lixin Cheng
language : en
Publisher: Frontiers Media SA
Release Date : 2023-09-05
Bioinformatics Analysis Of Omics Data For Biomarker Identification In Clinical Research Volume Ii written by Lixin Cheng and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-05 with Science categories.
This Research Topic is part of a series with, "Bioinformatics Analysis of Omics Data for Biomarker Identification in Clinical Research - Volume I" (https://www.frontiersin.org/research-topics/13816/bioinformatics-analysis-of-omics-data-for-biomarker-identification-in-clinical-research) The advances and the decreasing cost of omics data enable profiling of disease molecular features at different levels, including bulk tissues, animal models, and single cells. Large volumes of omics data enhance the ability to search for information for preclinical study and provide the opportunity to leverage them to understand disease mechanisms, identify molecular targets for therapy, and detect biomarkers of treatment response. Identification of stable, predictive, and interpretable biomarkers is a significant step towards personalized medicine and therapy. Omics data from genomics, transcriptomics, proteomics, epigenomics, metagenomics, and metabolomics help to determine biomarkers for prognostic and diagnostic applications. Preprocessing of omics data is of vital importance as it aims to eliminate systematic experimental bias and technical variation while preserving biological variation. Dozens of normalization methods for correcting experimental variation and bias in omics data have been developed during the last two decades, while only a few consider the skewness between different sample states, such as the extensive over-repression of genes in cancers. The choice of normalization methods determines the fate of identified biomarkers or molecular signatures. From these considerations, the development of appropriate normalization methods or preprocessing strategies may promote biomarker identification and facilitate clinical decision-making.
Bioinformatics Analysis Of Omics Data For Biomarker Identification In Clinical Research
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Author : Lixin Cheng
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-10
Bioinformatics Analysis Of Omics Data For Biomarker Identification In Clinical Research written by Lixin Cheng and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-10 with Science categories.
The Hidden World Of Protein Aggregation
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Author :
language : en
Publisher: Elsevier
Release Date : 2024-05-30
The Hidden World Of Protein Aggregation written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-30 with Science categories.
The Hidden World of Protein Aggregation, Volume 206 provides a comprehensive exploration of protein aggregation, uncovering the factors behind the formation of amorphous aggregates and ordered structures called amyloid fibrils. It delves into the advantages and disadvantages of protein aggregates, addressing topics such as cytotoxicity and disorders linked to misfolding. Specific chapters in this release include Protein Aggregation: An Overview, Pathways of Amyloid Fibril Formation and Aggregation, Factors Influencing Amyloid Fibril Formation, Morphological Features and Types of Aggregated Structures, Each big journey starts with a first step: Importance of Oligomerization, Liquid-Liquid Phase Separation as Triggering Factor of Fibril Formation, and more.Additional sections cover Experimental Techniques for Detecting and Evaluating the Amyloid Fibrils, Prediction of Protein Aggregation, Amyloid Fibril Cytotoxicity and Associated Disorders, Inhibitors of Amyloid Fibril Formation, Therapeutic Approaches in Proteinopathies, Functional Amyloids, Biotechnological Applications of Amyloid Fibrils, and The Hidden World of Protein Aggregation. - Provides an introduction to the folding of protein and associated conditions leading to aggregation and linked pathology - Discusses structural biology and computational methodologies for analysis of protein (mis)folding and aggregation - Describes functional amyloids and their biotechnological applications
Bioinformatics Tools And Web Server For Cancer Biomarker Development Volume Ii
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Author : Xiangqian Guo
language : en
Publisher: Frontiers Media SA
Release Date : 2022-06-16
Bioinformatics Tools And Web Server For Cancer Biomarker Development Volume Ii written by Xiangqian Guo and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-16 with Science categories.
Evolution Of Translational Omics
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Author : Institute of Medicine
language : en
Publisher: National Academies Press
Release Date : 2012-09-13
Evolution Of Translational Omics written by Institute of Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-09-13 with Science categories.
Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.
Artificial Intelligence Bioinformatics Development And Application Of Tools For Omics And Inter Omics Studies
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Author : Angelo Facchiano
language : en
Publisher: Frontiers Media SA
Release Date : 2020-06-18
Artificial Intelligence Bioinformatics Development And Application Of Tools For Omics And Inter Omics Studies written by Angelo Facchiano and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-18 with categories.
Bioinformatics Analysis Of Single Cell Sequencing Data And Applications In Precision Medicine
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Author : Jialiang Yang
language : en
Publisher: Frontiers Media SA
Release Date : 2020-02-27
Bioinformatics Analysis Of Single Cell Sequencing Data And Applications In Precision Medicine written by Jialiang Yang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-27 with categories.
Omics Data Integration Towards Mining Of Phenotype Specific Biomarkers In Cancer Volume Ii
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Author : Liang Cheng
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-29
Omics Data Integration Towards Mining Of Phenotype Specific Biomarkers In Cancer Volume Ii written by Liang Cheng and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-29 with Science categories.
Exploring Noninvasive Disease Biomarkers With Urinary Omics Analysis
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Author : Arup Giri
language : en
Publisher: Academic Press
Release Date : 2025-05-30
Exploring Noninvasive Disease Biomarkers With Urinary Omics Analysis written by Arup Giri and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-05-30 with Science categories.
Exploring Noninvasive Disease Biomarkers with Urinary Omics Analysis offers a transformative journey into the world of non-invasive diagnostics. This comprehensive volume delves into the molecular foundations of urinary biomarkers, illuminating the intricate signatures that indicate various pathological conditions and elucidating the mechanisms behind their release into urine. Readers will gain invaluable insights into cutting-edge analytical technologies, methodologies, and data integration techniques essential for biomarker discovery. From genomic approaches to transcriptomics, proteomics, and metabolomics, each chapter provides a thorough examination of the latest advancements, accompanied by practical guidance and case studies showcasing their clinical applications across diverse health conditions.In addition to the foundational knowledge, the book highlights the clinical applications of urinary omics in diagnosing renal disorders, metabolic syndromes, and infectious diseases. It equips professionals and students with the tools needed to navigate the complexities of urinary omics, revolutionize personalized medicine, and advance transformative healthcare solutions. The practical guidance and case studies included in the book make it an invaluable resource for those looking to implement these advanced diagnostic techniques in clinical settings. - Provides a comprehensive exploration of urinary omics, including an in-depth analysis of genomics, proteomics, and metabolomics - Highlights advances in analytical technologies for analyzing urinary biomarkers, offering a comprehensive overview - Elucidates clinical application across health conditions, highlighting a holistic examination of urine's potential as a diagnostic reservoir
Bioinformatics For Diagnosis Prognosis And Treatment Of Complex Diseases
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Author : Bairong Shen
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-25
Bioinformatics For Diagnosis Prognosis And Treatment Of Complex Diseases written by Bairong Shen and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-25 with Science categories.
The book introduces the bioinformatics tools, databases and strategies for the translational research, focuses on the biomarker discovery based on integrative data analysis and systems biological network reconstruction. With the coming of personal genomics era, the biomedical data will be accumulated fast and then it will become reality for the personalized and accurate diagnosis, prognosis and treatment of complex diseases. The book covers both state of the art of bioinformatics methodologies and the examples for the identification of simple or network biomarkers. In addition, bioinformatics software tools and scripts are provided to the practical application in the study of complex diseases. The present state, the future challenges and perspectives were discussed. The book is written for biologists, biomedical informatics scientists and clinicians, etc. Dr. Bairong Shen is Professor and Director of Center for Systems Biology, Soochow University; he is also Director of Taicang Center for Translational Bioinformatics.