Biological Implications Of Protein Nucleic Acid Interactions
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Biological Implications Of Protein Nucleic Acid Interactions
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Author : Jacek Augustyniak
language : en
Publisher: Elsevier Science & Technology
Release Date : 1980
Biological Implications Of Protein Nucleic Acid Interactions written by Jacek Augustyniak and has been published by Elsevier Science & Technology this book supported file pdf, txt, epub, kindle and other format this book has been release on 1980 with Science categories.
Protein Nucleic Acid Interactions
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Author : Phoebe A. Rice
language : en
Publisher: Royal Society of Chemistry
Release Date : 2008-05-22
Protein Nucleic Acid Interactions written by Phoebe A. Rice and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-05-22 with Science categories.
This book provides both in-depth background and up-to-date information in this area. The chapters are organized by general themes and principles, written by experts who illustrate topics with current findings. Topics covered include: - the role of ions and hydration in protein-nucleic acid interactions - transcription factors and combinatorial specificity - indirect readout of DNA sequence - single-stranded nucleic acid binding proteins - nucleic acid junctions and proteins, - RNA protein recognition - recognition of DNA damage. It will be a key reference for both advanced students and established scientists wishing to broaden their horizons.
Protein Nucleic Acid Interaction
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Author : Wolfram Saenger
language : en
Publisher:
Release Date : 1989
Protein Nucleic Acid Interaction written by Wolfram Saenger and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Science categories.
This volume contains a series of essays which describe a range of problems in the field of nucleic-acid interactions, investigated by a variety of techniques. An introductory chapter on DNA-protein interactions in the regulation of gene expression is followed by papers on selected model systems.
Impacts Of Molecular Structure On Nucleic Acid Protein Interactions
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Author : Vaclav Brazda
language : en
Publisher:
Release Date : 2023
Impacts Of Molecular Structure On Nucleic Acid Protein Interactions written by Vaclav Brazda and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with Molecular structure categories.
Interactions between nucleic acids and proteins are essential requirements for the viability of cellular life because they are indispensable for many basic biological processes. DNA is typically presented as a specific double-stranded helical structure, but nucleic acids have great structural flexibility. Current knowledge demonstrates that the structural conformations of nucleic acids play critical roles in protein-DNA interactions. This book presents a collection of research findings published in the Special Issue of the International Journal of Molecular Sciences, titled “Impacts of Molecular Structure on Nucleic Acid-Protein Interactions”.The breadth of research findings reported here demonstrates that the structural flexibility of nucleic acids plays critical roles in their interactions with proteins, with important implications across a range of human diseases, including cancer and some infectious diseases.Prof. Richard BowaterUniversity of East Anglia, Norwich, United KingdomProf. Václav BrázdaInstitute of Biophysics of the Czech Academy of Sciences, Brno, Czech Republic.
The Biology Of Nonspecific Dna Protein Interactions
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Author : Arnold Revzin
language : en
Publisher: CRC Press
Release Date : 1990-08-27
The Biology Of Nonspecific Dna Protein Interactions written by Arnold Revzin and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990-08-27 with Medical categories.
This important publication addresses the interactions of proteins with nonspecific binding sites on DNA as they play critical roles in fundamental cellular processes such as transcription, DNA replication, and recombination. The book presents current reviews of the biochemistry of representative nonspecific DNA-protein systems, and of their physiological functions. It includes chapters on the techniques used to characterize the complexes, on their thermodynamic properties, and on the role of nonspecific binding as gene regulatory proteins search for specific target sites on the chromosome. Systems considered include the effects of nonspecific binding in regulation of the lactose operon of Escherichia coli, the T4 bacteriophage gene 32 protein, the E. coli single strand binding (SSB) protein and recA protein, eukaryotic SSB's and histone-DNA complexes. The book presents those proteins displaying multiple modes of DNA binding as participants in more than one cellular process. This monograph combines rigorous descriptions of new findings for these important systems with provocative interpretations of the biological significance of the results. It is of great value to researchers ranging from graduate students to senior scientists in the areas of biochemistry, microbiology and molecular/cell biology.
Structural Studies Of Protein Nucleic Acid Interaction
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Author : Thomas A. Steitz
language : en
Publisher: CUP Archive
Release Date : 1993-09-16
Structural Studies Of Protein Nucleic Acid Interaction written by Thomas A. Steitz and has been published by CUP Archive this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-09-16 with Science categories.
In this 1993 text, Nobel Prize winner Professor Steitz reviews the wide-ranging research in structural studies of DNA-binding proteins and their complexes with DNA. The author clearly and concisely describes the uses of techniques in molecular genetics, DNA synthesis, protein crystallography and nuclear magnetic response.
Dna Protein Interactions
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Author : G. Geoff Kneale
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-02
Dna Protein Interactions written by G. Geoff Kneale and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-02 with Science categories.
The study of protein-nucleic acid interactions is currently one of the most rapidly growing areas of molecular biology. DNA binding proteins are at the very heart of the regulation and control of gene expression, replication, and recombination: Enzymes that recognize and either modify or cleave specific DNA sequences are equally important to the cell. Some of the techniques reported in this volume can be used to identify previously unknown DNA binding proteins from crude cell extracts. Virtually all are capable of giving direct information on the molecular basis of the interaction—the location of the DNA binding site; the strength and specificity of binding; the identities of individual groups on specific bases involved in binding; the specific amino acid residues of the protein that interact with the DNA; or the effects of protein binding on gross conformation and local structure of DNA. The recognition of DNA sequences by proteins is a complex phenomenon, involving specific hydrogen bonding contacts to the DNA bases ("direct readout") and/or interactions with the sugar-phos phate backbone ("indirect readout"). The latter interactions can also be highly specific because of sequence-dependent conformational changes in the DNA. In addition, intercalation of planar aromatic amino acid side-chains between the DNA bases can occur, most notably with single-stranded DNA binding proteins. Furthermore, when bound, many DNA binding proteins induce drastic structural changes in the DNA as an integral part of their function.
Protein Nucleic Acid Interactions
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Author : Phoebe A. Rice
language : en
Publisher:
Release Date : 2008
Protein Nucleic Acid Interactions written by Phoebe A. Rice and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.
A Laboratory Guide To In Vitro Studies Of Protein Dna Interactions
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Author : Jost
language : en
Publisher: Birkhäuser
Release Date : 2013-03-13
A Laboratory Guide To In Vitro Studies Of Protein Dna Interactions written by Jost and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-13 with Science categories.
A Safety Considerations Many techniques described here involve a number of hazards, such as high electrical current and voltage, radioactivity and highly toxic chemicals. It is absolutely essential that the instructions of equipment manufacturers be followed, and that particular attention be paid to the local and federal safety regulations. B Introduction The expression of prokaryotic and eukaryotic genes has been shown most often to be regulated at the level of mRNA synthesis. Thanks to the rapid development of methods for dissecting DNA sequences, cis-acting regulatory elements such as promoters and enhancers have been recognised. More recently, the widely expressed intuition that discrete sequences within these elements constitute binding sites for sequence-specific binding proteins has been confirmed, especially through the use of "footprinting" assays (for examples, Galas and Schmitz, 1978). This and similar assays have already resulted in the recognition, isolation and analysis of DNA-bind ing proteins for several genes. Excellent reviews exist of the structural studies on these transcription regulatory proteins and related DNA elements (for example, Glover, 1989 and Johnson and McKnight, 1989), to which the reader is referred for detailed information. To set the scene for applications of the techniques described in this volume, only the barest outline of previous studies is presented here. Protein-DNA interactions are dependent on very specific tertiary configurations of the binding protein which allow the closest contact with the DNA helix.
Dna Protein Interactions
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Author : A. Travers
language : en
Publisher: Springer Science & Business Media
Release Date : 1993-04-30
Dna Protein Interactions written by A. Travers and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-04-30 with Medical categories.
The binding of proteins to DNA and the manipulation of DNA by proteins are crucial aspects of the biological role of DNA in the living cell. This book provides a comprehensive and lucid discussion of the molecular interactions involved.