Blood Junction
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Blood Junction
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Author : Caroline Carver
language : en
Publisher: Mysterious Press
Release Date : 2009-06-27
Blood Junction written by Caroline Carver and has been published by Mysterious Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-06-27 with Fiction categories.
A Mystery Guild Featured Alternate In a stunning debut novel that won her the prestigious Crime Writers' Association New Writer's Award, Caroline Carver presents a gutwrenching, provocative adventure thriller set against the eerie, exotic backdrop of the Australian Outback--where a woman's search for the truth about horrific crimes will bring her to the crossroads of her life.
Blood Junction
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Author : CJ Carver
language : en
Publisher: Bonnier Publishing Fiction Ltd.
Release Date : 2015-10-22
Blood Junction written by CJ Carver and has been published by Bonnier Publishing Fiction Ltd. this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-10-22 with Fiction categories.
Winner of the CWA Debut Dagger, CJ Carver's debut thriller is a dark and gripping story set in a town with a pitch-dark legacy of blood. "A nightmarish adventure of close calls and surprising escapes . . . An exceptional first mystery" Publishers Weekly Journalist India Kane's trip to the Australian outback takes a horrifying turn when she arrives in the town of Cooinda to find that her best friend Lauren is missing. Seemingly no one knows what has happened to her, but it's not long before India finds herself arrested for a double murder that she didn't commit, caught up in the dark past of a small town hiding a devastating truth - one that could destroy a family, a friendship, and a nation. Set in the unforgiving landscape of the Australian outback, Blood Junction won the CWA's Debut Dagger and is CJ Carver's powerful and compulsive thriller about a woman on the run from a brutal killer, as well as from her own past.
The Tight Junction And Its Proteins More Than Just A Barrier
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Author : Michael Fromm
language : en
Publisher: MDPI
Release Date : 2020-11-20
The Tight Junction And Its Proteins More Than Just A Barrier written by Michael Fromm and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-20 with Science categories.
For a long time, the tight junction (TJ) was known to form and regulate the paracellular barrier between epithelia and endothelial cell sheets. Starting shortly after the discovery of the proteins forming the TJ—mainly the two families of claudins and TAMPs—several other functions have been discovered, a striking one being the surprising finding that some claudins form paracellular channels for small ions and/or water. This Special Issue includes 43 articles covering numerous dedicated topics including pathogens affecting the TJ barrier, TJ regulation via immune cells, the TJ as a therapeutic target, TJ and cell polarity, function and regulation by proteins of the tricellular TJ, TJ as a regulator of cellular processes, organ- and tissue-specific functions, TJ as sensors and reacting to environmental conditions, and last but not least, TJ proteins and cancer.
Molecular Structure And Function Of The Tight Junction
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Author : Michael Fromm
language : en
Publisher: John Wiley & Sons
Release Date : 2009-06-22
Molecular Structure And Function Of The Tight Junction written by Michael Fromm and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-06-22 with Medical categories.
Aim of this volume is to clarify the relationship between molecular structure and function of tight junction proteins, as well as their regulation and their role in diseases. Current research may form a basis for future diagnostic and therapeutic approaches to diseases which seem to have not much in common but are characterized by defects of organ barriers, like Crohn's disease, renal hypertension, inner ear deafness, and cancerous diseases. Topics include the functions of distinct tight junction proteins as barrier or channel formers for solutes and water, characteristics of the tight junction in inflammatory bowel diseases, posttranslational modifications of tight junction proteins, the relation between renal tight junction proteins and blood pressure control, and the molecular structure of claudin-claudin interactions NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.
Collected Papers
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Author : University College, London. Dept. of Physiology and Biochemistry
language : en
Publisher:
Release Date : 1894
Collected Papers written by University College, London. Dept. of Physiology and Biochemistry and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1894 with categories.
Experimental And Clinical Reconstructive Microsurgery
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Author : Masamichi Usui
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Experimental And Clinical Reconstructive Microsurgery written by Masamichi Usui and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Since the first successful digit replantation in Japan in 1965, the field of microvascular surgery has rapidly progressed throughout Japan and the world. Experimental and Clinical Reconstructive Microsurgery draws on the experience of a large number of experts in the areas of experimental microsurgery, limb and digit replantation, and composite tissue transplantation. The result is an extensive monograph covering the history and future prospects of microsurgery, essential microsurgical techniques for laboratory research, and the fundamental methods of harvesting tissues and their grafting techniques. Because the field of microsurgery includes a broad range of clinical disciplines, this book is a valuable resource to all orthopedic, traumatic, and plastic surgeons with an interest in microsurgery.
Blood Brain Barrier In Drug Discovery
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Author : Li Di
language : en
Publisher: John Wiley & Sons
Release Date : 2014-12-29
Blood Brain Barrier In Drug Discovery written by Li Di and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-29 with Medical categories.
Focused on central nervous system (CNS) drug discovery efforts,this book educates drug researchers about the blood-brain barrier(BBB) so they can affect important improvements in one of the mostsignificant – and most challenging – areas of drugdiscovery. • Written by world experts to provide practicalsolutions to increase brain penetration or minimize CNSside-effects • Reviews state-of-the-art in silico, in vitro, and invivo tools to assess brain penetration and advanced CNS drugdelivery strategies • Covers BBB physiology, medicinal chemistry designprinciples, free drug hypothesis for the BBB, and transportmechanisms including passive diffusion, uptake/efflux transporters,and receptor-mediated processes • Highlights the advances in modelling BBBpharmacokinetics and dynamics relationships (PK/PD) andphysiologically-based pharmacokinetics (PBPK) • Discusses case studies of successful CNS and non-CNSdrugs, lessons learned and paths to the market
Connexins The Gap Junction Proteins
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Author : Dr. Mahboob Ul Hussain
language : en
Publisher: Springer
Release Date : 2014-08-06
Connexins The Gap Junction Proteins written by Dr. Mahboob Ul Hussain and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-08-06 with Science categories.
Gap-junction proteins, connexins are important cellular entities that regulate various facets of cellular physiology. The connexins constitute large family of proteins. The present book provides basic overview about various aspects of connexin proteins. The book has tried to touch the fundamental aspects of connexin family. This book will be useful to broad audience that includes under-and post-graduate students, research scholars, clinicians, etc. The reference section at the end of the book will be helpful for those who seek to know deeper details about this family of proteins.
A Laboratory Guide To The Tight Junction
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Author : Jianghui Hou
language : en
Publisher: Academic Press
Release Date : 2020-04-24
A Laboratory Guide To The Tight Junction written by Jianghui Hou and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-24 with Science categories.
A Laboratory Guide to the Tight Junction offers broad coverage of the unique methods required to investigate its characteristics. The methods are described in detail, including its biochemical and biophysical principles, step-by-step process, data analysis, troubleshooting, and optimization. The coverage includes various cell, tissue, and animal models. Chapter 1 provides the foundations of cell biology of tight junction. Chapter 2 covers the Biochemical approaches for paracellular channels and is followed by chapter 3 providing the Biophysical approaches. Chapter 4 describes and discusses Histological approaches for tissue fixation and preparation. Chapter 5 discusses Light microscopy, while chapter 6 presents Electron microscopic approaches. Chapter 7 covers Transgenic manipulation in cell cultures, including DNA and siRNA, Mutagenesis, and viral infection. Chapter 8 covers transgenic manipulation in mice, including: Knockout, Knockin, siRNA knockdown, GFP/LacZ reporter, and overexpression. The final chapter discusses the future developments of new approaches for tight junction research. Researchers and advanced students in bioscience working on topics of cell junction, ion channel and membrane protein will benefit from the described methods. Clinicians and pathologists interested in tissue barrier diseases will also benefit from the biochemical and biophysical characterization of tight junctions in organ systems, and their connection to human diseases. Provides consistent and detailed research methods Covers various cell, tissue and animal models Includes step-by-step guidance from beginner to sophisticated levels
Handbook Of Nutrition Diet And The Eye
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Author : Victor R Preedy
language : en
Publisher: Academic Press
Release Date : 2014-04-01
Handbook Of Nutrition Diet And The Eye written by Victor R Preedy and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-04-01 with Technology & Engineering categories.
The Handbook of Nutrition, Diet and the Eye is the first book to thoroughly address common features and etiological factors in how dietary and nutritional factors affect the eye. The ocular system is perhaps one of the least studied organs in diet and nutrition, yet the consequences of vision loss can be devastating. One of the biggest contributors to complete vision loss in the western hemisphere is diabetes, precipitated by metabolic syndrome. In some developing countries, micronutrient deficiencies are major contributory factors to impaired vision. However, there are a range of ocular defects that have either their origin in nutritional deficiencies or excess or have been shown to respond favorably to nutritional components. The eye from the cornea to the retina may be affected by nutritional components. Effects may be physiological or molecular. This book represents essential reading for nutritionists, dietitians, optometrists, ophthalmologists, opticians, endocrinologists, and other clinicians and researchers interested in eye health and vision in general. Saves clinicians and researchers time in quickly accessing the very latest details on a broad range of nutrition, ocular health, and disease issues Provides a common language for nutritionists, nutrition researchers, optometrists, and ophthalmologists to discuss how dietary and nutritional factors, and related diseases and syndromes affect the eye Preclinical, clinical, and population studies will help nutritionists, dieticians, and clinicians map out key areas for research and further clinical recommendations