The Tight Junction And Its Proteins More Than Just A Barrier
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The Tight Junction And Its Proteins More Than Just A Barrier
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Author : Michael Fromm
language : en
Publisher: MDPI
Release Date : 2020-11-20
The Tight Junction And Its Proteins More Than Just A Barrier written by Michael Fromm and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-20 with Science categories.
For a long time, the tight junction (TJ) was known to form and regulate the paracellular barrier between epithelia and endothelial cell sheets. Starting shortly after the discovery of the proteins forming the TJ—mainly the two families of claudins and TAMPs—several other functions have been discovered, a striking one being the surprising finding that some claudins form paracellular channels for small ions and/or water. This Special Issue includes 43 articles covering numerous dedicated topics including pathogens affecting the TJ barrier, TJ regulation via immune cells, the TJ as a therapeutic target, TJ and cell polarity, function and regulation by proteins of the tricellular TJ, TJ as a regulator of cellular processes, organ- and tissue-specific functions, TJ as sensors and reacting to environmental conditions, and last but not least, TJ proteins and cancer.
Barriers And Channels Formed By Tight Junction Proteins Ii Volume 1258
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Author : Michael Fromm
language : en
Publisher: Wiley-Blackwell
Release Date : 2012-07-24
Barriers And Channels Formed By Tight Junction Proteins Ii Volume 1258 written by Michael Fromm and has been published by Wiley-Blackwell this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-07-24 with Science categories.
Tight junction proteins connect epithelial and endothelial cells and, importantly, form selective barriers and channels for paracellular transportation. Two types of tight junction proteins—the claudin family (claudins-1 to -27) and the TAMP family (occludin, Marvel-D2, and tricellulin)—can be distinguished molecularly and functionally. Recent work has focused on delineating the functional significance of differences in selective permeability, for example, by examining the regulatory mechanisms of tight junctions. This work is of great clinical importance as many inflammatory or infectious diseases are characterized by increased permeability and the manipulation of tight junctions presents a new horizon in the development of novel therapeutics. The volume Barriers and Channels Formed by Tight Junction Proteins II provides a detailed look at the recent advances in our understanding of tight junction regulation and dysregulation. The papers included focus on three major themes: inflammation and gastrointestinal function; epithelial transport, barrier modulation, and food components; and tight junctions in intestinal and renal epithelia. NOTE: Annals volumes are available for sale as individual books or as a journal. For more information on instutional journal subscriptions, please visit http://ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.111/(ISSN)1749-6632 ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information on becoming a member.
A Laboratory Guide To The Tight Junction
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Author : Jianghui Hou
language : en
Publisher: Academic Press
Release Date : 2020-04-24
A Laboratory Guide To The Tight Junction written by Jianghui Hou and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-24 with Science categories.
A Laboratory Guide to the Tight Junction offers broad coverage of the unique methods required to investigate its characteristics. The methods are described in detail, including its biochemical and biophysical principles, step-by-step process, data analysis, troubleshooting, and optimization. The coverage includes various cell, tissue, and animal models. Chapter 1 provides the foundations of cell biology of tight junction. Chapter 2 covers the Biochemical approaches for paracellular channels and is followed by chapter 3 providing the Biophysical approaches. Chapter 4 describes and discusses Histological approaches for tissue fixation and preparation. Chapter 5 discusses Light microscopy, while chapter 6 presents Electron microscopic approaches. Chapter 7 covers Transgenic manipulation in cell cultures, including DNA and siRNA, Mutagenesis, and viral infection. Chapter 8 covers transgenic manipulation in mice, including: Knockout, Knockin, siRNA knockdown, GFP/LacZ reporter, and overexpression. The final chapter discusses the future developments of new approaches for tight junction research. Researchers and advanced students in bioscience working on topics of cell junction, ion channel and membrane protein will benefit from the described methods. Clinicians and pathologists interested in tissue barrier diseases will also benefit from the biochemical and biophysical characterization of tight junctions in organ systems, and their connection to human diseases. Provides consistent and detailed research methods Covers various cell, tissue and animal models Includes step-by-step guidance from beginner to sophisticated levels
Barriers And Channels Formed By Tight Junction Proteins
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Author :
language : en
Publisher:
Release Date : 2011
Barriers And Channels Formed By Tight Junction Proteins written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.
Tight Junctions
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Author : Marcelino Cereijido
language : en
Publisher: CRC Press
Release Date : 2001-06-26
Tight Junctions written by Marcelino Cereijido and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-06-26 with Science categories.
As the first detailed overview of the subject, Tight Junctions brought together diverse perspectives from leading investigators to provide a multidisciplinary overview of the field. Since its publication in 1992, there has been an explosion of information about tight junctions, particularly in the area of molecular structure, cell and molecular biology, genetics and physiology. The field has advanced so fast and so far that it influences many areas of biology and now has practical implications for pharmacology of drug delivery and understanding a wide range of diseases altering epithelial permeability.
Molecular Structure And Function Of The Tight Junction
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Author : Michael Fromm
language : en
Publisher: John Wiley & Sons
Release Date : 2009-06-22
Molecular Structure And Function Of The Tight Junction written by Michael Fromm and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-06-22 with Medical categories.
Aim of this volume is to clarify the relationship between molecular structure and function of tight junction proteins, as well as their regulation and their role in diseases. Current research may form a basis for future diagnostic and therapeutic approaches to diseases which seem to have not much in common but are characterized by defects of organ barriers, like Crohn's disease, renal hypertension, inner ear deafness, and cancerous diseases. Topics include the functions of distinct tight junction proteins as barrier or channel formers for solutes and water, characteristics of the tight junction in inflammatory bowel diseases, posttranslational modifications of tight junction proteins, the relation between renal tight junction proteins and blood pressure control, and the molecular structure of claudin-claudin interactions NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.
Tight Junctions
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Author : Lorenza González-Mariscal
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-02-26
Tight Junctions written by Lorenza González-Mariscal and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-02-26 with Science categories.
This book provides state-of-the-art insight into Tight Junctions (TJs), the intersection of epithelial and endothelial cells in various tissues. Opening with an analysis of the evolutionary development of a transporting epithelium in early metazoans, the book describes current understanding of TJ structure and function information, including evidence supporting the presence of ion channels within TJs. Also deals with TJs of central nervous system myelin and at the blood brain barrier.
Molecular Biology Of The Cell
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Author : Bruce Alberts
language : en
Publisher:
Release Date : 2002
Molecular Biology Of The Cell written by Bruce Alberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytology categories.
The Paracellular Channel
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Author : Jianghui Hou
language : en
Publisher: Academic Press
Release Date : 2018-06-09
The Paracellular Channel written by Jianghui Hou and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-09 with Science categories.
The Paracellular Channel: Biology, Physiology and Disease serves as the first volume to offer a cohesive and unifying picture of the critical functions of paracellular channels (tight junctions) in different tissues. This new class of ion channel utilizes a completely different mechanism to create ion passage pathways across the cell junction. This volume outlines common principles that govern the organization and regulation of these diverse cellular structures, describes the methodology of study, and highlights the pathophysiologic consequence of abnormal structure and functions of the paracellular channels in human diseases. Coverage includes biochemical, biophysical, structural, physiologic analyses of the paracellular channel, and new technologies for recording and characterization.
Current Topics In Membranes
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Author :
language : en
Publisher: Academic Press
Release Date : 1992-01-08
Current Topics In Membranes written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-01-08 with Science categories.
Current Topics in Membranes